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Keywords: regulation
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Articles
Biochem J (2020) 477 (12): 2401–2419.
Published: 26 June 2020
... of which have antitoxins homologous to AbiEi. One such M. tuberculosis antitoxin, named Rv2827c, is required for growth and whilst the structure has previously been solved, the mode of regulation is unknown. To complete the gaps in our understanding, we first solved the structure of S. agalactiae AbiEi...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (12): 1771–1780.
Published: 26 June 2019
... a physiologically pivotal role in enzyme regulation, such as in ADP inhibition and redox response. Recently solved crystal structures of the γ-subunit of F 1 -ATPase from photosynthetic organisms revealed that the insertion region forms a β-hairpin structure, which is positioned along the central stalk...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (18): 2925–2939.
Published: 19 September 2018
... cyanobacteria ε subunit F 1 -ATPase γ subunit regulation ATP synthase occurs ubiquitously in energy-transducing membranes, such as thylakoid membranes in chloroplasts and cyanobacteria, inner membranes of mitochondria and plasma membranes of bacteria. Thus, ATP synthase is the key player for energy...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (24): 4035–4051.
Published: 27 November 2017
... junction regulation via interaction with putative CaM-binding motifs in connexins; however, evidence of direct interactions between CaM and connexins has remained elusive to date due to challenges related to the study of membrane proteins. Here, we report the first direct interaction of CaM with Cx45...
Articles
Biochem J (2015) 470 (2): 169–179.
Published: 20 August 2015
.... The molecular mechanism of the regulated PM insertion of BGT-1 during changes in osmotic stress is unknown. In the present study, we reveal a link between regulated PM insertion and N -glycosylation. Based on homology modelling, we identified two sites (Asn 171 and Asn 183 ) in the extracellular loop 2 (EL2...
Articles
Biochem J (2014) 463 (2): 215–224.
Published: 22 September 2014
... polymerase RpoS Salmonella σ factor regulation Transcription in bacteria is carried out by a multi-subunit RNAP (RNA polymerase) [ 1 ]. When the catalytically active core RNAP (α2ββ’ω, E) associates with one of several σ factors, the RNAP holoenzyme (Eσ) is directed towards a specific set...
Includes: Supplementary data
Articles
Biochem J (2013) 451 (1): 45–53.
Published: 14 March 2013
...Ismayil Tasdelen; Olivier van Beekum; Olena Gorbenko; Veerle Fleskens; Niels J. F. van den Broek; Arjen Koppen; Nicole Hamers; Ruud Berger; Paul J. Coffer; Arjan B. Brenkman; Eric Kalkhoven Reversible phosphorylation is a widespread molecular mechanism to regulate the function of cellular proteins...
Includes: Supplementary data
Articles
Biochem J (2012) 442 (3): 595–610.
Published: 24 February 2012
...Stephen J. Fuller; Liam J. McGuffin; Andrew K. Marshall; Alejandro Giraldo; Sampsa Pikkarainen; Angela Clerk; Peter H. Sugden The canonical pathway of regulation of the GCK (germinal centre kinase) III subgroup member, MST3 (mammalian Sterile20-related kinase 3), involves a caspase-mediated...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (1): 135–140.
Published: 14 June 2011
...Fumitaka Kadoya; Shigeyuki Kato; Kei Watanabe; Yasuyuki Kato-Yamada ATP binding to the ϵ subunit of F 1 -ATPase, a soluble subcomplex of TF o F 1 (F o F 1 -ATPase synthase from the thermophilic Bacillus strain PS3), affects the regulation of F 1 -ATPase activity by stabilizing the compact, ATPase...
Articles
Biochem J (2009) 418 (1): 145–154.
Published: 28 January 2009
...+ into the yeast vacuole, but they each had different cation transport kinetics. Most notably, there was variation in the regulation of the transporters. As found with AtCAX2 previously, only expression of an N-terminally truncated form of AtCAX5 in yeast was able to mediate Ca 2+ and Mn 2+ transport, indicating...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (2): 547–554.
Published: 23 December 2008
...Fuensanta W. Martínez-Rucobo; Luise Eckhardt-Strelau; Anke C. Terwisscha Van Scheltinga Saccharomyces cerevisiae Chs2 (chitin synthase 2) synthesizes the primary septum after mitosis is completed. It is essential for proper cell separation and is expected to be highly regulated. We have expressed...
Articles
Biochem J (2008) 415 (3): 409–416.
Published: 15 October 2008
... tests) and, in case of small samples ( n ≤6), non-parametric (Mann and Whitney) statistical tests. Results are means±S.E.M. Differences were considered significant at P <0.05. aquaporin calcium proton proteoliposome regulation structure–function Water is crucial for life...
Articles
Biochem J (2007) 408 (1): 123–130.
Published: 29 October 2007
... in several physiological processes has been investigated based on its properties as an energy source, a signalling molecule and as essential for tissue repair. It is noteworthy that lactate accumulation alters glycolytic flux independently from medium acidification, thereby this compound can regulate glucose...
Articles
Biochem J (2006) 393 (2): 591–599.
Published: 23 December 2005
... reading frames, of which most are organized at five operons, LEE1 , LEE2 , LEE3 , LEE4 and tir ( LEE5 ). The expression of the LEE genes is regulated in a complicated manner, and current knowledge is that there are at least two positive regulators, Ler (LEE-encoded regulator) and GrlA (global regulator...
Articles
Biochem J (2005) 386 (2): 281–289.
Published: 22 February 2005
.... Sequence analyses of the representative genes, ENT1 {equilibrative nucleoside transporter 1; also known as SLC29A1 [solute carrier family 29 (nucleoside transporters), member 1]} and ENT2 ( SLC29A2 ), suggest that protein kinase CK2-mediated phosphorylation may be involved in the regulation of es - and ei...
Articles
Biochem J (2004) 382 (1): 27–32.
Published: 10 August 2004
... Society, London 2004 ASCT2 glutamine hepatoma promoter regulation transporter Hepatoma cells transport and utilize glutamine at a much higher rate than do normal liver cells [ 1 ]. Glutamine is also an essential requirement for tumour cell growth. Expression of the cell-membrane...
Articles
Biochem J (2004) 378 (2): 609–616.
Published: 01 March 2004
...Lucia CICCHILLITTI; Sergio A. JIMENEZ; Arturo SALA; Biagio SAITTA We investigated the role of B-Myb, a cell-cycle-regulated transcription factor, in the expression of the α1 (I) pro-collagen gene (COL1A1) in scleroderma fibroblasts. Scleroderma or SSc (systemic sclerosis) is a fibrotic disease...
Articles
Biochem J (2003) 376 (2): 517–524.
Published: 01 December 2003
...Magdalena M. KACPRZAK; Irmina LEWANDOWSKA; Rowena G. MATTHEWS; Andrzej PASZEWSKI Roles played by homocysteine and choline in the regulation of MS (methionine synthase) have been examined in fungi. The Aspergillus nidulans metH gene encoding MS was cloned and characterized. Its transcription...
Articles
Biochem J (2003) 373 (3): 993–997.
Published: 01 August 2003
... for the expression of PAH in the liver and our results support a role for PCD/DCoH, through its interaction with HNF1α, in regulating the expression of PAH. 1 To whom correspondence should be addressed (e-mail John.Donlon@nuigalway.ie ). 28 8 2002 31 3 2003 8 4 2003 8 4 2003...
Articles
Biochem J (2002) 367 (1): 157–162.
Published: 01 October 2002
..., substrate specificity and regulation by nucleotides. We show that CDS activity, which is mainly found within the cytoplasmic membrane, is Mg 2+ -dependent and activated by K + ions. Among PAs containing saturated fatty acids, dipalmitoyl-PA is the preferred substrate [ K m = 0.23±0.03mM for Triton X-100 (v...
Articles
Biochem J (2002) 365 (3): 677–684.
Published: 01 August 2002
...Jiaxin NIU; Astrid SCHESCHONKA; Kirk M. DRUEY; Amanda DAVIS; Eleanor REED; Vladimir KOLENKO; Richard BODNAR; Tatyana VOYNO-YASENETSKAYA; Xiaoping DU; John KEHRL; Nickolai O. DULIN RGS3 belongs to a family of the regulators of G-protein signalling (RGS), which bind and inhibit the Gα subunits...
Articles
Biochem J (2002) 362 (2): 443–451.
Published: 22 February 2002
... in contractility. 1 To whom correspondence should be addressed (e-mail ash@ermine.ox.ac.uk ). 21 9 2001 23 11 2001 17 12 2001 The Biochemical Society, London ©2002 2002 calcium motility regulation Abbreviations used: actin(φ), rhodamine—phalloidin-labelled actin; DTT...
Articles
Biochem J (2001) 359 (3): 583–589.
Published: 25 October 2001
..., that respectively release Ca#+ from internal stores and stimulate protein kinase C [1]. PtdIns(4,5)P # and other phosphoinositides serve many additional critical functions in animal cells, by regulating the actin cytoskeleton, vesicular trafficking, protein activities, nuclear functions and endocytosis [2 6...
Articles
Biochem J (2000) 351 (3): 613–619.
Published: 24 October 2000
... activity to be stimulated in an insulin-dependent manner. The PKC-specific inhibitors bisindolylmaleimide and Gö 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLCγ and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent...
Articles
Biochem J (2000) 350 (3): 709–716.
Published: 08 September 2000
...Charles C. MCCORMICK; Wai Ping LI; Monica CALERO Previous studies have established that constitutive calcium-dependent (‘low-output’) nitric oxide synthase (NOS) is regulated by oxygen tension. We have investigated the role of oxygen tension in the synthesis of NO by the ‘high-output’ calcium...
Articles
Biochem J (2000) 350 (1): 245–251.
Published: 09 August 2000
...József DUDÁS; Giuliano RAMADORI; Thomas KNITTEL; Katrin NEUBAUER; Dirk RADDATZ; Krisztina EGEDY; Ilona KOVALSZKY Proteoglycan assembly in malignant tumours is subject to profound changes. The significance of these alterations is not well understood; especially, their role in nuclear regulation...
Articles
Biochem J (2000) 348 (1): 29–35.
Published: 09 May 2000
.... The expression of the transcripts was higher in subconfluent than in confluent cultures and was well correlated with the production of hyaluronan by the cells. Stimulation of mesothelial cells with platelet-derived growth factor-BB induced an up-regulation of mRNA for HAS2 to a maximum after 6 h of stimulation...
Articles
Biochem J (1999) 341 (3): 821–829.
Published: 26 July 1999
...) and complement receptor 1 (CD35), which inhibit the activation pathways, and CD59, which regulates membrane attack complex formation [1]. DAF acts to accelerate decay of C3}C5 convertases, whereas MCP is a cofactor for cleavage and inactivation of C3b by the serine protease factor I. Although the functions...
Articles
Biochem J (1999) 341 (3): 577–584.
Published: 26 July 1999
... developed a system to study this regulation that uses microsomes from cells defective in the first step in GPI biosynthesis (class A, C and H lymphoma mutants) and the second reaction in the pathway (G9PLAP.85). With this mixed-microsome system, the deacetylation of GlcNAc-PI was almost completely dependent...