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Keywords: reverse electron transport
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Articles

Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Edwin T. Gibbs, II, Chad A. Lerner, Mark A. Watson, Hoi-Shan Wong, Akos A. Gerencser, Martin D. Brand
Journal: Biochemical Journal
Biochem J (2023) 480 (5): 363–384.
https://doi.org/10.1042/BCJ20220611
Published: 15 March 2023
...Edwin T. Gibbs, II; Chad A. Lerner; Mark A. Watson; Hoi-Shan Wong; Akos A. Gerencser; Martin D. Brand Superoxide/hydrogen peroxide production by site I Q in complex I of the electron transport chain is conventionally assayed during reverse electron transport (RET) from ubiquinol to NAD. However...
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Articles

Being right on Q: shaping eukaryotic evolution

Dave Speijer
Journal: Biochemical Journal
Biochem J (2016) 473 (22): 4103–4127.
https://doi.org/10.1042/BCJ20160647
Published: 10 November 2016
... of Evolution — T. Dobzhansky FADH 2 /NADH ratio mitochondria peroxisomes reactive oxygen species reverse electron transport uncoupling Figure 1. Schematic depiction of ROS formation in Complex I and elsewhere due to high QH 2 levels during β-oxidation. ( A ) Glucose oxidation (low F/N...
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Includes: Supplementary data