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Keywords: selenium
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Biochem J (2014) 462 (1): 67–75.
Published: 24 July 2014
... 2014 20 5 2014 20 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Selenoproteins contain the rare amino acid selenocysteine. Reduced selenium levels in the brain lead to a complex neurological phenotype affecting cortical and hippocampal GABAergic...
Includes: Multimedia, Supplementary data
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Biochem J (2013) 450 (2): 427–432.
Published: 15 February 2013
... -isopentenyladenosine (i 6 A) isopentenyl tRNA transferase (IPT) isopentenylation selenium tRNA modification Selenoproteins contain the rare amino acid Sec (selenocysteine) which is co-translationally inserted into protein in response to UGA codons (reviewed in [ 1 ]). The human genome contains 25 genes...
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Biochem J (2009) 422 (1): 11–22.
Published: 29 July 2009
...Frederick P. Bellinger; Arjun V. Raman; Mariclair A. Reeves; Marla J. Berry Selenoproteins are proteins containing selenium in the form of the 21st amino acid, selenocysteine. Members of this protein family have many diverse functions, but their synthesis is dependent on a common set of cofactors...
Includes: Multimedia, Supplementary data
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Biochem J (2006) 394 (1): 207–216.
Published: 27 January 2006
... selenium (Se) deficiency can result in a compensatory increase of other non-Se-dependent antioxidants, such as HO-1 (haem oxygenase-1) that may help to counteract the damaging effects of oxidant stress. However, the role of individual selenoproteins in regulating vascular-derived protective gene responses...
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Biochem J (2005) 386 (2): 221–226.
Published: 22 February 2005
...Ulrich SCHWEIZER; Florian STRECKFUß; Paco PELT; Bradley A. CARLSON; Dolph L. HATFIELD; Josef KÖHRLE; Lutz SCHOMBURG Liver-specific inactivation of Trsp , the gene for selenocysteine tRNA, removes SePP (selenoprotein P) from plasma, causing serum selenium levels to fall from 298 μg/l to 50 μg/l...
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Biochem J (2005) 386 (2): E5.
Published: 22 February 2005
...Des R. RICHARDSON How is the essential micronutrient, selenium (Se), transported in the serum and then donated to tissues? In this issue of the Biochemical Journal , Schweizer and colleagues demonstrate, using conditional and total mouse knockout models, that SePP (selenoprotein P) is the major...
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Biochem J (2004) 381 (3): 841–846.
Published: 27 July 2004
...Yoshiro SAITO; Noriko SATO; Masaki HIRASHIMA; Gen TAKEBE; Shigeharu NAGASAWA; Kazuhiko TAKAHASHI Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region...
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Biochem J (2003) 370 (1): 283–290.
Published: 15 February 2003
...Shani SHILO; Anna ARONIS; Rita KOMARNITSKY; Oren TIROSH There is a known connection between selenium supplementation and chemo-protective anti-cancer activity. This biological phenomenon may be due to the ability of selenium to instigate cellular apoptosis. However, the mechanism by which selenium...
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Biochem J (2000) 346 (1): 1–8.
Published: 08 February 2000
...Debbie MUSTACICH; Garth POWIS The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a conserved -Cys-Val-Asn-Val-Gly-Cys- redox catalytic site, to glutathione reductases...
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Biochem J (1999) 340 (2): 439–444.
Published: 25 May 1999
... was decreased in A549 cells by the lowering of the fetal bovine serum content in the culture medium and was recovered by the addition of selenium. To study the role of Sec in TR activity, we have isolated a full-length clone of the rat TR cDNA (3.3 kb) and have expressed it in COS-1 cells in a transient...