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1-29 of 29
Keywords: regulation
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Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2401–2419.
Published: 26 June 2020
... of which have antitoxins homologous to AbiEi. One such M. tuberculosis antitoxin, named Rv2827c, is required for growth and whilst the structure has previously been solved, the mode of regulation is unknown. To complete the gaps in our understanding, we first solved the structure of S. agalactiae AbiEi...
Includes: Supplementary data
Articles
The β-hairpin region of the cyanobacterial F 1 -ATPase γ-subunit plays a regulatory role in the enzyme activity
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Journal:
Biochemical Journal
Biochem J (2019) 476 (12): 1771–1780.
Published: 26 June 2019
... a physiologically pivotal role in enzyme regulation, such as in ADP inhibition and redox response. Recently solved crystal structures of the γ-subunit of F 1 -ATPase from photosynthetic organisms revealed that the insertion region forms a β-hairpin structure, which is positioned along the central stalk...
Includes: Supplementary data
Articles
Structure of the γ–ε complex of cyanobacterial F 1 -ATPase reveals a suppression mechanism of the γ subunit on ATP hydrolysis in phototrophs
Available to PurchaseSatoshi Murakami, Kumiko Kondo, Shinya Katayama, Satoshi Hara, Ei-ichiro Sunamura, Eiki Yamashita, Georg Groth, Toru Hisabori
Journal:
Biochemical Journal
Biochem J (2018) 475 (18): 2925–2939.
Published: 19 September 2018
... ( [email protected] ) 25 6 2018 23 7 2018 25 7 2018 27 7 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ADP inhibition cyanobacteria ε subunit F 1 -ATPase γ subunit regulation ATP synthase occurs...
Includes: Supplementary data
Articles
Direct visualization of interaction between calmodulin and connexin45
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Journal:
Biochemical Journal
Biochem J (2017) 474 (24): 4035–4051.
Published: 27 November 2017
... junction regulation via interaction with putative CaM-binding motifs in connexins; however, evidence of direct interactions between CaM and connexins has remained elusive to date due to challenges related to the study of membrane proteins. Here, we report the first direct interaction of CaM with Cx45...
Articles
Role of N-glycosylation in renal betaine transport
Available to PurchaseEva S. Schweikhard, Birgitta C. Burckhardt, Friedericke Joos, Cristina Fenollar-Ferrer, Lucy R. Forrest, Stephen A. Kempson, Christine Ziegler
Journal:
Biochemical Journal
Biochem J (2015) 470 (2): 169–179.
Published: 20 August 2015
.... The molecular mechanism of the regulated PM insertion of BGT-1 during changes in osmotic stress is unknown. In the present study, we reveal a link between regulated PM insertion and N -glycosylation. Based on homology modelling, we identified two sites (Asn 171 and Asn 183 ) in the extracellular loop 2 (EL2...
Articles
Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σ S subunit of RNA polymerase
Available to PurchasePaola Cavaliere, Fabienne Levi-Acobas, Claudine Mayer, Frederick A. Saul, Patrick England, Patrick Weber, Bertrand Raynal, Véronique Monteil, Jacques Bellalou, Ahmed Haouz, Françoise Norel
Journal:
Biochemical Journal
Biochem J (2014) 463 (2): 215–224.
Published: 22 September 2014
... ]. Bacteria use different strategies to overcome this obstacle by resorting to regulatory factors such as Rsd, 6S RNA and ppGpp [ 5 ]. All these factors act at the expense of Eσ 70 , thus promoting the formation of alternative holoenzymes such as Eσ S . Another important regulator that increases σ S...
Includes: Supplementary data
Articles
The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity
Available to PurchaseIsmayil Tasdelen, Olivier van Beekum, Olena Gorbenko, Veerle Fleskens, Niels J. F. van den Broek, Arjen Koppen, Nicole Hamers, Ruud Berger, Paul J. Coffer, Arjan B. Brenkman, Eric Kalkhoven
Journal:
Biochemical Journal
Biochem J (2013) 451 (1): 45–53.
Published: 14 March 2013
...Ismayil Tasdelen; Olivier van Beekum; Olena Gorbenko; Veerle Fleskens; Niels J. F. van den Broek; Arjen Koppen; Nicole Hamers; Ruud Berger; Paul J. Coffer; Arjan B. Brenkman; Eric Kalkhoven Reversible phosphorylation is a widespread molecular mechanism to regulate the function of cellular proteins...
Includes: Supplementary data
Articles
A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)
Open AccessStephen J. Fuller, Liam J. McGuffin, Andrew K. Marshall, Alejandro Giraldo, Sampsa Pikkarainen, Angela Clerk, Peter H. Sugden
Journal:
Biochemical Journal
Biochem J (2012) 442 (3): 595–610.
Published: 24 February 2012
...Stephen J. Fuller; Liam J. McGuffin; Andrew K. Marshall; Alejandro Giraldo; Sampsa Pikkarainen; Angela Clerk; Peter H. Sugden The canonical pathway of regulation of the GCK (germinal centre kinase) III subgroup member, MST3 (mammalian Sterile20-related kinase 3), involves a caspase-mediated...
Includes: Supplementary data
Articles
ATP binding to the ϵ subunit of thermophilic ATP synthase is crucial for efficient coupling of ATPase and H + pump activities
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Journal:
Biochemical Journal
Biochem J (2011) 437 (1): 135–140.
Published: 14 June 2011
...Fumitaka Kadoya; Shigeyuki Kato; Kei Watanabe; Yasuyuki Kato-Yamada ATP binding to the ϵ subunit of F 1 -ATPase, a soluble subcomplex of TF o F 1 (F o F 1 -ATPase synthase from the thermophilic Bacillus strain PS3), affects the regulation of F 1 -ATPase activity by stabilizing the compact, ATPase...
Articles
Comparative analysis of CAX2-like cation transporters indicates functional and regulatory diversity
Available to PurchaseClare Edmond, Toshiro Shigaki, Sophie Ewert, Matthew D. Nelson, James M. Connorton, Vesela Chalova, Zeenat Noordally, Jon K. Pittman
Journal:
Biochemical Journal
Biochem J (2009) 418 (1): 145–154.
Published: 28 January 2009
...+ into the yeast vacuole, but they each had different cation transport kinetics. Most notably, there was variation in the regulation of the transporters. As found with AtCAX2 previously, only expression of an N-terminally truncated form of AtCAX5 in yeast was able to mediate Ca 2+ and Mn 2+ transport, indicating...
Includes: Supplementary data
Articles
Yeast chitin synthase 2 activity is modulated by proteolysis and phosphorylation
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Journal:
Biochemical Journal
Biochem J (2009) 417 (2): 547–554.
Published: 23 December 2008
...Fuensanta W. Martínez-Rucobo; Luise Eckhardt-Strelau; Anke C. Terwisscha Van Scheltinga Saccharomyces cerevisiae Chs2 (chitin synthase 2) synthesizes the primary septum after mitosis is completed. It is essential for proper cell separation and is expected to be highly regulated. We have expressed...
Articles
Structure–function analysis of plant aquaporin At PIP2;1 gating by divalent cations and protons
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Journal:
Biochemical Journal
Biochem J (2008) 415 (3): 409–416.
Published: 15 October 2008
... be addressed (email [email protected] ). 30 1 2008 15 7 2008 21 7 2008 21 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 aquaporin calcium proton proteoliposome regulation structure–function Water is crucial for life, and in most...
Articles
Lactate favours the dissociation of skeletal muscle 6-phosphofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis
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Journal:
Biochemical Journal
Biochem J (2007) 408 (1): 123–130.
Published: 29 October 2007
... in several physiological processes has been investigated based on its properties as an energy source, a signalling molecule and as essential for tissue repair. It is noteworthy that lactate accumulation alters glycolytic flux independently from medium acidification, thereby this compound can regulate glucose...
Articles
Multiple functions of l0036 in the regulation of the pathogenicity island of enterohaemorrhagic Escherichia coli O157:H7
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Journal:
Biochemical Journal
Biochem J (2006) 393 (2): 591–599.
Published: 23 December 2005
... reading frames, of which most are organized at five operons, LEE1 , LEE2 , LEE3 , LEE4 and tir ( LEE5 ). The expression of the LEE genes is regulated in a complicated manner, and current knowledge is that there are at least two positive regulators, Ler (LEE-encoded regulator) and GrlA (global regulator...
Articles
Subtype-specific regulation of equilibrative nucleoside transporters by protein kinase CK2
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Journal:
Biochemical Journal
Biochem J (2005) 386 (2): 281–289.
Published: 22 February 2005
.... Sequence analyses of the representative genes, ENT1 {equilibrative nucleoside transporter 1; also known as SLC29A1 [solute carrier family 29 (nucleoside transporters), member 1]} and ENT2 ( SLC29A2 ), suggest that protein kinase CK2-mediated phosphorylation may be involved in the regulation of es - and ei...
Articles
Glutamine availability up-regulates expression of the amino acid transporter protein ASCT2 in HepG2 cells and stimulates the ASCT2 promoter
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Journal:
Biochemical Journal
Biochem J (2004) 382 (1): 27–32.
Published: 10 August 2004
... ] (GenBank® accession number U53347). ASCT2 glutamine hepatoma promoter regulation transporter Hepatoma cells transport and utilize glutamine at a much higher rate than do normal liver cells [ 1 ]. Glutamine is also an essential requirement for tumour cell growth. Expression...
Articles
B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts
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Journal:
Biochemical Journal
Biochem J (2004) 378 (2): 609–616.
Published: 01 March 2004
...Lucia CICCHILLITTI; Sergio A. JIMENEZ; Arturo SALA; Biagio SAITTA We investigated the role of B-Myb, a cell-cycle-regulated transcription factor, in the expression of the α1 (I) pro-collagen gene (COL1A1) in scleroderma fibroblasts. Scleroderma or SSc (systemic sclerosis) is a fibrotic disease...
Articles
Transcriptional regulation of methionine synthase by homocysteine and choline in Aspergillus nidulans
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Journal:
Biochemical Journal
Biochem J (2003) 376 (2): 517–524.
Published: 01 December 2003
...Magdalena M. KACPRZAK; Irmina LEWANDOWSKA; Rowena G. MATTHEWS; Andrzej PASZEWSKI Roles played by homocysteine and choline in the regulation of MS (methionine synthase) have been examined in fungi. The Aspergillus nidulans metH gene encoding MS was cloned and characterized. Its transcription...
Articles
Effects of dietary glycerol on the expression of pterin carbinolamine dehydratase in the rat
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Journal:
Biochemical Journal
Biochem J (2003) 373 (3): 993–997.
Published: 01 August 2003
... for the expression of PAH in the liver and our results support a role for PCD/DCoH, through its interaction with HNF1α, in regulating the expression of PAH. Biochem. J. (2003) 373, 993 997 (Printed in Great Britain) 993 Effects of dietary glycerol on the expression of pterin carbinolamine dehydratase in the rat...
Articles
Cytidine diphosphate-diacylglycerol synthesis in Mycobacterium smegmatis
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Journal:
Biochemical Journal
Biochem J (2002) 367 (1): 157–162.
Published: 01 October 2002
..., substrate specificity and regulation by nucleotides. We show that CDS activity, which is mainly found within the cytoplasmic membrane, is Mg 2+ -dependent and activated by K + ions. Among PAs containing saturated fatty acids, dipalmitoyl-PA is the preferred substrate [ K m = 0.23±0.03mM for Triton X-100 (v...
Articles
RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain
Available to PurchaseJiaxin NIU, Astrid SCHESCHONKA, Kirk M. DRUEY, Amanda DAVIS, Eleanor REED, Vladimir KOLENKO, Richard BODNAR, Tatyana VOYNO-YASENETSKAYA, Xiaoping DU, John KEHRL, Nickolai O. DULIN
Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 677–684.
Published: 01 August 2002
...Jiaxin NIU; Astrid SCHESCHONKA; Kirk M. DRUEY; Amanda DAVIS; Eleanor REED; Vladimir KOLENKO; Richard BODNAR; Tatyana VOYNO-YASENETSKAYA; Xiaoping DU; John KEHRL; Nickolai O. DULIN RGS3 belongs to a family of the regulators of G-protein signalling (RGS), which bind and inhibit the Gα subunits...
Articles
Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility
Available to PurchaseDavid BURTON, Hassan ABDULRAZZAK, Adam KNOTT, Kathryn ELLIOTT, Charles REDWOOD, Hugh WATKINS, Steven MARSTON, Chris ASHLEY
Journal:
Biochemical Journal
Biochem J (2002) 362 (2): 443–451.
Published: 22 February 2002
... in contractility. 1 To whom correspondence should be addressed (e-mail [email protected] ). 21 9 2001 23 11 2001 17 12 2001 The Biochemical Society, London ©2002 2002 calcium motility regulation Abbreviations used: actin(φ), rhodamine—phalloidin-labelled actin; DTT...
Articles
AtPIP5K1, an Arabidopsis thaliana phosphatidylinositol phosphate kinase, synthesizes PtdIns(3,4)P2 and PtdIns(4,5)P2 in vitro and is inhibited by phosphorylation
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Journal:
Biochemical Journal
Biochem J (2001) 359 (3): 583–589.
Published: 25 October 2001
..., that respectively release Ca#+ from internal stores and stimulate protein kinase C [1]. PtdIns(4,5)P # and other phosphoinositides serve many additional critical functions in animal cells, by regulating the actin cytoskeleton, vesicular trafficking, protein activities, nuclear functions and endocytosis [2 6...
Articles
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase Cγ and protein kinase Cα signalling cascade
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Journal:
Biochemical Journal
Biochem J (2000) 351 (3): 613–619.
Published: 24 October 2000
... activity to be stimulated in an insulin-dependent manner. The PKC-specific inhibitors bisindolylmaleimide and Gö 6976 abolish insulin-induced PLD2 activation in HEK-293 cells co-expressing the insulin receptor, PLCγ and PLD2, confirming that not only PLD1, but PLD2 as well, is regulated in a PKC-dependent...
Articles
Oxygen tension limits nitric oxide synthesis by activated macrophages
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Journal:
Biochemical Journal
Biochem J (2000) 350 (3): 709–716.
Published: 08 September 2000
...Charles C. MCCORMICK; Wai Ping LI; Monica CALERO Previous studies have established that constitutive calcium-dependent (‘low-output’) nitric oxide synthase (NOS) is regulated by oxygen tension. We have investigated the role of oxygen tension in the synthesis of NO by the ‘high-output’ calcium...
Articles
Effect of heparin and liver heparan sulphate on interaction of HepG2-derived transcription factors and their cis-acting elements: altered potential of hepatocellular carcinoma heparan sulphate
Available to PurchaseJózsef DUDÁS, Giuliano RAMADORI, Thomas KNITTEL, Katrin NEUBAUER, Dirk RADDATZ, Krisztina EGEDY, Ilona KOVALSZKY
Journal:
Biochemical Journal
Biochem J (2000) 350 (1): 245–251.
Published: 09 August 2000
...József DUDÁS; Giuliano RAMADORI; Thomas KNITTEL; Katrin NEUBAUER; Dirk RADDATZ; Krisztina EGEDY; Ilona KOVALSZKY Proteoglycan assembly in malignant tumours is subject to profound changes. The significance of these alterations is not well understood; especially, their role in nuclear regulation...
Articles
Expression of human hyaluronan synthases in response to external stimuli
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Journal:
Biochemical Journal
Biochem J (2000) 348 (1): 29–35.
Published: 09 May 2000
.... The expression of the transcripts was higher in subconfluent than in confluent cultures and was well correlated with the production of hyaluronan by the cells. Stimulation of mesothelial cells with platelet-derived growth factor-BB induced an up-regulation of mRNA for HAS2 to a maximum after 6 h of stimulation...
Articles
Molecular and functional analysis of mouse decay accelerating factor (CD55)
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Journal:
Biochemical Journal
Biochem J (1999) 341 (3): 821–829.
Published: 26 July 1999
... complement in a cell-lysis assay, and a soluble, recombinant form of mouse DAF inhibited complement in a haemolytic assay. complement murine regulation Biochem. J. (1999) 341, 821 829 (Printed in Great Britain) 821 Molecular and functional analysis of mouse decay accelerating factor (CD55) Claire L...
Articles
Stimulation of glycosylphosphatidylinositol biosynthesis in mammaliancell-free systems by GTP hydrolysis: evidence for the involvement of membrane fusion
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Journal:
Biochemical Journal
Biochem J (1999) 341 (3): 577–584.
Published: 26 July 1999
... developed a system to study this regulation that uses microsomes from cells defective in the first step in GPI biosynthesis (class A, C and H lymphoma mutants) and the second reaction in the pathway (G9PLAP.85). With this mixed-microsome system, the deacetylation of GlcNAc-PI was almost completely dependent...
