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Keywords: pyruvate dehydrogenase complex
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Articles

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly

Swetha Vijayakrishnan, Philip Callow, Margaret A. Nutley, Donna P. McGow, David Gilbert, Peter Kropholler, Alan Cooper, Olwyn Byron, J. Gordon Lindsay
Journal: Biochemical Journal
Biochem J (2011) 437 (3): 565–574.
https://doi.org/10.1042/BJ20101784
Published: 13 July 2011
...Swetha Vijayakrishnan; Philip Callow; Margaret A. Nutley; Donna P. McGow; David Gilbert; Peter Kropholler; Alan Cooper; Olwyn Byron; J. Gordon Lindsay Crucial to glucose homoeostasis in humans, the hPDC (human pyruvate dehydrogenase complex) is a massive molecular machine comprising multiple copies...
View article titled, Variation in the organization and subunit composition of the mammalian <span class="search-highlight">pyruvate</span> <span class="search-highlight">dehydrogenase</span> <span class="search-highlight">complex</span> E2&#x2F;E3BP core assembly
Open the PDF for Variation in the organization and subunit composition of the mammalian <span class="search-highlight">pyruvate</span> <span class="search-highlight">dehydrogenase</span> <span class="search-highlight">complex</span> E2/E3BP core assembly in another window
Includes: Supplementary data
Articles

Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet

Byounghoon Hwang, Nam Ho Jeoung, Robert A. Harris
Journal: Biochemical Journal
Biochem J (2009) 423 (2): 243–252.
https://doi.org/10.1042/BJ20090390
Published: 25 September 2009
... of the pyruvate dehydrogenase complex by phosphorylation will inhibit fatty acid oxidation, promote ectopic fat accumulation and worsen insulin sensitivity. This was examined by feeding wild-type and PDHK4 knockout mice a high saturated fat diet for 8 months. Fasting blood glucose levels increased gradually...
View article titled, Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet
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Articles

Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins

Marina A. Schwab, Sven W. Sauer, Jürgen G. Okun, Leo G. J. Nijtmans, Richard J. T. Rodenburg, Lambert P. van den Heuvel, Stefan Dröse, Ulrich Brandt, Georg F. Hoffmann, Henk Ter Laak, Stefan Kölker, Jan A. M. Smeitink
Journal: Biochemical Journal
Biochem J (2006) 398 (1): 107–112.
https://doi.org/10.1042/BJ20060221
Published: 27 July 2006
... inhibition of PDHc (pyruvate dehydrogenase complex) by propionyl-CoA in purified porcine enzyme and in submitochondrial particles from bovine heart being in the same range as the inhibition induced by acetyl-CoA, the physiological product and known inhibitor of PDHc. Evaluation of similar monocarboxylic CoA...
View article titled, Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins
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Articles

Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation

Nam Ho Jeoung, Pengfei Wu, Mandar A. Joshi, Jerzy Jaskiewicz, Cheryl B. Bock, Anna A. Depaoli-Roach, Robert A. Harris
Journal: Biochemical Journal
Biochem J (2006) 397 (3): 417–425.
https://doi.org/10.1042/BJ20060125
Published: 13 July 2006
...Nam Ho Jeoung; Pengfei Wu; Mandar A. Joshi; Jerzy Jaskiewicz; Cheryl B. Bock; Anna A. Depaoli-Roach; Robert A. Harris The PDC (pyruvate dehydrogenase complex) is strongly inhibited by phosphorylation during starvation to conserve substrates for gluconeogenesis. The role of PDHK4 (pyruvate...
View article titled, Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation
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Articles

Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor α (PPARα)

Mark J. HOLNESS, Karen BULMER, Geoffrey F. GIBBONS, Mary C. SUGDEN
Journal: Biochemical Journal
Biochem J (2002) 366 (3): 839–846.
https://doi.org/10.1042/bj20020754
Published: 15 September 2002
...Mark J. HOLNESS; Karen BULMER; Geoffrey F. GIBBONS; Mary C. SUGDEN In insulin deficiency, increased lipid delivery and oxidation suppress skeletal-muscle glucose oxidation by inhibiting pyruvate dehydrogenase complex (PDC) activity via enhanced protein expression of pyruvate dehydrogenase kinase...
View article titled, Up-regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) protein expression in oxidative skeletal muscle does not require the obligatory participation of peroxisome-proliferator-activated receptor α (PPARα)
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Articles

Evaluation of the role of peroxisome-proliferator-activated receptor α in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism

Mark J. HOLNESS, Nicholas D. SMITH, Karen BULMER, Teresa HOPKINS, Geoffrey F. GIBBONS, Mary C. SUGDEN
Journal: Biochemical Journal
Biochem J (2002) 364 (3): 687–694.
https://doi.org/10.1042/bj20011841
Published: 15 June 2002
...Mark J. HOLNESS; Nicholas D. SMITH; Karen BULMER; Teresa HOPKINS; Geoffrey F. GIBBONS; Mary C. SUGDEN Inactivation of cardiac pyruvate dehydrogenase complex (PDC) after prolonged starvation and in response to hyperthyroidism is associated with enhanced protein expression of pyruvate dehydrogenase...
View article titled, Evaluation of the role of peroxisome-proliferator-activated receptor α in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism
Open the PDF for Evaluation of the role of peroxisome-proliferator-activated receptor α in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism in another window
Articles

Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply

Mary C. SUGDEN, Maria L. LANGDOWN, Robert A. HARRIS, Mark J. HOLNESS
Journal: Biochemical Journal
Biochem J (2000) 352 (3): 731–738.
https://doi.org/10.1042/bj3520731
Published: 08 December 2000
... in which requires factors in addition to a change in lipid supply. 1 To whom correspondence should be addressed (e-mail [email protected] ). 17 8 2000 20 9 2000 9 10 2000 The Biochemical Society, London © 2000 2000 pyruvate dehydrogenase complex hyperthyroidism...
View article titled, Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply
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Articles

Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression

Mary C. SUGDEN, Alexandra KRAUS, Robert A. HARRIS, Mark J. HOLNESS
Journal: Biochemical Journal
Biochem J (2000) 346 (3): 651–657.
https://doi.org/10.1042/bj3460651
Published: 07 March 2000
... by re- INTRODUCTION Regulation of the activity of the pyruvate dehydrogenase complex (PDC) is an important component of the regulation of glucose homeostasis. Activation of PDC promotes glucose disposal, whereas suppression of PDC activity is crucial to glucose conservation in prolonged starvation, when...
View article titled, Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression
Open the PDF for Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression in another window