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Keywords: reactive oxygen species (ROS)
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Articles
Biochem J (2016) 473 (14): 2141–2154.
Published: 12 July 2016
...-deficient F9 cells were reversed, suggesting that SPS1 played a role in supporting and/or sustaining cancer. In addition, the overexpression of mouse or human GLRX1 led to a reversal of observed increases in reactive oxygen species (ROS) in the F9 SPS1/GLRX1-deficient cells and resulted in levels that were...
Includes: Supplementary data
Articles
Biochem J (2015) 468 (2): 325–336.
Published: 22 May 2015
... Gasdermin A3 GSDM family reactive oxygen species (ROS) The skin is one of the largest organs in the human body. The epidermis consists of stratified squamous epithelium and has an outermost cornified layer that forms a protective barrier against the external environment. The skin prevents the...
Includes: Supplementary data
Articles
Biochem J (2015) 466 (2): 369–378.
Published: 20 February 2015
... oxidoreductin 1-α (ERO1α), a target of CHOP, is an important oxidizing enzyme that regulates reactive oxygen species (ROS), which play a prominent role in hepatocellular death during acute liver failure (ALF). However, little is known about how CHOP facilitates ROS-induced hepatocellular injury. The present...
Includes: Supplementary data
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Biochem J (2014) 464 (1): 157–168.
Published: 23 October 2014
... cardiovascular diseases. deacetylation forkhead box O3 (FOXO3) hypoxia sirtuin3 (SIRT3) reactive oxygen species (ROS) mitochondrial antioxidant enzyme The oxygen supply to cells or tissues is reduced during aging and in many pathological conditions, including cancer, diabetic retinopathy and...
Includes: Supplementary data
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Biochem J (2014) 463 (1): 53–63.
Published: 08 September 2014
...Tatsuro Kawamura; Yasumitsu Kondoh; Makoto Muroi; Makoto Kawatani; Hiroyuki Osada Induction of excessive levels of reactive oxygen species (ROS) by small-molecule compounds has been considered a potentially effective therapeutic strategy against cancer cells, which are often subjected to chronic...
Includes: Supplementary data
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Biochem J (2014) 462 (3): 475–487.
Published: 22 August 2014
... compounds affect both complex I and ATP synthase in mammalian mitochondria. ATP synthase biguanide complex I metformin NADH:quinone oxidoreductase reactive oxygen species (ROS) Metformin is the most commonly prescribed drug for Type II diabetes. It decreases blood glucose by mechanisms...
Articles
Biochem J (2014) 462 (2): 337–345.
Published: 07 August 2014
... modification protein–protein interaction reactive oxygen species (ROS) The NADPH oxidase complex generates ROS (reactive oxygen species) by transferring electrons from NADPH across biological membranes to dioxygen. These reactions occur through the membrane catalytic subunit which presents conserved...
Articles
Biochem J (2014) 461 (2): 189–203.
Published: 26 June 2014
... development, which probably depends on its multiple activities. chaperone DJ-1/PfpI malaria peroxiredoxin Plasmodium reactive oxygen species (ROS) 17 1 2014 17 4 2014 23 4 2014 23 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Malaria...
Includes: Supplementary data
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Biochem J (2014) 459 (2): 251–263.
Published: 28 March 2014
... oxide synthase (nNOS) neuroprotection 8-nitro-cGMP phosphorylation redox signalling reactive oxygen species (ROS) In the nervous system, NO is involved in multiple physiological and pathological processes, including neurotransmission, development, neuroprotection, apoptosis, vascular...
Articles
Biochem J (2013) 456 (3): 337–346.
Published: 22 November 2013
..., thereby inhibiting hypoxia-induced cellular responses. hypoxia hypoxia-inducible factor (HIF) hypoxic pulmonary vasoconstriction peroxiredoxin-5 reactive oxygen species (ROS) redox-sensitive GFP (roGFP) Adaptation to low levels of oxygen (hypoxia) is critical for survival, as all...
Includes: Supplementary data
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Biochem J (2013) 454 (2): 201–208.
Published: 09 August 2013
... -cysteine (NAC) reactive oxygen species (ROS) proteasome inhibitor Both proteasome inhibitors and ROS (reactive oxygen species) inducers are important emerging classes of anticancer drugs. In general, proteasome inhibitors hinder proteasome function resulting in cancer cell death, and ROS inducers...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (3): 381–391.
Published: 05 October 2012
... by its ring-like nucleoid or accumulation of Mn(II) [ 4 – 11 ]. Deinococcus radiodurans DNA protection during starvation (Dps) ferroxidase activity green fluorescent protein (GFP) nucleoid organization reactive oxygen species (ROS) To remove divalent cations, proteins were...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (2): 281–289.
Published: 26 September 2012
... unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cell death energy metabolism mitochondrion Src tyrosine kinase reactive oxygen species (ROS) Mitochondrial serine/threonine phosphorylation has been investigated in...
Includes: Supplementary data
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Biochem J (2012) 446 (1): 23–36.
Published: 27 July 2012
... 12 3 2012 23 5 2012 23 5 2012 activin receptor type II B autophagy–lysosome system myostatin nuclear factor κB (NF-κB) reactive oxygen species (ROS) skeletal muscle wasting tumoral factor ubiquitin–proteasome system © 2012 The Author(s) 2012 This is an open-access...
Includes: Supplementary data
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Biochem J (2012) 445 (3): 441–448.
Published: 13 July 2012
..., CA 92093, U.S.A. 2 To whom correspondence should be addressed (email runnellw@umdnj.edu ). 8 2 2012 27 4 2012 15 5 2012 15 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cell stress Mg 2+ reactive oxygen species (ROS...
Includes: Supplementary data
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Biochem J (2012) 444 (1): 27–38.
Published: 26 April 2012
... compilation © 2012 Biochemical Society 2012 peroxisome-proliferator-activated receptor δ (PPARδ) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatidylinositol 3-kinase (PI3K) senescence reactive oxygen species (ROS) UVB Cellular senescence is the permanent and...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 735–746.
Published: 16 April 2012
... 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis CS055 differentiation histone deacetylase inhibitor (HDACi) leukaemia proliferation inhibition reactive oxygen species (ROS) Leukaemia, also known as blood cancer, is characterized by rapid cell...
Includes: Supplementary data
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Biochem J (2012) 443 (1): 75–84.
Published: 14 March 2012
... (fetal bovine serum; Gibco), 100 units/ml penicillin, 100 μg/ml streptomycin and 0.25 μg/ml amphotericin B (Gibco) in a humidified atmosphere of 5% CO 2 and 95% air at 37°C. apoptosis lipocalin neuroprotection prostaglandin D synthase reactive oxygen species (ROS) SH-SY5Y Oxidative...
Includes: Supplementary data
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Biochem J (2012) 441 (2): 719–730.
Published: 21 December 2011
... 6 2011 3 10 2011 4 10 2011 4 10 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 mitochondrion nitric oxide oxidative stress peroxynitrite reactive oxygen species (ROS) reactive oxygen species (ROS) signalling cGMP is a cyclic nucleotide...
Includes: Supplementary data
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Biochem J (2011) 438 (3): 433–436.
Published: 26 August 2011
... Journal compilation © 2011 Biochemical Society 2011 citrate carrier (CIC) gene regulation immune cell nitric oxide (NO) prostaglandin E 2 reactive oxygen species (ROS) Inflammation is an immune response to infection, tissue injury and other noxious insults [ 1 ]. It is characterized by...
Includes: Supplementary data
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Biochem J (2011) 438 (3): 485–494.
Published: 26 August 2011
... reactive oxygen species (ROS) superoxide reductase Since the early 1990s, several reports of new classes of non-haem iron protein isolation and characterization have been published [ 6 – 16 ]. However, only in 1999 was the real function of some of these proteins assigned [ 17 ]. The so-called SORs...
Includes: Supplementary data
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Biochem J (2011) 436 (3): 687–698.
Published: 27 May 2011
... were gated out and 10000 cells were examined. apoptosis DNA damage mitochondrion phosphoinositide 3-kinase (PI3K) reactive oxygen species (ROS) spermatozoon Defective sperm function is the single most common defined cause of human infertility [ 1 ]. Furthermore, the DNA damage...
Articles
Biochem J (2011) 435 (3): 545–551.
Published: 13 April 2011
... development and/or progression. apoptosis B-cell lymphocytic-leukaemia proto-oncogene 2 (Bcl-2) mitochondrion reactive oxygen species (ROS) The role of mitochondria in programmed cell death has been studied extensively over the last few decades. It is now well established that stress signals...
Articles
Biochem J (2011) 435 (2): 489–498.
Published: 29 March 2011
... Biochemical Society 2011 promoter analysis reactive oxygen species (ROS) small ubiquitin-related modifier 2/3 (SUMO2/3) specificity protein 1 (Sp1) transcription To identify the regions and the corresponding transcription factors of the promoter mediating responses to oxidative stress, site...
Includes: Supplementary data
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Biochem J (2010) 430 (3): 439–451.
Published: 27 August 2010
...@bio.uniroma2.it ). 6 4 2010 17 6 2010 30 6 2010 30 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 apoptosis glucose glutathione mitogen-activated protein kinase (MAPK) p53 reactive oxygen species (ROS) Oxidative stress is considered to be...
Includes: Supplementary data
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Biochem J (2010) 428 (2): 183–190.
Published: 13 May 2010
...) 2′,7′-dichlorofluorescein (DCF) lysosome oxidative stress reactive oxygen species (ROS) transition metal The molecular mechanisms behind AMD (age-related macular degeneration) are much debated but far from understood, even though it is the most common cause of visual impairment among the...
Articles
Biochem J (2009) 424 (3): 491–500.
Published: 10 December 2009
... response to oxidative stress and physiological stimuli [ 4 – 7 ]. Compartmentation of selected redox couple changes may further the specificity in the redox control of signal transduction. cysteine nuclear factor-erythroid 2-related factor 2 (Nrf2) reactive oxygen species (ROS) redox thiol...
Articles
Biochem J (2009) 423 (1): 109–118.
Published: 14 September 2009
... inositol pyrophosphate inositol hexakisphosphate kinase (IP6K) Kcs1 metabolism Rad53 reactive oxygen species (ROS) Inositol pyrophosphates in both lower eukaryotes such as yeast as well as mammalian cells are generated by the sequential phosphorylation of IP 3 (inositol trisphosphate) [ 1 , 2...
Articles
Biochem J (2009) 422 (3): 521–531.
Published: 27 August 2009
... nuclear factor κB (NF-κB) reactive oxygen species (ROS) thioredoxin transcription Thioredoxins are a class of ubiquitously expressed redox proteins containing a conserved consensus amino acid sequence (Cys-Gly-Pro-Cys) in their catalytic centre. They exist either in a reduced dithiol form or in...
Articles
Biochem J (2009) 418 (3): 595–604.
Published: 25 February 2009
... © 2009 Biochemical Society 2009 apoptosis membrane attack complex (MAC) oxidative phosphorylation reactive oxygen species (ROS) Trypanosoma cruzi trypanosomatid Trypanosoma cruzi is a protozoan parasite of the order Kinetoplastida that causes Chagas' disease, an infection that...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (1): 1–13.
Published: 12 December 2008
... ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. complex I hydrogen peroxide mitochondrion reactive oxygen species (ROS) respiratory chain superoxide...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 414 (1): 53–61.
Published: 29 July 2008
... reactive oxygen species (ROS) Water channels, aquaporins, have been identified in most organisms, including plants, and have specific physiological functions related to water facilitation in many tissues [ 1 – 3 ]. Aquaporins are tetramers and each subunit forms a pore. Many plant aquaporin...
Includes: Supplementary data
Articles
Biochem J (2008) 413 (3): 389–404.
Published: 15 July 2008
.... 1 To whom correspondence should be addressed ( C.W.Gourlay@kent.ac.uk ). 8 2 2008 9 5 2008 13 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 actin apoptosis mitochondrion programmed cell death (PCD) reactive oxygen species (ROS...
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Biochem J (2008) 413 (1): 1–13.
Published: 12 June 2008
...@leeds.ac.uk . 4 2 2008 22 4 2008 22 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 chaperone mitochondrion Parkinson's disease reactive oxygen species (ROS) ubiquitin Parkinson's disease (PD) is the second most common neurodegenerative disease...
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Biochem J (2007) 406 (1): 105–114.
Published: 26 July 2007
... Biochemical Society 2007 hydrogen peroxide NADPH oxidase (NOX) NOX4 NOX4 inhibitor reactive oxygen species (ROS) superoxide NOX4 is a member of the NOX (NADPH oxidase) family of NADPH oxidases. These enzymes transport electrons from cytoplasmic NADPH across cell and organelle membranes to...
Articles
Biochem J (2007) 405 (3): 523–531.
Published: 13 July 2007
... 2006 28 3 2007 16 4 2007 16 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Arabidopsis thaliana cytosolic aconitase ferritin iron homoeostasis iron-regulatory protein 1 (IRP1) reactive oxygen species (ROS) As the major cofactor of...
Articles
Biochem J (2007) 405 (3): 559–568.
Published: 13 July 2007
... factor (Hb-EGF) matrix metalloproteinase (MMP) mobile phone irradiation NADH oxidase reactive oxygen species (ROS) The intensive use of mobile or cellular phones in the last 20 years has aroused concern about possible health problems that may be caused by the microwave irradiation which is...
Articles
Biochem J (2007) 405 (2): 251–259.
Published: 27 June 2007
... © 2007 Biochemical Society 2007 heparin-binding epidermal growth factor-like growth factor (HB-EGF) hepatocyte NADPH oxidase (NOX) nuclear factor-κB (NF-κB) reactive oxygen species (ROS) transforming growth factor (TGF) TGF-β (transforming growth factor-β) belongs to a family of...
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Biochem J (2007) 405 (1): 1–9.
Published: 13 June 2007
... oxidase (COX) hypoxia-inducible factor-1 (HIF-1) mitochondrial respiratory chain oxidative phosphorylation reactive oxygen species (ROS) tricarboxylic acid cycle The evolution of multicellular organisms on Earth was dependent upon two critical events. The first event, ∼2.5 billion years ago...
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Biochem J (2007) 403 (2): 323–334.
Published: 26 March 2007
...@fmed.edu.uy ). 22 8 2006 5 12 2006 14 12 2006 14 12 2006 The Biochemical Society, London 2007 free radicals mitochondrial superoxide dismutase programmed cell death (PCD) reactive oxygen species (ROS) Trypanosoma cruzi Apoptosis is characterized by a series of...
Includes: Supplementary data
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Biochem J (2007) 402 (2): 271–278.
Published: 12 February 2007
... 10 2006 The Biochemical Society, London 2007 lipopolysaccharide mitochondria mitogen-activated protein kinase (MAPK) reactive oxygen species (ROS) signalling uncoupling protein 2 (UCP2) Innate immunity, the host's first line of defense against pathogens, relies on many cells...
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Biochem J (2006) 395 (2): 405–415.
Published: 28 March 2006
... apoptosis metallothionein mitochondria NADH:ubiquinone oxidoreductase reactive oxygen species (ROS) rotenone The production of ATP through the process of OXPHOS (oxidative phosphorylation) involves the successive transport of electrons through four mitochondrial enzyme complexes. The first of...
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Biochem J (2005) 392 (1): 93–102.
Published: 08 November 2005
.../EBP) reactive oxygen species (ROS) RTP801 gene Metals are trace elements that are essential for life. However, certain metals, including arsenic, and their derivatives confer toxic effects on the body, which are manifested in carcinogenesis, neurotoxicity and immunotoxicity [ 1 ]. Two...
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Biochem J (2005) 390 (2): 377–394.
Published: 23 August 2005
... reactive oxygen species (ROS) reperfusion The heart is a pump that converts chemical energy into mechanical work. The power produced by cardiac muscle is generated almost entirely by the oxidation of carbon fuels with oxygen, and to a great extent the fuels are provided by coronary (myocardial...
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Biochem J (2005) 387 (2): 531–540.
Published: 05 April 2005
... cells nuclear factor κB (NF-κB) reactive oxygen species (ROS) The cytoskeleton is involved in many aspects of cellular function, such as cell movement [ 1 ], muscle contraction [ 2 ], phagocytosis [ 3 ] and mitosis [ 4 ]. Several studies suggested a link between cytoskeleton dynamics and...
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Biochem J (2005) 387 (1): 47–55.
Published: 22 March 2005
... pstorz@bidmc.harvard.edu ). 23 8 2004 26 10 2004 4 11 2004 4 11 2004 The Biochemical Society, London 2005 A20 apoptosis necrosis nuclear factor κB (NF-κB) oxidative stress reactive oxygen species (ROS) ROS (reactive oxygen species) are metabolic by-products...
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Biochem J (2004) 382 (2): 641–650.
Published: 24 August 2004
... apoptosis arsenite heat shock protein (HSP) matrixassisted laser-desorption ionization–time-of-flight mass spectrometry (MALDI–TOF-MS) oxidative stress reactive oxygen species (ROS) Arsenic is a well-known carcinogen and possibly acts as a tumour promoter in the process of carcinogenesis [ 1...
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Biochem J (2004) 381 (3): e1.
Published: 27 July 2004
... stress reactive oxygen species (ROS) The regulation of intracellular levels of ROS (reactive oxygen species) such as H 2 O 2 , • O 2 − (superoxide anions) and • OH (hydroxyl radicals) is a matter of life and death. ROS are the unavoidable by-products of the metabolic processes essential for...
Articles
Biochem J (2004) 381 (2): 447–452.
Published: 06 July 2004
... ). 9 2 2004 6 4 2004 26 4 2004 26 4 2004 The Biochemical Society, London 2004 amphipathic Candida dihydroethidium histatin membrane reactive oxygen species (ROS) Antimicrobial peptides are found throughout Nature, and form a cornerstone of innate defence...
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Biochem J (2004) 380 (2): 393–400.
Published: 01 June 2004
... The Biochemical Society, London ©2004 2004 catalase A mitochondria peroxisome protein co-targeting reactive oxygen species (ROS) Saccharomyces cerevisiae Abbreviations used: Cox3, cytochrome c oxidase subunit III; CPY, carboxypeptidase Y; Cta1p, catalase A protein; GFP, green...