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Keywords: signal transduction
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Articles
Biochem J (2022) 479 (3): 445–462.
Published: 11 February 2022
... Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. glucose transport GLUT4 insulin membrane traffic membrane trafficking kinetics signal transduction In the 100th year of the discovery of insulin we reflect...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (6): 931–950.
Published: 22 March 2019
... interactions to intracellular signal transduction. This could either be achieved by removing the potential for CUB-mediated interactions, as in the mouse variant, or by removing the potential for intracellular signal transduction stimulated through CUB domain interactions, as in zebrafish variants. The DCBLD1...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (2): 405–419.
Published: 31 January 2019
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 lipid kinases nuclear factor kappa B protein–protein interactions signal transduction tumor suppressor gene Type II phosphatidylinositol 4-kinases II (PtdIns 4-kinases II) feed into two...
Includes: Supplementary data
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Biochem J (2018) 475 (16): 2621–2636.
Published: 29 August 2018
... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 abiotic stress autophosphorylation calcium CBL–CIPK signal transduction substrate phosphorylation A typical plant cell responds to environmental stress conditions...
Includes: Supplementary data
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Biochem J (2016) 473 (19): 2973–2994.
Published: 27 September 2016
..., inflammation, and kinase-mediated signal transduction that lead to either cell survival or cell death. This review focuses on the central signaling mechanisms that respond to UVR and the subsequent cellular changes. Given the prevalence of NMSC and the resulting health care burden, many of these pathways...
Articles
Biochem J (2016) 473 (17): 2671–2685.
Published: 30 August 2016
... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . Parkinson's disease protein kinases Rab GTPase signal transduction Our knowledge of the origins of Parkinson's disease has...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (2): 145–155.
Published: 05 January 2016
... in the release of HCV. HCV morphogenesis signal transduction SNARE α-taxilin HCV (hepatitis C virus) is a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Worldwide, there are more than 170 million people chronically infected with HCV. HCV is a member...
Includes: Supplementary data
Articles
Biochem J (2015) 471 (3): 415–430.
Published: 16 October 2015
... of binding has been determined by kinetic and mutational analyses. bisubstrate inhibitor cell migration CK2 ecto-kinase protein kinase inhibitor protein phosphorylation signal transduction Protein kinases are implicated in a wide variety of human diseases, with special reference...
Articles
Biochem J (2015) 470 (1): 1–14.
Published: 06 August 2015
...; published by Portland Press Limited 2015 autotrophy growth control kinase LST8 nutrition plant signalling plant RAPTOR signal transduction target of rapamycin (TOR) Growth in living organisms is not a simple sum of available energy and nutrients, but instead represents a regulated...
Articles
Biochem J (2015) 469 (2): 199–210.
Published: 06 July 2015
... [ 18 ]. The essential role of blood platelets in haemostasis and thrombosis relies on their ability to efficiently respond to extracellular signals upon vascular injury and to organize a complex network of signal transduction pathways leading to secretion, aggregation and thrombus formation [ 1...
Articles
Biochem J (2015) 469 (1): 59–69.
Published: 19 June 2015
.... Gβγ G-protein p101 p87 phosphoinositide 3-kinase γ (PI3Kγ) signal transduction Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that transduce extracellular signals to trigger PtdIns(3,4,5) P 3 synthesis, an essential second messenger at the plasma membrane. PtdIns(3,4,5) P...
Articles
Biochem J (2015) 468 (2): 203–214.
Published: 22 May 2015
... 1 2015 13 3 2015 31 3 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 Akt post-translational modification protein function protein kinase B signal transduction The serine/threonine protein kinase Akt (also known as protein kinase B or PKB...
Articles
Biochem J (2015) 466 (3): 511–524.
Published: 06 March 2015
...–pathogen interactions microarray STAT transcription factor signal transduction Interferons (IFNs) are a subset of cytokines that mediate cellular homoeostatic responses to virus infection. IFNs represent a family of molecules which can be divided into three main sub-families: Type I, Type II...
Articles
Biochem J (2014) 460 (3): 399–410.
Published: 29 May 2014
... induce distinct signalling responses. These findings may offer means of specifically perturbing a signalling pathway activated by one co-receptor. co-stimulation immunology nuclear factor κB (NF-κB) phosphorylation signal transduction T-cell CD4 + T-cells initiate and direct...
Includes: Supplementary data
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Biochem J (2014) 458 (3): 559–573.
Published: 28 February 2014
... 2014 7 1 2014 γ-aminobutyric acid (GABA) blood pressure/hypertension ion homoeostasis K + –Cl − co-transporter 2 (KCC2) K + –Cl − co-transporter 3 (KCC3) Na + –Cl − co-transporter (NCC) Na + –K + –2Cl − co-transporter 1 (NKCC1) protein kinase signal transduction...
Articles
Biochem J (2014) 458 (1): 41–56.
Published: 20 January 2014
... for orchestrating neuronal cell polarity and embryo development. 5-amino-4-imidazolecarboxamide riboside (AICAR) AMP-activated protein kinase-related kinase (AMPK-related kinase) monoclonal antibody phenformin SAD-A/SAD-B kinase signal transduction Inactivating mutations in the LKB1 kinase...
Includes: Supplementary data
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Biochem J (2014) 457 (3): 451–461.
Published: 10 January 2014
... and promote PKD association with the plasma and intracellular membranes after stimulation with hormones, growth factors, neurotransmitters, chemokines and bioactive lipids [ 1 , 2 ]. cardiac myocyte four-and-a-half LIM (FHL) histone deacetylase neurohormonal stimulation protein kinase signal...
Includes: Supplementary data
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Biochem J (2013) 455 (2): 207–216.
Published: 27 September 2013
...-tagged TRAF6 were lysed in the immunoprecipitation buffer, and were performed as previously described [ 17 ]. adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1 (APPL1) gluconeogenesis insulin resistance signal transduction ubiquitination Insulin...
Includes: Supplementary data
Articles
Biochem J (2013) 454 (1): 1–11.
Published: 26 July 2013
... be addressed (email federicm@uniroma2.it ). 22 1 2013 14 5 2013 3 6 2013 atherosclerosis cardiovascular disease diabetes inflammation macrophage signal transduction T2DM (Type 2 diabetes mellitus) is a disease characterized by high blood glucose caused by either tissue...
Articles
Biochem J (2013) 453 (1): 115–123.
Published: 13 June 2013
... Journal compilation © 2013 Biochemical Society 2013 calcium and diacylglycerol-regulated guanine-nucleotide-exchange factor I (CalDAG-GEFI) cAMP platelet platelet inhibition protein phosphorylation Rap1b signal transduction pCMV-Sport-CalDAG-GEFI was a gift from Dr Jill Crittenden...
Articles
Biochem J (2013) 453 (1): e1–e2.
Published: 13 June 2013
...)-binding protein signal transduction two-pore channel In recent times a number of potential NAADP (nicotinic acid–adenine dinucleotide phosphate) receptor proteins/Ca 2+ channels have been described. More than 10 years ago, Hohenegger et al. [ 1 ] showed that biochemically purified RyR1...
Articles
Biochem J (2012) 447 (2): 261–269.
Published: 26 September 2012
...) Parkinsonism signal transduction PD (Parkinson's disease) is the most common locomotion disorder and the second most common neurodegenerative disease. Clinically, PD patients suffer from resting tremor, rigidity, bradykinesia and altered gait [ 1 , 2 ]. A severe dopaminergic neuron loss and a decrease...
Includes: Supplementary data
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Biochem J (2012) 447 (1): 1–16.
Published: 12 September 2012
... phosphotyrosine signalling phosphotyrosine-binding domain (PTB domain) receptor tyrosine kinase signal transduction Src homology and collagen homology (Shc) Src homology 2 domain (SH2 domain) In the ensuing twenty years since Shc was first identified, three additional related proteins have been...
Articles
Biochem J (2012) 447 (1): 159–166.
Published: 12 September 2012
... kinase (RSK) signal transduction Son of Sevenless (SOS) Cells respond to an array of biological and environmental stimuli which trigger intracellular signalling pathways governing a diversity of cellular states. Differences in the magnitude and duration of signalling can lead to very different...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (1): 115–125.
Published: 26 April 2012
... of an application of this approach to the MAPK (mitogen-activated protein kinase) pathway}. However, as quantitative information on signal transduction pathways is rarely available, most mathematical models of signal transduction pathways are yet to be experimentally substantiated. Among the Wnt-activated...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (2): 515–523.
Published: 27 March 2012
...Man-Ho Oh; Hyoung Seok Kim; Xia Wu; Steven D. Clouse; Raymond E. Zielinski; Steven C. Huber The receptor kinase BRI1 (BRASSINOSTEROID-INSENSITIVE 1) is a key component in BR (brassinosteroid) perception and signal transduction, and has a broad impact on plant growth and development. In the present...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (3): 851–858.
Published: 16 January 2012
... 2011 7 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 Gβγ G-protein p101 phosphoinositide 3-kinase γ (PI3Kγ) signal transduction Class I PI3Ks (phosphoinositide 3-kinases) are second-messenger-generating enzymes, which transform extracellular...
Articles
Biochem J (2012) 441 (1): 325–337.
Published: 14 December 2011
... of WNK isoforms is controlled by trans-autophosphorylation. These results provide novel insights into the WNK signal transduction pathway and provide genetic evidence confirming the essential role that SPAK/OSR1 play in controlling NKCC1 function. They also reveal a role in which the downstream SPAK/OSR1...
Includes: Supplementary data
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Biochem J (2012) 441 (1): 255–264.
Published: 14 December 2011
.... 1 To whom correspondence should be addressed (email rserrano@ibmcp.upv.es ). 14 7 2011 12 9 2011 15 9 2011 15 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 pH homoeostasis signal transduction Gcn2 Saccharomyces cerevisiae amino...
Articles
Biochem J (2011) 439 (1): 45–55.
Published: 14 September 2011
... [ 19 ]. Furthermore, PKCδ-induced polymerization of actin requires its interaction with cortactin [ 20 ]. autotaxin (ATX) cell migration lysophosphatidic acid (LPA) lysophospholipase D (lysoPLD) signal transduction © The Authors Journal compilation © 2011 Biochemical Society 2011...
Articles
Biochem J (2011) 437 (2): 169–183.
Published: 28 June 2011
... 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis internalization neuropilin signal transduction vascular endothelial growth factor (VEGF) vascular endothelial growth factor receptor (VEGFR) VEGF denotes a family of five related mammalian...
Includes: Multimedia, Supplementary data
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Biochem J (2011) 437 (1): 157–167.
Published: 14 June 2011
... 5 2011 6 5 2011 6 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 movement disorder neurodegeneration protein kinase signal transduction tau tubulin kinase peptide substrate (TTBKtide) Previous studies have revealed that mutations within...
Includes: Supplementary data
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Biochem J (2011) 435 (1): 73–83.
Published: 15 March 2011
...@ucalgary.ca ). 13 7 2010 23 12 2010 11 1 2011 11 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 inhibitory protein phylogenetics protein phosphatase 1 (PP1) nucleus signal transduction TAP-tag One of the earliest discovered, and most...
Includes: Supplementary data
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Biochem J (2011) 434 (1): e1–e2.
Published: 27 January 2011
... © 2011 Biochemical Society 2011 inhibitor of NF-κB kinase ϵ (IKKϵ) inhibitor of NF-κB kinase IKKα (IKKα) inhibitor of NF-κB kinase IKKβ (IKKβ) signal transduction TANK-binding kinase 1 (TBK-1) Toll-like receptor (TLR) tumour necrosis factor Innate immunity is a highly complex...
Articles
Biochem J (2010) 432 (2): 267–273.
Published: 12 November 2010
... context in the absence of any factor specific to GG neurons. 22 4 2010 29 7 2010 26 8 2010 26 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 bicarbonate cGMP guanylate cyclase (GC) Grueneburg ganglion (GG) receptor signal transduction...
Articles
Biochem J (2010) 430 (1): 141–149.
Published: 28 July 2010
... To whom correspondence should be addressed (email nuria.barbarroja.exts@juntadeandalucia.es ). 23 2 2010 19 5 2010 3 6 2010 3 6 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 inflammation insulin resistance obesity signal transduction...
Articles
Biochem J (2010) 427 (2): 305–312.
Published: 29 March 2010
... signal transduction of EPO-R, as shown by enhanced phosphorylation levels of selected downstream effectors. This activity translates to enhanced proliferation, increased protection against apoptosis and a reduced level of cells in sub-G 1 in response to low EPO levels. We show that these cellular...
Articles
Biochem J (2010) 425 (1): 53–54.
Published: 14 December 2009
... limitations, the most serious being the inherent lack of specificity of these compounds. cell regulation chemical biology chemical inhibitor protein kinase signal transduction Table 1 Suggested criteria for the publication of studies using protein kinase inhibitors in intact cells...
Articles
Biochem J (2009) 424 (3): 439–448.
Published: 10 December 2009
... be addressed (email uozumi@biophy.che.tohoku.ac.jp ). 10 8 2009 21 9 2009 28 9 2009 28 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 phosphorylation potassium channel Snf1-related protein kinase (SnRK) signal transduction stomata transport...
Includes: Supplementary data
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Biochem J (2009) 422 (1): 119–128.
Published: 29 July 2009
...@ibms.sinica.edu.tw ). 26 2 2009 6 5 2009 1 6 2009 1 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cell-surface protein CUB domain epidermal growth factor-like repeat (EGF-like repeat) glycoprotein signal transduction Sonic Hedgehog The SCUBE...
Articles
Biochem J (2009) 420 (2): 155–162.
Published: 13 May 2009
...Horacio Bach; Dennis Wong; Yossef Av-Gay In Mycobacterium tuberculosis , signal transduction is mediated by 11 serine/threonine kinases, but no tyrosine kinases have been identified thus far. The protein encoded by the ORF (open reading frame) Rv2232 has been annotated as a member of the HAD...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (1): 141–148.
Published: 13 March 2009
...) signal transduction ROCK (Rho-associated coiled-coil kinase) [also called ROK (Rho-associated kinase) and Rho kinase] is a large (160 kDa) serine/threonine kinase ubiquitously expressed in mammalian tissue. ROCK was identified as the first major effector of the small G-protein Rho [ 1 – 3...
Articles
Biochem J (2009) 419 (1): 185–194.
Published: 13 March 2009
... ). 12 6 2008 10 12 2008 17 12 2008 17 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cell death lipid rafts palmitoylation signal transduction tumour necrosis factor receptor (TNFR) Cell death can be induced by a family of death...
Includes: Supplementary data
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Biochem J (2009) 417 (3): 737–746.
Published: 16 January 2009
... transducer and activator of transcription 3 (STAT3) signal transduction JAK2-overexpressing Ba/F3 cells stably expressing wt, K5R or d715 were washed and transferred to RPMI medium without growth factors. Cells were counted and the cell viability was assessed on a daily basis by flow cytometry using 7...
Articles
Biochem J (2008) 415 (2): 241–245.
Published: 25 September 2008
... be recognized and bound by signal transduction molecules containing SH2 (Src homology 2) domains. Therefore Grb (growth-factor-receptor-bound protein) 2 and 7, APS [adapter protein with PH (pleckstrin homology) and SH2 domains], Lnk, PI3K (phosphoinositide 3-kinase), PLCγ (phospholipase Cγ) and other proteins...
Articles
Biochem J (2008) 415 (1): 145–154.
Published: 12 September 2008
... transduction structure–activity analysis Ras and members of the Ras family are low-molecular-mass monomeric GTP-binding proteins that act as molecular switches by coupling extracellular signals to different cellular responses. Signal transduction through Ras and other members of the Ras family occurs...
Articles
Biochem J (2008) 413 (1): 37–49.
Published: 12 June 2008
... 2 (FRS2) fluorescent lifetime imagining microscopy (FLIM) mitogen-activated protein kinase (MAPK) signal transduction systems biology temporal control tyrosine kinase The present study examines the effects of perturbing the growth factor binding, particularly with respect...
Articles
Biochem J (2008) 412 (2): e3–e5.
Published: 14 May 2008
... Society 2008 AMP-activated protein kinase (AMPK) cancer LKB1 mammalian target of rapamycin (mTOR) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) signal transduction The rapid proliferation of cancer cells requires extensive rewiring of metabolic pathways to meet increased...
Articles
Biochem J (2008) 412 (1): 153–162.
Published: 25 April 2008
... to GPCRs (LPA 1–5 ) in mammalian cells [ 17 , 32 – 34 ]. We have shown that LPA-induced intracellular signalling transduction, IL-8 and IL-13Rα2 secretion were dependent on Gα i proteins [ 15 – 19 ]. To examine whether LPA-induced COX-2 expression was through Gα i -protein-coupled receptors, HBEpCs were...
Articles
Biochem J (2008) 412 (1): 65–72.
Published: 25 April 2008
... factor for T-cells and is a potent inducer of the chemokine MCP-1 (monocyte chemoattractant protein-1). Recent studies have focused on the negative regulation of IL-6 signal transduction through the IL-6-induced feedback inhibitors SOCS (suppressor of cytokine signalling) 1 and SOCS3 or the protein...
Includes: Supplementary data