... form of the retromer component VPS35 (D620N), which has been linked to PD. This has enabled us to test proposed effects of this mutation in a setting where the relative expression reflects the physiological occurrence. We confirm that this mutation compromises VPS35 association with the WASH complex...

... to dysfunctional retromer, resulting in the degradation of the lysosomal sorting receptor, sortilin. However, how a soluble lysosomal protein can modulate the function of a cytosolic protein, retromer, is not known. In this work, we show that deletion of CLN5 not only results in retromer dysfunction, but also...

...Caroline S. Binda; Yasuko Nakamura; Jeremy M. Henley; Kevin A. Wilkinson Retromer is an evolutionarily conserved endosomal trafficking complex that mediates the retrieval of cargo proteins from a degradative pathway for sorting back to the cell surface. To promote cargo recycling, the core retromer...

...Michael E. Harbour; Sophia Y. Breusegem; Matthew N. J. Seaman The retromer complex is a conserved endosomal protein sorting complex that sorts membrane proteins into nascent endosomal tubules. The recognition of membrane proteins is mediated by the cargo-selective retromer complex, a stable trimer...

... phosphoinositide phox-homology domain (PX domain) retromer sorting nexin (SNX) Eukaryotic cells contain numerous membrane-bound organelles involved in secretion and endocytosis. Transmembrane proteins, lipids and other critical cargo molecules must be selectively sorted and transported between...

...Suzanne Gokool; Daniel Tattersall; Jonathan V. Reddy; Matthew N. J. Seaman The retromer complex is a conserved cytoplasmic coat complex that mediates the endosome-to-Golgi retrieval of vacuole/lysosome hydrolase receptors in yeast and mammals. The recognition of cargo proteins by the retromer...

...Ester Damen; Elmar Krieger; Jens E. Nielsen; Jelle Eygensteyn; Jeroen E. M. Van Leeuwen The retromer complex is involved in the retrograde transport of the CI-M6PR (cation-independent mannose 6-phosphate receptor) from endosomes to the Golgi. It is a hetero-trimeric complex composed of Vps26...