...Tristram A. J. Ryan; Roger J. S. Preston; Luke A. J. O'Neill The interplay between innate immunity and coagulation after infection or injury, termed immunothrombosis, is the primary cause of disseminated intravascular coagulation (DIC), a condition that occurs in sepsis. Thrombosis associated...

... The Authors Journal compilation © 2013 Biochemical Society 2013 Alzheimer’s disease heart failure Parkinson’s disease sepsis synaptic vesicle vascular dementia Cholinergic neurons in the CNS (central nervous system) and in the periphery secrete the neurotransmitter ACh (acetylcholine...

... caspase 11 inhibitor of apoptosis protein (IAP) lipopolysaccharide (LPS) sepsis ES (embryonic stem) cell lines from the murine 129 strain are frequently used to derive genetically modified mice [ 1 ]. A recent report examining the role of caspase 1 in an endotoxin-induced murine model of sepsis...

...Damon A. Lowes; Helen F. Galley Oxidative stress and mitochondrial dysfunction are common features in patients with sepsis and organ failure. Within mitochondria, superoxide is converted into hydrogen peroxide by MnSOD (manganese-containing superoxide dismutase), which is then detoxified by either...

... response albumin glutathione S-transferase (GST) hepatic nuclear factor 1 (HNF1) sepsis ubiquitin-specific protease 3 (USP3) The acute-phase response is an innate immune system reaction to infection, burns and other acute injuries. In the acute-phase response, pro-inflammatory factors...

... ]. The suppression of G6Pase expression probably contributes to the diminished hepatic glucose production and the hypoglycaemia observed in the later stages of sepsis [ 14 ]. Receptor binding of TNF leads to the activation of transcription factors such as NFκB (nuclear factor κB) and AP-1 (activator protein-1), via...

... to increased IL6DEX-NP binding. IL6DEX-NP appears to be an important negative regulator of gene expression in vitro and in vivo . cytokine gene regulation sepsis transcription transcription factor Abbreviations used: DEX, dexamethasone; EMSA, electrophoretic mobility-shift assay; GST...

...Kumudika I. de SILVA; Asif N. DAUD; JiangPing DENG; Stephen B. JONES; Richard L. GAMELLI; Ravi SHANKAR Interleukin-6 (IL-6), a potent myeloid mitogen, and the immunosuppressive prostanoid prostaglandin E 2 (PGE 2 ) are elevated following thermal injury and sepsis. We have previously demonstrated...

..., London ©2002 2002 peroxynitrite sepsis tyrosine nitration Abbreviations used: COPD, chronic obstructive pulmonary disease; hr, human recombinant; IFN-γ, interferon-γ; LPS, lipopolysaccharide; MALDI-TOF MS, matrix-assisted laser-desorption ionization–time-of-flight MS; Mn-SOD, manganese...

... 2002 neurodegenerative nitrosative stress oxidative stress peroxynitrite sepsis Abbreviations used: C-PTIO, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline 1-oxyl 3-oxide; DTPA, diethylenetriaminepenta-acetic acid; IFN-γ, interferon-γ; LPS, lipopolysaccharide; Mn-Salen, manganese...

...Christiane DEVAL; Sylvie MORDIER; Christiane OBLED; Daniel BECHET; Lydie COMBARET; Didier ATTAIX; Marc FERRARA Alteration of skeletal muscle protein breakdown is a hallmark of a set of pathologies, including sepsis, with negative consequences for recovery. The aim of the present study was to search...

... and progression of periodontitis. The Biochemical Society, London © 2001 2001 pathogenesis periodontitis proteolysis sepsis zymogen activation Biochem. J. (2001) 353, 325 331 (Printed in Great Britain) 325 Activation of blood coagulation factor IX by gingipains R, arginine-specific cysteine...