... (NADPH oxidase 4) induces cellular senescence in human endothelial cells; however, intracellular targets for Nox4 remained elusive. In the present study, we show that Nox4 induces mitochondrial dysfunction in human endothelial cells. Nox4 depletion induced alterations in mitochondrial morphology...

... senescence model. Cellular aging appears to promote a Nox4 interaction with mitochondria that disrupts complex I in the electron transport chain and increases the detection of mitochondrial H 2 O 2 . Nox4 appears to maintain a highly interconnected mitochondrial network, which may influence mitochondrial...

... about the cellular events that underlie premature senescence, or how to impede these events. In the present study we demonstrate that PPARδ (peroxisome-proliferator-activated receptor δ) regulates UVB-induced premature senescence of normal keratinocytes. Activation of PPARδ by GW501516, a specific...

...) transporter, designated BCD1 (BUSH-AND-CHLOROTIC-DWARF 1), contributes to iron homoeostasis during stress responses and senescence in Arabidopsis . The BCD1 gene is induced by excessive iron, but repressed by iron deficiency. It is also induced by cellular and tissue damage occurring under osmotic stress...

... with mortalin; (ii) their co- and exclusive localizations in vivo ; (iii) their involvement in tumorigenesis; and (iv) their functional distinction in pathways involved in senescence. Recombinant GST-tagged mortalin was prepared as described previously [ 33 ]. Purified recombinant GST-tagged mortalin...

...Eveline HUTTER; Kathrin RENNER; Gerald PFISTER; Petra STÖCKL; Pidder JANSEN-DÜRR; Erich GNAIGER Limitation of lifespan in replicative senescence is related to oxidative stress, which is probably both the cause and consequence of impaired mitochondrial respiratory function. The respiration...

... and hyperoxia-induced senescence. In both cases, an increased nuclear apoE level was observed, particularly in cells that accumulated lipofuscin. Nuclear apoE was translocated to the cytosol when mitotic nuclear disassembly occurred and this was associated with an increase in total cellular apoE levels. ApoE...

...Werner ZWERSCHKE; Sybille MAZUREK; Petra STÖCKL; Eveline HÜTTER; Erich EIGENBRODT; Pidder JANSEN-DÜRR Cellular senescence is considered a major tumour-suppressor mechanism in mammals, and many oncogenic insults, such as the activation of the ras proto-oncogene, trigger initiation of the senescence...

... results in a cell-cycle arrest that within a few days can become irreversible. Arrested cells acquire a senescent-like phenotype, which consists of several characteristic morphological alterations and increased activity of senescence-associated β-galactosidase. The induction of the premature senescence...

... by an increased incidence of chromosome abnormalities and induction of the senescence phenotype. The results presented here indicate that TNQX is a highly potent and selective anti-telomerase agent with good potential for further development as a promising anti-cancer agent. Abbreviations used: hTERT...

... expression of both genes in primary quiescent cells, cDcoH mRNA, but not cDcoHα mRNA, was dramatically decreased in primary senescent cells. The highest levels of cDcoHα mRNA were found in the kidney, liver, heart and ovarian follicles, while the major tissues expressing cDcoH were hypothalamus, kidney...

... days of antisense induction, with markedly decreased intracellular Ca#+ mobilization by thrombin, decreased DNA synthesis and growth arrest, indicating that the protein has an important function in Ca#+ homoeostasis, growth and proliferation. Key words: InsP $ , senescence, signal transduction...