... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . adipocytes molecular mechanisms receptor tyrosine kinases transforming growth factors The transforming growth factor β...

... with Portland Press and the Biochemical Society under a transformative agreement with UC. biological networks computational models epidermal growth factor receptor extracellular signal-regulated kinases mitogen-activated protein kinases receptor tyrosine kinases The extracellular signal...

... eukaryotic gene expression extracellular signal-regulated kinases gene regulatory networks receptor tyrosine kinases The extracellular signal-regulated kinases (ERK) are a subset of the mitogen-activated protein kinases (MAPKs) that regulate many aspects of cellular physiology, including cell...

...Piyali Majumder; Kaushik Chanda; Debajyoti Das; Brijesh Kumar Singh; Partha Chakrabarti; Nihar Ranjan Jana; Debashis Mukhopadhyay Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) share a common hallmark of insulin resistance. Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK...

... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . phosphorylation/dephosphorylation receptor tyrosine kinases receptors All organisms must perceive external cues for adaptation of their physiology to changing...

...Fozia Ahmed; Michael D. Paul; Kalina Hristova Tropomyosin receptor kinase B (Trk-B) belongs to the second largest family of membrane receptors, Receptor Tyrosine Kinases (RTKs). Trk-B is known to interact with three different neurotrophins: Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin-4...

...Monica Gonzalez-Magaldi; Jacqueline M. McCabe; Haley N. Cartwright; Ningze Sun; Daniel J. Leahy Receptor Tyrosine Kinases (RTKs) comprise a diverse group of cell-surface receptors that mediate key signaling events during animal development and are frequently activated in cancer. We show here...

...Stephen C. Artim; Anatoly Kiyatkin; Mark A. Lemmon The tropomyosin-related kinase (Trk) family consists of three receptor tyrosine kinases (RTKs) called TrkA, TrkB, and TrkC. These RTKs are regulated by the neurotrophins, a class of secreted growth factors responsible for the development...

... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 epithelial-to-mesenchymal transition receptor tyrosine kinases signaling Anti-PRL rabbit polyclonal antibody was generated in the previous study [ 28 ]. The following commercially...

...Fozia Ahmed; Kalina Hristova Receptor tyrosine kinases (RTKs) are cell surface receptors which control cell growth and differentiation, and play important roles in tumorigenesis. Despite decades of RTK research, the mechanism of RTK activation in response to their ligands is still under debate...

... antibodies. molecular scaffolds receptor tyrosine kinases receptors signaling Axl is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase (RTK) family [ 1 ]. TAM receptors are characterized by two extracellular immunoglobulin(Ig)-like domains and two fibronectin type 3-like domains...

...Zimple Kurlawala; Rain Dunaway; Parag P. Shah; Julie A. Gosney; Leah J. Siskind; Brian P. Ceresa; Levi J. Beverly Insulin-like growth factor-1 receptor (IGF1R) is a receptor tyrosine kinase that mediates growth, proliferation and survival. Dysregulation of IGF pathway contributes to the initiation...

...Daryl E. Klein Inhibiting receptor tyrosine kinases has been a cornerstone of cancer therapeutics for decades. Treatment strategies largely involve small-molecule kinase inhibitors and monoclonal antibodies. For receptors activated by constitutively dimeric ligands, another potential mechanism...

... into the sequence–structure–function relationships of the M-CSF/c-FMS interaction and of ligand/receptor tyrosine kinase interactions in general. Correspondence: Mickey Kosloff ( [email protected] ), Noam Levaot ( [email protected] ) or Niv Papo ( [email protected] ) * These authors contributed...