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Regulation of PARP1/2 and the tankyrases: emerging parallels

Matthew Jessop, Benjamin J. Broadway, Katy Miller, Sebastian Guettler

Biochem J (2024) 481 (17): 1097–1123.

https://doi.org/10.1042/BCJ20230230

Published: 23 August 2024

... BY) . ADP-ribosylation DNA damage response enzyme regulation PARP tankyrase signal transduction The post-translational modification (PTM) of biomolecules is a key currency in signal transduction, driving decision making in virtually every aspect of cell function [ 1 ]. The impact of signalling...

View article titled, Regulation of PARP1/2 and the tankyrases: emerging parallels

Articles

GLUT4 On the move

Daniel J. Fazakerley, Francoise Koumanov, Geoffrey D. Holman

Biochem J (2022) 479 (3): 445–462.

https://doi.org/10.1042/BCJ20210073

Published: 11 February 2022

... Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. glucose transport GLUT4 insulin membrane traffic membrane trafficking kinetics signal transduction In the 100th year of the discovery of insulin we reflect...

View article titled, GLUT4 On the move

Includes: Supplementary data

Articles

The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

Anna M. Schmoker, Alicia M. Ebert, Bryan A. Ballif

Biochem J (2019) 476 (6): 931–950.

https://doi.org/10.1042/BCJ20190022

Published: 22 March 2019

... 2019 cancer cell signaling DCBLD1 DCBLD2 development signal transduction The d iscoidin, C U B , and L CCL d omain-containing (DCBLD) receptor family consists of two paralogous type-I transmembrane proteins, DCBLD1 and DCBLD2, which are conserved across vertebrates. DCBLD2...

View article titled, The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

Includes: Supplementary data

Articles

Silencing of type II phosphatidylinositol 4-kinase β stabilizes prostate apoptosis response-4 and induces apoptosis in cancer cells

Sonica Chaudhry, Vibhor Joshi, Naveen Bojjireddy, Maikho Thoh, Santosh K. Sandur, Gosukonda Subrahmanyam

Biochem J (2019) 476 (2): 405–419.

https://doi.org/10.1042/BCJ20180732

Published: 31 January 2019

... Press Limited on behalf of the Biochemical Society 2019 lipid kinases nuclear factor kappa B protein–protein interactions signal transduction tumor suppressor gene Type II phosphatidylinositol 4-kinases II (PtdIns 4-kinases II) feed into two important signaling pathways mediated...

View article titled, Silencing of type II phosphatidylinositol 4-kinase β stabilizes prostate apoptosis response-4 and induces apoptosis in cancer cells

Includes: Supplementary data

Articles

Arabidopsis calcineurin B-like proteins differentially regulate phosphorylation activity of CBL-interacting protein kinase 9

Akhilesh K. Yadav, Saroj K. Jha, Sibaji K. Sanyal, Sheng Luan, Girdhar K. Pandey

Biochem J (2018) 475 (16): 2621–2636.

https://doi.org/10.1042/BCJ20180372

Published: 29 August 2018

... P.G. College, Ballia, Uttar Pradesh 277001, India. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 abiotic stress autophosphorylation calcium CBL–CIPK signal transduction substrate phosphorylation A typical plant cell responds...

View article titled, Arabidopsis calcineurin B-like proteins differentially regulate phosphorylation activity of CBL-interacting protein kinase 9

Includes: Supplementary data

Articles

Molecular signaling cascades involved in nonmelanoma skin carcinogenesis

Robert P. Feehan, Lisa M. Shantz

Biochem J (2016) 473 (19): 2973–2994.

https://doi.org/10.1042/BCJ20160471

Published: 27 September 2016

..., inflammation, and kinase-mediated signal transduction that lead to either cell survival or cell death. This review focuses on the central signaling mechanisms that respond to UVR and the subsequent cellular changes. Given the prevalence of NMSC and the resulting health care burden, many of these pathways...

View article titled, Molecular signaling cascades involved in nonmelanoma skin carcinogenesis

Articles

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A.S. Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Philip Wing-Lok Ho, Shu-Leong Ho, Alastair D. Reith, Dario R. Alessi

Biochem J (2016) 473 (17): 2671–2685.

https://doi.org/10.1042/BCJ20160557

Published: 30 August 2016

... BY) . Parkinson's disease protein kinases Rab GTPase signal transduction Our knowledge of the origins of Parkinson's disease has been transformed by the identification of genes whose mutation in humans leads to Mendelian inherited disease [ 1 , 2 ]. One of these genes encodes the leucine-rich repeat...

View article titled, Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Includes: Supplementary data

Articles

Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus

Fabian Elgner, Christian Donnerhak, Huimei Ren, Regina Medvedev, André Schreiber, Lorenz Weber, Markus Heilmann, Daniela Ploen, Kiyoshi Himmelsbach, Malin Finkernagel, Karin Klingel, Eberhard Hildt

Biochem J (2016) 473 (2): 145–155.

https://doi.org/10.1042/BJ20150717

Published: 05 January 2016

...-taxilin as a novel factor that controls the release of HCV and thereby contributes to a deeper understanding about the pathways involved in the release of HCV. HCV morphogenesis signal transduction SNARE α-taxilin HCV (hepatitis C virus) is a major cause of chronic hepatitis, liver...

View article titled, Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus

Includes: Supplementary data

Articles

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity

Giorgio Cozza, Sofia Zanin, Stefania Sarno, Elena Costa, Cristina Girardi, Giovanni Ribaudo, Mauro Salvi, Giuseppe Zagotto, Maria Ruzzene, Lorenzo A. Pinna

Biochem J (2015) 471 (3): 415–430.

https://doi.org/10.1042/BJ20141127

Published: 16 October 2015

... of binding has been determined by kinetic and mutational analyses. bisubstrate inhibitor cell migration CK2 ecto-kinase protein kinase inhibitor protein phosphorylation signal transduction Protein kinases are implicated in a wide variety of human diseases, with special reference...

View article titled, Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity

Articles

TOR signalling in plants

Daniel Rexin, Christian Meyer, Christophe Robaglia, Bruce Veit

Biochem J (2015) 470 (1): 1–14.

https://doi.org/10.1042/BJ20150505

Published: 06 August 2015

...; published by Portland Press Limited 2015 autotrophy growth control kinase LST8 nutrition plant signalling plant RAPTOR signal transduction target of rapamycin (TOR) Figure 3 TOR expression during vegetative development ( a ) GUS activity in the leaf primordia of an Arabidopsis...

View article titled, TOR signalling in plants

Articles

The focal adhesion kinase Pyk2 links Ca 2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets

Ilaria Canobbio, Lina Cipolla, Gianni F. Guidetti, Daria Manganaro, Caterina Visconte, Soochong Kim, Mitsuhiko Okigaki, Marco Falasca, Satya P. Kunapuli, Mauro Torti

Biochem J (2015) 469 (2): 199–210.

https://doi.org/10.1042/BJ20150048

Published: 06 July 2015

... in the regulation of Ca 2+ -dependent protein-tyrosine phosphorylation. calcium G protein-coupled receptor (GPCR) platelets protein phosphorylation signal transduction tyrosine kinase thrombin The essential role of blood platelets in haemostasis and thrombosis relies on their ability...

View article titled, The focal adhesion kinase Pyk2 links Ca 2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets

Articles

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

Aliaksei Shymanets, Prajwal, Oscar Vadas, Cornelia Czupalla, Jaclyn LoPiccolo, Michael Brenowitz, Alessandra Ghigo, Emilio Hirsch, Eberhard Krause, Reinhard Wetzker, Roger L. Williams, Christian Harteneck, Bernd Nürnberg

Biochem J (2015) 469 (1): 59–69.

https://doi.org/10.1042/BJ20150099

Published: 19 June 2015

... discriminative regulation and functions. Gβγ G-protein p101 p87 phosphoinositide 3-kinase γ (PI3Kγ) signal transduction Hydrogen–deuterium exchange coupled to MS (HDX-MS) analyses of PI3Kγ in the presence and absence of an anti-p110γ monoclonal antibody [mAb(A) p110γ ] were performed following...

View article titled, Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

Articles

Akt/PKB: one kinase, many modifications

Guillermo Risso, Matías Blaustein, Berta Pozzi, Pablo Mammi, Anabella Srebrow

Biochem J (2015) 468 (2): 203–214.

https://doi.org/10.1042/BJ20150041

Published: 22 May 2015

... 1 2015 13 3 2015 31 3 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 Akt post-translational modification protein function protein kinase B signal transduction The serine/threonine protein kinase Akt (also known as protein kinase B or PKB...

View article titled, Akt/PKB: one kinase, many modifications

Articles

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1

Katarzyna Blaszczyk, Adam Olejnik, Hanna Nowicka, Lilla Ozgyin, Yi-Ling Chen, Stefan Chmielewski, Kaja Kostyrko, Joanna Wesoly, Balint Laszlo Balint, Chien-Kuo Lee, Hans A.R. Bluyssen

Biochem J (2015) 466 (3): 511–524.

https://doi.org/10.1042/BJ20140644

Published: 06 March 2015

... microarray STAT transcription factor signal transduction Figure 1 The IFNα response in STAT1 KO cells is abrogated ( A , C ) 2fTGH and U3C; ( B , D ) MEF WT and MS1KO were treated with IFNα for indicated times. For ( A ) and ( B ), protein lysates were isolated and analyzed by Western blot...

View article titled, STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1

Articles

T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses

Sigrid S. Skånland, Kristine Moltu, Torunn Berge, Einar M. Aandahl, Kjetil Taskén

Biochem J (2014) 460 (3): 399–410.

https://doi.org/10.1042/BJ20140040

Published: 29 May 2014

...) phosphorylation signal transduction T-cell CD4 + T-cells initiate and direct an adaptive immune response, whereas CD8 + cytotoxic T-cells are essential for the elimination of cells infected with intracellular pathogens. In addition to their role in clearing infectious diseases, T-cells...

View article titled, T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses

Includes: Supplementary data

Articles

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters

Paola de los Heros, Dario R. Alessi, Robert Gourlay, David G. Campbell, Maria Deak, Thomas J. Macartney, Kristopher T. Kahle, Jinwei Zhang

Biochem J (2014) 458 (3): 559–573.

https://doi.org/10.1042/BJ20131478

Published: 28 February 2014

... might be a potent strategy to enhance cellular Cl − extrusion, with potential therapeutic implications. The following antibodies were raised in sheep and affinity-purified on the appropriate antigen by the Division of Signal Transduction Therapy Unit at the University of Dundee: anti-KCC1...

View article titled, The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K + –Cl − co-transporters

Articles

Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Vanessa P. Houde, Maria Stella Ritorto, Robert Gourlay, Joby Varghese, Paul Davies, Natalia Shpiro, Kei Sakamoto, Dario R. Alessi

Biochem J (2014) 458 (1): 41–56.

https://doi.org/10.1042/BJ20131324

Published: 20 January 2014

... (AICAR) AMP-activated protein kinase-related kinase (AMPK-related kinase) monoclonal antibody phenformin SAD-A/SAD-B kinase signal transduction Inactivating mutations in the LKB1 kinase tumour suppressor gene cause the inherited Peutz–Jeghers cancer syndrome, in which patients...

View article titled, Investigation of LKB1 Ser 431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

Includes: Supplementary data

Articles

Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

Konstantina Stathopoulou, Friederike Cuello, Alexandra J. Candasamy, Elizabeth M. Kemp, Elisabeth Ehler, Robert S. Haworth, Metin Avkiran

Biochem J (2014) 457 (3): 451–461.

https://doi.org/10.1042/BJ20131026

Published: 10 January 2014

...-and-a-half LIM (FHL) histone deacetylase neurohormonal stimulation protein kinase signal transduction The PKD (protein kinase D) family of serine/threonine kinases consists of three members, PKD1, PKD2 and PKD3, and belongs to the CaMK (Ca 2+ /calmodulin-dependent protein kinase) superfamily...

View article titled, Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

Includes: Supplementary data

Articles

TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

Kenneth K. Y. Cheng, Karen S. L. Lam, Yu Wang, Donghai Wu, Mingliang Zhang, Baile Wang, Xiaomu Li, Ruby L. C. Hoo, Zhe Huang, Gary Sweeney, Aimin Xu

Biochem J (2013) 455 (2): 207–216.

https://doi.org/10.1042/BJ20130760

Published: 27 September 2013

... signal transduction via an endosomal compartment Cell 2004 116 445 456 19 Pilecka I. Sadowski L. Kalaidzidis Y. Miaczynska M. Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment Exp. Cell Res. 2011 317 1093 1107 20 Liu M...

View article titled, TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt

Includes: Supplementary data

Articles

Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Robert Stöhr, Massimo Federici

Biochem J (2013) 454 (1): 1–11.

https://doi.org/10.1042/BJ20130121

Published: 26 July 2013

... disease, with several studies reporting that the risk of macrovascular complications (stroke and myocardial infarction) is 2–4-fold higher in people with diabetes than in non-diabetics [ 3 ]. Insulin is able to directly stimulate signal transduction in endothelial cells [ 4 ] with both pro- and anti...

View article titled, Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Articles

N-terminal tagging of two-pore channels interferes with NAADP action

Andreas H. Guse

Biochem J (2013) 453 (1): e1–e2.

https://doi.org/10.1042/BJ20130676

Published: 13 June 2013

...)-binding protein signal transduction two-pore channel In recent times a number of potential NAADP (nicotinic acid–adenine dinucleotide phosphate) receptor proteins/Ca 2+ channels have been described. More than 10 years ago, Hohenegger et al. [ 1 ] showed that biochemically purified RyR1...

View article titled, N-terminal tagging of two-pore channels interferes with NAADP action

Articles

Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca 2+ -dependent activation of platelet Rap1b GTPase

Gianni Francesco Guidetti, Daria Manganaro, Alessandra Consonni, Ilaria Canobbio, Cesare Balduini, Mauro Torti

Biochem J (2013) 453 (1): 115–123.

https://doi.org/10.1042/BJ20130131

Published: 13 June 2013

... I (CalDAG-GEFI) cAMP platelet platelet inhibition protein phosphorylation Rap1b signal transduction Integrin α IIb β 3 -mediated fibrinogen binding and platelet aggregation are essential events in haemostasis and thrombosis. Resting platelets are unable to aggregate because integrin α...

View article titled, Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca 2+ -dependent activation of platelet Rap1b GTPase

Articles

DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection

Qiang Zhang, Junbing Wu, Rong Wu, Jun Ma, Guiping Du, Renjie Jiao, Yong Tian, Zheng Zheng, Zengqiang Yuan

Biochem J (2012) 447 (2): 261–269.

https://doi.org/10.1042/BJ20120598

Published: 26 September 2012

... 2012 8 8 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 DJ-1 fission 1 (mitochondrial outer membrane) homologue (Fis1) Parkinsonism signal transduction PD (Parkinson's disease) is the most common locomotion disorder and the second most common...

View article titled, DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection

Includes: Supplementary data

Articles

Teaching an old dogma new tricks: twenty years of Shc adaptor signalling

Melanie K. B. Wills, Nina Jones

Biochem J (2012) 447 (1): 1–16.

https://doi.org/10.1042/BJ20120769

Published: 12 September 2012

... phosphotyrosine signalling phosphotyrosine-binding domain (PTB domain) receptor tyrosine kinase signal transduction Src homology and collagen homology (Shc) Src homology 2 domain (SH2 domain) Fundamentally, the ability of Shc proteins to engage in controlled signal propagation in a given cell...

View article titled, Teaching an old dogma new tricks: twenty years of Shc adaptor signalling

Articles

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

Madhurima Saha, Audrey Carriere, Mujeeburahiman Cheerathodi, Xiaocui Zhang, Geneviève Lavoie, John Rush, Philippe P. Roux, Bryan A. Ballif

Biochem J (2012) 447 (1): 159–166.

https://doi.org/10.1042/BJ20120938

Published: 12 September 2012

.... 14-3-3 negative feedback phosphorylation ribosomal S6 kinase (RSK) signal transduction Son of Sevenless (SOS) Cells respond to an array of biological and environmental stimuli which trigger intracellular signalling pathways governing a diversity of cellular states. Differences...

View article titled, RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

Includes: Supplementary data

Articles

A new validated mathematical model of the Wnt signalling pathway predicts effective combinational therapy by sFRP and Dkk

Yuri Kogan, Karin E. Halevi-Tobias, Gili Hochman, Anna K. Baczmanska, Luc Leyns, Zvia Agur

Biochem J (2012) 444 (1): 115–125.

https://doi.org/10.1042/BJ20111887

Published: 26 April 2012

... is a well-mixed external compartment. The estimation of K su-in is based on a similar assumption for intracellular cytoplasmatic volume. computational modelling Dickkopf (Dkk) ordinary differential equation (ODE) secreted Frizzled-related protein (sFRP) signal transduction Wnt pathway...

View article titled, A new validated mathematical model of the Wnt signalling pathway predicts effective combinational therapy by sFRP and Dkk

Includes: Supplementary data

Articles

Calcium/calmodulin inhibition of the Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase provides a possible link between calcium and brassinosteroid signalling

Man-Ho Oh, Hyoung Seok Kim, Xia Wu, Steven D. Clouse, Raymond E. Zielinski, Steven C. Huber

Biochem J (2012) 443 (2): 515–523.

https://doi.org/10.1042/BJ20111871

Published: 27 March 2012

...Man-Ho Oh; Hyoung Seok Kim; Xia Wu; Steven D. Clouse; Raymond E. Zielinski; Steven C. Huber The receptor kinase BRI1 (BRASSINOSTEROID-INSENSITIVE 1) is a key component in BR (brassinosteroid) perception and signal transduction, and has a broad impact on plant growth and development. In the present...

View article titled, Calcium/calmodulin inhibition of the Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase provides a possible link between calcium and brassinosteroid signalling

Includes: Supplementary data

Articles

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ

Aliaksei Shymanets, Mohammad R. Ahmadian, Katja T. Kössmeier, Reinhard Wetzker, Christian Harteneck, Bernd Nürnberg

Biochem J (2012) 441 (3): 851–858.

https://doi.org/10.1042/BJ20111664

Published: 16 January 2012

... (email [email protected] ). 14 9 2011 4 11 2011 7 11 2011 7 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Gβγ G-protein p101 phosphoinositide 3-kinase γ (PI3Kγ) signal transduction Class I PI3Ks (phosphoinositide 3...

View article titled, The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ

Articles

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Jacob O. Thastrup, Fatema H. Rafiqi, Alberto C. Vitari, Eulalia Pozo-Guisado, Maria Deak, Youcef Mehellou, Dario R. Alessi

Biochem J (2012) 441 (1): 325–337.

https://doi.org/10.1042/BJ20111879

Published: 14 December 2011

... of WNK isoforms is controlled by trans-autophosphorylation. These results provide novel insights into the WNK signal transduction pathway and provide genetic evidence confirming the essential role that SPAK/OSR1 play in controlling NKCC1 function. They also reveal a role in which the downstream SPAK/OSR1...

View article titled, SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Includes: Supplementary data

Articles

A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress

Guillem Hueso, Rafael Aparicio-Sanchis, Consuelo Montesinos, Silvia Lorenz, José R. Murguía, Ramón Serrano

Biochem J (2012) 441 (1): 255–264.

https://doi.org/10.1042/BJ20111264

Published: 14 December 2011

.... 1 To whom correspondence should be addressed (email [email protected] ). 14 7 2011 12 9 2011 15 9 2011 15 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 pH homoeostasis signal transduction Gcn2 Saccharomyces cerevisiae amino...

View article titled, A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress

Articles

Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways

Jing Zhao, Donghong He, Evgeny Berdyshev, Mintao Zhong, Ravi Salgia, Andrew J. Morris, Susan S. Smyth, Viswanathan Natarajan, Yutong Zhao

Biochem J (2011) 439 (1): 45–55.

https://doi.org/10.1042/BJ20110274

Published: 14 September 2011

... ). 10 2 2011 2 6 2011 22 6 2011 22 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 autotaxin (ATX) cell migration lysophosphatidic acid (LPA) lysophospholipase D (lysoPLD) signal transduction A549 and HSAEpC (primary human small airway...

View article titled, Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways

Articles

Signal transduction by vascular endothelial growth factor receptors

Sina Koch, Sònia Tugues, Xiujuan Li, Laura Gualandi, Lena Claesson-Welsh

Biochem J (2011) 437 (2): 169–183.

https://doi.org/10.1042/BJ20110301

Published: 28 June 2011

... in diseases that involve tissue growth and inflammation, such as cancer. The present review will outline the current understanding and consequent biology of VEGF receptor signalling. Figure 2 VEGFR1 tyrosine phosphorylation sites and signal transduction Schematic outline of activated and dimerized...

View article titled, <span class="search-highlight">Signal</span> <span class="search-highlight">transduction</span> by vascular endothelial growth factor receptors

Includes: Multimedia, Supplementary data

Articles

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Michale Bouskila, Noor Esoof, Laurie Gay, Emily H. Fang, Maria Deak, Michael J. Begley, Lewis C. Cantley, Alan Prescott, Kate G. Storey, Dario R. Alessi

Biochem J (2011) 437 (1): 157–167.

https://doi.org/10.1042/BJ20110276

Published: 14 June 2011

... disorder neurodegeneration protein kinase signal transduction tau tubulin kinase peptide substrate (TTBKtide) Previous studies have revealed that mutations within TTBK2 (tau tubulin kinase 2) cause a serious autosomal dominant inherited movement disorder termed SCA11 (spinocerebellar ataxia...

View article titled, TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Includes: Supplementary data

Articles

Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

George W. Templeton, Mhairi Nimick, Nicholas Morrice, David Campbell, Marilyn Goudreault, Anne-Claude Gingras, Atsushi Takemiya, Ken-ichiro Shimazaki, Greg B. G. Moorhead

Biochem J (2011) 435 (1): 73–83.

https://doi.org/10.1042/BJ20101035

Published: 15 March 2011

[email protected] ). 13 7 2010 23 12 2010 11 1 2011 11 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 inhibitory protein phylogenetics protein phosphatase 1 (PP1) nucleus signal transduction TAP-tag Protein phosphorylation, the addition...

View article titled, Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit

Includes: Supplementary data

Articles

Counter-regulation in the IKK family

Luke A. J. O'Neill

Biochem J (2011) 434 (1): e1–e2.

https://doi.org/10.1042/BJ20102168

Published: 27 January 2011

... 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 inhibitor of NF-κB kinase ϵ (IKKϵ) inhibitor of NF-κB kinase IKKα (IKKα) inhibitor of NF-κB kinase IKKβ (IKKβ) signal transduction TANK-binding kinase 1 (TBK-1) Toll-like receptor (TLR) tumour necrosis factor...

View article titled, Counter-regulation in the IKK family

Articles

Guanylate cyclase-G, expressed in the Grueneberg ganglion olfactory subsystem, is activated by bicarbonate

Ying-Chi Chao, Chien-Jui Cheng, Hsiu-Ting Hsieh, Chih-Ching Lin, Chien-Chang Chen, Ruey-Bing Yang

Biochem J (2010) 432 (2): 267–273.

https://doi.org/10.1042/BJ20100617

Published: 12 November 2010

... proteins [ 2 , 3 ] or via the small GTPase Rac and p21-activated kinase pathway [ 4 ]. bicarbonate cGMP guanylate cyclase (GC) Grueneburg ganglion (GG) receptor signal transduction HEK-293T cells were plated on a 35-mm glass-bottom dish. One day later, cells were transiently transfected...

View article titled, Guanylate cyclase-G, expressed in the Grueneberg ganglion olfactory subsystem, is activated by bicarbonate

Articles

The obese healthy paradox: is inflammation the answer?

Nuria Barbarroja, Rosario López-Pedrera, Maria Dolores Mayas, Eduardo García-Fuentes, Lourdes Garrido-Sánchez, M. Macías-González, Rajaa El Bekay, Antonio Vidal-Puig, Francisco J. Tinahones

Biochem J (2010) 430 (1): 141–149.

https://doi.org/10.1042/BJ20100285

Published: 28 July 2010

... The Authors Journal compilation © 2010 Biochemical Society 2010 inflammation insulin resistance obesity signal transduction 1 To whom correspondence should be addressed (email [email protected] ). 23 2 2010 19 5 2010 3 6 2010 3 6 2010...

View article titled, The obese healthy paradox: is inflammation the answer?

Articles

Insertion of an NPVY sequence into the cytosolic domain of the erythropoietin receptor selectively affects erythropoietin-mediated signalling and function

Tamar Liron, Tal Nahari, Miriam C. Souroujon, Drorit Neumann

Biochem J (2010) 427 (2): 305–312.

https://doi.org/10.1042/BJ20091951

Published: 29 March 2010

... phosphorylation signal transduction We have recently demonstrated that insertion of an NPVY, and not an NPVF, sequence into the EPO-R cytosolic domain led to improved maturation of EPO-R and increased its cell-surface levels [ 42 ]. In the present study we set out to examine whether the NPVY insert can...

View article titled, Insertion of an NPVY sequence into the cytosolic domain of the erythropoietin receptor selectively affects erythropoietin-mediated signalling and function

Articles

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Philip Cohen

Biochem J (2010) 425 (1): 53–54.

https://doi.org/10.1042/BJ20091428

Published: 14 December 2009

... © The Authors Journal compilation © 2010 Biochemical Society 2010 cell regulation chemical biology chemical inhibitor protein kinase signal transduction Over the past 15 years I have been involved in exploiting cell-permeable chemical inhibitors of protein kinases to understand...

View article titled, Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation

Articles

Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase

Aiko Sato, Yuki Sato, Yoichiro Fukao, Masayuki Fujiwara, Taishi Umezawa, Kazuo Shinozaki, Takao Hibi, Mitsutaka Taniguchi, Hiroshi Miyake, Derek B. Goto, Nobuyuki Uozumi

Biochem J (2009) 424 (3): 439–448.

https://doi.org/10.1042/BJ20091221

Published: 10 December 2009

... kinase (SnRK) signal transduction stomata transport The aerial epidermal tissues of higher plants contain stomatal pores that play an important role in enabling gas exchange with the external environment, providing CO 2 for photosynthesis and releasing O 2 . On the other hand, these pores...

View article titled, Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase

Includes: Supplementary data

Articles

Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans

Ming-Tzu Tsai, Chien-Jui Cheng, Yuh-Charn Lin, Chun-Chuan Chen, Ann-Ru Wu, Min-Tzu Wu, Cheng-Chin Hsu, Ruey-Bing Yang

Biochem J (2009) 422 (1): 119–128.

https://doi.org/10.1042/BJ20090341

Published: 29 July 2009

... Biochemical Society 2009 cell-surface protein CUB domain epidermal growth factor-like repeat (EGF-like repeat) glycoprotein signal transduction Sonic Hedgehog Figure 1 Protein sequence alignment of human (h) and zebrafish (z) SCUBE2 The putative signal peptide cleavage sites are marked...

View article titled, Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans

Articles

Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA

Horacio Bach, Dennis Wong, Yossef Av-Gay

Biochem J (2009) 420 (2): 155–162.

https://doi.org/10.1042/BJ20090478

Published: 13 May 2009

...Horacio Bach; Dennis Wong; Yossef Av-Gay In Mycobacterium tuberculosis , signal transduction is mediated by 11 serine/threonine kinases, but no tyrosine kinases have been identified thus far. The protein encoded by the ORF (open reading frame) Rv2232 has been annotated as a member of the HAD...

View article titled, Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA

Includes: Supplementary data

Articles

The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity

Amber L. Couzens, Vivian Saridakis, Michael P. Scheid

Biochem J (2009) 419 (1): 141–148.

https://doi.org/10.1042/BJ20081376

Published: 13 March 2009

... formation. cytoskeleton protein kinase Rho Rho-associated coiled-coil kinase (ROCK) signal transduction ROCK (Rho-associated coiled-coil kinase) [also called ROK (Rho-associated kinase) and Rho kinase] is a large (160 kDa) serine/threonine kinase ubiquitously expressed in mammalian tissue...

View article titled, The hydrophobic motif of ROCK2 requires association with the N-terminal extension for kinase activity

Articles

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

Aurélie Rossin, Mathieu Derouet, Fadi Abdel-Sater, Anne-Odile Hueber

Biochem J (2009) 419 (1): 185–194.

https://doi.org/10.1042/BJ20081212

Published: 13 March 2009

... Cruz. cell death lipid rafts palmitoylation signal transduction tumour necrosis factor receptor (TNFR) Cell death can be induced by a family of death receptors including Fas (TNFRSF6/CD95/Apo-1), TNFR1 [TNF (tumour necrosis factor) receptor 1; TNFRSF1A], and the two TRAIL (TNF-related...

View article titled, Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

Includes: Supplementary data

Articles

Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors

Annemarie Meenhuis, Mahban Irandoust, Albert Wölfler, Onno Roovers, Marijke Valkhof, Ivo P. Touw

Biochem J (2009) 417 (3): 737–746.

https://doi.org/10.1042/BJ20081153

Published: 16 January 2009

... transducer and activator of transcription 3 (STAT3) signal transduction The G-CSFR [G-CSF (granulocyte colony-stimulating factor) receptor; now referred to as CSF3R] is the major haematopoietic growth-factor receptor involved in neutrophil development [ 1 ]. The CSF3R contains four conserved...

View article titled, Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors

Articles

Adaptor protein Lnk associates with Tyr 568 in c-Kit

Saskia Gueller, Sigal Gery, Verena Nowak, Liqin Liu, Hubert Serve, H. Phillip Koeffler

Biochem J (2008) 415 (2): 241–245.

https://doi.org/10.1042/BJ20080102

Published: 25 September 2008

... be recognized and bound by signal transduction molecules containing SH2 (Src homology 2) domains. Therefore Grb (growth-factor-receptor-bound protein) 2 and 7, APS [adapter protein with PH (pleckstrin homology) and SH2 domains], Lnk, PI3K (phosphoinositide 3-kinase), PLCγ (phospholipase Cγ) and other proteins...

View article titled, Adaptor protein Lnk associates with Tyr 568 in c-Kit

Articles

G-protein binding features and regulation of the RalGDS family member, RGL2

Elisa Ferro, David Magrini, Paolo Guazzi, Thomas H. Fischer, Sara Pistolesi, Rebecca Pogni, Gilbert C. White, II, Lorenza Trabalzini

Biochem J (2008) 415 (1): 145–154.

https://doi.org/10.1042/BJ20080255

Published: 12 September 2008

... by their phosphorylation by PKA. exchange factor Ral guanine nucleotide dissociation stimulator (RalGDS) family Ras effector signal transduction structure–activity analysis Ras and members of the Ras family are low-molecular-mass monomeric GTP-binding proteins that act as molecular switches by coupling...

View article titled, G-protein binding features and regulation of the RalGDS family member, RGL2

Articles

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

Zamal Ahmed, Annika C. Schüller, Klaus Suhling, Carolyn Tregidgo, John E. Ladbury

Biochem J (2008) 413 (1): 37–49.

https://doi.org/10.1042/BJ20071594

Published: 12 June 2008

... Society 2008 Aperts syndrome fibroblast growth factor receptor 2 (FGFR2) fibroblast growth factor receptor substrate 2 (FRS2) fluorescent lifetime imagining microscopy (FLIM) mitogen-activated protein kinase (MAPK) signal transduction systems biology temporal control tyrosine kinase...

View article titled, Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

Articles

Cancer therapy: staying current with AMPK

David A. Fruman, Aimee L. Edinger

Biochem J (2008) 412 (2): e3–e5.

https://doi.org/10.1042/BJ20080823

Published: 14 May 2008

... target of rapamycin (mTOR) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) signal transduction The authors point out that the current work only establishes the efficacy of AMPK activators in a tumour driven by hyperactive PI3K/Akt signalling. It will be important to test...

View article titled, Cancer therapy: staying current with AMPK

Articles

Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E 2 release via C/EBPβ in human bronchial epithelial cells

Donghong He, Viswanathan Natarajan, Randi Stern, Irina A. Gorshkova, Julian Solway, Ernst Wm. Spannhake, Yutong Zhao

Biochem J (2008) 412 (1): 153–162.

https://doi.org/10.1042/BJ20071649

Published: 25 April 2008

.... bioactive phospholipid gene expression receptor tyrosine kinase (RTK) signal transduction transcription factor © The Authors Journal compilation © 2008 Biochemical Society 2008 7 12 2007 29 1 2008 25 2 2008 25 2 2008 1 To whom correspondence should be addressed...

View article titled, Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E 2 release via C/EBPβ in human bronchial epithelial cells

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