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Keywords: serine protease
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Articles
Biochem J (2020) 477 (9): 1779–1794.
Published: 15 May 2020
...Signe Skovbjerg; Lasse Holt-Danborg; Annika W. Nonboe; Zebin Hong; Ásdís K. Frost; Christine R. Schar; Cecilia C. Thomas; Lars Vitved; Jan K. Jensen; Lotte K. Vogel The membrane-bound serine protease matriptase belongs to a rare subset of serine proteases that display significant activity in the...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (16): 2355–2369.
Published: 28 August 2019
...Lina Wang; Ce Zhang; Shijin Sun; Yue Chen; Yae Hu; Hao Wang; Meng Liu; Ningzheng Dong; Qingyu Wu Hepsin is a transmembrane serine protease implicated in many biological processes, including hepatocyte growth, urinary protein secretion, auditory nerve development, and cancer metastasis. Zymogen...
Articles
Biochem J (2019) 476 (10): 1445–1463.
Published: 21 May 2019
...Raghupathi Kummari; Shubhankar Dutta; Lalith K. Chaganti; Kakoli Bose High-temperature requirement protease A4 (HtrA4) is a secretary serine protease whose expression is up-regulated in pre-eclampsia (PE) and hence is a possible biomarker of PE. It has also been altered in cancers such as...
Includes: Supplementary data
Articles
Biochem J (2015) 472 (2): 169–181.
Published: 13 November 2015
...Claudio Ciferri; Michael T. Lipari; Wei-Ching Liang; Alberto Estevez; Julie Hang; Scott Stawicki; Yan Wu; Paul Moran; Mike Elliott; Charles Eigenbrot; Kenneth J. Katschke; Menno van Lookeren Campagne; Daniel Kirchhofer High temperature requirement A1 (HtrA1) is a trypsin-fold serine protease...
Articles
Biochem J (2012) 446 (1): 69–77.
Published: 27 July 2012
... Resonance Bank ( http://www.bmrb.wisc.edu/ ) under accession number 18334. 1 To whom correspondence should be addressed (email avas@ibch.ru ). canonical inhibitor disulfide Fagopyrum esculentum α-hairpinin NMR serine protease Plants have to resist unfavourable environmental...
Articles
Biochem J (2012) 441 (3): 909–919.
Published: 16 January 2012
... processing serine protease Cell lines used in the present study were purchased from American Type Culture Collection (A.T.C.C.) and maintained as recommended. MCF7 human breast carcinoma cells, the resultant MCF7 transfectant cell lines and murine NIH 3T3 fibroblasts were cultured in a humidified 5...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (2): 313–322.
Published: 28 June 2011
... cells as its primary defense against tumour cells and viral pathogens, i.e. NK (natural killer) cells and CTLs (cytotoxic T-lymphocytes). Both types of cytotoxic cells harbour cytotoxic granules that are released upon target cell recognition. These granules contain serine proteases, also called...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (3): 733–742.
Published: 13 April 2011
...Pitter F. Huesgen; Helder Miranda; XuanTam Lam; Manuela Perthold; Holger Schuhmann; Iwona Adamska; Christiane Funk Cyanobacteria require efficient protein-quality-control mechanisms to survive under dynamic, often stressful, environmental conditions. It was reported that three serine proteases...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (1): 167–174.
Published: 15 March 2011
.../ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Arabidopsis thaliana complex formation degenerated protease domain DEG7 serine protease taxonomic distribution Deg/HtrA (for deg radation of...
Includes: Supplementary data
Articles
Biochem J (2010) 430 (2): 179–189.
Published: 13 August 2010
... approaches that target proteases, for which structural features are conserved among family members. Recent crystal structures of antibody–protease complexes provide exciting insight into the variety of ways antibodies can interfere with the catalytic machinery of serine proteases. The studies revealed the...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 419 (3): 555–564.
Published: 14 April 2009
... human pathogen whose antibiotic resistance is steadily increasing and no efficient vaccine is as yet available. This serious threat drives extensive studies on staphylococcal physiology and pathogenicity pathways, especially virulence factors. Spl (serine protease-like) proteins encoded by an operon...
Includes: Supplementary data
Articles
Biochem J (2008) 412 (3): 447–457.
Published: 28 May 2008
... murine and human serine proteases, including trypsin, mupain-1 was found to be highly selective for murine uPA and did not even measurably inhibit human uPA. The cyclic structure of mupain-1 was indispensable for binding. Alanine scanning mutagenesis identified Arg 6 of mupain-1 as the P1 residue and...
Articles
Biochem J (2008) 412 (1): 81–91.
Published: 25 April 2008
...Robert Stallmach; Sergio M. Gloor TTSPs [type II TMPRSSs (transmembrane serine proteases)] are a growing family of trypsin-like enzymes with, in some cases, restricted tissue distribution. To investigate the expression of TTSPs in the nervous system, we performed a PCR-based screening approach with...
Articles
Biochem J (2007) 404 (1): 81–87.
Published: 26 April 2007
... transcriptional activity due to the lack of the transactivation domain. Previously, it has been shown that STAT5γ, generated by an unidentified nuclear serine protease, plays an important role in myeloid cell differentiation and is aberrantly expressed in acute myeloid leukaemia. To better understand this...
Articles
Biochem J (2007) 404 (1): 45–50.
Published: 26 April 2007
... artificial RNA was an effective cofactor for FSAP mediated PDGF-BB degradation, whereas the effect of DNA was weak. RNA-induced cleavage of PDGF-BB was inhibited by serine protease inhibitors. The pattern of PDGF-BB cleavage was identical with either heparin or RNA as a cofactor. One of the cleavage sites in...
Articles
Biochem J (2006) 400 (3): 467–476.
Published: 28 November 2006
...Michèle Brillard-Bourdet; Ahmed Hamdaoui; Eric Hajjar; Christian Boudier; Nathalie Reuter; Laurence Ehret-Sabatier; Joseph G. Bieth; Francis Gauthier We have purified to homogeneity two forms of a new serine protease inhibitor specific for elastase/chymotrypsin from the ovary gland of the desert...
Includes: Supplementary data
Articles
Biochem J (2004) 383 (2): 311–318.
Published: 08 October 2004
... sprue chain-length specificity gliadin peptide prolyl endopeptidase serine protease subsite specificity Prolyl endopeptidases, or prolyl oligopeptidases, are a family of serine proteases with the unique ability to hydrolyse the peptide bond on the carboxyl side of a proline residue. These...
Includes: Supplementary data
Articles
Biochem J (2004) 381 (3): 895–904.
Published: 27 July 2004
...MURWANTOKO; Masato YANO; Yoshifumi UETA; Ai MURASAKI; Hidenobu KANDA; Chio OKA; Masashi KAWAICHI HtrA1, a member of the mammalian HtrA (high temperature requirement A) serine protease family, has a highly conserved protease domain followed by a PDZ domain. Accumulating evidence has indicated that...
Articles
Biochem J (2003) 374 (1): 97–107.
Published: 15 August 2003
...Cailin CHEN; Andrew L. DARROW; Jian-shen QI; Michael R. D'ANDREA; Patricia ANDRADE-GORDON We have identified a novel serine protease designated EOS by sequence identity searches. The deduced protein contains 284 amino gcids with an active form containing 248 amino acids starting from an Ile-Val-Gly...
Articles
Biochem J (2003) 373 (3): 689–702.
Published: 01 August 2003
... (complement protein subcomponents C 1r/C1s, u rchin embryonic growth factor and b one morphogenetic protein 1) domains, three LDLR ( l ow- d ensity- l ipoprotein r eceptor class A) domains and a C-terminal serine-protease domain. All m-matriptase-2 protein domain boundaries corresponded with intron/exon...
Articles
Biochem J (2003) 371 (3): 1021–1025.
Published: 01 May 2003
... acetyl- Lys -Phe-Phe-Pro-Leu-Glu-NH 2 inhibited hK1 in the range 20–30 nM (letters in italics denote the d -form of the amino acid). The peptide acetyl- Lys -Phe-Phe-Pro-Leu-Glu-NH 2 was a weak inhibitor for other serine proteases, as indicated by the higher K i values compared with hK1, but this peptide...
Articles
Biochem J (2003) 371 (2): 631–640.
Published: 15 April 2003
...Gérard GARNIER; Antonella CIRCOLO; Yuanyuan XU; John E. VOLANAKIS C1r and C1s are the serine proteases that form the catalytic unit of the C1 complex, the first component of complement. In the present study, we found that the genes encoding murine C1r and C1s are duplicated. One set of these genes...
Articles
Biochem J (2003) 369 (3): 603–610.
Published: 01 February 2003
...Ignacio FAJARDO; Gunnar PEJLER Tryptase is a serine protease that is stored at low pH in the mast cell secretory granules in complex with heparin proteoglycan. When mast cells are activated, e.g. during allergic responses, the tryptase/heparin complexes are released together with a variety of other...
Articles
Biochem J (2003) 369 (1): 191–198.
Published: 01 January 2003
..., the 38kDa subunit is closely related to serine proteases of the trypsin family. The sequences in the vicinity of the active-site histidine, aspartic acid and serine residues, and critical cysteine residues involved in disulphide formation, are well conserved, but the catalytic serine residue is...
Articles
Biochem J (2002) 368 (1): 233–242.
Published: 15 November 2002
..., AY038182 for WAP10, AY047609 for WAP11, AF454506 for WAP12a, AF454507 for WAP12b, AF454505 for WAP13 and AF488306 for WAP14. 5 6 2002 13 8 2002 2 9 2002 2 9 2002 The Biochemical Society, London ©2002 2002 epididymis serine protease transcript Abbreviations...
Articles
Biochem J (2002) 366 (3): 965–970.
Published: 15 September 2002
... serine protease synthetic substrate Abbreviations used: Abz, o -aminobenzoic acid; ACT, α 1 -antichymotrypsin; CMK, chloromethyl ketone; DTNB, 5,5′-dithio-bis(2-nitrobenzoic acid); EDDnp, N -(2,4-dinitrophenyl)ethylenediamine; HNE, human neutrophil elastase; PAR, protease-activated receptor...
Articles
Biochem J (2002) 363 (2): 387–393.
Published: 08 April 2002
... 2002 anticoagulant bifunctional inhibitor prothrombin time serine protease tissue factor Abbreviations used: FVIIa, Factor VIIa; TF, tissue factor; FX, Factor X; FXa, Factor Xa; FIX, Factor IX; Fmoc, fluoren-9-ylmethoxycarbonyl; TF 1–219 and TF 1–243 , Escherichia coli -derived...
Articles
Biochem J (2002) 363 (2): 411–416.
Published: 08 April 2002
...Raffaella TOSO; Mirko PINOTTI; Katherine A. HIGH; Eleanor S. POLLAK; Francesco BERNARDI Activated Factor VII (FVIIa) is a vitamin-K-dependent serine protease that initiates blood clotting after interacting with its cofactor tissue factor (TF). The complex FVIIa—TF is responsible for the activation...
Articles
Biochem J (2000) 351 (2): 335–340.
Published: 10 October 2000
...-lactam ring, as well as other structural features required for recognition by their target enzymes. b- Lactam derivatives have also been shown to inhibit a range of other enzymes with nucleophilic serine residues, including mam- malian serine proteases such as elastase [2 5] and prostate- specific...
Articles
Biochem J (2000) 350 (3): 701–707.
Published: 08 September 2000
... IX Factor VIII serine protease site-directed mutagenesis Biochem. J. (2000) 350, 701 707 (Printed in Great Britain) 701 Surface-loop residue Lys316 in blood coagulation Factor IX is a major determinant for Factor X but not antithrombin recognition Joost A. KOLKMAN* and Koen MERTENS*‹1...