... redox signalling quinone reductase Human quinone reductases 1 and 2 (NQO1 and NQO2) are members of an ancient family of quinone reductase (QR) enzymes, which are flavin-dependent oxidoreductases that catalyse the obligate two-electron reduction in quinones and other electrophiles. NQO1 and NQO2...

... ( [email protected] ) or Ayelén Mariana Distéfano ( [email protected] ) 16 2 2022 30 3 2022 4 4 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 cell death ferroptosis redox signalling Regulated cell death...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . disulphide bonds redox signalling zinc The bacterial heme nitric oxide/oxygen (H-NOX) protein family was identified in 2003 through homology to the heme-binding domain of soluble guanylate cyclase...

..., C424S, and C424L. Mutations were confirmed by sequencing. enzyme activity nitrosation pyruvate kinase redox signalling Correspondence: Malcolm D. Walkinshaw ( [email protected] ) * These authors contributed equally to this work. 27 7 2018 21 9 2018 24 9...

...). cyanobacteria FurB/Zur heme binding redox signalling zinc loading The FUR (Ferric uptake regulator) family is a widespread group of prokaryotic transcription factors mainly controlling the homeostasis of metals such as iron (Fur subfamily), zinc (Zur, Zinc uptake regulator), manganese (Mur...

... for metabolism or signalling. In this context, it is important to understand: (i) how NRF2-mediated redox signalling, or (ii) the autophagy-mediated antioxidant/reductant pathways sense cellular damage in the context of cellular pathogenesis. Recent studies indicate that the modification of protein thiols plays...

...Shingo Kasamatsu; Yasuo Watanabe; Tomohiro Sawa; Takaaki Akaike; Hideshi Ihara Phosphorylation is considered a main mechanism modulating nNOS (neuronal nitric oxide synthase) function to reduce NO production. In the present study, the effects of nNOS phosphorylation on redox signalling, including...

... © The Authors Journal compilation © 2012 Biochemical Society 2012 Arabidopsis thaliana cytosolic isoform 1 glyceraldehyde-3-phosphate dehydrogenase (AtGapC1) deglutathionylation glutathionylation glycolysis oxidative stress redox signalling GAPDH was also identified as a target...

... sensor of redox signalling at this switch in cellular responses is autophagy. Autophagic activities are mediated by a complex molecular machinery including more than 30 Atg (AuTophaGy-related) proteins and 50 lysosomal hydrolases. Autophagosomes form membrane structures, sequester damaged, oxidized...

...-nitrosation. 1 To whom correspondence should be addressed (email [email protected] ). difference in gel electrophoresis (DIGE) mitochondria nitric oxide (NO) redox signalling S-nitrosation S-nitrosylation 23 4 2010 9 6 2010 10 6 2010 10 6 2010 © 2010...

... signalling. Electrophilic lipids affect redox signalling through the post-translational modification of critical cysteine residues in proteins. However, the therapeutic potential as well as the precise mechanisms of action of electrophilic lipids in cancer cells is poorly understood. In the present study, we...

... these effects. Taken together, these results demonstrate for the first time the feasibility of activating specific redox signalling pathways with an electrophile by selectively targeting specific compartments within the cell. apoptosis 15-deoxy-Δ 12,14 -prostaglandin J 2 haem(heme) mitochondrion...

...% of hydrogen peroxide generated in the matrix. Therefore, mitochondrial Prxs have the potential to play a major role in mitochondrial redox signalling, but the extent of this role and the mechanisms involved are currently unclear. Two complementary approaches have been used to determine kinetic parameters...

...) Kelch-like ECH-associated protein 1 (Keap1) nuclear factor-erythroid 2-related factor 2 (Nrf-2) redox signalling thiol HO (haem oxygenase)-1 has been shown to be an important mediator of cellular protection against oxidative stress in a number of pathologies, including atherosclerosis [ 1...

... Society 2008 endoplasmic reticulum protein 72 kDa (ERp72) NADPH oxidase (Nox1) reactive oxygen species redox signalling pCMV2-Flag-ERp72 has been described previously [ 12 ]. Rat ERp72 cDNA was subcloned into pGEX-2T at BamHI and SmaI sites. pcDNA3.0-Nox1, pEFBOS-NOXO1 and pEFBOS-NOXA1...

... 2008 nitric oxide mitochondria protein thiols redox signalling ischaemic (ischemic) preconditioning S-nitrosylation The paper selected for this ‘Readers' Choice’ article, “Direct evidence for S-nitrosation of mitochondrial complex I” by Burwell et al. [ 1 ] from the laboratory of Paul...

... ). 3 5 2007 8 5 2007 9 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cytochrome c oxidase haem (heme) mitochondria nitric oxide redox signalling Nitric oxide (NO) is an unusual signalling molecule since its biological responses are primarily...

...James W. Baty; Mark B. Hampton; Christine C. Winterbourn Thiol proteins are important in cellular antioxidant defenses and redox signalling. It is postulated that reactive oxidants cause selective thiol oxidation, but relative sensitivities of different cell proteins and critical targets...

... transduction pathways. Compartmentation is an important aspect of such pathways, but little is known about its role in redox signalling. We measured the redox states of cytosolic and nuclear Trx1 (thioredoxin-1) and mitochondrial Trx2 (thioredoxin-2) using redox Western blot methodologies during endogenous ROS...

...@;rm.unicatt.it). 28 7 1999 13 12 1999 17 1 2000 The Biochemical Society, London © 2000 2000 c-Jun N-terminal kinase lymphocyte activation redox signalling Biochem. J. (2000) 347, 173 181 (Printed in Great Britain) 173 Endogenous oxygen radicals modulate protein tyrosine...