... of obesity, type 2 diabetes and cardiovascular disease. The ER is gaining recognition as a key organelle in integrating cellular stress responses. ER homeostasis is tightly regulated by a complex antioxidant system, which includes the seven ER-resident selenoproteins — 15 kDa selenoprotein, type 2...

... correspondence should be addressed (email [email protected] ). 13 4 2012 17 5 2012 17 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cancer glutathione selenium cytotoxicity selenoprotein thioredoxin thioredoxin reductase 1 Selenium plays...

... 2011 17 5 2011 17 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 buthionine sulfoximine reactive oxygen species selenium tolerance selenoprotein sulfur vascular plant Unlike some bacteria and animals, vascular plants have not been shown...

...Frederick P. Bellinger; Arjun V. Raman; Mariclair A. Reeves; Marla J. Berry Selenoproteins are proteins containing selenium in the form of the 21st amino acid, selenocysteine. Members of this protein family have many diverse functions, but their synthesis is dependent on a common set of cofactors...

... transcription activating factor] is a transcription activating factor for a number of RNA Pol III- and RNA Pol II-dependent genes including the Trsp [Sec tRNA gene], which in turn controls the expression of all selenoproteins. Here, the role of STAF in regulating expression of Sec tRNA and selenoproteins...

... on mammalian MsrA and MsrBs including their roles in disease, evolution and function of selenoprotein forms of MsrA and MsrB, and the biochemistry of these enzymes. Msrs catalyse the reduction of free and protein-bound methionine sulfoxides to methionine. Two distinct enzyme families have evolved...

...) and a second one, SPS2, was identified as a selenoprotein in mammals. Earlier in vitro studies showed SPS2, but not SPS1, synthesized selenophosphate from selenide, whereas SPS1 may utilize a different substrate. The roles of these enzymes in selenoprotein synthesis in vivo remain unknown. To address...

...Sergey V. Novoselov; Deame Hua; Alexey V. Lobanov; Vadim N. Gladyshev Sec (selenocysteine) is a rare amino acid in proteins. It is co-translationally inserted into proteins at UGA codons with the help of SECIS (Sec insertion sequence) elements. A full set of selenoproteins within a genome, known...

...Des R. RICHARDSON How is the essential micronutrient, selenium (Se), transported in the serum and then donated to tissues? In this issue of the Biochemical Journal , Schweizer and colleagues demonstrate, using conditional and total mouse knockout models, that SePP (selenoprotein P) is the major...

...Yoshiro SAITO; Noriko SATO; Masaki HIRASHIMA; Gen TAKEBE; Shigeharu NAGASAWA; Kazuhiko TAKAHASHI Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region...