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1-18 of 18
Keywords: selenium
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Articles
Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals
Available to PurchaseRyuta Tobe, Bradley A. Carlson, Jang Hoe Huh, Nadia P. Castro, Xue-Ming Xu, Petra A. Tsuji, Sang-Goo Lee, Jeyoung Bang, Ji-Woon Na, Young-Yun Kong, Daniel Beaglehole, Eileen Southon, Harold Seifried, Lino Tessarollo, David S. Salomon, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee
Journal:
Biochemical Journal
Biochem J (2016) 473 (14): 2141–2154.
Published: 12 July 2016
... Jae Lee Selenophosphate synthetase (SPS) was initially detected in bacteria and was shown to synthesize selenophosphate, the active selenium donor. However, mammals have two SPS paralogues, which are designated SPS1 and SPS2. Although it is known that SPS2 catalyses the synthesis of selenophosphate...
Includes: Supplementary data
Articles
Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice
Available to PurchaseSandra Seeher, Bradley A. Carlson, Angela C. Miniard, Eva K. Wirth, Yassin Mahdi, Dolph L. Hatfield, Donna M. Driscoll, Ulrich Schweizer
Journal:
Biochemical Journal
Biochem J (2014) 462 (1): 67–75.
Published: 24 July 2014
... 2014 20 5 2014 20 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 Selenoproteins contain the rare amino acid selenocysteine. Reduced selenium levels in the brain lead to a complex neurological phenotype affecting cortical and hippocampal GABAergic...
Includes: Multimedia, Supplementary data
Articles
Mammalian Trit1 is a tRNA [Ser]Sec -isopentenyl transferase required for full selenoprotein expression
Available to PurchaseNoelia Fradejas, Bradley A. Carlson, Eddy Rijntjes, Niels-Peter Becker, Ryuta Tobe, Ulrich Schweizer
Journal:
Biochemical Journal
Biochem J (2013) 450 (2): 427–432.
Published: 15 February 2013
... -isopentenyladenosine (i 6 A) isopentenyl tRNA transferase (IPT) isopentenylation selenium tRNA modification Selenoproteins contain the rare amino acid Sec (selenocysteine) which is co-translationally inserted into protein in response to UGA codons (reviewed in [ 1 ]). The human genome contains 25 genes...
Articles
Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2012) 447 (1): 167–174.
Published: 12 September 2012
... supplemented cells with either SPO 3 or selenium and subsequently determined total as well as specific activities of cellular TrxR1, together with extent of drug-induced cell death. We found that cDDP became less cytotoxic after incubation of A549 or HCT116 cells with lower SPO 3 concentrations (100–300 μM...
Includes: Supplementary data
Articles
Ojia Skaff, David I. Pattison, Philip E. Morgan, Rushad Bachana, Vimal K. Jain, K. Indira Priyadarsini, Michael J. Davies
Journal:
Biochemical Journal
Biochem J (2012) 441 (1): 305–316.
Published: 14 December 2011
..., HOSCN targets cysteine residues with considerable selectivity. In the light of this reactivity, we hypothesized that Sec (selenocysteine) residues should also be rapidly oxidized by HOSCN, as selenium atoms are better nucleophiles than sulfur. Such oxidation might inactivate critical Sec-containing...
Articles
Regulation and function of selenoproteins in human disease
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 422 (1): 11–22.
Published: 29 July 2009
...Frederick P. Bellinger; Arjun V. Raman; Mariclair A. Reeves; Marla J. Berry Selenoproteins are proteins containing selenium in the form of the 21st amino acid, selenocysteine. Members of this protein family have many diverse functions, but their synthesis is dependent on a common set of cofactors...
Includes: Multimedia, Supplementary data
Articles
The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice
Available to PurchaseBradley A. Carlson, Ulrich Schweizer, Christine Perella, Rajeev K. Shrimali, Lionel Feigenbaum, Liya Shen, Svetlana Speransky, Thomas Floss, Soon-Jeong Jeong, Jennifer Watts, Victoria Hoffmann, Gerald F. Combs, Jr, Vadim N. Gladyshev, Dolph L. Hatfield
Journal:
Biochemical Journal
Biochem J (2009) 418 (1): 61–71.
Published: 28 January 2009
.... Heterozygous Trsp -knockout mice ( Trsp + / − ) in a C57Bl/6 genetic background were from a previous study in our laboratory [ 5 ]. Mice were maintained on standard rodent diet, NIH-31A, containing adequate amounts of selenium as described in [ 36 ] and the care of animals was in accordance...
Articles
Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp -knockout mice
Available to PurchaseKostja Renko, Margarethe Werner, Ingrid Renner-Müller, Trevor G. Cooper, Ching Hei Yeung, Birgit Hollenbach, Marcus Scharpf, Josef Köhrle, Lutz Schomburg, Ulrich Schweizer
Journal:
Biochemical Journal
Biochem J (2008) 409 (3): 741–749.
Published: 15 January 2008
...Kostja Renko; Margarethe Werner; Ingrid Renner-Müller; Trevor G. Cooper; Ching Hei Yeung; Birgit Hollenbach; Marcus Scharpf; Josef Köhrle; Lutz Schomburg; Ulrich Schweizer SePP (selenoprotein P) is central for selenium transport and distribution. Targeted inactivation of the Sepp gene in mice leads...
Articles
Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 394 (1): 207–216.
Published: 27 January 2006
... selenium (Se) deficiency can result in a compensatory increase of other non-Se-dependent antioxidants, such as HO-1 (haem oxygenase-1) that may help to counteract the damaging effects of oxidant stress. However, the role of individual selenoproteins in regulating vascular-derived protective gene responses...
Articles
Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply
Available to PurchaseUlrich SCHWEIZER, Florian STRECKFUß, Paco PELT, Bradley A. CARLSON, Dolph L. HATFIELD, Josef KÖHRLE, Lutz SCHOMBURG
Journal:
Biochemical Journal
Biochem J (2005) 386 (2): 221–226.
Published: 22 February 2005
...Ulrich SCHWEIZER; Florian STRECKFUß; Paco PELT; Bradley A. CARLSON; Dolph L. HATFIELD; Josef KÖHRLE; Lutz SCHOMBURG Liver-specific inactivation of Trsp , the gene for selenocysteine tRNA, removes SePP (selenoprotein P) from plasma, causing serum selenium levels to fall from 298 μg/l to 50 μg/l...
Articles
More roles for selenoprotein P: local selenium storage and recycling protein in the brain
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Journal:
Biochemical Journal
Biochem J (2005) 386 (2): E5.
Published: 22 February 2005
...Des R. RICHARDSON How is the essential micronutrient, selenium (Se), transported in the serum and then donated to tissues? In this issue of the Biochemical Journal , Schweizer and colleagues demonstrate, using conditional and total mouse knockout models, that SePP (selenoprotein P) is the major...
Articles
Domain structure of bi-functional selenoprotein P
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Journal:
Biochemical Journal
Biochem J (2004) 381 (3): 841–846.
Published: 27 July 2004
...Yoshiro SAITO; Noriko SATO; Masaki HIRASHIMA; Gen TAKEBE; Shigeharu NAGASAWA; Kazuhiko TAKAHASHI Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region...
Articles
Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency
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Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 21–26.
Published: 15 February 2004
...Ulrich SCHWEIZER; Marten MICHAELIS; Josef KÖHRLE; Lutz SCHOMBURG Mice deficient in selenoprotein P exhibit a disturbed selenium distribution and reduced activities of other selenoenzymes and display defects in growth and motor co-ordination. We have normalized selenoenzyme activities and rescued...
Articles
Selenite sensitizes mitochondrial permeability transition pore opening in vitro and in vivo: a possible mechanism for chemo-protection
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2003) 370 (1): 283–290.
Published: 15 February 2003
...Shani SHILO; Anna ARONIS; Rita KOMARNITSKY; Oren TIROSH There is a known connection between selenium supplementation and chemo-protective anti-cancer activity. This biological phenomenon may be due to the ability of selenium to instigate cellular apoptosis. However, the mechanism by which selenium...
Articles
Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency
Available to PurchaseXiaojun REN, Shujuan GAO, Delin YOU, Hualiang HUANG, Zi LIU, Ying MU, Junqiu LIU, Yan ZHANG, Ganglin YAN, Guimin LUO, Tongshu YANG, Jiacong SHEN
Journal:
Biochemical Journal
Biochem J (2001) 359 (2): 369–374.
Published: 08 October 2001
... into selenium-containing 2F3-scFv (Se-2F3-scFv) by chemical modification of the reactive serine; the GPX activity of the Se-2F3-scFv was 3394units/ μ mol, which approaches the activity of rabbit liver GPX. 1 To whom correspondence should be addressed (e-mail [email protected] ). The Biochemical...
Articles
Thioredoxin reductase
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Journal:
Biochemical Journal
Biochem J (2000) 346 (1): 1–8.
Published: 08 February 2000
...Debbie MUSTACICH; Garth POWIS The mammalian thioredoxin reductases (TrxRs) are a family of selenium-containing pyridine nucleotide-disulphide oxidoreductases with mechanistic and sequence identity, including a conserved -Cys-Val-Asn-Val-Gly-Cys- redox catalytic site, to glutathione reductases...
Articles
Thioredoxin reductase is the major selenoprotein expressed in human umbilical-vein endothelial cells and is regulated by protein kinase C
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 342 (1): 111–117.
Published: 10 August 1999
...Sue M. ANEMA; Simon W. WALKER; A. Forbes HOWIE; John R. ARTHUR; Fergus NICOL; Geoff J. BECKETT Damage to the endothelium by reactive oxygen species favours atherogenesis. Such damage can be prevented by selenium, which is thought to exert its actions through the expression of selenoproteins...
Articles
Functional expression of rat thioredoxin reductase: selenocysteine insertion sequence element is essential for the active enzyme
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 340 (2): 439–444.
Published: 25 May 1999
... was decreased in A549 cells by the lowering of the fetal bovine serum content in the culture medium and was recovered by the addition of selenium. To study the role of Sec in TR activity, we have isolated a full-length clone of the rat TR cDNA (3.3 kb) and have expressed it in COS-1 cells in a transient...