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Keywords: reactive oxygen species (ROS)
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Biochem J (2015) 468 (2): 325–336.
Published: 22 May 2015
... and induced autophagy. The potential pro-autophagic activity of Gsdma3 was suppressed through an intramolecular inhibition mechanism between N- and C-terminus. And this mechanism was conserved in Gasdermin family. autophagy Gasdermin A3 GSDM family reactive oxygen species (ROS...
Includes: Supplementary data
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Biochem J (2015) 466 (2): 369–378.
Published: 20 February 2015
... oxidoreductin 1-α (ERO1α), a target of CHOP, is an important oxidizing enzyme that regulates reactive oxygen species (ROS), which play a prominent role in hepatocellular death during acute liver failure (ALF). However, little is known about how CHOP facilitates ROS-induced hepatocellular injury. The present...
Includes: Supplementary data
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Biochem J (2014) 464 (1): 157–168.
Published: 23 October 2014
... (SIRT3) reactive oxygen species (ROS) mitochondrial antioxidant enzyme The oxygen supply to cells or tissues is reduced during aging and in many pathological conditions, including cancer, diabetic retinopathy and cardiovascular diseases [ 1 ]. Low oxygen supply results in hypoxic stress...
Includes: Supplementary data
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Biochem J (2014) 463 (1): 53–63.
Published: 08 September 2014
...Tatsuro Kawamura; Yasumitsu Kondoh; Makoto Muroi; Makoto Kawatani; Hiroyuki Osada Induction of excessive levels of reactive oxygen species (ROS) by small-molecule compounds has been considered a potentially effective therapeutic strategy against cancer cells, which are often subjected to chronic...
Includes: Supplementary data
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Biochem J (2014) 462 (3): 475–487.
Published: 22 August 2014
... therapeutic applications, including cancer, diabetes and malaria. ATP synthase biguanide complex I metformin NADH:quinone oxidoreductase reactive oxygen species (ROS) © 2014 Author(s) 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence...
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Biochem J (2014) 462 (2): 337–345.
Published: 07 August 2014
... plasma membranes may reduce the presence of FRE1. heterologous expression NADPH oxidase Pichia pastoris post-translational modification protein–protein interaction reactive oxygen species (ROS) The NADPH oxidase complex generates ROS (reactive oxygen species) by transferring electrons...
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Biochem J (2014) 459 (2): 251–263.
Published: 28 March 2014
... is involved in neuroprotection against apoptosis via HO-1 (haem oxygenase 1) expression in cerebellar granule neurons. neuronal nitric oxide synthase (nNOS) neuroprotection 8-nitro-cGMP phosphorylation redox signalling reactive oxygen species (ROS) In the nervous system, NO is involved...
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Biochem J (2013) 456 (3): 337–346.
Published: 22 November 2013
... hypoxia-induced cellular responses. hypoxia hypoxia-inducible factor (HIF) hypoxic pulmonary vasoconstriction peroxiredoxin-5 reactive oxygen species (ROS) redox-sensitive GFP (roGFP) Adaptation to low levels of oxygen (hypoxia) is critical for survival, as all multicellular organisms...
Includes: Supplementary data
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Biochem J (2013) 454 (2): 201–208.
Published: 09 August 2013
... Journal compilation © 2013 Biochemical Society 2013 catalase Forkhead box protein M1 (FOXM1) N -acetyl- L -cysteine (NAC) reactive oxygen species (ROS) proteasome inhibitor Both proteasome inhibitors and ROS (reactive oxygen species) inducers are important emerging classes of anticancer...
Includes: Supplementary data
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Biochem J (2012) 447 (3): 381–391.
Published: 05 October 2012
... production, the non-specific DNA-binding protein Dps (DNA protection during starvation) features prominently. Deinococcus radiodurans DNA protection during starvation (Dps) ferroxidase activity green fluorescent protein (GFP) nucleoid organization reactive oxygen species (ROS) Members...
Includes: Supplementary data
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Biochem J (2012) 447 (2): 281–289.
Published: 26 September 2012
... death energy metabolism mitochondrion Src tyrosine kinase reactive oxygen species (ROS) Mitochondrial serine/threonine phosphorylation has been investigated in terms of the mitochondrial compartments in which it occurs, and the results of the mitochondrial serine/threonine phosphoproteome...
Includes: Supplementary data
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Biochem J (2012) 446 (1): 23–36.
Published: 27 July 2012
... is properly cited. activin receptor type II B autophagy–lysosome system myostatin nuclear factor κB (NF-κB) reactive oxygen species (ROS) skeletal muscle wasting tumoral factor ubiquitin–proteasome system All experiments performed on mice adhered to the approved protocols stated...
Includes: Supplementary data
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Biochem J (2012) 445 (3): 441–448.
Published: 13 July 2012
... The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cell stress Mg 2+ reactive oxygen species (ROS) transient receptor potential melastatin 7 (TRPM7) All chemicals, unless otherwise stated, were obtained from Sigma. STS, a broad inhibitor of protein kinases...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 735–746.
Published: 16 April 2012
... proliferation inhibition reactive oxygen species (ROS) Leukaemia, also known as blood cancer, is characterized by rapid cell proliferation and abnormal cell function and is a lethal disease of the bone marrow and blood. It is usually categorized into four main types, acute myeloid leukaemia, chronic...
Includes: Supplementary data
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Biochem J (2012) 443 (1): 75–84.
Published: 14 March 2012
... levels were then measured by quantitative PCR as described above. apoptosis lipocalin neuroprotection prostaglandin D synthase reactive oxygen species (ROS) SH-SY5Y Cells were lysed in RIPA buffer containing 50 mM Tris/HCl (pH 8.0), 150 mM NaCl, 0.1% SDS, 0.5% sodium deoxycholate, 1...
Includes: Supplementary data
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Biochem J (2011) 438 (3): 433–436.
Published: 26 August 2011
... 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 citrate carrier (CIC) gene regulation immune cell nitric oxide (NO) prostaglandin E 2 reactive oxygen species (ROS) Inflammation is an immune response to infection, tissue injury and other noxious insults...
Includes: Supplementary data
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Biochem J (2011) 435 (3): 545–551.
Published: 13 April 2011
...) mitochondrion reactive oxygen species (ROS) The role of mitochondria in programmed cell death has been studied extensively over the last few decades. It is now well established that stress signals induce changes in mitochondrial membrane permeability, resulting in the release of cytochrome c from...
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Biochem J (2011) 435 (2): 489–498.
Published: 29 March 2011
... To whom correspondence should be addressed (email [email protected] ). 14 9 2010 24 1 2011 3 2 2011 3 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 promoter analysis reactive oxygen species (ROS) small ubiquitin-related modifier 2/3 (SUMO2...
Includes: Supplementary data
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Biochem J (2010) 428 (2): 183–190.
Published: 13 May 2010
... evaluated. age-related macular degeneration (AMD) 2′,7′-dichlorofluorescein (DCF) lysosome oxidative stress reactive oxygen species (ROS) transition metal Using a modification [ 15 ] of a technique described by Myhre et al. [ 26 ], H 2 DCF was exposed to cytochrome c with or without...
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Biochem J (2009) 424 (3): 491–500.
Published: 10 December 2009
... stimulant SFN (sulforaphane; 5 μM). cysteine nuclear factor-erythroid 2-related factor 2 (Nrf2) reactive oxygen species (ROS) redox thiol thioredoxin Previous studies have highlighted the independence of different thiol/disulfide redox couples [ 1 – 3 ]. These critical observations provide...
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Biochem J (2009) 423 (1): 109–118.
Published: 14 September 2009
... Journal compilation © 2009 Biochemical Society 2009 inositol pyrophosphate inositol hexakisphosphate kinase (IP6K) Kcs1 metabolism Rad53 reactive oxygen species (ROS) Eukaryotic cells are constantly exposed to exogenous and endogenous agents that cause DNA damage. This can lead...
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Biochem J (2009) 417 (1): 1–13.
Published: 12 December 2008
...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. complex I hydrogen peroxide mitochondrion reactive oxygen species (ROS) respiratory chain superoxide Mitochondria...
Includes: Multimedia, Supplementary data
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Biochem J (2008) 414 (1): 53–61.
Published: 29 July 2008
... oxygen species (ROS) Water channels, aquaporins, have been identified in most organisms, including plants, and have specific physiological functions related to water facilitation in many tissues [ 1 – 3 ]. Aquaporins are tetramers and each subunit forms a pore. Many plant aquaporin homologues...
Includes: Supplementary data
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Biochem J (2008) 413 (1): 1–13.
Published: 12 June 2008
... Parkinson's disease reactive oxygen species (ROS) ubiquitin Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease (for reviews, see [ 1 – 3 ]). It is a slow debilitating disease generally diagnosed in the sixth decade of life. The disease...
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Biochem J (2007) 406 (1): 105–114.
Published: 26 July 2007
... induced with 1 μg/ml tet, TC). The dose–response curve was fitted with a four-parameter Hill sigmoid curve for the determination of the EC 50 ( n =4). hydrogen peroxide NADPH oxidase (NOX) NOX4 NOX4 inhibitor reactive oxygen species (ROS) superoxide NOX4 is a member of the NOX (NADPH...
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Biochem J (2007) 405 (3): 559–568.
Published: 13 July 2007
... oxidase reactive oxygen species (ROS) © 2007 Biochemical Society 2007 3 11 2006 23 4 2007 25 4 2007 25 4 2007 1 To whom correspondence should be addressed (email [email protected] ). A group of enzymes that are known to rapidly respond to extracellular...
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Biochem J (2007) 405 (1): 1–9.
Published: 13 June 2007
... (COX) hypoxia-inducible factor-1 (HIF-1) mitochondrial respiratory chain oxidative phosphorylation reactive oxygen species (ROS) tricarboxylic acid cycle Since the time of Louis Pasteur (1822–1895) it has been recognized that cells preferentially metabolize glucose by respiration when O 2...
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Biochem J (2007) 402 (2): 271–278.
Published: 12 February 2007
... 10 2006 The Biochemical Society, London 2007 lipopolysaccharide mitochondria mitogen-activated protein kinase (MAPK) reactive oxygen species (ROS) signalling uncoupling protein 2 (UCP2) UCP2 (uncoupling protein 2) is a carrier protein located in the inner mitochondrial...
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Biochem J (2005) 390 (2): 377–394.
Published: 23 August 2005
... The Biochemical Society, London 2005 F 1 F o -ATPase ischaemia mitochondria reactive oxygen species (ROS) reperfusion The heart is a pump that converts chemical energy into mechanical work. The power produced by cardiac muscle is generated almost entirely by the oxidation of carbon fuels...
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Biochem J (2005) 387 (2): 531–540.
Published: 05 April 2005
... cells nuclear factor κB (NF-κB) reactive oxygen species (ROS) The cytoskeleton is involved in many aspects of cellular function, such as cell movement [ 1 ], muscle contraction [ 2 ], phagocytosis [ 3 ] and mitosis [ 4 ]. Several studies suggested a link between cytoskeleton dynamics...
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Biochem J (2005) 387 (1): 47–55.
Published: 22 March 2005
... The Biochemical Society, London 2005 A20 apoptosis necrosis nuclear factor κB (NF-κB) oxidative stress reactive oxygen species (ROS) ROS (reactive oxygen species) are metabolic by-products produced during many physiological processes, and have been increasingly recognized as critical components...
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Biochem J (2004) 382 (2): 641–650.
Published: 24 August 2004
... protein (HSP) matrixassisted laser-desorption ionization–time-of-flight mass spectrometry (MALDI–TOF-MS) oxidative stress reactive oxygen species (ROS) Arsenic is a well-known carcinogen and possibly acts as a tumour promoter in the process of carcinogenesis [ 1 – 4 ]. Although arsenic has been...
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Biochem J (2004) 381 (3): e1.
Published: 27 July 2004
... 5 2004 26 5 2004 The Biochemical Society, London 2004 glutathione glutathionylation kinase mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase kinase (MEKK1) oxidative stress reactive oxygen species (ROS) 1 To whom correspondence should...
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Biochem J (2004) 380 (2): 393–400.
Published: 01 June 2004
..., protein co-tar- geting, reactive oxygen species (ROS), Saccharomyces cerevisiae. INTRODUCTION In all eukaryotic cells, peroxisomes and mitochondria share a great variety of enzymic reactions that are catalysed by isoenzymes present in both organelles. For some of these enzymes it is known that they can...