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Articles

Platelet Rho GTPases–a focus on novel players, roles and relationships

Robert Goggs, Christopher M. Williams, Harry Mellor, Alastair W. Poole
Journal: Biochemical Journal
Biochem J (2015) 466 (3): 431–442.
https://doi.org/10.1042/BJ20141404
Published: 06 March 2015
... studies suggest that Rif plays no critical functions in platelets, likely due to functional overlap with other Rho GTPases. In contrast, RhoG is essential for normal granule secretion downstream of the collagen receptor GPVI. The central defect in RhoG −/− platelets is reduced dense granule secretion...
View articletitled, Platelet Rho GTPases–a focus on novel players, roles and relationships
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Articles

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

Guy A. Rutter, Timothy J. Pullen, David J. Hodson, Aida Martinez-Sanchez
Journal: Biochemical Journal
Biochem J (2015) 466 (2): 203–218.
https://doi.org/10.1042/BJ20141384
Published: 20 February 2015
...Guy A. Rutter; Timothy J. Pullen; David J. Hodson; Aida Martinez-Sanchez Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis in man and many other animals. Defective insulin secretion underlies all forms of diabetes mellitus, a disease currently reaching...
View articletitled, Pancreatic β-cell identity, glucose sensing and the control of insulin secretion
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Articles

Amyloid β-peptide-dependent activation of human platelets: essential role for Ca 2+ and ADP in aggregation and thrombus formation

Ilaria Canobbio, Gianni F. Guidetti, Barbara Oliviero, Daria Manganaro, Dina Vara, Mauro Torti, Giordano Pula
Journal: Biochemical Journal
Biochem J (2014) 462 (3): 513–523.
https://doi.org/10.1042/BJ20140307
Published: 22 August 2014
... in platelet intracellular Ca 2+ that stimulates α-granule and dense granule secretion and leads to the release of the secondary agonist ADP. Released ADP acts in an autocrine manner as a stimulant for critical signalling pathways leading to the activation of platelets. This includes the activation...
View articletitled, Amyloid β-peptide-dependent activation of human platelets: essential role for Ca 2+ and ADP in aggregation and thrombus formation
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Includes: Supplementary data
Articles

Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation

Yue Wang, Yusuf Ali, Chun-Yan Lim, Wanjin Hong, Zhiping P. Pang, Weiping Han
Journal: Biochemical Journal
Biochem J (2014) 458 (3): 491–498.
https://doi.org/10.1042/BJ20131176
Published: 28 February 2014
...Yue Wang; Yusuf Ali; Chun-Yan Lim; Wanjin Hong; Zhiping P. Pang; Weiping Han Numerous studies have focused on the regulation of leptin signalling and the functions of leptin in energy homoeostasis; however, little is known about how leptin secretion is regulated. In the present study we studied...
View articletitled, Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation
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Includes: Supplementary data
Articles

Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells

Kyubo Kim, Youlia M. Petrova, Brenton L. Scott, Rupesh Nigam, Anurag Agrawal, Christopher M. Evans, Zoulikha Azzegagh, Alejandra Gomez, Elsa M. Rodarte, Vesa M. Olkkonen, Rustam Bagirzadeh, Lucia Piccotti, Binhui Ren, Joo-Heon Yoon, James A. McNew, Roberto Adachi, Michael J. Tuvim, Burton F. Dickey
Journal: Biochemical Journal
Biochem J (2012) 446 (3): 383–394.
https://doi.org/10.1042/BJ20120057
Published: 28 August 2012
... Airway mucin secretion and MC (mast cell) degranulation must be tightly controlled for homoeostasis of the lungs and immune system respectively. We found the exocytic protein Munc18b to be highly expressed in mouse airway epithelial cells and MCs, and localized to the apical pole of airway secretory...
View articletitled, Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells
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Includes: Supplementary data
Articles

Caf1A usher possesses a Caf1 subunit-like domain that is crucial for Caf1 fibre secretion

Xiaodi Yu, Ganeshram R. Visweswaran, Zoe Duck, Srisailam Marupakula, Sheila MacIntyre, Stefan D. Knight, Anton V. Zavialov
Journal: Biochemical Journal
Biochem J (2009) 418 (3): 541–551.
https://doi.org/10.1042/BJ20080992
Published: 25 February 2009
... displayed significant structural similarity. Although UMD is in the middle of the predicted amphipathic β-barrel of Caf1A, the usher still assembled in the membrane in the absence of this domain. UMD did not bind Caf1M–Caf1 complexes, but its presence was shown to be essential for Caf1 fibre secretion...
View articletitled, Caf1A usher possesses a Caf1 subunit-like domain that is crucial for Caf1 fibre secretion
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Includes: Supplementary data
Articles

Secretion of cryptococcal phospholipase B1 (PLB1) is regulated by a glycosylphosphatidylinositol (GPI) anchor

Julianne T. Djordjevic, Maurizio Del Poeta, Tania C. Sorrell, Kylie M. Turner, Lesley C. Wright
Journal: Biochemical Journal
Biochem J (2005) 389 (3): 803–812.
https://doi.org/10.1042/BJ20050063
Published: 26 July 2005
...Julianne T. Djordjevic; Maurizio Del Poeta; Tania C. Sorrell; Kylie M. Turner; Lesley C. Wright The secreted, multifunctional enzyme PLB1 (phospholipase B1 protein encoded by the PLB1 gene) is a virulence determinant of the pathogenic fungus Cryptococcus neoformans , but the mechanism of its...
View articletitled, Secretion of cryptococcal phospholipase B1 (PLB1) is regulated by a glycosylphosphatidylinositol (GPI) anchor
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Articles

Molecular and biochemical characterization of an endo-β-1,3-glucanase from the pinewood nematode Bursaphelenchus xylophilus acquired by horizontal gene transfer from bacteria

Taisei KIKUCHI, Hajime SHIBUYA, John T. JONES
Journal: Biochemical Journal
Biochem J (2005) 389 (1): 117–125.
https://doi.org/10.1042/BJ20042042
Published: 21 June 2005
... in the nematode's secretions. The deduced amino acid sequence of the gene is very similar to glycosyl hydrolase family 16 proteins. The recombinant protein, expressed in Escherichia coli , preferentially hydrolysed the β-1,3-glucan laminarin, and had very low levels of activity on β-1,3-1,4-glucan, lichenan...
View articletitled, Molecular and biochemical characterization of an endo-β-1,3-glucanase from the pinewood nematode Bursaphelenchus xylophilus acquired by horizontal gene transfer from bacteria
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Articles

Positive co-operative activity and dimerization of the isolated ABC ATPase domain of HlyB from Escherichia coli

Houssain BENABDELHAK, Lutz SCHMITT, Carsten HORN, Kornelia JUMEL, Mark A. BLIGHT, I. Barry HOLLAND
Journal: Biochemical Journal
Biochem J (2005) 386 (3): 489–495.
https://doi.org/10.1042/BJ20041282
Published: 08 March 2005
...Houssain BENABDELHAK; Lutz SCHMITT; Carsten HORN; Kornelia JUMEL; Mark A. BLIGHT; I. Barry HOLLAND The ATPase activity of the ABC (ATP-binding cassette) ATPase domain of the HlyB (haemolysin B) transporter is required for secretion of Escherichia coli haemolysin via the type I pathway. Although ABC...
View articletitled, Positive co-operative activity and dimerization of the isolated ABC ATPase domain of HlyB from Escherichia coli
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Articles

The septin Sept5/CDCrel-1 competes with α-SNAP for binding to the SNARE complex

Crestina L. BEITES, Kristen A. CAMPBELL, William S. TRIMBLE
Journal: Biochemical Journal
Biochem J (2005) 385 (2): 347–353.
https://doi.org/10.1042/BJ20041090
Published: 07 January 2005
.../PAGE followed by Western blotting. docking filament membrane fusion secretion septin SNARE complex During the exocytosis of synaptic vesicles at the nerve terminal a host of presynaptic proteins ultimately interact to allow release of neurotransmitters into the synaptic cleft...
View articletitled, The septin Sept5/CDCrel-1 competes with α-SNAP for binding to the SNARE complex
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Articles

Cell viability and secretion of active proteins in Schizosaccharomyces pombe do not require the chaperone function of calnexin

Alexandre MARÉCHAL, Pierre-Luc TANGUAY, Mario CALLEJO, Renée GUÉRIN, Guy BOILEAU, Luis A. ROKEACH
Journal: Biochemical Journal
Biochem J (2004) 380 (2): 441–448.
https://doi.org/10.1042/bj20031546
Published: 01 June 2004
...Alexandre MARÉCHAL; Pierre-Luc TANGUAY; Mario CALLEJO; Renée GUÉRIN; Guy BOILEAU; Luis A. ROKEACH Folding of newly synthesized proteins within the ER (endoplasmic reticulum) is a rate-limiting step in protein secretion. Thus ER molecular chaperones and foldases have a major impact in determining...
View articletitled, Cell viability and secretion of active proteins in Schizosaccharomyces pombe do not require the chaperone function of calnexin
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Articles

A role for palmitoylation in the quality control, assembly and secretion of apolipoprotein B

Gonzalo L. VILAS, Luc G. BERTHIAUME
Journal: Biochemical Journal
Biochem J (2004) 377 (1): 121–130.
https://doi.org/10.1042/bj20030951
Published: 01 January 2004
... in a functional truncated apoB variant (apoB-29) and abolished by mutagenesis. This Cys-1085Ser mutation resulted in secretion of smaller and denser lipoprotein particles containing 80% less cholesteryl ester and triacylglycerol than wild-type controls. We show that palmitoylation of apoB-29 occurs in the ER...
View articletitled, A role for palmitoylation in the quality control, assembly and secretion of apolipoprotein B
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Articles

A role for Sec1/Munc18 proteins in platelet exocytosis

Todd D. SCHRAW, Paula P. LEMONS, William L. DEAN, Sidney W. WHITEHEART
Journal: Biochemical Journal
Biochem J (2003) 374 (1): 207–217.
https://doi.org/10.1042/bj20030610
Published: 15 August 2003
... proteins, we examined the effects of Munc18-based peptides (Munc18a peptide 3 and Munc18c peptide 3). Addition of the peptides to permeabilized platelets inhibits secretion from all three platelet granules. These peptides also inhibit agonist-induced aggregation in saponin-permeabilized platelets...
View articletitled, A role for Sec1/Munc18 proteins in platelet exocytosis
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Articles

Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression

Gabriela da SILVA XAVIER, Isabelle LECLERC, Aniko VARADI, Takashi TSUBOI, S. Kelly MOULE, Guy A. RUTTER
Journal: Biochemical Journal
Biochem J (2003) 371 (3): 761–774.
https://doi.org/10.1042/bj20021812
Published: 01 May 2003
... achieved pharmacologically with 5-amino-4-imidazolecarboxamide riboside (AICAR), or by adenoviral overexpression of a truncated, constitutively active form of the enzyme (AMPKα1.T 172 D), blocked glucose-stimulated insulin secretion. In MIN6 cells, activation of AMPK suppressed glucose metabolism...
View articletitled, Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
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Articles

In vitro fusion between Saccharomyces cerevisiae secretory vesicles and cytoplasmic-side-out plasma membrane vesicles

Lorena ARRASTUA, Eider SAN SEBASTIAN, Ana F. QUINCOCES, Claude ANTONY, Unai UGALDE
Journal: Biochemical Journal
Biochem J (2003) 370 (2): 641–649.
https://doi.org/10.1042/bj20021736
Published: 01 March 2003
... methods developed in this study. 1 To whom correspondence should be addressed (e-mail [email protected] ). 6 11 2002 15 11 2002 15 11 2002 The Biochemical Society, London ©2003 2003 mathematical analysis membrane fusion octadecylrhodamine B-chloride (R18) secretion...
View articletitled, In vitro fusion between Saccharomyces cerevisiae secretory vesicles and cytoplasmic-side-out plasma membrane vesicles
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Articles

JFC1 is transcriptionally activated by nuclear factor-κB and up-regulated by tumour necrosis factor α in prostate carcinoma cells

Sergio D. CATZ, Bernard M. BABIOR, Jennifer L. JOHNSON
Journal: Biochemical Journal
Biochem J (2002) 367 (3): 791–799.
https://doi.org/10.1042/bj20020345
Published: 01 November 2002
... 23 7 2002 The Biochemical Society, London ©2002 2002 PI 3-kinase promoter secretion transcription Abbreviations used: CRE, cAMP response element; EBV, Epstein—Barr virus; IκB, inhibitor κB; IKK, IκB kinase; jfc1-LUC, jfc1 luciferase construct; NF-κB, nuclear factor-κB; PI...
View articletitled, JFC1 is transcriptionally activated by nuclear factor-κB and up-regulated by tumour necrosis factor α in prostate carcinoma cells
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Articles

Utilization of green fluorescent protein as a marker for studying the expression and turnover of the monocarboxylate permease Jen1p of Saccharomyces cerevisiae

Sandra PAIVA, Arthur L. KRUCKEBERG, Margarida CASAL
Journal: Biochemical Journal
Biochem J (2002) 363 (3): 737–744.
https://doi.org/10.1042/bj3630737
Published: 24 April 2002
... transport secretion ubiquitination endocytosis Abbreviations used: CMAC-Arg, 7-amino-4-chloromethylcoumaryl- l -arginine amide dihydrochloride; GFP, green fluorescent protein; ORF, open reading frame; Ub, ubiquitin. Biochem. J. (2002) 363, 737 744 (Printed in Great Britain) 737 Utilization...
View articletitled, Utilization of green fluorescent protein as a marker for studying the expression and turnover of the monocarboxylate permease Jen1p of Saccharomyces cerevisiae
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Articles

Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells

Renu K. JAIN, Paul B. M. JOYCE, Miguel MOLINETE, Philippe A. HALBAN, Sven-Ulrik GORR
Journal: Biochemical Journal
Biochem J (2001) 360 (3): 645–649.
https://doi.org/10.1042/bj3600645
Published: 10 December 2001
...Renu K. JAIN; Paul B. M. JOYCE; Miguel MOLINETE; Philippe A. HALBAN; Sven-Ulrik GORR Green fluorescent protein (GFP) is used extensively as a reporter protein to monitor cellular processes, including intracellular protein trafficking and secretion. In general, this approach depends on GFP acting...
View articletitled, Oligomerization of green fluorescent protein in the secretory pathway of endocrine cells
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Articles

Cholesterol-dependent interaction of syncollin with the membrane of the pancreatic zymogen granule

Alois HODEL, Seong J. AN, Neal J. HANSEN, Jared LAWRENCE, Barbara WÄSLE, Michael SCHRADER, J. Michael EDWARDSON
Journal: Biochemical Journal
Biochem J (2001) 356 (3): 843–850.
https://doi.org/10.1042/bj3560843
Published: 08 June 2001
... subunits, and its association with the membrane may be stabilized by electrostatic interactions with either other proteins or phospholipids. 12 12 2000 23 3 2001 10 4 2001 The Biochemical Society, London ©2001 2001 exocrine pancreas exocytosis secretion secretory granule...
View articletitled, Cholesterol-dependent interaction of syncollin with the membrane of the pancreatic zymogen granule
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Articles

Purification of Golgi casein kinase from bovine milk

Jennifer S. DUNCAN, Mark C. WILKINSON, Robert D. BURGOYNE
Journal: Biochemical Journal
Biochem J (2000) 350 (2): 463–468.
https://doi.org/10.1042/bj3500463
Published: 23 August 2000
... 2000 27 6 2000 The Biochemical Society, London © 2000 2000 milk protein phosphorylation secretion secretory pathway Biochem. J. (2000) 350, 463 468 (Printed in Great Britain) 463 Purification of Golgi casein kinase from bovine milk Jennifer S. DUNCAN*1, Mark C. WILKINSON...
View articletitled, Purification of Golgi casein kinase from bovine milk
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Articles

Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform

Henriette KOCH, Kay HOFMANN, Nils BROSE
Journal: Biochemical Journal
Biochem J (2000) 349 (1): 247–253.
https://doi.org/10.1042/bj3490247
Published: 26 June 2000
... lung protein profile secretion Biochem. J. (2000) 349, 247 253 (Printed in Great Britain) 247 Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform Henriette KOCH*, Kay HOFMANN‹ and Nils BROSE*1 *Max-Planck-Institut fu$ r experimentelle Medizin...
View articletitled, Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform
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Articles

Role of lipids in the translocation of proteins across membranes

Frank VAN VOORST, Ben DE KRUIJFF
Journal: Biochemical Journal
Biochem J (2000) 347 (3): 601–612.
https://doi.org/10.1042/bj3470601
Published: 25 April 2000
... function. 1 To whom correspondence should be addressed (e-mail F.vanvoorst@;chem.uu.nl). The Biochemical Society, London © 2000 2000 lipidprotein interactions secretion SecY/Sec61 targeting signal Biochem. J. (2000) 347, 601 612 (Printed in Great Britain) 601 REVIEW ARTICLE Role...
View articletitled, Role of lipids in the translocation of proteins across membranes
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Articles

Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes

Yoshihiko URATANI, Keiko TAKIGUCHI-HAYASHI, Nobuhiko MIYASAKA, Michio SATO, Ming-hao JIN, Yasuyoshi ARIMATSU
Journal: Biochemical Journal
Biochem J (2000) 346 (3): 817–826.
https://doi.org/10.1042/bj3460817
Published: 07 March 2000
... secretion Biochem. J. (2000) 346, 817 826 (Printed in Great Britain) 817 Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes Yoshihiko URATANI1, Keiko TAKIGUCHI-HAYASHI, Nobuhiko...
View articletitled, Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes
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Articles

The malonyl-CoA–long-chain acyl-CoA axis in the maintenance of mammalian cell function

Victor A. ZAMMIT
Journal: Biochemical Journal
Biochem J (1999) 343 (3): 505–515.
https://doi.org/10.1042/bj3430505
Published: 25 October 1999
... fatty acids liver secretion Biochem. J. (1999) 343, 505 515 (Printed in Great Britain) 505 REVIEW ARTICLE The malonyl-CoA long-chain acyl-CoA axis in the maintenance of mammalian cell function Victor A. ZAMMIT1 Cell Biochemistry, Hannah Research Institute, Ayr, KA6 5HL, Scotland, U.K. Long-chain...
View articletitled, The malonyl-CoA–long-chain acyl-CoA axis in the maintenance of mammalian cell function
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Articles

Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI)

Charlotte V. BURKE, Carol W. BUETTGER, Elizabeth A. DAVIS, Steven J. MCCLANE, Franz M. MATSCHINSKY, Steven E. RAPER
Journal: Biochemical Journal
Biochem J (1999) 342 (2): 345–352.
https://doi.org/10.1042/bj3420345
Published: 24 August 1999
... the human wild-type islet GK or one of four mutant forms of GK, (the MODY-2 mutants E70K, E300K and V203A and the GK-HI mutant V455M) were transduced into glucose-responsive insulin-secreting β-HC9 cells and tested functionally in order to initiate the first analysis in vivo of recombinant wild-type...
View articletitled, Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI)
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Articles

Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue

Christina WASMEIER, John C. HUTTON
Journal: Biochemical Journal
Biochem J (1999) 341 (3): 563–569.
https://doi.org/10.1042/bj3410563
Published: 26 July 1999
..., including glucose and depolarizing concentrations of K + . In MIN6 cells, the glucose dose-response and time course of phogrin phosphorylation paralleled that of insulin secretion. Like secretion, glucose- or K + -stimulated phosphorylation required the presence of Ca 2+ . The calmodulin antagonist W-7...
View articletitled, Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue
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Articles

Metabolic characteristics of a human hepatoma cell line stably transfected with hormone-sensitive lipase

Richard J. PEASE, David WIGGINS, E. David SAGGERSON, Jeni TREE, Geoffrey F. GIBBONS
Journal: Biochemical Journal
Biochem J (1999) 341 (2): 453–460.
https://doi.org/10.1042/bj3410453
Published: 08 July 1999
... from the wild-type cells. The excess loss of labelled TAG was primarily due to an increased TAG fatty acid oxidation. Free fatty acid release into the medium was not increased in the transfectants, nor was the very low rate of lipoprotein lipid secretion. Also, there was no increased net trafficking...
View articletitled, Metabolic characteristics of a human hepatoma cell line stably transfected with hormone-sensitive lipase
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Articles

Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain

Joseph F. SUCIC, Joan M. MOEHRING, Noel M. INOCENCIO, Jason W. LUCHINI, Thomas J. MOEHRING
Journal: Biochemical Journal
Biochem J (1999) 339 (3): 639–647.
https://doi.org/10.1042/bj3390639
Published: 26 April 1999
... with either a secreted form of the human insulin pro-receptor or the precursor form of von Willebrand factor resulted in both proproteins being processed; RPE.40 cells were unable to process either precursor protein in the absence of co-expressed PACE4. Northern analysis demonstrated that untransfected RPE.40...
View articletitled, Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain
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Articles

Functional expression, quantification and cellular localization of the Hxt2 hexose transporter of Saccharomyces cerevisiae tagged with the green fluorescent protein

Arthur L. KRUCKEBERG, Ling YE, Jan A. BERDEN, Karel van DAM
Journal: Biochemical Journal
Biochem J (1999) 339 (2): 299–307.
https://doi.org/10.1042/bj3390299
Published: 08 April 1999
... secretion yeast Biochem. J. (1999) 339, 299 307 (Printed in Great Britain) 299 Functional expression, quantification and cellular localization of the Hxt2 hexose transporter of Saccharomyces cerevisiae tagged with the green fluorescent protein Arthur L. KRUCKEBERG, Ling YE, Jan A. BERDEN and Karel VAN...
View articletitled, Functional expression, quantification and cellular localization of the Hxt2 hexose transporter of Saccharomyces cerevisiae tagged with the green fluorescent protein
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Articles

Basic fibroblast growth factor does not prevent heparan sulphate proteoglycan catabolism in intact cells, but it alters the distribution of the glycosaminoglycan degradation products

Sarka TUMOVA, Brian A. HATCH, Douglas J. LAW, Karen J. BAME
Journal: Biochemical Journal
Biochem J (1999) 337 (3): 471–481.
https://doi.org/10.1042/bj3370471
Published: 25 January 1999
..., the interaction with the growth factor alters the distribution of heparan sulphate-degradation products, presumably by preventing secretion of the short heparanase-derived species. Our findings show that most of the free and bFGF-bound heparan sulphate chains are destined for lysosomes, which would be consistent...
View articletitled, Basic fibroblast growth factor does not prevent heparan sulphate proteoglycan catabolism in intact cells, but it alters the distribution of the glycosaminoglycan degradation products
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