... phosphotyrosine signalling phosphotyrosine-binding domain (PTB domain) receptor tyrosine kinase signal transduction Src homology and collagen homology (Shc) Src homology 2 domain (SH2 domain) Although the finer details of Shc regulation are still subject to investigation, it is evident that numerous...

...Ilaria Lamberto; Haina Qin; Roberta Noberini; Lakshmanane Premkumar; Caroline Bourgin; Stefan J. Riedl; Jianxing Song; Elena B. Pasquale The EphA4 receptor tyrosine kinase interacts with ephrin ligands to regulate many processes, ranging from axon guidance and nerve regeneration to cancer...

...) receptor tyrosine kinase Cells were serum-starved for 4 h prior to stimulation. Detergent lysates were prepared for quantitative immunoblotting, and immunoblots were performed using enhanced chemiluminescence, as described previously [ 19 , 20 ]. Blots comparing lysates prepared on the same day...

... will probably vary between cancer types and subtypes [ 1 ]. cancer fibroblast growth factor (FGF) fibroblast growth factor receptor (FGFR) receptor tyrosine kinase signalling therapy Cancers may be hereditary or sporadic depending on whether the tumour-causing mutations occur in the germline...

...Christina Wehrle; Paul Van Slyke; Daniel J. Dumont Tie2 [where ‘Tie’ is an acronym from t yrosine kinase with I g and E GF (epidermal growth factor) homology domains] is a receptor tyrosine kinase expressed predominantly on the surface of endothelial cells. Activated by its ligands...

...Nicole K. Noren; Nai-Ying Yang; Morgan Silldorff; Ravi Mutyala; Elena B. Pasquale Receptor tyrosine kinases of the Eph family become tyrosine phosphorylated and initiate signalling events upon binding of their ligands, the ephrins. Eph receptors such as EphA2 and EphB4 are highly expressed...

... To whom correspondence should be addressed (email [email protected] ). 15 1 2008 26 6 2008 30 6 2008 30 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 adaptor protein c-Kit Lnk protein–protein interaction receptor tyrosine kinase signal...

...-Kit-mediated signalling. c-Kit belongs to the family of type III RTKs (receptor tyrosine kinases) and plays a major role in survival, expansion and differentiation of haematopoietic progenitor cells, as well as stem cells involved in reproduction and pigmentation (for a review, see [ 1 ]). Moreover...

... receptor tyrosine kinase signal transduction PI3K (phosphoinositide 3-kinase) and Ras are pivotal players in signal transduction pathways that co-ordinate proliferation, survival and migration in normal and transformed cells. PI3Ks are composed of regulatory and catalytic subunits...

... should be addressed (email [email protected] ). 7 6 2005 19 7 2005 28 7 2005 The Biochemical Society, London 2005 computational modelling extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) receptor tyrosine kinase signalling...

... Society, London 2005 Cbl E3 ligase receptor tyrosine kinase T-cell receptor thymocyte ubiquitin The mammalian Cbl family of proteins consists of three homologues known as c-Cbl, Cbl-b and Cbl-3 ( Figure 1 ). All three share highly conserved regions in their N-terminal halves which...

... domain monoclonal antibody platelet receptor tyrosine kinase 21 5 2004 11 11 2004 3 12 2004 3 12 2004 The Biochemical Society, London 2005 The digested protein sample was dried in a SpeedVac (Thermo Electron, Waltham, MA, U.S.A.) and redissolved in 0.1...

...Craig C. MALBON Cell signalling via receptor tyrosine kinases, such as the insulin receptor, and via heterotrimeric G-proteins, such as Gα i , Gα s and Gα q family members, constitute two of most avidly studied paradigms in cell biology. That elements of these two populous signalling pathways must...

... factor receptor. Key words: Akt/protein serine/threonine kinase B (PKB), macrophage-stimulating protein (MSP), protein phosphatase, protein phosphorylation, receptor tyrosine kinase, Ron. INTRODUCTION Receptor tyrosine kinases (RTKs) can be regulated by PTPs (protein tyrosine phosphatases [1]) in many...

... 2001 21 6 2001 The Biochemical Society, London ©2001 2001 mass spectrometry phosphotyrosine receptor tyrosine kinase Abbreviations used: ESI, electrospray ionization; FBS, fetal bovine serum; Flk-1, fetal liver kinase-1; Flt-1, fms-like tyrosine kinase-1; HUVECs, human...

...-mail [email protected] ). 29 11 2000 4 5 2001 21 6 2001 The Biochemical Society, London ©2001 2001 c-Fms ERK okadaic acid receptor tyrosine kinase signalling Abbreviations used: CSF-1, colony-stimulating factor-1; CSF-1R, CSF-1 receptor; WT, wild type; PP2A, protein...

..., in a phosphorylation-dependent fashion, when co-expressed in human embryonic kidney 293 cells. Furthermore, we demonstrate that in the two-hybrid assay, both Shc and Sck SH2 domains can associate with the related receptor Flt1. angiogenesis receptor tyrosine kinase signalling VEGF. Biochem. J. (2000) 347, 501...

... the experimental data. 1 To whom correspondence should be addressed (e-mail liyayon@;wiccmail.weizmann.ac.il). 13 4 1999 19 8 1999 1 10 1999 The Biochemical Society, London © 2000 2000 heparan sulphate molecular docking proteoglycans receptor tyrosine kinase Biochem. J...

...Sherry MOU; Diana LINNEKIN Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical in haemopoiesis. Recently we found that the Src family member Lyn is highly expressed in SCF-responsive cells, associates with c-Kit and is activated within minutes of the addition of SCF...