... phosphotyrosine signalling phosphotyrosine-binding domain (PTB domain) receptor tyrosine kinase signal transduction Src homology and collagen homology (Shc) Src homology 2 domain (SH2 domain) Fundamentally, the ability of Shc proteins to engage in controlled signal propagation in a given cell...

...Ilaria Lamberto; Haina Qin; Roberta Noberini; Lakshmanane Premkumar; Caroline Bourgin; Stefan J. Riedl; Jianxing Song; Elena B. Pasquale The EphA4 receptor tyrosine kinase interacts with ephrin ligands to regulate many processes, ranging from axon guidance and nerve regeneration to cancer...

...) receptor tyrosine kinase In support of this hypothesis, we found that inhibition of PI3K using LY294002 only modestly affected MEK and ERK phosphorylation stimulated by high (1 nM) or subsaturating (0.01 nM) doses of FGF ( Figures 2a and 2 b), whereas PI3K inhibition substantially reduced PDGF...

... growth factor (FGF) fibroblast growth factor receptor (FGFR) receptor tyrosine kinase signalling therapy Human cancers usually develop through a multi-stage process that may extend over decades. During cancer development, normal cells are progressively transformed into highly malignant...

...Christina Wehrle; Paul Van Slyke; Daniel J. Dumont Tie2 [where ‘Tie’ is an acronym from t yrosine kinase with I g and E GF (epidermal growth factor) homology domains] is a receptor tyrosine kinase expressed predominantly on the surface of endothelial cells. Activated by its ligands...

...Nicole K. Noren; Nai-Ying Yang; Morgan Silldorff; Ravi Mutyala; Elena B. Pasquale Receptor tyrosine kinases of the Eph family become tyrosine phosphorylated and initiate signalling events upon binding of their ligands, the ephrins. Eph receptors such as EphA2 and EphB4 are highly expressed...

... To whom correspondence should be addressed (email [email protected] ). 15 1 2008 26 6 2008 30 6 2008 30 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 adaptor protein c-Kit Lnk protein–protein interaction receptor tyrosine kinase signal...

...% FBS overnight and stimulated with 100 ng/ml SCF for the indicated periods of time unless stated otherwise. The Biochemical Society, London 2006 Cbl degradation Src family kinase stem cell factor receptor/c-Kit receptor tyrosine kinase ubiquitin ligase c-Kit belongs to the family...

... Society, London 2006 mathematical modelling phosphoinositide 3-kinase (PI3K) platelet-derived growth factor (PDGF) Ras receptor tyrosine kinase signal transduction 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed (email...

... should be addressed (email [email protected] ). 7 6 2005 19 7 2005 28 7 2005 The Biochemical Society, London 2005 computational modelling extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) receptor tyrosine kinase signalling...

... Society, London 2005 Cbl E3 ligase receptor tyrosine kinase T-cell receptor thymocyte ubiquitin The mammalian Cbl family of proteins consists of three homologues known as c-Cbl, Cbl-b and Cbl-3 ( Figure 1 ). All three share highly conserved regions in their N-terminal halves which...

... growth-arrest-specific gene 6 (Gas6) laminin-like globular domain monoclonal antibody platelet receptor tyrosine kinase Gas6 (growth-arrest-specific gene 6) is a vitamin K-dependent protein that activates the Axl family of receptors, which includes Axl (Ufo/Ark), Sky (Dtk/Tyro3/Rse/Brt/Tif...

...Craig C. MALBON Cell signalling via receptor tyrosine kinases, such as the insulin receptor, and via heterotrimeric G-proteins, such as Gα i , Gα s and Gα q family members, constitute two of most avidly studied paradigms in cell biology. That elements of these two populous signalling pathways must...

... factor receptor. Key words: Akt/protein serine/threonine kinase B (PKB), macrophage-stimulating protein (MSP), protein phosphatase, protein phosphorylation, receptor tyrosine kinase, Ron. INTRODUCTION Receptor tyrosine kinases (RTKs) can be regulated by PTPs (protein tyrosine phosphatases [1]) in many...

... 2001 21 6 2001 The Biochemical Society, London ©2001 2001 mass spectrometry phosphotyrosine receptor tyrosine kinase Abbreviations used: ESI, electrospray ionization; FBS, fetal bovine serum; Flk-1, fetal liver kinase-1; Flt-1, fms-like tyrosine kinase-1; HUVECs, human...

...-mail [email protected] ). 29 11 2000 4 5 2001 21 6 2001 The Biochemical Society, London ©2001 2001 c-Fms ERK okadaic acid receptor tyrosine kinase signalling Abbreviations used: CSF-1, colony-stimulating factor-1; CSF-1R, CSF-1 receptor; WT, wild type; PP2A, protein...

... we describe the identification of the adaptor protein, Shc-like protein (Sck), as a binding INTRODUCTION Vascular endothelial growth factor (VEGF) is a key angiogenic growth factor that binds to two receptor tyrosine kinases, fms- like tyrosine kinase (Flt1) and kinase insert domain-containing...

... signalling of receptor tyrosine kinases. Receptor dimerization leads to an increase in kinase activity, resulting in autophosphorylation and the induction of diverse biological Abbreviations used: FGF, fibroblast growth factor ; FGFR, FGF receptor ; FGF1 (aFGF), acidic FGF; FGF2 (bFGF), basic FGF; DSS...

...Sherry MOU; Diana LINNEKIN Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical in haemopoiesis. Recently we found that the Src family member Lyn is highly expressed in SCF-responsive cells, associates with c-Kit and is activated within minutes of the addition of SCF...