... viruses boosts viral pathogenicity through its interactions with host cell proteins. By combining the polyvalency of its large unstructured regions with the binding selectivity and strength of its folded core domain, Nef can associate with many different host cell proteins, thereby disrupting...

... highlighted Trp 404 and His 405 as a putative point of Av3 interaction with DmNa v 1. His 405 conservation in arthropod Na v s compared with tyrosine in vertebrate Na v s may represent an ancient substitution that explains the contemporary selectivity of Av3. Trp 404 and His 405 localization near the membrane...

... feedback inhibition by its end product isoleucine. To understand the molecular basis of the high selectivity of the inhibitor and the mechanism of feedback inhibition, we determined the crystal structure of Li CMSC (C-terminal regulatory domain of Li CMS) in complex with isoleucine, and performed...

... leukaemia virus)1, PIM2, PIM3, PKD1 (protein kinase D1), HIPK2 (homeodomain-interacting protein kinase 2) and DYRK1a (dual-specificity tyrosine-phosphorylated and -regulated kinase 1a). In contrast, TBB is significantly more selective toward CK2, although it also inhibits PIM1 and PIM3. In an attempt...

...Jun Chen; Fan Deng; Jun Li; Q. Jane Wang The PKD (protein kinase D) family are novel DAG (diacylglycerol) receptors. The twin C1 domains of PKD, designated C1a and C1b, have been shown to bind DAG or phorbol esters. However, their ligand-binding activities and selectivities have not been fully...

... containing reduced amide bonds, which had a great selectivity between bacterial and mammalian cells. A structureŐactivity relationship study on pseudopeptides indicated that the decrease in α-helicity and the increase in net positive charge in the backbone, caused by the incorporation of a reduced amide bond...