... redox regulatory protein, is a novel secreted protein with potent anti-inflammatory properties. PAMM is secreted from mature human adipocytes but not preadipocytes. Overexpression of PAMM significantly attenuated lipopolysaccharide (LPS)-induced macrophage inflammation. Incubation of macrophages...

...Jehad Shaikhali; Céline Davoine; Kristoffer Brännström; Nicolas Rouhier; Joakim Bygdell; Stefan Björklund; Gunnar Wingsle The eukaryotic mediator integrates regulatory signals from promoter-bound transcription factors (TFs) and transmits them to RNA polymerase II (Pol II) machinery. Although redox...

... 13 5 2014 20 5 2014 20 5 2014 cholinergic glutathione peroxidase neurodegeneration parvalbumin redox selenium © The Authors Journal compilation © 2014 Biochemical Society 2014 Selenoproteins contain the rare amino acid selenocysteine. Reduced selenium levels...

...Xudong Wang; Gail J. Mick; Edmund Maser; Kenneth McCormick With the exception of the oxidation of G6P (glucose 6-phosphate) by H6PDH (hexose-6-phosphate dehydrogenase), scant information is available about other endogenous substrates affecting the redox state or the regulation of key enzymes which...

...-phosphogluconolactonase Plasmodium malaria redox G6PD (glucose-6-phosphate dehydrogenase) deficiency is the most common human enzyme defect and is associated with resistance to malaria, most probably due to decreased levels of reducing equivalents in the form of NADPH [ 1 ]. Malaria is one of the most severe...

...Barry R. Imhoff; Jason M. Hansen The redox status of the extracellular compartment has only just been elucidated as a mechanism controlling intracellular signal transduction and correlates with aging, diabetes, heart disease and lung fibrosis. In the present paper, we describe a mechanism by which...

... contains the FAD cofactor covalently bound to His 121 . It was previously demonstrated that the H121A substitution results in a ≈100 mV decrease in the midpoint redox potential and a ≈40-fold decrease in turnover number compared to wild-type enzyme [Motteran, Pilone, Molla, Ghisla and Pollegioni (2001...

... a model whereby the redox environment within the cell selectively regulates stress signalling through MEKK1 versus ASK1, and may thereby participate in the induction of apoptosis by oxidative stress. 1 To whom correspondence should be addressed (e-mail [email protected] ). A full...

...-polyethylene glycol-maleimide redox tumour suppressor nuclear accumulation Biochem. J. (2000) 351, 87 93 (Printed in Great Britain) 87 p53 protein oxidation in cultured cells in response to pyrrolidine dithiocarbamate : a novel method for relating the amount of p53 oxidation in vivo to the regulation...

... are functionally distinct, as discussed in the present review. In energy metabolism, H 4 MPT permits redox-flux features that are distinct from the pathway on H 4 folate. In the reductive direction, ATP is consumed in the entry of carbon from CO 2 into the H 4 folate pathway, but not in entry into the H 4 MPT...