...Aidan P. McCann; Christopher J. Scott; Sandra Van Schaeybroeck; James F. Burrows In recent times, our knowledge of the roles ubiquitin plays in multiple cellular processes has expanded exponentially, with one example being the role of ubiquitin in receptor endocytosis and trafficking. This has...

... Ig-like molecules with one to three Ig-like loops. Furthermore, nectins and Necls cis -interact with membrane receptors and integrins, some of which are associated with the nectin-mediated cell adhesions, and play roles in the regulation of many cellular functions, such as cell polarization, movement...

... for extracellular ATP has been well studied in mammals over the last 40 years, investigations of such a role in plants are at an early stage. Recently, the first plant receptor for extracellular ATP, DOes not Respond to Nucleotides (DORN1), was identified in Arabidopsis thaliana by mutant screening. DORN1 encodes...

... against human IL-13Rα1 (IL-13 receptor α1) subunit that prevent activation of the receptor complex by both IL-4 and IL-13. We describe the crystal structures of the Fab fragment of antibody 10G5H6 alone and in complex with D3 (ectodomain 3) of IL-13Rα1. Although the structure showed significant domain...

... to affect the platelet aggregation process. The toxin associates with platelet intracellular binding sites and induces aggregation in platelet-rich plasma in a dose-dependent manner. We identified the adhesion receptor glycoprotein Ib-IX-V as fusicoccin target. The toxin promotes the binding...

...Ying-Chi Chao; Chien-Jui Cheng; Hsiu-Ting Hsieh; Chih-Ching Lin; Chien-Chang Chen; Ruey-Bing Yang GC (guanylate cyclase)-G is the most recently identified member of the receptor GC family. However, the regulation of its activity and protein expression in the mammalian olfactory system remains...

... (glycosylphosphatidylinositol)-anchored ALP (alkaline phosphatase), the toxin also binds a 250 kDa membrane protein. Since this protein is the same size as cadherin, which in lepidopteran insects is an important Cry toxin receptor, we developed an anti-AaeCad antibody. This antibody detects a 250 kDa protein in immunoblots...

...Hrvoje Banfic; Dora Visnjic; Nikica Mise; Sanjeevi Balakrishnan; Simona Deplano; Yuri E. Korchev; Jan Domin Although the class II phosphoinositide 3-kinase enzymes PI3K-C2α and PI3K-C2β act acutely downstream of cell surface receptors they have also been localized to nuclei in mammalian cells...

...Duorong XU; Zhenqi SHI; Jay McDONALD; George PAN; Xuemei CAO; Xueqing YU; Xu FENG Members of the tumour necrosis factor receptor family play a pivotal role in cell differentiation, function and apoptosis. However, signalling by many members of the family remains to be elucidated. In the present...

... GC-G. It encodes a potential type I transmembrane receptor, with the characteristic domain structure common to all members of the family of membrane GCs, including an extracellular, putative ligand-binding domain, a single membrane-spanning segment and cytoplasmic protein kinase-like and cyclase...

...Eivind F. FINNE; Else MUNTHE; Hans-Christian AASHEIM Ephrins are ligands for the Eph receptor tyrosine kinases, which play important roles in patterning nervous and vascular systems. Ephrin-A1 is a glycosylphosphatidylinositol-anchored ligand that binds to the EphA receptor tyrosine kinases...

... adaptor protein AP-2 clathrin coated pit endocytosis receptor Abbreviations used: ANTH, AP180 N-terminal homology; AP, adaptor (or assembly) protein; CALM, clathrin assembly lymphoid myeloid leukaemia; CIN85, Cbl-interacting protein of 85 kDa; Dab2, Disabled protein 2; E1, ubiquitin...

...Laura CERCHIA; Domenico LIBRI; Maria Stella CARLOMAGNO; Vittorio de FRANCISCIS Substitution of Cys-634 in the extracellular domain of the Ret tyrosine kinase receptor causes its dimerization and activation of its transforming potential. To gain further insight into the molecular basis leading...

... basement membrane cell–matrix interaction protein module receptor recombinant protein Abbreviations used: DMEM, Dulbecco's modified Eagle's medium; ECM, extracellular matrix; FBS, fetal bovine serum; LG, laminin-G-domain-like; RT-PCR, reverse-transcription PCR; WGA, wheat-germ agglutinin...

..., London ©2003 2003 Cry toxin insect receptor Abbreviations used: AP, alkaline phosphatase; APN, aminopeptidase N; BBMV, brush-border membrane vesicle; BCIP, 5-bromo-4-chloroindol-3-yl phosphate toluidine; Bt, Bacillus thuringiensis ; Cry, crystalline inclusion protein; GPI, glycosyl...

..., at the Department of Biology, Åbo Akademi University (e-mail [email protected] ). 24 6 2002 29 10 2002 5 11 2002 5 11 2002 The Biochemical Society, London ©2003 2003 calcium entry receptor sphingolipid Abbreviations used: 2-APB, 2-aminoethoxydiphenylborate; [Ca 2...

...Charlotte A. LEWIS; Paul A. TOWNSEND; Clare M. ISACKE CD44 is the principal cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and binding to this ligand underlies CD44-mediated cell attachment and migration. As would be expected for a widely expressed adhesion...

... with either a Met or an Asn residue immediately C-terminal. Equilibrium competition experiments INTRODUCTION Integrins are a family of cell-surface heterodimeric glycoprotein receptors that mediate a host of cell cell and cell matrix inter- actions underlying numerous physiological processes [1]. Integrin...

... (e-mail [email protected]). 26 5 1999 6 9 1999 24 9 1999 The Biochemical Society, London © 1999 1999 adhesion mutagenesis receptor Biochem. J. (1999) 344, 527 533 (Printed in Great Britain) 527 Fine mapping of inhibitory anti-a5 monoclonal antibody epitopes...

..., distinctive from those of C3a, using chemical modifications, enzymic cleavage and synthetic peptide fragments. The results indicate that: (i) the N-terminal region (< 10 amino acids) plays little role in ASP receptor binding and triacylglycerol synthesis stimulation; (ii) the native C-terminal region had...

... 1999 lectins receptor sialic acid sialyl-lactose siglecs Biochem. J. (1999) 341, 355 361 (Printed in Great Britain) 355 Molecular analysis of sialoside binding to sialoadhesin by NMR and site-directed mutagenesis Paul R. CROCKER Mary VINSON‹1, Sørge KELMŒ, and Kurt DRICKAMER2 *Department...

...+ , but not all heavy-metal ions, evoke an increase in [Ca 2+ ] i in hepatocytes by stimulating release of the hormone-sensitive intracellular Ca 2+ stores and that they may do so by interacting with a specific cell-surface ion receptor. This putative ion receptor may be important in allowing hepatocytes...