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Keywords: signaling
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Articles
Biochem J (2021) 478 (9): 1689–1703.
Published: 10 May 2021
... transforming growth factor β (TGF-β), a master regulator of the fibrotic signaling cascade. Based on mRNA and protein expression profiling data, we found that αVβ1 integrin is the most abundant member of the αV integrin family in either quiescent or TGF-β1-activated primary human HSCs. Unexpectedly, either...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (24): 4729–4744.
Published: 18 December 2020
... cell wall fungicide intracellular transport signaling sterols Membrane embedded proteins are affected by their lipid environment in similar ways as they are by aqueous factors like pH or ionic strength. In this sense, abnormal sterols can be considered powerful disruptors of normal function...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (21): 4207–4220.
Published: 09 November 2020
...Monica Gonzalez-Magaldi; Jacqueline M. McCabe; Haley N. Cartwright; Ningze Sun; Daniel J. Leahy Receptor Tyrosine Kinases (RTKs) comprise a diverse group of cell-surface receptors that mediate key signaling events during animal development and are frequently activated in cancer. We show here...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (10): 1879–1892.
Published: 28 May 2020
...Manoj Kumar; Komal Sharma; Akhilesh K. Yadav; Kajal Kanchan; Madhu Baghel; Suneel Kateriya; Girdhar K. Pandey Calcium (Ca 2+ ) signaling is involved in the regulation of diverse biological functions through association with several proteins that enable them to respond to abiotic and biotic stresses...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (7): 1287–1308.
Published: 17 April 2020
...Kaustav Gangopadhyay; Bharat Manna; Swarnendu Roy; Sunitha Kumari; Olivia Debnath; Subhankar Chowdhury; Amit Ghosh; Rahul Das T-cell receptor (TCR) signaling is initiated by recruiting ZAP-70 to the cytosolic part of TCR. ZAP-70, a non-receptor tyrosine kinase, is composed of an N-terminal tandem...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (10): 1419–1431.
Published: 21 May 2019
...Takuya Kojima; Yosuke Funato; Hiroaki Miki Phosphatase of regenerating liver (PRL) is overexpressed in metastatic cancers and actively drives their malignant progression. Many studies on cultured cancer cells have implied PRL overexpression as a stimulant for cellular signaling involved in cell...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (1): 115–135.
Published: 15 January 2019
... Cu(I)/Ag(I) concentrations to help maintain metal ion homeostasis. The CusS histidine kinase is a homodimeric integral membrane protein that binds to periplasmic Cu(I)/Ag(I) and transduces a signal to its cytoplasmic kinase domain. However, the mechanism of how metal binding in the periplasm...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (19): 3073–3086.
Published: 10 October 2018
... signaling, but the mechanism of inactivation of the Axl receptor is poorly understood. In the present study, we show that IQGAP1 modulates Axl signaling. IQGAP1 is a scaffold protein that integrates cell signaling pathways by binding several growth factor receptors and intracellular signaling molecules. Our...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (18): 2907–2923.
Published: 19 September 2018
...Blanca E. Ruiz-Medina; Denisse A. Cadena-Medina; Edmundo Esparza; Amy J. Arrieta; Robert A. Kirken Regulation of intracellular signaling pathways in lymphocytes is critical for cell homeostasis and immune response. Interleukin-2 (IL-2), a key regulator of lymphocytes, signals following receptor...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (14): 2329–2353.
Published: 31 July 2018
...Mary Mirvis; Tim Stearns; W. James Nelson The cilium, once considered a vestigial structure, is a conserved, microtubule-based organelle critical for transducing extracellular chemical and mechanical signals that control cell polarity, differentiation, and proliferation. The cilium undergoes cycles...
Articles
Biochem J (2018) 475 (2): 455–476.
Published: 31 January 2018
...-proliferative, multinucleated syncytium. This syncytium covers the placenta and manages the exchange of nutrients and gases between maternal and fetal circulation. We recently reported protein kinase A (PKA) to be part of a macromolecular signaling complex with ezrin and gap junction protein connexin 43 (Cx43...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (18): 3087–3088.
Published: 31 August 2017
... on behalf of the Biochemical Society 2017 inhibition receptor tyrosine kinases signaling c-FMS, perhaps better known as colony-stimulating factor 1 receptor (CSF1R) or macrophage colony-stimulating factor receptor (M-CSFR), is a receptor tyrosine kinase (RTK) in the PDGFR subfamily...
Articles
Biochem J (2017) 474 (14): 2379–2388.
Published: 06 July 2017
...) that requires hundreds of sequences to identify functionally critical sectors, the propagation and dissipation of perturbations within proteins and the higher-order couplings deduced from detailed NMR experiments. Our results thus shed light on the possible mechanistic origins of signaling through...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (5): 771–780.
Published: 20 February 2017
...Akshay Bareja; Conrad P. Hodgkinson; Alan J. Payne; Richard E. Pratt; Victor J. Dzau We have recently shown that hypoxia and Akt-induced stem cell factor (HASF) protects the heart from ischemia-induced damage and promotes cardiomyocyte proliferation. While we have identified certain signaling...
Articles
Biochem J (2015) 471 (1): 101–109.
Published: 21 September 2015
... in a variety of cancers. EphA3 activation is believed to follow a ‘seeding mechanism’ model, in which ligand binding to the monomeric receptor acts as a trigger for signal-productive receptor clustering. We study EphA3 lateral interactions on the surface of live cells and we demonstrate that EphA3 forms dimers...
Includes: Supplementary data