... bp and that a specific surface salt bridge limits the DNA site size for HBsu. Surface exposure of the highly conserved Lys 3 , achieved by substitution of its salt-bridging partner Asp 26 with Ala, leads to enhanced DNA compaction by HBsu-D26A (where D26A stands for the mutant Asp 26 →Ala...

...). The formation of a salt bridge between Ile 153 and Asp 343 drives the conversion of FVIIa from being zymogen-like to the active form. In the present paper, we describe the novel FVII mutant V154G (Val 154 →Gly mutation; residue 17 in the chymotrypsin numbering system), found in three FVII-deficient patients...