... therefore have therapeutic potentials for these diseases. Resveratrol (RSV), a natural active substance found in fruits and nuts, has been reported to effectively reduce the intracellular lipid accumulation, but the underlying mechanisms of RSV remain elusive. Here, we show that RSV triggers an endoplasmic...

... inhibitors reportedly lower plasma triglyceride levels and increase HDL (high-density lipoprotein) cholesterol levels. RSV (resveratrol), a major constituent of red wine, is known to lower LDL (low-density lipoprotein) cholesterol levels, but its mechanism of action is still unclear. In the present study, we...

...Sara Fröjdö; Delphine Cozzone; Hubert Vidal; Luciano Pirola Resveratrol, a polyphenol found in fruits, possesses chemopreventive and chemotherapeutic properties and has been shown to increase lifespan in yeast and metazoans, including mice. Genetic evidence and in vitro enzymatic measurements...

... deacetylase activity resveratrol SIR2 (silent information regulator 2) sirtuin (SIRT1–7) It is a little known fact that the first sirtuin gene, SIR2 from Saccharomyces cerevisiae , was originally known as MAR1 (for mating-type regulator 1). Klar and collegues [ 1 ] discovered MAR1 by virtue...

...Jiandi Zhang Resveratrol mimics calorie restriction to extend lifespan of Caenorhabditis elegans , yeast and Drosophila , possibly through activation of Sir2 (silent information regulator 2), a NAD + -dependent histone deacetylase. In the present study, resveratrol is shown to inhibit the insulin...

...Giada A. Locatelli; Monica Savio; Luca Forti; Igor Shevelev; Kristijan Ramadan; Lucia A. Stivala; Vanio Vannini; Ulrich Hübscher; Silvio Spadari; Giovanni Maga Resveratrol, a natural compound found in many dietary plants and in red wine, plays an important role in the prevention of many human...

...Gilly REGEV-SHOSHANI; Oded SHOSEYOV; Itzhak BILKIS; Zohar KEREM Plant polyphenols, including dietary polyphenols such as resveratrol, are important components in the plant antioxidant and defence systems. They are also known to exert beneficial effects on human health through diet...