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Keywords: reactive oxygen species
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Articles
Biochem J (2019) 476 (20): 3019–3032.
Published: 28 October 2019
...Christophe Bailly Reactive oxygen species (ROS) are versatile compounds which can have toxic or signalling effects in a wide range living organisms, including seeds. They have been reported to play a pivotal role in the regulation of seed germination and dormancy but their mechanisms of action are...
Articles
Biochem J (2019) 476 (19): 2835–2850.
Published: 11 October 2019
... p38 platelet adhesion and activation reactive oxygen species Correspondence: Ulhas P. Naik ( ulhas.naik@jefferson.edu ) 24 5 2019 10 9 2019 16 9 2019 17 9 2019 Human whole blood was drawn, with informed consent, by venipuncture from healthy adult volunteers...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (15): 2235–2237.
Published: 15 August 2019
... Biochemical Society 2019 bioenergetics mitochondria reactive oxygen species The work performed by Goldberg et al. [ 3 ] addresses important issues surrounding BCKA oxidation within mitochondria, however, some important questions remain open. Exogenous bicarbonate was used in the present study to...
Articles
Biochem J (2019) 476 (6): 965–974.
Published: 22 March 2019
...). Published by Portland Press Limited on behalf of the Biochemical Society 2019 abscisic acid Arabidopsis thaliana glutathione reactive oxygen species seed longevity vigour Seeds age during storage and the resulting loss of seed vigour and viability can impact crop yields and sustainable...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (4): 699–703.
Published: 28 February 2019
... bacteria. Strategies aimed at interfering with the balance of intracellular metal ions represent a promising approach for the control of invasive microbial infections. cell homeostasis iron metabolism metalloenzymes reactive oxygen species Group A Streptococcus (GAS; Streptococcus pyogenes...
Articles
Biochem J (2018) 475 (21): 3451–3470.
Published: 09 November 2018
...Rebecca A. Dewhirst; Stephen C. Fry l -Ascorbate, dehydro- l -ascorbic acid (DHA), and 2,3-diketo- l -gulonate (DKG) can all quench reactive oxygen species (ROS) in plants and animals. The vitamin C oxidation products thereby formed are investigated here. DHA and DKG were incubated aerobically at...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (19): 3105–3121.
Published: 12 October 2018
...Ravi Prakash Sanyal; Amol Samant; Vishal Prashar; Hari Sharan Misra; Ajay Saini Superoxide dismutases (SODs, EC 1.15.1.1) belong to an important group of antioxidant metalloenzymes. Multiple SODs exist for scavenging of reactive oxygen species (ROS) in different cellular compartments to maintain an...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (16): 2713–2731.
Published: 02 August 2017
... to singlet O 2 formation [ 103 ]. When the ozone level overwhelms the antioxidant defense systems in the lung, reactive oxygen species (ROS) can then reach the CNS through the bloodstream, causing oxidative stress [ 104 ] and damage in dopaminergic neurons of the substantia nigra in the animals...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (6): 877–883.
Published: 07 March 2017
...Christine H. Foyer; Alexander V. Ruban; Graham Noctor Concepts of the roles of reactive oxygen species (ROS) in plants and animals have shifted in recent years from focusing on oxidative damage effects to the current view of ROS as universal signalling metabolites. Rather than having two opposing...
Articles
Biochem J (2016) 473 (24): 4527–4550.
Published: 09 December 2016
... and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associated reactive oxygen species (ROS). One outcome of excessive levels of ROS is the modification of the structure and function of cellular proteins and lipids, leading to cellular...
Articles
Biochem J (2016) 473 (22): 4103–4127.
Published: 10 November 2016
...Dave Speijer Reactive oxygen species (ROS) formation by mitochondria is an incompletely understood eukaryotic process. I proposed a kinetic model [BioEssays (2011) 33 , 88–94] in which the ratio between electrons entering the respiratory chain via FADH 2 or NADH (the F/N ratio) is a crucial...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (21): 3903–3921.
Published: 27 October 2016
... compared with controls. Moreover, treatment with submaximal concentrations of Ca 2+ -mobilizing hormones markedly increased the levels of mitochondrial reactive oxygen species (ROS) in hepatocytes from alcohol-fed rats, but did not affect ROS levels in controls. The changes in mitochondrial Ca 2+ handling...
Articles
Biochem J (2016) 473 (19): 2937–2953.
Published: 27 September 2016
... ]. As will be discussed below, SAM486A has been used in combination with other agents as a strategy to more completely deplete polyamines for therapeutic benefit. cancer therapy chemoprevention epigenetics polyamines reactive oxygen species spermine oxidase Polyamines have been...
Articles
Biochem J (2016) 473 (19): 3371–3383.
Published: 27 September 2016
... Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . hemoglobin oxidative stress reactive oxygen species Hemoglobin (Hb)-based oxygen carriers (HBOC, colloquially termed ‘blood substitutes’) have the...
Articles
Biochem J (2016) 473 (15): 2295–2314.
Published: 28 July 2016
... 2016 aging calcium signalling exercise exercise training mitochondrial protein import mitochondrial reticulum mitophagy mtDNA muscle disuse p53 PPARγ co-activator-1α (PGC-1α) reactive oxygen species Tfam Tfeb The mitochondrial content of any tissue is one of the most highly...
Articles
Biochem J (2016) 473 (1): 99–107.
Published: 09 December 2015
...Goodwin G. Jinesh; Naomi M. Laing; Ashish M. Kamat Cancer cells are capable of sphere formation (transformation) through reactive oxygen species (ROS) and glycolysis shift. Transformation is linked to tumorigenesis and therapy resistance, hence targeting regulators of ROS and glycolysis is...
Articles
Biochem J (2015) 466 (3): 537–546.
Published: 06 March 2015
... and severe hyperglycaemia (T1D) [ 1 – 3 ]. Reactive oxygen species (ROS), including H 2 O 2 , play a central role in the immune-mediated β-cell death [ 1 , 2 ]. One mechanism by which ROS brings about cell death begins with nicks in ssDNA and activation of the poly(ADP-ribose) polymerase (PARP)–poly...
Includes: Supplementary data
Articles
Biochem J (2015) 466 (2): 401–413.
Published: 20 February 2015
... cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although levels of intracellular iron, ferritin/CD71 protein and reactive oxygen species did not correlate with iron-induced cell survival changes, we identified mitochondrial damage (via TEM) and reduced...
Includes: Supplementary data
Articles
Biochem J (2014) 463 (2): 191–199.
Published: 22 September 2014
... FGF21 gene transcription. Mimicking mitochondrial dysfunction using respiratory chain/oxidative phosphorylation inhibitors resulted in enhanced expression and release of FGF21 by muscle cells. The increased production of reactive oxygen species, subsequent induction of p38 MAPK (mitogen-activated...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (2): 361–368.
Published: 20 December 2013
... and the cytoplasm. Loss of TRPML1 leads to production of reactive oxygen species, and to mitochondrial deterioration. iron lysosomal storage disease mitochondrion reactive oxygen species transient receptor potential (TRP) channel TRPML1 is a member of the mucolipin family of TRP...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (3): 417–426.
Published: 22 November 2013
...-sensitivity of mitochondrial respiration and lowers coupling efficiency of glucose-stimulated oxidative phosphorylation. These mitochondrial defects coincide with an increased level of ROS (reactive oxygen species), impaired GSIS (glucose-stimulated insulin secretion) and decreased cell viability. Palmitate...
Articles
Biochem J (2013) 450 (2): 295–301.
Published: 15 February 2013
... production of reactive oxygen species through regulation of membrane potential and intracellular pH. H v channels have also been suggested to play a role in sperm physiology in the human. However, the functions of the H v channel at the whole-body level are not fully understood. In the present paper we show...
Includes: Supplementary data
Articles
Biochem J (2011) 438 (2): 325–335.
Published: 12 August 2011
... decreased tolerance to selenate, we propose that selenium toxicity can also be caused by selenate's disruption of glutathione biosynthesis leading to enhanced levels of damaging ROS (reactive oxygen species). 1 To whom correspondence should be addressed (email dougvh@coastal.edu ). 4 1 2011...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (2): 301–311.
Published: 28 June 2011
...Ryan J. Mailloux; Tyler Dumouchel; Céline Aguer; Rob deKemp; Rob Beanlands; Mary-Ellen Harper UCP3 (uncoupling protein-3) mitigates mitochondrial ROS (reactive oxygen species) production, but the mechanisms are poorly understood. Previous studies have also examined UCP3 effects, including decreased...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2011) 435 (3): 679–688.
Published: 13 April 2011
... catalytic activity of complex I; conversely H89, a specific PKA inhibitor, suppressed these cAMP-dependent activations. Furthermore, in the present paper we report a 3-fold increase in cellular levels of ROS (reactive oxygen species), in particular superoxide anion, mainly produced by DS-HSF mitochondria...
Includes: Supplementary data
Articles
Biochem J (2011) 433 (2): 393–402.
Published: 22 December 2010
... mineralized bone nodule formation in mouse 2T3 pre-osteoblasts. BMP-2 elicited a rapid generation of ROS (reactive oxygen species) concomitant with increased activation of NAD(P)H oxidase. NAC and DPI inhibited BMP-2-induced ROS production and NAD(P)H oxidase activity respectively. NAD(P)H oxidases display...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (3): 603–610.
Published: 14 April 2009
...Katja Lehmann; Jörg P. Müller; Bernhard Schlott; Philipp Skroblin; Dagmar Barz; Johannes Norgauer; Reinhard Wetzker Neutrophils release reactive oxygen species (ROS) as part of the innate inflammatory immune response. Phosphoinositide 3-kinase γ (PI3Kγ), which is induced by the bacterial peptide N...
Includes: Supplementary data
Articles
Biochem J (2008) 416 (1): 55–63.
Published: 28 October 2008
...Wei Chen; Wei Hao Shang; Yoshifumi Adachi; Kunitaka Hirose; David M. Ferrari; Tohru Kamata Emerging evidence indicates that Nox (NADPH oxidase) 1-generated ROS (reactive oxygen species) play critical regulatory roles in various cellular processes, yet little is known of direct targets for the...
Articles
Biochem J (2008) 415 (1): 57–65.
Published: 12 September 2008
... © 2008 Biochemical Society 2008 Caco-2 cells Nox1 Rac1 reactive oxygen species small GTPase superoxide Superoxide and its reaction products (H 2 O 2 , HOCl and OH•) have been reported to play a crucial role in non-phagocytes in a range of physiological processes such as proliferation...
Articles
Biochem J (2008) 412 (3): e17–e19.
Published: 28 May 2008
... evidence has emerged that HIF-1α is also responsive to many stimuli under normoxic conditions, including thrombin, growth factors, vasoactive peptides, insulin, lipopolysaccharide and cytokines such as TNF-α (tumour necrosis factor-α), and in many cases reactive oxygen species are involved. One important...
Articles
Biochem J (2008) 411 (3): 531–541.
Published: 14 April 2008
...-dependent mechanism of c-Src activation following H/R injury and found that ROS (reactive oxygen species) generated by endosomal Noxs (NADPH oxidases) are critical for this process. Endocytosis following H/R was required for the activation of endosomal Noxs, c-Src activation, and the ability of c-Src to...
Articles
Biochem J (2008) 411 (1): 191–199.
Published: 13 March 2008
... 12 2007 4 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 H 2 O 2 molecular chaperone oxidative stress peroxidatic cysteine peroxiredoxin IV (Prx IV) reactive oxygen species Exposure to ROS (reactive oxygen species) has long been recognized as...
Articles
Biochem J (2007) 407 (2): 255–266.
Published: 25 September 2007
... activity by Rab5 may reflect one such mechanism [ 15 ]. More pertinently, however, the regulation of appropriate enzyme activities by ROS (reactive oxygen species) may be crucial in this regard. ROS are generated endogenously in response to both physiological and pathological stimuli, including growth...
Articles
Biochem J (2007) 406 (2): 215–221.
Published: 13 August 2007
... demonstrated that morphine suppressed DOX-induced inhibition of cell proliferation and programmed cell death in a concentration-dependent, and naloxone as well as pertussis toxin-irreversible, manner. Further studies showed that morphine inhibited ROS (reactive oxygen species) generation, and prevented DOX...
Articles
Biochem J (2007) 406 (1): 77–83.
Published: 26 July 2007
...Adrien Rossary; Khelifa Arab; Jean-Paul Steghens The strong ROS (reactive oxygen species) production, part of an antioxidant response of human fibroblasts triggered by DHA (docosahexaenoic acid; C 22:6 , n −3 ), served as a model for deciphering the relative contribution of NOX (NADPH oxidase) to...
Articles
Biochem J (2007) 406 (1): 125–129.
Published: 26 July 2007
... 3 5 2007 3 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 brain mitochondrion electron transfer hydrogen peroxide production NADH:ubiquinone oxidoreductase (Complex I) reactive oxygen species succinate Mitochondria are the major site of ROS...
Articles
Biochem J (2007) 405 (3): e5.
Published: 13 July 2007
... (epidermal growth factor) receptor, which is in turn activated by the release of reactive oxygen species. 1 email j.s.c.arthur@dundee.ac.uk . 6 6 2007 8 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 extracellular-signal-regulated kinase (ERK...
Articles
Biochem J (2007) 405 (1): 173–179.
Published: 13 June 2007
... matrix aconitase activity against superoxide-mediated inactivation. It has long been known that Ca 2+ overload leads to the state of mitochondrial membrane permeability transition [ 15 , 16 ] and the opening of PTPs following increased mitochondrial production of reactive oxygen species [ 33 ]. The...
Articles
Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... The Biochemical Society, London 2007 antioxidant cancer DNA repair nitric oxide reactive oxygen species In 1996, I co-authored in the Biochemical Journal an article speculating on the role of oxygen radicals and other ‘reactive species’ (RS; defined in the legend to Figure 1 ) in...
Articles
Biochem J (2006) 398 (1): 73–82.
Published: 27 July 2006
...Yaw L. Siow; Kathy K. W. Au-Yeung; Connie W. H. Woo; Karmin O Hyperhomocysteinaemia is an independent risk factor for cardiovascular diseases due to atherosclerosis. The development of atherosclerosis involves reactive oxygen species-induced oxidative stress in vascular cells. Our previous study...
Articles
Biochem J (2006) 396 (1): 61–69.
Published: 26 April 2006
... any similarity to the response to H 2 O 2 . We also failed to detect induction of reactive oxygen species in homocysteine- and cysteine-treated cells, using fluorogenic probes. These results indicate that homocysteine- and cysteine-induced growth defect is not due to the oxidative stress. However, we...
Includes: Supplementary data
Articles
Biochem J (2006) 394 (3): 627–634.
Published: 24 February 2006
... regulation of respiration, for reactive oxygen species generation and for a potential role of S-nitrosation in cardioprotection are discussed. 1 To whom correspondence should be addressed (email paul_brookes@urmc.rochester.edu ). 30 8 2005 17 11 2005 30 11 2005 21 12 2005...
Articles
Biochem J (2006) 393 (1): 431–439.
Published: 12 December 2005
... membrane potential mitochondria pyruvate reactive oxygen species uncoupling protein (UCP) Several mitochondrial UCPs (uncoupling proteins) have been described so far (for reviews, see [ 1 – 3 ]). First identified in 1976 [ 4 , 5 ], UCP1 is expressed in the brown adipose tissue of mammals [ 6...
Articles
Biochem J (2006) 393 (1): 321–329.
Published: 12 December 2005
... The Biochemical Society, London 2006 methionine sulphoxide reductase promoter reactive oxygen species transcriptional start site The overproduction of ROS (reactive oxygen species) can result in various deleterious effects. In order to protect against these harmful ROS, aerobic...
Articles
Biochem J (2005) 390 (2): 501–511.
Published: 23 August 2005
... Biochemical Society, London 2005 cytochrome c oxidase Drosophila melanogaster electron transport mitochondria mitochondrial respiration reactive oxygen species The nature of the mechanisms underlying the aging process is presently unclear; however, the age-related deterioration of...
Articles
Biochem J (2005) 389 (2): 289–295.
Published: 05 July 2005
... levels during pathogenesis indicate that the D -arabitol concentration rises dramatically as infection progresses, and D -arabitol was shown in an in vitro system to be capable of quenching reactive oxygen species involved in host plant defence reactions. ARD1p may therefore play an important role in...
Articles
Biochem J (2005) 389 (1): 83–89.
Published: 21 June 2005
...Gillian HUGHES; Michael P. MURPHY; Elizabeth C. LEDGERWOOD ROS (reactive oxygen species) from mitochondrial and non-mitochondrial sources have been implicated in TNFα (tumour necrosis factor α)-mediated signalling. In the present study, a new class of specific mitochondria-targeted antioxidants...
Articles
Biochem J (2005) 388 (1): 93–101.
Published: 10 May 2005
... hyperoxia mitochondrion reactive oxygen species superoxide dismutase yeast Although O 2 is essential for the livelihood of aerobic organisms, exposure to higher than normal O 2 concentrations can be detrimental to cells. In laboratory animals, hyperoxia exposure (>90% O 2 ) causes death...
Includes: Supplementary data
Articles
Biochem J (2005) 386 (3): 401–416.
Published: 08 March 2005
...Yvonne GROEMPING; Katrin RITTINGER The NADPH oxidase of professional phagocytes is a crucial component of the innate immune response due to its fundamental role in the production of reactive oxygen species that act as powerful microbicidal agents. The activity of this multi-protein enzyme is...
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Biochem J (2005) 386 (3): 543–547.
Published: 08 March 2005
...@jhmi.edu ). 24 6 2004 14 10 2004 21 10 2004 21 10 2004 The Biochemical Society, London 2005 N 1 -acetylpolyamine oxidase (PAO) hydrogen peroxide (H 2 O 2 ) polyamine reactive oxygen species spermidine/spermine N 1 -acetyltransferase (SSAT) spermine oxidase [SMO...