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Keywords: ryanodine receptor
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Articles
Reduced threshold for store overload-induced Ca 2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease
Available to PurchaseWenqian Chen, Andrea Koop, Yingjie Liu, Wenting Guo, Jinhong Wei, Ruiwu Wang, David H. MacLennan, Robert T. Dirksen, Sui Rong Wayne Chen
Journal:
Biochemical Journal
Biochem J (2017) 474 (16): 2749–2761.
Published: 07 August 2017
...Wenqian Chen; Andrea Koop; Yingjie Liu; Wenting Guo; Jinhong Wei; Ruiwu Wang; David H. MacLennan; Robert T. Dirksen; Sui Rong Wayne Chen Mutations in the skeletal muscle ryanodine receptor (RyR1) cause malignant hyperthermia (MH) and central core disease (CCD), whereas mutations in the cardiac...
Articles
Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca 2+ release and catecholaminergic polymorphic ventricular tachycardia
Available to PurchaseZhen Tan, Zhichao Xiao, Jinhong Wei, Jingqun Zhang, Qiang Zhou, Chris D. Smith, Alma Nani, Guogen Wu, Long-Sheng Song, Thomas G. Back, Michael Fill, S. R. Wayne Chen
Journal:
Biochemical Journal
Biochem J (2016) 473 (22): 4159–4172.
Published: 10 November 2016
... a diverse class of drugs with different receptor affinities and pleiotropic properties. We reported that among 14 β-blockers tested previously, only carvedilol effectively suppressed cardiac ryanodine receptor (RyR2)-mediated spontaneous Ca 2+ waves during store Ca 2+ overload, also known as store overload...
Articles
Suppression of ryanodine receptor function prolongs Ca 2+ release refractoriness and promotes cardiac alternans in intact hearts
Available to PurchaseXiaowei Zhong, Bo Sun, Alexander Vallmitjana, Tao Mi, Wenting Guo, Mingke Ni, Ruiwu Wang, Ang Guo, Henry J. Duff, Anne M. Gillis, Long-Sheng Song, Leif Hove-Madsen, Raul Benitez, S.R. Wayne Chen
Journal:
Biochemical Journal
Biochem J (2016) 473 (21): 3951–3964.
Published: 27 October 2016
...) are thought to be the primary cause of cardiac alternans that can lead to cardiac arrhythmias and sudden death. Despite its important role in arrhythmogenesis, the mechanism underlying Ca 2+ alternans remains poorly understood. Here, we investigated the role of cardiac ryanodine receptor (RyR2), the major Ca...
Includes: Supplementary data
Articles
FKBPs facilitate the termination of spontaneous Ca 2+ release in wild-type RyR2 but not CPVT mutant RyR2
Available to PurchaseJoe Z. Zhang, Helen M.M. Waddell, Ella Wu, Jhanvi Dholakia, Chidinma A. Okolo, Janet C. McLay, Peter P. Jones
Journal:
Biochemical Journal
Biochem J (2016) 473 (14): 2049–2060.
Published: 12 July 2016
...Joe Z. Zhang; Helen M.M. Waddell; Ella Wu; Jhanvi Dholakia; Chidinma A. Okolo; Janet C. McLay; Peter P. Jones FK506-binding proteins 12.6 (FKBP12.6) and 12 (FKBP12) tightly associate with the cardiac ryanodine receptor (RyR2). Studies suggest that dissociation of FKBP12.6 from mutant forms of RyR2...
Includes: Supplementary data
Articles
Non-β-blocking R -carvedilol enantiomer suppresses Ca 2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure
Available to PurchaseJingqun Zhang, Qiang Zhou, Chris D. Smith, Haiyan Chen, Zhen Tan, Biyi Chen, Alma Nani, Guogen Wu, Long-Sheng Song, Michael Fill, Thomas G. Back, S.R. Wayne Chen
Journal:
Biochemical Journal
Biochem J (2015) 470 (2): 233–242.
Published: 20 August 2015
... racemic carvedilol, R -carvedilol directly reduces the open duration of the cardiac ryanodine receptor (RyR2), suppresses spontaneous Ca 2+ oscillations in human embryonic kidney (HEK) 293 cells, Ca 2+ waves in cardiomyocytes in intact hearts and stress-induced VT in mice harbouring a catecholaminergic...
Includes: Supplementary data
Articles
Role of Cys 3602 in the function and regulation of the cardiac ryanodine receptor
Available to PurchaseTao Mi, Zhichao Xiao, Wenting Guo, Yijun Tang, Florian Hiess, Jianmin Xiao, Yundi Wang, Joe Z. Zhang, Lin Zhang, Ruiwu Wang, Peter P. Jones, S. R. Wayne Chen
Journal:
Biochemical Journal
Biochem J (2015) 467 (1): 177–190.
Published: 20 March 2015
...Tao Mi; Zhichao Xiao; Wenting Guo; Yijun Tang; Florian Hiess; Jianmin Xiao; Yundi Wang; Joe Z. Zhang; Lin Zhang; Ruiwu Wang; Peter P. Jones; S. R. Wayne Chen The cardiac Ca 2+ release channel [ryanodine receptor type 2 (RyR2)] is modulated by thiol reactive agents, but the molecular basis of RyR2...
Articles
The cardiac ryanodine receptor luminal Ca 2+ sensor governs Ca 2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice
Available to PurchaseJingqun Zhang, Biyi Chen, Xiaowei Zhong, Tao Mi, Ang Guo, Qiang Zhou, Zhen Tan, Guogen Wu, Alexander W. Chen, Michael Fill, Long-Sheng Song, S. R. Wayne Chen
Journal:
Biochemical Journal
Biochem J (2014) 461 (1): 99–106.
Published: 13 June 2014
... the role of the newly identified RyR2 (ryanodine receptor 2)-resident luminal Ca 2+ sensor in determining SCW propensity, CPVT susceptibility and cardiac hypertrophy in Casq2 -KO (knockout) mice. We crossbred Casq2 -KO mice with RyR2 mutant (E4872Q +/− ) mice, which lack RyR2-resident SR luminal Ca 2...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 459 (2): 265–273.
Published: 28 March 2014
...Spyros Zissimopoulos; Jason Marsh; Laurence Stannard; Monika Seidel; F. Anthony Lai Oligomerization of all three mammalian ryanodine receptor isoforms, a structural requirement for normal intracellular Ca 2+ release channel function, is displayed by the discrete N-terminal domain which assembles...
Articles
Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulum
Available to PurchaseDaniela Rossi, Cristina Bencini, Marina Maritati, Francesca Benini, Stefania Lorenzini, Enrico Pierantozzi, Angela Maria Scarcella, Cecilia Paolini, Feliciano Protasi, Vincenzo Sorrentino
Journal:
Biochemical Journal
Biochem J (2014) 458 (2): 407–417.
Published: 14 February 2014
... of the sarcoplasmic reticulum). It requires the assembly of a large multiprotein complex containing the RyR (ryanodine receptor) and additional proteins, including triadin and calsequestrin. The signals which drive these proteins to the j-SR and how they assemble to form this multiprotein complex are poorly...
Includes: Supplementary data
Articles
Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca 2+ release
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Journal:
Biochemical Journal
Biochem J (2013) 455 (3): 367–375.
Published: 10 October 2013
...Xixi Tian; Yijun Tang; Yingjie Liu; Ruiwu Wang; S. R. Wayne Chen RyR2 (cardiac ryanodine receptor)-mediated Ca 2+ release in cardiomyocytes terminates when the sarcoplasmic reticulum Ca 2+ content depletes to a threshold level, known as the termination threshold. Despite its importance, little...
Articles
Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization
Available to PurchaseOri Rokach, Nina D. Ullrich, Martin Rausch, Vincent Mouly, Haiyan Zhou, Francesco Muntoni, Francesco Zorzato, Susan Treves
Journal:
Biochemical Journal
Biochem J (2013) 455 (2): 169–177.
Published: 27 September 2013
... on the transverse tubules is transformed into a chemical gradient (Ca 2+ increase) by activation of the ryanodine receptor located on the sarcoplasmic reticulum membrane. In the present study, we characterized for the first time the excitation–contraction coupling machinery of an immortalized human skeletal muscle...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 451 (2): 177–184.
Published: 28 March 2013
...Samir A. Khan; Ana M. Rossi; Andrew M. Riley; Barry V. L. Potter; Colin W. Taylor IP 3 R (IP 3 [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca 2+ channels and both are regulated by thiol reagents. In DT40 cells stably expressing...
Includes: Supplementary data
Articles
FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease
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Journal:
Biochemical Journal
Biochem J (2009) 419 (2): 273–278.
Published: 27 March 2009
...Spyros Zissimopoulos; N. Lowri Thomas; Wan W. Jamaluddin; F. Anthony Lai In the present paper we show that distinct human RyR2 (ryanodine receptor type 2) inherited mutations expressed in mammalian cells exhibit either unaltered or increased FKBP12.6 (12.6 kDa FK506-binding protein) binding...
Includes: Supplementary data
Articles
Caffeine induces Ca 2+ release by reducing the threshold for luminal Ca 2+ activation of the ryanodine receptor
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Journal:
Biochemical Journal
Biochem J (2008) 414 (3): 441–452.
Published: 27 August 2008
...Huihui Kong; Peter P. Jones; Andrea Koop; Lin Zhang; Henry J. Duff; S. R. Wayne Chen Caffeine has long been used as a pharmacological probe for studying RyR (ryanodine receptor)-mediated Ca 2+ release and cardiac arrhythmias. However, the precise mechanism by which caffeine activates RyRs...
Articles
SRP-27 is a novel component of the supramolecular signalling complex involved in skeletal muscle excitation–contraction coupling
Available to PurchaseChristophe Bleunven, Susan Treves, Xia Jinyu, Elisa Leo, Michel Ronjat, Michel De Waard, Georg Kern, Bernhard E. Flucher, Francesco Zorzato
Journal:
Biochemical Journal
Biochem J (2008) 411 (2): 343–349.
Published: 27 March 2008
... of the SR, as well as in the perinuclear membrane systems and the nuclear envelope of myotubes and adult fibres. SRP-27 co-sediments with the RyR (ryanodine receptor) macromolecular complex in high-salt sucrose-gradient centrifugation, and is pulled-down by anti-RyR as well as by maurocalcin, a well...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 411 (2): 415–423.
Published: 27 March 2008
...Jaya P. Gangopadhyay; Noriaki Ikemoto In the present study we show that the interaction of the CaM (calmodulin)-binding domain (Lys 3614 –Asn 3643 ) with the Cys 4114 –Asn 4142 region (a region included in the CaM-like domain) serves as an intrinsic regulator of the RyR1 (type-1 ryanodine receptor...
Articles
Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification
Available to PurchaseXavier Altafaj, Julien France, Janos Almassy, Istvan Jona, Daniela Rossi, Vincenzo Sorrentino, Kamel Mabrouk, Michel De Waard, Michel Ronjat
Journal:
Biochemical Journal
Biochem J (2007) 406 (2): 309–315.
Published: 13 August 2007
...Xavier Altafaj; Julien France; Janos Almassy; Istvan Jona; Daniela Rossi; Vincenzo Sorrentino; Kamel Mabrouk; Michel De Waard; Michel Ronjat We have previously shown that MCa (maurocalcine), a toxin from the venom of the scorpion Maurus palmatus , binds to RyR1 (type 1 ryanodine receptor...
Articles
K201 (JTV519) suppresses spontaneous Ca 2+ release and [ 3 H]ryanodine binding to RyR2 irrespective of FKBP12.6 association
Available to PurchaseDonald J. Hunt, Peter P. Jones, Ruiwu Wang, Wenqian Chen, Jeff Bolstad, Keyun Chen, Yakhin Shimoni, S. R. Wayne Chen
Journal:
Biochemical Journal
Biochem J (2007) 404 (3): 431–438.
Published: 29 May 2007
... and controversial. It is believed to stabilize the closed state of the RyR2 (cardiac ryanodine receptor) by increasing its affinity for the FKBP12.6 (12.6 kDa FK506 binding protein) [Wehrens, Lehnart, Reiken, Deng, Vest, Cervantes, Coromilas, Landry and Marks (2004) Science 304 , 292–296]. In the present study, we...
Articles
Malignant hyperthermia mutation sites in the Leu 2442 –Pro 2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area
Available to PurchaseMark L. Bannister, Tomoyo Hamada, Takashi Murayama, Peta J. Harvey, Marco G. Casarotto, Angela F. Dulhunty, Noriaki Ikemoto
Journal:
Biochemical Journal
Biochem J (2007) 401 (1): 333–339.
Published: 11 December 2006
... and central domains of RyR1 (ryanodine receptor 1) stabilize the closed state of the channel, but mutation in these domains weakens the interdomain interaction and destabilizes the channel. DP4 (domain peptide 4), a peptide corresponding to residues Leu 2442 –Pro 2477 of the central domain, also weakens...
Articles
Sylvie Ducreux, Francesco Zorzato, Ana Ferreiro, Heinz Jungbluth, Francesco Muntoni, Nicole Monnier, Clemens R. Müller, Susan Treves
Journal:
Biochemical Journal
Biochem J (2006) 395 (2): 259–266.
Published: 28 March 2006
...Sylvie Ducreux; Francesco Zorzato; Ana Ferreiro; Heinz Jungbluth; Francesco Muntoni; Nicole Monnier; Clemens R. Müller; Susan Treves More than 80 mutations in the skeletal muscle ryanodine receptor gene have been found to be associated with autosomal dominant forms of malignant hyperthermia...
Articles
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
Available to PurchaseKalanethee PAUL-PLETZER, Takeshi YAMAMOTO, Noriaki IKEMOTO, Leslie S. JIMENEZ, Hiromi MORIMOTO, Philip G. WILLIAMS, Jianjie MA, Jerome PARNESS
Journal:
Biochemical Journal
Biochem J (2005) 387 (3): 905–909.
Published: 26 April 2005
... [ 3 H]azidodantrolene and synthetic domain peptides have demonstrated that this drug targets amino acids 590–609 [termed DP1 (domain peptide 1)] of RyR1 (ryanodine receptor 1), the skeletal muscle RyR isoform. Although the identical sequence exists in the cardiac isoform, RyR2 (residues 601–620...
Articles
Activation of ryanodine receptors induces calcium influx in a neuroblastoma cell line lacking calcium influx factor activity
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 386 (2): 291–296.
Published: 22 February 2005
.... These observations have prompted the question whether 401L cells possess the signalling machinery that permits non-voltage-gated Ca 2+ influx to occur. We tested the hypothesis that ryanodine-sensitive Ca 2+ pools and activation of RyRs (ryanodine receptors) constitute a signalling pathway capable of inducing Ca 2...
Articles
The recombinant dihydropyridine receptor II–III loop and partly structured ‘ C ’ region peptides modify cardiac ryanodine receptor activity
Available to PurchaseAngela F. DULHUNTY, Yamuna KARUNASEKARA, Suzanne M. CURTIS, Peta J. HARVEY, Philip G. BOARD, Marco G. CASAROTTO
Journal:
Biochemical Journal
Biochem J (2005) 385 (3): 803–813.
Published: 24 January 2005
...Angela F. DULHUNTY; Yamuna KARUNASEKARA; Suzanne M. CURTIS; Peta J. HARVEY; Philip G. BOARD; Marco G. CASAROTTO A physical association between the II–III loop of the DHPR (dihydropryidine receptor) and the RyR (ryanodine receptor) is essential for excitation–contraction coupling in skeletal...
Articles
Central core disease mutations R4892W, I4897T and G4898E in the ryanodine receptor isoform 1 reduce the Ca 2+ sensitivity and amplitude of Ca 2+ -dependent Ca 2+ release
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 382 (2): 557–564.
Published: 24 August 2004
...Guo Guang DU; Vijay K. KHANNA; Xinghua GUO; David H. MacLENNAN Three CCD (central core disease) mutants, R4892W (Arg 4892 →Trp), I4897T and G4898E, in the pore region of the skeletal-muscle Ca 2+ -release channel RyR1 (ryanodine receptor 1) were characterized using a newly developed assay...
Articles
Unravelling calcium-release channel gating: clues from a hot disease
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 380 (1): e1–e3.
Published: 15 May 2004
...Tommie V. McCARTHY; John J. MACKRILL Ryanodine receptors (RyRs) are a family of intracellular channels that mediate Ca 2+ release from the endoplasmic and sarcoplasmic reticulum. More than 50 distinct point mutations in one member of this family, RyR1, cause malignant hyperthermia, a potentially...
Articles
Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A
Available to PurchaseChul Won LEE, Eun Hui LEE, Koh TAKEUCHI, Hideo TAKAHASHI, Ichio SHIMADA, Kazuki SATO, Song Yub SHIN, D. Han KIM, Jae Il KIM
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 385–394.
Published: 15 January 2004
... specifically with the skeletal ryanodine receptor (RyR1), which is a Ca 2+ -release channel in the sarcoplasmic reticulum, but with considerably different affinities. IpTx a activates RyR1 with nanomolar affinity, whereas peptide A activates RyR1 at micromolar concentrations. To investigate the molecular basis...
Articles
Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 357–366.
Published: 15 January 2004
...Susan CURRIE; Christopher M. LOUGHREY; Margaret-Anne CRAIG; Godfrey L. SMITH Cardiac ryanodine receptors (RyR2s) play a critical role in excitation–contraction coupling by providing a pathway for the release of Ca 2+ from the sarcoplasmic reticulum into the cytosol. RyR2s exist as macromolecular...
Articles
Mastoparan binds to glycogen phosphorylase to regulate sarcoplasmic reticular Ca2+ release in skeletal muscle
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2003) 371 (1): 81–88.
Published: 01 April 2003
...Yutaka HIRATA; Masanori ATSUMI; Yasushi OHIZUMI; Norimichi NAKAHATA The ryanodine receptor, a Ca 2+ -releasing channel in sarcoplasmic reticulum (SR), plays an important role in the excitation—contraction coupling of skeletal muscle. In a previous study [Hirata, Nakahata and Ohizumi (2000) Mol...
Articles
The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segment
Available to PurchaseDaniel GREEN, Suzi PACE, Suzanne M. CURTIS, Magdalena SAKOWSKA, Graham D. LAMB, Angela F. DULHUNTY, Marco G. CASAROTTO
Journal:
Biochemical Journal
Biochem J (2003) 370 (2): 517–527.
Published: 01 March 2003
...Daniel GREEN; Suzi PACE; Suzanne M. CURTIS; Magdalena SAKOWSKA; Graham D. LAMB; Angela F. DULHUNTY; Marco G. CASAROTTO An α-helical II—III loop segment of the dihydropyridine receptor activates the ryanodine receptor calcium-release channel. We describe a novel manipulation in which this agonist's...
Articles
In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6
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Journal:
Biochemical Journal
Biochem J (2003) 370 (2): 579–589.
Published: 01 March 2003
...Christopher H. GEORGE; Rina SORATHIA; Benedicte M.A. BERTRAND; F. Anthony LAI The ryanodine receptor complex (RyR), a large oligomeric assembly that functions as a Ca 2+ -release channel in the sarcoplasmic reticulum (SR)/endoplasmic reticulum (ER), comprises four RyR subunits and four FK506...
Articles
Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells
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Journal:
Biochemical Journal
Biochem J (2003) 369 (3): 441–445.
Published: 01 February 2003
...Michael C. ASHBY; Ole H. PETERSEN; Alexei V. TEPIKIN In pancreatic acinar cells, agonists evoke intracellular Ca 2+ transients which are initiated in the apical region of these polarized cells. There are contradictory experimental data concerning Ca 2+ release from ryanodine receptors (RyRs...
Articles
Evidence that zymogen granules do not function as an intracellular Ca2+ store for the generation of the Ca2+ signal in rat parotid acinar cells
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Journal:
Biochemical Journal
Biochem J (2002) 363 (1): 59–66.
Published: 22 March 2002
... probably resulted from contamination by the endoplasmic reticulum (ER), because calnexin, a marker protein of the ER, was also detected in the same preparation. Furthermore, Western blotting and reverse transcriptase-PCR analysis failed to provide evidence for the expression of ryanodine receptors in rat...
Articles
Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12
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Journal:
Biochemical Journal
Biochem J (2002) 361 (2): 401–407.
Published: 08 January 2002
...Sheila L. DARGAN; Edward J. A. LEA; Alan P. DAWSON FK506-binding protein (FKBP12) is highly expressed in neuronal tissue, where it is proposed to localize calcineurin to intracellular calcium-release channels, ryanodine receptors and Ins(1,4,5) P 3 receptors (InsP 3 Rs). The effects of FKBP12...
Articles
Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells
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Journal:
Biochemical Journal
Biochem J (2001) 360 (1): 17–22.
Published: 08 November 2001
... of internal Ca 2+ stores by infusion of EGTA activated a Ca 2+ current with similar characteristics and time course. The current was highly Ca 2+ -selective and showed strong inward rectification, all typical of I crac . The activator of ryanodine receptor (RyR), cADP-ribose (cADPR), facilitated activation...
Articles
Pharmacological characterization of the putative cADP-ribose receptor
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Journal:
Biochemical Journal
Biochem J (2001) 359 (2): 451–457.
Published: 08 October 2001
... should be addressed (e-mail [email protected] ). 23 4 2001 10 7 2001 21 8 2001 The Biochemical Society, London ©2001 2001 Ca 2+ -induced Ca 2+ release calmodulin ryanodine receptor Abbreviations used: cADPR, cADP-ribose; CICR, Ca 2+ -induced...
Articles
Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites
Available to PurchaseMarkus KLINGER, Elisa BOFILL-CARDONA, Bernd MAYER, Christian NANOFF, Michael FREISSMUTH, Martin HOHENEGGER
Journal:
Biochemical Journal
Biochem J (2001) 355 (3): 827–833.
Published: 24 April 2001
... than compounds that inactivate calmodulin. Suramin and its analogue NF307 inhibit the interaction of calmodulin with the ryanodine receptor. We have investigated whether inhibition of calmodulin binding to target proteins is a general property of these compounds. Suramin inhibited binding of [ 125 I...
Articles
Regulation of ATP-induced calcium release in COS-7 cells by calcineurin
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Journal:
Biochemical Journal
Biochem J (2000) 348 (1): 173–181.
Published: 09 May 2000
...). 7 12 1999 18 2 2000 17 3 2000 The Biochemical Society, London © 2000 2000 endoplasmic reticulum inositol trisphosphate receptor FK506-binding protein phosphorylation ryanodine receptor Biochem. J. (2000) 348, 173 181 (Printed in Great Britain) 173 Regulation of ATP...
Articles
Biphasic modulation of ryanodine binding to sarcoplasmic reticulum vesicles of skeletal muscle by Zn2+ ions
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Journal:
Biochemical Journal
Biochem J (2000) 345 (2): 279–286.
Published: 10 January 2000
...Ruo-Hong XIA; Xiao-Yang CHENG; Hui WANG; Ke-Ying CHEN; Qin-Qin WEI; Xiao-Hui ZHANG; Pei-Hong ZHU With the use of a [ 3 H]ryanodine binding assay, the modulation of skeletal muscle ryanodine receptor (RyR1) by Zn 2+ was investigated. In the presence of 100 μ M free Ca 2+ concentration ([Ca 2+ ] f...
Articles
cADP-ribose potentiates cytosolic Ca2+ elevation and Ca2+ entry via L-type voltage-activated Ca2+ channels in NG108-15 neuronal cells
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Journal:
Biochemical Journal
Biochem J (2000) 345 (2): 207–215.
Published: 10 January 2000
... receptors as a direct agonist and also interacts with L-type VACCs as an indirect agonist, i.e. via a retrograde signal. Ca 2+ influx FK506 β-NAD + ryanodine receptor Ca 2+ signalling Biochem. J. (2000) 345, 207 215 (Printed in Great Britain) 207 cADP-ribose potentiates cytosolic Ca2+ elevation...
Articles
Effects of photoreleased cADP-ribose on calcium transients and calcium sparks in myocytes isolated from guinea-pig and rat ventricle
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Journal:
Biochemical Journal
Biochem J (1999) 342 (2): 269–273.
Published: 24 August 1999
... calcium transients. The slow time-course for development of the full effect on whole-cell calcium transients might be taken to indicate that the influence of cADPR on CICR may involve complex molecular interactions rather than a simple direct action of cADPR on the ryanodine-receptor channels. Biochem. J...
