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Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity

Shawn Lu Wen Tan, Hui Min Tan, Erez Israeli, Indah Fatihah, Vignesh Ramachandran, Shamsia Bte Ali, Shane Jun An Goh, Jillian Wee, Alicia Qian Ler Tan, Wai Leong Tam, Weiping Han

Biochem J (2023) 480 (24): 2045–2058.

https://doi.org/10.1042/BCJ20230317

Published: 18 December 2023

... to Erastin but instead appeared to correlate with increased resistance to the SLC7A11 inhibitor. cancer therapeutic hepatocellular carcinoma reactive oxygen species selenocystine SLC7A11 To further interrogate the role of SLC7A11 in modulating sensitivity to l -selenocystine, we generated...

View article titled, Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity

Includes: Supplementary data

Articles

Calcium signalling components underlying NPK homeostasis: potential avenues for exploration

In Collection

Plants and climate change: the role of plants in achieving net zero

Sonam Pahuja, Malathi Bheri, Diksha Bisht, Girdhar K. Pandey

Biochem J (2023) 480 (13): 1015–1034.

https://doi.org/10.1042/BCJ20230156

Published: 07 July 2023

... involved in their respective signalling and homeostasis. calcium signalling homeostasis nitrogen phosphorus potassium reactive oxygen species N, being one of the most essential macronutrients, is involved in the biogenesis of amino acids, nucleic acids and other nitrogen-containing...

View article titled, Calcium signalling components underlying NPK homeostasis: potential avenues for exploration

Articles

Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis

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Plants and climate change: the role of plants in achieving net zero

Lokesh K. Saini, Manisha Sharma, Barkha Ravi, Soma Ghosh, Sonam Pahuja, Nidhi Singh, Girdhar K. Pandey

Biochem J (2023) 480 (9): 555–571.

https://doi.org/10.1042/BCJ20230026

Published: 28 April 2023

... by Portland Press Limited on behalf of the Biochemical Society 2023 Armadillo protein E3 ligase methyl voilogen oxidative stress plant U-box protein reactive oxygen species Plants are constantly exposed to unfavorable environmental conditions such as abiotic and biotic stress conditions...

View article titled, Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis

Articles

Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Edwin T. Gibbs, II, Chad A. Lerner, Mark A. Watson, Hoi-Shan Wong, Akos A. Gerencser, Martin D. Brand

Biochem J (2023) 480 (5): 363–384.

https://doi.org/10.1042/BCJ20220611

Published: 15 March 2023

.... and Roessler , M.M. ( 2016 ) Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I . Biochim. Biophys. Acta 1857 , 872 – 883 10.1016/j.bbabio.2015.12.009 8 Robb , E.L. , Hall , A.R. , Prime , T.A. , Eaton , S. , Szibor , M...

View article titled, Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Articles

Oxidative signalling in seed germination and early seedling growth: an emerging role for ROS trafficking and inter-organelle communication

Christophe Bailly, Livia Merendino

Biochem J (2021) 478 (10): 1977–1984.

https://doi.org/10.1042/BCJ20200934

Published: 28 May 2021

..., which are regulated by plant hormones, have been shown to depend on reactive oxygen species metabolism and to be related to mitochondrial retrograde signalling. Here we review the recent outcomes in this field of research and highlight the emerging role of ROS communication between organelles and cell...

View article titled, Oxidative signalling in seed germination and early seedling growth: an emerging role for ROS trafficking and inter-organelle communication

Articles

The signalling role of ROS in the regulation of seed germination and dormancy

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019 , Seeds

Christophe Bailly

Biochem J (2019) 476 (20): 3019–3032.

https://doi.org/10.1042/BCJ20190159

Published: 28 October 2019

...Christophe Bailly Reactive oxygen species (ROS) are versatile compounds which can have toxic or signalling effects in a wide range living organisms, including seeds. They have been reported to play a pivotal role in the regulation of seed germination and dormancy but their mechanisms of action...

View article titled, The signalling role of ROS in the regulation of seed germination and dormancy

Articles

Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets

Pravin Patel, Meghna U. Naik, Kalyan Golla, Noor F. Shaik, Ulhas P. Naik

Biochem J (2019) 476 (19): 2835–2850.

https://doi.org/10.1042/BCJ20190410

Published: 11 October 2019

... calcium CIB1 p38 platelet adhesion and activation reactive oxygen species Mitogen-activated protein kinases (MAPK) are a family of serine/threonine protein kinases that are central mediators of many cellular functions from proliferation to apoptosis. MAPK are activated by a kinase signaling...

View article titled, Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets

Includes: Supplementary data

Articles

New tools for an old question: dependence of ATP and bicarbonate for branched-chain keto acids oxidation

Henver S. Brunetta, Graham P. Holloway

Biochem J (2019) 476 (15): 2235–2237.

https://doi.org/10.1042/BCJ20190368

Published: 15 August 2019

... bioenergetics mitochondria reactive oxygen species The work performed by Goldberg et al. [ 3 ] addresses important issues surrounding BCKA oxidation within mitochondria, however, some important questions remain open. Exogenous bicarbonate was used in the present study to stimulate BCKA metabolism...

View article titled, New tools for an old question: dependence of ATP and bicarbonate for branched-chain keto acids oxidation

Articles

Abscisic acid-determined seed vigour differences do not influence redox regulation during ageing

In Collection

Seeds

Christina Schausberger, Thomas Roach, Wolfgang Stöggl, Erwann Arc, William E. Finch-Savage, Ilse Kranner

Biochem J (2019) 476 (6): 965–974.

https://doi.org/10.1042/BCJ20180903

Published: 22 March 2019

... glutathione reactive oxygen species seed longevity vigour © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 22 11 2018 26 2 2019 28 2 2019 28 2 2019 Non-aged A12 seeds took 3.4 ± 0.1 days to reach 25% germination (T 25...

View article titled, Abscisic acid-determined seed vigour differences do not influence redox regulation during ageing

Includes: Supplementary data

Articles

An ion for an iron: streptococcal metal homeostasis under oxidative stress

Nicholas S. Jakubovics

Biochem J (2019) 476 (4): 699–703.

https://doi.org/10.1042/BCJ20190017

Published: 28 February 2019

... resistance and contributes significantly to Group A Streptococcus virulence . Infect. Immun. 85 , e00091-17 10.1128/IAI.00091-17 cell homeostasis iron metabolism metalloenzymes reactive oxygen species Group A Streptococcus (GAS; Streptococcus pyogenes ) is an opportunistic...

View article titled, An ion for an iron: streptococcal metal homeostasis under oxidative stress

Articles

The oxidation of dehydroascorbic acid and 2,3-diketogulonate by distinct reactive oxygen species

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Rebecca A. Dewhirst, Stephen C. Fry

Biochem J (2018) 475 (21): 3451–3470.

https://doi.org/10.1042/BCJ20180688

Published: 09 November 2018

...Rebecca A. Dewhirst; Stephen C. Fry l -Ascorbate, dehydro- l -ascorbic acid (DHA), and 2,3-diketo- l -gulonate (DKG) can all quench reactive oxygen species (ROS) in plants and animals. The vitamin C oxidation products thereby formed are investigated here. DHA and DKG were incubated aerobically...

View article titled, The oxidation of dehydroascorbic acid and 2,3-diketogulonate by distinct reactive oxygen species

Includes: Supplementary data

Articles

Biochemical and functional characterization of OsCSD3, a novel CuZn superoxide dismutase from rice

Ravi Prakash Sanyal, Amol Samant, Vishal Prashar, Hari Sharan Misra, Ajay Saini

Biochem J (2018) 475 (19): 3105–3121.

https://doi.org/10.1042/BCJ20180516

Published: 12 October 2018

...Ravi Prakash Sanyal; Amol Samant; Vishal Prashar; Hari Sharan Misra; Ajay Saini Superoxide dismutases (SODs, EC 1.15.1.1) belong to an important group of antioxidant metalloenzymes. Multiple SODs exist for scavenging of reactive oxygen species (ROS) in different cellular compartments to maintain...

View article titled, Biochemical and functional characterization of OsCSD3, a novel CuZn superoxide dismutase from rice

Includes: Supplementary data

Articles

A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases

Athinoula L. Petrou, Athina Terzidaki

Biochem J (2017) 474 (16): 2713–2731.

https://doi.org/10.1042/BCJ20161058

Published: 02 August 2017

... 2017 free energy of activation neurodegenerative disorders oxidative stress reactive oxygen species singlet oxygen Oxidative stress is known to be an imbalance between the production of free radicals in the human body and the ability of the body to counteract their dangerous effects...

View article titled, A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases

Includes: Supplementary data

Articles

Viewing oxidative stress through the lens of oxidative signalling rather than damage

Christine H. Foyer, Alexander V. Ruban, Graham Noctor

Biochem J (2017) 474 (6): 877–883.

https://doi.org/10.1042/BCJ20160814

Published: 07 March 2017

...Christine H. Foyer; Alexander V. Ruban; Graham Noctor Concepts of the roles of reactive oxygen species (ROS) in plants and animals have shifted in recent years from focusing on oxidative damage effects to the current view of ROS as universal signalling metabolites. Rather than having two opposing...

View article titled, Viewing oxidative stress through the lens of oxidative signalling rather than damage

Articles

Molecular mechanisms of ROS production and oxidative stress in diabetes

Philip Newsholme, Vinicius Fernandes Cruzat, Kevin Noel Keane, Rodrigo Carlessi, Paulo Ivo Homem de Bittencourt, Jr

Biochem J (2016) 473 (24): 4527–4550.

https://doi.org/10.1042/BCJ20160503C

Published: 09 December 2016

... and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associated reactive oxygen species (ROS). One outcome of excessive levels of ROS is the modification of the structure and function of cellular proteins and lipids, leading to cellular dysfunction including...

View article titled, Molecular mechanisms of ROS production and oxidative stress in diabetes

Articles

Being right on Q: shaping eukaryotic evolution

Dave Speijer

Biochem J (2016) 473 (22): 4103–4127.

https://doi.org/10.1042/BCJ20160647

Published: 10 November 2016

...Dave Speijer Reactive oxygen species (ROS) formation by mitochondria is an incompletely understood eukaryotic process. I proposed a kinetic model [BioEssays (2011) 33 , 88–94] in which the ratio between electrons entering the respiratory chain via FADH 2 or NADH (the F/N ratio) is a crucial...

View article titled, Being right on Q: shaping eukaryotic evolution

Includes: Supplementary data

Articles

The effect of chronic alcohol consumption on mitochondrial calcium handling in hepatocytes

Guoqiang Wang, Elisabeth Mémin, Ishwarya Murali, Lawrence D. Gaspers

Biochem J (2016) 473 (21): 3903–3921.

https://doi.org/10.1042/BCJ20160255

Published: 27 October 2016

... with controls. Moreover, treatment with submaximal concentrations of Ca 2+ -mobilizing hormones markedly increased the levels of mitochondrial reactive oxygen species (ROS) in hepatocytes from alcohol-fed rats, but did not affect ROS levels in controls. The changes in mitochondrial Ca 2+ handling are expected...

View article titled, The effect of chronic alcohol consumption on mitochondrial calcium handling in hepatocytes

Articles

Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design

Gary G.A. Silkstone, Rebecca S. Silkstone, Michael T. Wilson, Michelle Simons, Leif Bülow, Kristian Kallberg, Khuanpiroon Ratanasopa, Luca Ronda, Andrea Mozzarelli, Brandon J. Reeder, Chris E. Cooper

Biochem J (2016) 473 (19): 3371–3383.

https://doi.org/10.1042/BCJ20160243

Published: 27 September 2016

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . hemoglobin oxidative stress reactive oxygen species Hemoglobin (Hb)-based oxygen carriers (HBOC, colloquially termed ‘blood substitutes’) have the potential to be transfused in place of packed red...

View article titled, Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design

Articles

Targeting polyamine metabolism for cancer therapy and prevention

Tracy R. Murray-Stewart, Patrick M. Woster, Robert A. Casero, Jr

Biochem J (2016) 473 (19): 2937–2953.

https://doi.org/10.1042/BCJ20160383

Published: 27 September 2016

.../SAT1), N 1 -acetylpolyamine oxidase (PAOX/APAO/PAO), and spermine oxidase (SMOX/PAOh1/SMO) ( Figure 1 ) [ 24 ]. cancer therapy chemoprevention epigenetics polyamines reactive oxygen species spermine oxidase Polyamines have been implicated in several critical cellular functions...

View article titled, Targeting polyamine metabolism for cancer therapy and prevention

Articles

Unravelling the mechanisms regulating muscle mitochondrial biogenesis

David A. Hood, Liam D. Tryon, Heather N. Carter, Yuho Kim, Chris C.W. Chen

Biochem J (2016) 473 (15): 2295–2314.

https://doi.org/10.1042/BCJ20160009

Published: 28 July 2016

... on behalf of the Biochemical Society 2016 aging calcium signalling exercise exercise training mitochondrial protein import mitochondrial reticulum mitophagy mtDNA muscle disuse p53 PPARγ co-activator-1α (PGC-1α) reactive oxygen species Tfam Tfeb The mitochondrial content of any...

View article titled, Unravelling the mechanisms regulating muscle mitochondrial biogenesis

Articles

Smac mimetic with TNF-α targets Pim-1 isoforms and reactive oxygen species production to abrogate transformation from blebbishields

Goodwin G. Jinesh, Naomi M. Laing, Ashish M. Kamat

Biochem J (2016) 473 (1): 99–107.

https://doi.org/10.1042/BJ20150877

Published: 09 December 2015

...Goodwin G. Jinesh; Naomi M. Laing; Ashish M. Kamat Cancer cells are capable of sphere formation (transformation) through reactive oxygen species (ROS) and glycolysis shift. Transformation is linked to tumorigenesis and therapy resistance, hence targeting regulators of ROS and glycolysis...

View article titled, Smac mimetic with TNF-α targets Pim-1 isoforms and reactive oxygen species production to abrogate transformation from blebbishields

Articles

TRPM2-mediated intracellular Zn 2+ release triggers pancreatic β-cell death

Paul T. Manna, Tim S. Munsey, Nada Abuarab, Fangfang Li, Aruna Asipu, Gareth Howell, Alicia Sedo, Wei Yang, Jacqui Naylor, David J. Beech, Lin-Hua Jiang, Asipu Sivaprasadarao

Biochem J (2015) 466 (3): 537–546.

https://doi.org/10.1042/BJ20140747

Published: 06 March 2015

... taken with an LSM 510 inverted confocal microscope using a 40× oil-immersion objective. apoptosis calcium reactive oxygen species Type 1 diabetes transient receptor potential (melastatin) 2 (TRPM2) channels zinc Human embryonic kidney (HEK)-293 and insulin secreting (INS1) cells were...

View article titled, TRPM2-mediated intracellular Zn 2+ release triggers pancreatic β-cell death

Includes: Supplementary data

Articles

Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

Kyle Bauckman, Edward Haller, Nicholas Taran, Stephanie Rockfield, Abigail Ruiz-Rivera, Meera Nanjundan

Biochem J (2015) 466 (2): 401–413.

https://doi.org/10.1042/BJ20140878

Published: 20 February 2015

... cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although levels of intracellular iron, ferritin/CD71 protein and reactive oxygen species did not correlate with iron-induced cell survival changes, we identified mitochondrial damage (via TEM) and reduced...

View article titled, Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

Includes: Supplementary data

Articles

FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling

Francesc Ribas, Joan Villarroya, Elayne Hondares, Marta Giralt, Francesc Villarroya

Biochem J (2014) 463 (2): 191–199.

https://doi.org/10.1042/BJ20140403

Published: 22 September 2014

.... Mimicking mitochondrial dysfunction using respiratory chain/oxidative phosphorylation inhibitors resulted in enhanced expression and release of FGF21 by muscle cells. The increased production of reactive oxygen species, subsequent induction of p38 MAPK (mitogen-activated protein kinase) and activation...

View article titled, FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling

Includes: Supplementary data

Articles

Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?

Jessica Coblentz, Claudette St. Croix, Kirill Kiselyov

Biochem J (2014) 457 (2): 361–368.

https://doi.org/10.1042/BJ20130647

Published: 20 December 2013

... channel permeable to cations, including Fe 2+ . Our data suggest that TRPML1 redistributes Fe 2+ between the lysosomes and the cytoplasm. Loss of TRPML1 leads to production of reactive oxygen species, and to mitochondrial deterioration. iron lysosomal storage disease mitochondrion reactive...

View article titled, Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?

Includes: Supplementary data

Articles

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

Jonathan Barlow, Charles Affourtit

Biochem J (2013) 456 (3): 417–426.

https://doi.org/10.1042/BJ20131002

Published: 22 November 2013

...-sensitivity of mitochondrial respiration and lowers coupling efficiency of glucose-stimulated oxidative phosphorylation. These mitochondrial defects coincide with an increased level of ROS (reactive oxygen species), impaired GSIS (glucose-stimulated insulin secretion) and decreased cell viability. Palmitate...

View article titled, Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

Articles

Autoimmune disorder phenotypes in Hvcn1 -deficient mice

Mari Sasaki, Akihiro Tojo, Yoshifumi Okochi, Nana Miyawaki, Daisuke Kamimura, Akihito Yamaguchi, Masaaki Murakami, Yasushi Okamura

Biochem J (2013) 450 (2): 295–301.

https://doi.org/10.1042/BJ20121188

Published: 15 February 2013

... the production of reactive oxygen species through regulation of membrane potential and intracellular pH. H v channels have also been suggested to play a role in sperm physiology in the human. However, the functions of the H v channel at the whole-body level are not fully understood. In the present paper we show...

View article titled, Autoimmune disorder phenotypes in Hvcn1 -deficient mice

Includes: Supplementary data

Articles

Adenosine 5′-phosphosulfate reductase (APR2) mutation in Arabidopsis implicates glutathione deficiency in selenate toxicity

Kevron Grant, Nicole M. Carey, Miguel Mendoza, John Schulze, Marinus Pilon, Elizabeth A. H. Pilon-Smits, Doug van Hoewyk

Biochem J (2011) 438 (2): 325–335.

https://doi.org/10.1042/BJ20110025

Published: 12 August 2011

... tolerance to selenate, we propose that selenium toxicity can also be caused by selenate's disruption of glutathione biosynthesis leading to enhanced levels of damaging ROS (reactive oxygen species). 1 To whom correspondence should be addressed (email [email protected] ). 4 1 2011 10 5...

View article titled, Adenosine 5′-phosphosulfate reductase (APR2) mutation in Arabidopsis implicates glutathione deficiency in selenate toxicity

Includes: Supplementary data

Articles

Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration

Ryan J. Mailloux, Tyler Dumouchel, Céline Aguer, Rob deKemp, Rob Beanlands, Mary-Ellen Harper

Biochem J (2011) 437 (2): 301–311.

https://doi.org/10.1042/BJ20110571

Published: 28 June 2011

...Ryan J. Mailloux; Tyler Dumouchel; Céline Aguer; Rob deKemp; Rob Beanlands; Mary-Ellen Harper UCP3 (uncoupling protein-3) mitigates mitochondrial ROS (reactive oxygen species) production, but the mechanisms are poorly understood. Previous studies have also examined UCP3 effects, including decreased...

View article titled, Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration

Includes: Multimedia, Supplementary data

Articles

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

Daniela Valenti, Gabriella Arcangela Manente, Laura Moro, Ersilia Marra, Rosa Anna Vacca

Biochem J (2011) 435 (3): 679–688.

https://doi.org/10.1042/BJ20101908

Published: 13 April 2011

... activity of complex I; conversely H89, a specific PKA inhibitor, suppressed these cAMP-dependent activations. Furthermore, in the present paper we report a 3-fold increase in cellular levels of ROS (reactive oxygen species), in particular superoxide anion, mainly produced by DS-HSF mitochondria. ROS...

View article titled, Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

Includes: Supplementary data

Articles

Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation

Chandi C. Mandal, Suthakar Ganapathy, Yves Gorin, Kalyankar Mahadev, Karen Block, Hanna E. Abboud, Stephen E. Harris, Goutam Ghosh-Choudhury, Nandini Ghosh-Choudhury

Biochem J (2011) 433 (2): 393–402.

https://doi.org/10.1042/BJ20100357

Published: 22 December 2010

... and mineralized bone nodule formation in mouse 2T3 pre-osteoblasts. BMP-2 elicited a rapid generation of ROS (reactive oxygen species) concomitant with increased activation of NAD(P)H oxidase. NAC and DPI inhibited BMP-2-induced ROS production and NAD(P)H oxidase activity respectively. NAD(P)H oxidases display...

View article titled, Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation

Includes: Supplementary data

Articles

PI3Kγ controls oxidative bursts in neutrophils via interactions with PKCα and p47phox

Katja Lehmann, Jörg P. Müller, Bernhard Schlott, Philipp Skroblin, Dagmar Barz, Johannes Norgauer, Reinhard Wetzker

Biochem J (2009) 419 (3): 603–610.

https://doi.org/10.1042/BJ20081268

Published: 14 April 2009

...Katja Lehmann; Jörg P. Müller; Bernhard Schlott; Philipp Skroblin; Dagmar Barz; Johannes Norgauer; Reinhard Wetzker Neutrophils release reactive oxygen species (ROS) as part of the innate inflammatory immune response. Phosphoinositide 3-kinase γ (PI3Kγ), which is induced by the bacterial peptide N...

View article titled, PI3Kγ controls oxidative bursts in neutrophils via interactions with PKCα and p47phox

Includes: Supplementary data

Articles

A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72

Wei Chen, Wei Hao Shang, Yoshifumi Adachi, Kunitaka Hirose, David M. Ferrari, Tohru Kamata

Biochem J (2008) 416 (1): 55–63.

https://doi.org/10.1042/BJ20071259

Published: 28 October 2008

...Wei Chen; Wei Hao Shang; Yoshifumi Adachi; Kunitaka Hirose; David M. Ferrari; Tohru Kamata Emerging evidence indicates that Nox (NADPH oxidase) 1-generated ROS (reactive oxygen species) play critical regulatory roles in various cellular processes, yet little is known of direct targets...

View article titled, A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72

Articles

Activation of NADPH oxidase 1 in tumour colon epithelial cells

Yukio Nisimoto, Ryoko Tsubouchi, Becky A. Diebold, Shanlou Qiao, Hisamitsu Ogawa, Takuya Ohara, Minoru Tamura

Biochem J (2008) 415 (1): 57–65.

https://doi.org/10.1042/BJ20080300

Published: 12 September 2008

... in the gastrointestinal tract and in two colon cancer cell lines, Caco-2 cells and T84, as well as in the transformed cell line HEK-293 (human embryonic kidney 293), and to a lesser extent in HeLa human cervical carcinoma cells [ 15 ]. In addition, Nox1 has also emerged as a major ROS (reactive oxygen species) source...

View article titled, Activation of NADPH oxidase 1 in tumour colon epithelial cells

Articles

The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison

Agnes Görlach, Steve Bonello

Biochem J (2008) 412 (3): e17–e19.

https://doi.org/10.1042/BJ20080920

Published: 28 May 2008

... evidence has emerged that HIF-1α is also responsive to many stimuli under normoxic conditions, including thrombin, growth factors, vasoactive peptides, insulin, lipopolysaccharide and cytokines such as TNF-α (tumour necrosis factor-α), and in many cases reactive oxygen species are involved. One important...

View article titled, The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison

Articles

Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury

Qiang Li, Yulong Zhang, Jennifer J. Marden, Botond Banfi, John F. Engelhardt

Biochem J (2008) 411 (3): 531–541.

https://doi.org/10.1042/BJ20071534

Published: 14 April 2008

...-dependent mechanism of c-Src activation following H/R injury and found that ROS (reactive oxygen species) generated by endosomal Noxs (NADPH oxidases) are critical for this process. Endocytosis following H/R was required for the activation of endosomal Noxs, c-Src activation, and the ability of c-Src...

View article titled, Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury

Articles

Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells

Timothy J. Tavender, Alyson M. Sheppard, Neil J. Bulleid

Biochem J (2008) 411 (1): 191–199.

https://doi.org/10.1042/BJ20071428

Published: 13 March 2008

.... Furthermore, Prx IV oligomeric interactions are stabilized by additional non-catalytic disulfide bonds, indicative of a primary role other than peroxide elimination. 1 To whom correspondence should be addressed (email [email protected] ). Exposure to ROS (reactive oxygen species) has...

View article titled, Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells

Articles

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

Ian H. Batty, Jeroen van der Kaay, Alex Gray, Joan F. Telfer, Miles J. Dixon, C. Peter Downes

Biochem J (2007) 407 (2): 255–266.

https://doi.org/10.1042/BJ20070558

Published: 25 September 2007

... 2007 2 8 2007 2 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 lipid phosphatase phosphoinositide 3-kinase (PI3K) protein phosphatase reactive oxygen species PIs (phosphoinositides) play a central role in intracellular signalling, acting...

View article titled, The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

Articles

Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor κB transcriptional activation in neuroblastoma SH-SY5Y cells

Xin Lin, Qing Li, Yu-Jun Wang, Ya-Wen Ju, Zhi-Qiang Chi, Min-Wei Wang, Jing-Gen Liu

Biochem J (2007) 406 (2): 215–221.

https://doi.org/10.1042/BJ20070186

Published: 13 August 2007

... demonstrated that morphine suppressed DOX-induced inhibition of cell proliferation and programmed cell death in a concentration-dependent, and naloxone as well as pertussis toxin-irreversible, manner. Further studies showed that morphine inhibited ROS (reactive oxygen species) generation, and prevented DOX...

View article titled, Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor κB transcriptional activation in neuroblastoma SH-SY5Y cells

Articles

Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts

Adrien Rossary, Khelifa Arab, Jean-Paul Steghens

Biochem J (2007) 406 (1): 77–83.

https://doi.org/10.1042/BJ20061009

Published: 26 July 2007

...Adrien Rossary; Khelifa Arab; Jean-Paul Steghens The strong ROS (reactive oxygen species) production, part of an antioxidant response of human fibroblasts triggered by DHA (docosahexaenoic acid; C 22:6 , n −3 ), served as a model for deciphering the relative contribution of NOX (NADPH oxidase...

View article titled, Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts

Articles

Succinate modulation of H 2 O 2 release at NADH:ubiquinone oxidoreductase (Complex I) in brain mitochondria

Franco Zoccarato, Lucia Cavallini, Silvia Bortolami, Adolfo Alexandre

Biochem J (2007) 406 (1): 125–129.

https://doi.org/10.1042/BJ20070215

Published: 26 July 2007

... 2007 3 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 brain mitochondrion electron transfer hydrogen peroxide production NADH:ubiquinone oxidoreductase (Complex I) reactive oxygen species succinate Mitochondria are the major site of ROS (reactive...

View article titled, Succinate modulation of H 2 O 2 release at NADH:ubiquinone oxidoreductase (Complex I) in brain mitochondria

Articles

MAPK activation by radio waves

J. Simon C. Arthur

Biochem J (2007) 405 (3): e5.

https://doi.org/10.1042/BJ20070762

Published: 13 July 2007

... (epidermal growth factor) receptor, which is in turn activated by the release of reactive oxygen species. 1 email [email protected] . 6 6 2007 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 extracellular-signal-regulated kinase (ERK) mitogen...

View article titled, MAPK activation by radio waves

Articles

Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis

Pedro Iñarrea, Hadi Moini, Derick Han, Daniel Rettori, Ignacio Aguiló, Maria Angeles Alava, María Iturralde, Enrique Cadenas

Biochem J (2007) 405 (1): 173–179.

https://doi.org/10.1042/BJ20061809

Published: 13 June 2007

... aconitase Cu,Zn-superoxide dismutase (SOD1) disulfide bond mitochondrial intermembrane space reactive oxygen species thioredoxin reductase (TxrR-1) Recent studies on the subcellular distribution of SOD (superoxide dismutase) demonstrated that SOD1 (Cu,Zn-SOD) is localized not only...

View article titled, Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis

Articles

Oxidative stress and cancer: have we moved forward?

Barry Halliwell

Biochem J (2007) 401 (1): 1–11.

https://doi.org/10.1042/BJ20061131

Published: 11 December 2006

... species can chlorinate cytosine and adenine (reviewed in [ 2 ]). Attack of RS on proteins and lipids might also aggravate DNA damage ( Figure 2 ). The Biochemical Society, London 2007 antioxidant cancer DNA repair nitric oxide reactive oxygen species In 1996, I co-authored...

View article titled, Oxidative stress and cancer: have we moved forward?

Articles

Homocysteine stimulates phosphorylation of NADPH oxidase p47 phox and p67 phox subunits in monocytes via protein kinase Cβ activation

Yaw L. Siow, Kathy K. W. Au-Yeung, Connie W. H. Woo, Karmin O

Biochem J (2006) 398 (1): 73–82.

https://doi.org/10.1042/BJ20051810

Published: 27 July 2006

...Yaw L. Siow; Kathy K. W. Au-Yeung; Connie W. H. Woo; Karmin O Hyperhomocysteinaemia is an independent risk factor for cardiovascular diseases due to atherosclerosis. The development of atherosclerosis involves reactive oxygen species-induced oxidative stress in vascular cells. Our previous study...

View article titled, Homocysteine stimulates phosphorylation of NADPH oxidase p47 phox and p67 phox subunits in monocytes via protein kinase Cβ activation

Articles

Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast

Arun Kumar, Lijo John, Md. Mahmood Alam, Ankit Gupta, Gayatri Sharma, Beena Pillai, Shantanu Sengupta

Biochem J (2006) 396 (1): 61–69.

https://doi.org/10.1042/BJ20051411

Published: 26 April 2006

... any similarity to the response to H 2 O 2 . We also failed to detect induction of reactive oxygen species in homocysteine- and cysteine-treated cells, using fluorogenic probes. These results indicate that homocysteine- and cysteine-induced growth defect is not due to the oxidative stress. However, we...

View article titled, Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast

Includes: Supplementary data

Articles

Direct evidence for S-nitrosation of mitochondrial complex I

Lindsay S. Burwell, Sergiy M. Nadtochiy, Andrew J. Tompkins, Sara Young, Paul S. Brookes

Biochem J (2006) 394 (3): 627–634.

https://doi.org/10.1042/BJ20051435

Published: 24 February 2006

... regulation of respiration, for reactive oxygen species generation and for a potential role of S-nitrosation in cardioprotection are discussed. 1 To whom correspondence should be addressed (email [email protected] ). 30 8 2005 17 11 2005 30 11 2005 21 12 2005...

View article titled, Direct evidence for S-nitrosation of mitochondrial complex I

Articles

Identification and analysis of the promoter region of the human methionine sulphoxide reductase A gene

Antonella De Luca, Paolo Sacchetta, Carmine Di Ilio, Bartolo Favaloro

Biochem J (2006) 393 (1): 321–329.

https://doi.org/10.1042/BJ20050973

Published: 12 December 2005

... The Biochemical Society, London 2006 methionine sulphoxide reductase promoter reactive oxygen species transcriptional start site The overproduction of ROS (reactive oxygen species) can result in various deleterious effects. In order to protect against these harmful ROS, aerobic organisms have...

View article titled, Identification and analysis of the promoter region of the human methionine sulphoxide reductase A gene

Articles

Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose

Julien Mozo, Gilles Ferry, Aurélie Studeny, Claire Pecqueur, Marianne Rodriguez, Jean A. Boutin, Frédéric Bouillaud

Biochem J (2006) 393 (1): 431–439.

https://doi.org/10.1042/BJ20050494

Published: 12 December 2005

... mitochondrial activity. A model is proposed using the known passive transport of pyruvate by UCP1. 1 To whom correspondence should be addressed (email [email protected] ). glycolysis membrane potential mitochondria pyruvate reactive oxygen species uncoupling protein (UCP) The Biochemical...

View article titled, Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose

Articles

Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster

Melissa Ferguson, Robin J. Mockett, Yi Shen, William C. Orr, Rajindar S. Sohal

Biochem J (2005) 390 (2): 501–511.

https://doi.org/10.1042/BJ20042130

Published: 23 August 2005

... 2004 15 4 2005 25 4 2005 26 4 2005 The Biochemical Society, London 2005 cytochrome c oxidase Drosophila melanogaster electron transport mitochondria mitochondrial respiration reactive oxygen species The nature of the mechanisms underlying the aging process...

View article titled, Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster

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