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Keywords: signal transduction
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Biochem J (2022) 479 (3): 445–462.
Published: 11 February 2022
... by the participation of University of Bath in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. glucose transport GLUT4 insulin membrane traffic membrane trafficking kinetics signal transduction In the 100th year...
Includes: Supplementary data
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Biochem J (2019) 476 (6): 931–950.
Published: 22 March 2019
... Limited on behalf of the Biochemical Society 2019 cancer cell signaling DCBLD1 DCBLD2 development signal transduction The d iscoidin, C U B , and L CCL d omain-containing (DCBLD) receptor family consists of two paralogous type-I transmembrane proteins, DCBLD1 and DCBLD2, which...
Includes: Supplementary data
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Biochem J (2016) 473 (19): 2973–2994.
Published: 27 September 2016
..., inflammation, and kinase-mediated signal transduction that lead to either cell survival or cell death. This review focuses on the central signaling mechanisms that respond to UVR and the subsequent cellular changes. Given the prevalence of NMSC and the resulting health care burden, many of these pathways...
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Biochem J (2016) 473 (2): 145–155.
Published: 05 January 2016
... infected with HCV. HCV is a member of the Flaviviridae family that contains a single-stranded positive-sense RNA genome of approximately 9600 bases [ 1 , 2 ]. HCV morphogenesis signal transduction SNARE α-taxilin This study identifies α-taxilin as a novel factor that controls...
Includes: Supplementary data
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Biochem J (2015) 471 (3): 415–430.
Published: 16 October 2015
... and its multifunctional mode of binding has been determined by kinetic and mutational analyses. bisubstrate inhibitor cell migration CK2 ecto-kinase protein kinase inhibitor protein phosphorylation signal transduction Protein kinases are implicated in a wide variety of human diseases...
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Biochem J (2015) 470 (1): 1–14.
Published: 06 August 2015
...; published by Portland Press Limited 2015 autotrophy growth control kinase LST8 nutrition plant signalling plant RAPTOR signal transduction target of rapamycin (TOR) Figure 1 A graphic summary of the generic roles of TOR in co-ordinating cellular growth and metabolic outputs...
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Biochem J (2015) 468 (2): 203–214.
Published: 22 May 2015
... modification protein function protein kinase B signal transduction The serine/threonine protein kinase Akt (also known as protein kinase B or PKB) is a member of the AGC family of protein kinases, conserved from primitive metazoans to humans. Akt is involved in the regulation of many different...
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Biochem J (2014) 460 (3): 399–410.
Published: 29 May 2014
... perturbing a signalling pathway activated by one co-receptor. co-stimulation immunology nuclear factor κB (NF-κB) phosphorylation signal transduction T-cell Freshly purified T-cells were suspended to 2.5×10 6 cells/ml in RPMI 1640 GlutaMAX medium containing 10% FBS. Per condition, 2.5...
Includes: Supplementary data
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Biochem J (2014) 458 (3): 559–573.
Published: 28 February 2014
... isoforms. γ-aminobutyric acid (GABA) blood pressure/hypertension ion homoeostasis K + –Cl − co-transporter 2 (KCC2) K + –Cl − co-transporter 3 (KCC3) Na + –Cl − co-transporter (NCC) Na + –K + –2Cl − co-transporter 1 (NKCC1) protein kinase signal transduction In eukaryotic cells...
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Biochem J (2014) 457 (3): 451–461.
Published: 10 January 2014
...-and-a-half LIM (FHL) histone deacetylase neurohormonal stimulation protein kinase signal transduction The PKD (protein kinase D) family of serine/threonine kinases consists of three members, PKD1, PKD2 and PKD3, and belongs to the CaMK (Ca 2+ /calmodulin-dependent protein kinase) superfamily...
Includes: Supplementary data
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Biochem J (2013) 454 (1): 1–11.
Published: 26 July 2013
... of IL-4 or IL-13 to their specific receptors, a cytoplasmic cascade is initiated which culminates in the phosphorylation of STAT (signal transduction and activator of transcription) 6 [ 27 ]. Phosphorylated STAT6 is then able to translocate into the nucleus where it induces the expression of its target...
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Biochem J (2013) 453 (1): e1–e2.
Published: 13 June 2013
... protein would probably induce a conformational change of the channel protein thereby inducing channel opening [ 8 ]. Ca 2+ signalling nicotinic acid–adenine dinucleotide phosphate (NAADP) nicotinic acid–adenine dinucleotide phosphate (NAADP)-binding protein signal transduction two-pore...
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Biochem J (2012) 447 (2): 261–269.
Published: 26 September 2012
... 2012 8 8 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 DJ-1 fission 1 (mitochondrial outer membrane) homologue (Fis1) Parkinsonism signal transduction PD (Parkinson's disease) is the most common locomotion disorder and the second most common...
Includes: Supplementary data
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Biochem J (2012) 447 (1): 1–16.
Published: 12 September 2012
... phosphotyrosine signalling phosphotyrosine-binding domain (PTB domain) receptor tyrosine kinase signal transduction Src homology and collagen homology (Shc) Src homology 2 domain (SH2 domain) The cell's capacity to recognize and respond to diverse stimuli is contingent upon two fundamental phenomena...
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Biochem J (2012) 447 (1): 159–166.
Published: 12 September 2012
... negative feedback phosphorylation ribosomal S6 kinase (RSK) signal transduction Son of Sevenless (SOS) Cells respond to an array of biological and environmental stimuli which trigger intracellular signalling pathways governing a diversity of cellular states. Differences in the magnitude...
Includes: Supplementary data
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Biochem J (2012) 444 (1): 115–125.
Published: 26 April 2012
... 2 2 2012 22 2 2012 22 2 2012 computational modelling Dickkopf (Dkk) ordinary differential equation (ODE) secreted Frizzled-related protein (sFRP) signal transduction Wnt pathway The Wnt signalling pathway controls mechanisms that direct cell proliferation, polarity...
Includes: Supplementary data
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Biochem J (2012) 441 (3): 851–858.
Published: 16 January 2012
.... 1 To whom correspondence should be addressed (email bernd.nuernberg@uni-tuebingen.de ). 14 9 2011 4 11 2011 7 11 2011 7 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Gβγ G-protein p101 phosphoinositide 3-kinase γ (PI3Kγ) signal...
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Biochem J (2012) 441 (1): 325–337.
Published: 14 December 2011
... of WNK isoforms is controlled by trans-autophosphorylation. These results provide novel insights into the WNK signal transduction pathway and provide genetic evidence confirming the essential role that SPAK/OSR1 play in controlling NKCC1 function. They also reveal a role in which the downstream SPAK/OSR1...
Includes: Supplementary data
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Biochem J (2012) 441 (1): 255–264.
Published: 14 December 2011
.... 1 To whom correspondence should be addressed (email rserrano@ibmcp.upv.es ). 14 7 2011 12 9 2011 15 9 2011 15 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 pH homoeostasis signal transduction Gcn2 Saccharomyces cerevisiae amino...
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Biochem J (2011) 437 (2): 169–183.
Published: 28 June 2011
... ]. Interestingly, the pattern of tyrosine phosphorylation of VEGFR1 depends on the ligand, i.e. PlGF, but not VEGFA, induces phosphorylation of Tyr 1309 [ 46 ] ( Figure 2 ). Figure 2 VEGFR1 tyrosine phosphorylation sites and signal transduction Schematic outline of activated and dimerized VEGFR1...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 434 (1): e1–e2.
Published: 27 January 2011
... © 2011 Biochemical Society 2011 inhibitor of NF-κB kinase ϵ (IKKϵ) inhibitor of NF-κB kinase IKKα (IKKα) inhibitor of NF-κB kinase IKKβ (IKKβ) signal transduction TANK-binding kinase 1 (TBK-1) Toll-like receptor (TLR) tumour necrosis factor Innate immunity is a highly complex...
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Biochem J (2010) 432 (2): 267–273.
Published: 12 November 2010
.... GCs can be activated by extracellular peptide ligands [ 1 ], weakly by intracellular calcium-binding proteins [ 2 , 3 ] or via the small GTPase Rac and p21-activated kinase pathway [ 4 ]. bicarbonate cGMP guanylate cyclase (GC) Grueneburg ganglion (GG) receptor signal transduction...
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Biochem J (2010) 430 (1): 141–149.
Published: 28 July 2010
... compilation © 2010 Biochemical Society 2010 inflammation insulin resistance obesity signal transduction The present study included 24 MO (morbidly obese) subjects [BMI (body mass index) 56±6.8 kg/m 2 ] (12 women and 12 men) who underwent bariatric surgery with mixed techniques, combining gastric...
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Biochem J (2009) 422 (1): 119–128.
Published: 29 July 2009
...@ibms.sinica.edu.tw ). © The Authors Journal compilation © 2009 Biochemical Society 2009 cell-surface protein CUB domain epidermal growth factor-like repeat (EGF-like repeat) glycoprotein signal transduction Sonic Hedgehog The SCUBE [ s ignal peptide, CUB domain, E GF (epidermal growth factor...
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Biochem J (2009) 420 (2): 155–162.
Published: 13 May 2009
...Horacio Bach; Dennis Wong; Yossef Av-Gay In Mycobacterium tuberculosis , signal transduction is mediated by 11 serine/threonine kinases, but no tyrosine kinases have been identified thus far. The protein encoded by the ORF (open reading frame) Rv2232 has been annotated as a member of the HAD...
Includes: Supplementary data
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Biochem J (2009) 419 (1): 141–148.
Published: 13 March 2009
... ]. cytoskeleton protein kinase Rho Rho-associated coiled-coil kinase (ROCK) signal transduction ROCK (Rho-associated coiled-coil kinase) [also called ROK (Rho-associated kinase) and Rho kinase] is a large (160 kDa) serine/threonine kinase ubiquitously expressed in mammalian tissue. ROCK was identified...
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Biochem J (2009) 419 (1): 185–194.
Published: 13 March 2009
... with Laemmli buffer. cell death lipid rafts palmitoylation signal transduction tumour necrosis factor receptor (TNFR) Cell death can be induced by a family of death receptors including Fas (TNFRSF6/CD95/Apo-1), TNFR1 [TNF (tumour necrosis factor) receptor 1; TNFRSF1A], and the two TRAIL (TNF...
Includes: Supplementary data
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Biochem J (2008) 415 (2): 241–245.
Published: 25 September 2008
... be recognized and bound by signal transduction molecules containing SH2 (Src homology 2) domains. Therefore Grb (growth-factor-receptor-bound protein) 2 and 7, APS [adapter protein with PH (pleckstrin homology) and SH2 domains], Lnk, PI3K (phosphoinositide 3-kinase), PLCγ (phospholipase Cγ) and other proteins...
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Biochem J (2008) 415 (1): 145–154.
Published: 12 September 2008
... compilation © 2008 Biochemical Society 2008 exchange factor Ral guanine nucleotide dissociation stimulator (RalGDS) family Ras effector signal transduction structure–activity analysis Ras and members of the Ras family are low-molecular-mass monomeric GTP-binding proteins that act...
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Biochem J (2008) 413 (1): 37–49.
Published: 12 June 2008
... imagining microscopy (FLIM) mitogen-activated protein kinase (MAPK) signal transduction systems biology temporal control tyrosine kinase 1 To whom correspondence should be addressed (email j.ladbury@biochem.ucl.ac.uk ). 26 11 2007 19 3 2008 28 3 2008 28 3 2008...
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Biochem J (2008) 412 (2): e3–e5.
Published: 14 May 2008
...) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) signal transduction The rapid proliferation of cancer cells requires extensive rewiring of metabolic pathways to meet increased bioenergetic and biosynthetic demands [ 1 ]. A recent push to understand precisely how cancer cell metabolism...
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Biochem J (2008) 412 (1): 103–112.
Published: 25 April 2008
... 1 2008 31 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 allosteric protein G-protein-coupled receptor (GPCR) inverse agonist M 3 muscarinic acetylcholine receptor (M 3 R) mutagenesis signal transduction CCh (carbachol), atropine sulfate...
Includes: Supplementary data
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Biochem J (2008) 412 (1): 65–72.
Published: 25 April 2008
... factor for T-cells and is a potent inducer of the chemokine MCP-1 (monocyte chemoattractant protein-1). Recent studies have focused on the negative regulation of IL-6 signal transduction through the IL-6-induced feedback inhibitors SOCS (suppressor of cytokine signalling) 1 and SOCS3 or the protein...
Includes: Supplementary data