... in the regulation of Sec synthesis, wherein SPS1 deficiency resulted in the down-regulation of genes involved in pyridoxal phosphate (PLP, an active form of vitamin B 6 ), which is used as a cofactor of selenocysteine lyase (SCL), D -selenocysteine, α,β-lyase [ 16 ] and SecS [ 9 ]. It was also reported that SCL...

...Anton A. Turanov; Valentina A. Shchedrina; Robert A. Everley; Alexei V. Lobanov; Sun Hee Yim; Stefano M. Marino; Steven P. Gygi; Dolph L. Hatfield; Vadim N. Gladyshev SelS (Selenoprotein S) is a selenocysteine-containing protein with roles in ER (endoplasmic reticulum) function and inflammation...

...Frederick P. Bellinger; Arjun V. Raman; Mariclair A. Reeves; Marla J. Berry Selenoproteins are proteins containing selenium in the form of the 21st amino acid, selenocysteine. Members of this protein family have many diverse functions, but their synthesis is dependent on a common set of cofactors...

...Xue-Ming Xu; Bradley A. Carlson; Robert Irons; Heiko Mix; Nianxin Zhong; Vadim N. Gladyshev; Dolph L. Hatfield Selenophosphate synthetase (SelD) generates the selenium donor for selenocysteine biosynthesis in eubacteria. One homologue of SelD in eukaryotes is SPS1 (selenophosphate synthetase 1...

...Ulrich SCHWEIZER; Florian STRECKFUß; Paco PELT; Bradley A. CARLSON; Dolph L. HATFIELD; Josef KÖHRLE; Lutz SCHOMBURG Liver-specific inactivation of Trsp , the gene for selenocysteine tRNA, removes SePP (selenoprotein P) from plasma, causing serum selenium levels to fall from 298 μg/l to 50 μg/l...