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Keywords: ribozyme
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Biochem J (2006) 394 (2): 511–518.
Published: 10 February 2006
... co-receptor usage of the virus from CCR5 to CXCR4. These receptors therefore make attractive candidates for therapeutic intervention, and we have investigated the silencing of their genes by using ribozymes and single-stranded antisense RNAs. In the present study, we demonstrate using ribozymes that...
Includes: Supplementary data
Biochem J (2000) 352 (3): 865–874.
Published: 08 December 2000
... route and consequently allows its secretion. To further characterize the role of Grp94 in BSDL secretion, we have studied the effect of a ribozyme specifically targeted to Grp94 mRNA. This ribozyme has been transfected into AR4-2J cells, and we have shown that a decrease in Grp94 expression leads to a...