... endocytosis human disease inositol phosphatase membrane traffic phosphoinositide secretory pathway Phosphoinositides are a family of lipid molecules that play critical roles in the cell [ 1 , 2 ]. Derived from phosphorylation of phosphatidylinositol (PtdIns), phosphoinositides consist of two...

... 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endomannosidase endoplasmic reticulum-associated degradation (ERAD) free oligosaccharide N-glycosylation protein quality control secretory pathway ERAD [ER (endoplasmic reticulum)-associated degradation...

... in cancer and how viral pathogens ranging from HIV-1 to herpesviruses have evolved to usurp the PACS sorting machinery to promote virus assembly, viral spread and immunoevasion. Akt cancer furin herpesvirus HIV-1 Nef phosphofurin acidic cluster sorting (PACS)-1/2 polycystin-2 secretory pathway...

.../ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Previous chemical genetics approaches have identified further inhibitors of secretory pathway function that appear to cause similar effects to those of BFA. Two...

...) canonical TRP (TRPC) secretory pathway trans -Golgi network The TRP (transient receptor potential) protein superfamily consists of calcium-permeable non-selective cation channels first described in a Drosophila phototransduction mutant associated with a defect in light-induced calcium entry [ 1...

... trafficking membrane microdomains prostate-specific membrane antigen (PSMA) secretory pathway PSMA (prostate-specific membrane antigen) [ 1 ] was initially immunoisolated from a lymph node metastasis of a prostate carcinoma [ 2 ]. Increased expression of PSMA in prostate cancer cells with respect...

...-residing serpins in the surveillance of subtilase-like enzymes along the constitutive and regulated secretory pathways of metazoans including a role in the defence of intruders that turn PCs to their propagation. Spn4A is a serpin that is derived by alternative splicing from the Drosophila melanogaster...

... 2002 congenital disorders of glycosylation type IIb glycoprotein biosynthesis Golgi apparatus secretory pathway transport Abbreviations used: BFA, Brefeldin A; CHO, Chinese-hamster ovary; conA, concanavalin A; CST, castanospermine; endo H, endo-β- N -acetylglucosaminidase; ER...

...Jennifer S. DUNCAN; Mark C. WILKINSON; Robert D. BURGOYNE Caseins and many other secretory proteins are phosphorylated during their transport through the secretory pathway by a protein kinase present within Golgi compartments. Molecular analysis of the Golgi casein kinase (GCK) has not been...

... for cleavage after paired basic amino acids. At steady state, Kex2 is predominantly localized in late Golgi compartments and initiates the proteolytic maturation of pro-protein precursors that transit the distal secretory pathway. However, Kex2 localization is not static, and its itinerary apparently involves...