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Keywords: signalling
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Articles
In Collection
Cell signaling in the 21st century
Sarah E. Garnish, Christopher R. Horne, Yanxiang Meng, Samuel N. Young, Annette V. Jacobsen, Joanne M. Hildebrand, James M. Murphy
Journal:
Biochemical Journal
Biochem J (2024) 481 (17): 1125–1142.
Published: 27 August 2024
... for their capacity to block R30E MLKL-mediated cell death, to identify co-effectors in the terminal steps of necroptotic signalling. We identified 13 compounds — ABT-578, AR-A014418, AZD1480, AZD5363, Idelalisib, Ipatasertib, LJI308, PHA-793887, Rapamycin, Ridaforolimus, SMI-4a, Temsirolimus and Tideglusib — each...
Includes: Supplementary data
Articles
In Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (18): 1445–1457.
Published: 21 September 2023
... in discovering and probing mechanisms of cell–cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to understand its biology, provide a read-out...
Articles
In Collection
Cell death and survival
Catia L. Pierotti, Annette V. Jacobsen, Christoph Grohmann, Ruby K. Dempsey, Nima Etemadi, Joanne M. Hildebrand, Cheree Fitzgibbon, Samuel N. Young, Katherine A. Davies, Wilhelmus J. A. Kersten, John Silke, Kym N. Lowes, Hélène Jousset Sabroux, David C. S. Huang, Mark F. van Delft, James M. Murphy, Guillaume Lessene
Journal:
Biochemical Journal
Biochem J (2023) 480 (9): 665–684.
Published: 12 May 2023
... that additionally target RIPK1 and raises the prospect that serendipitous targeting of necroptosis signalling may contribute to their clinical efficacy in some settings. Correspondence: James M. Murphy ( [email protected] ) or Guillaume Lessene ( [email protected] ) * Co-senior authors. 9 2...
Includes: Supplementary data
Articles
Sarika Khasnis, Hildegonda Veenstra, Michael J. McClellan, Opeoluwa Ojeniyi, C. David Wood, Michelle J. West
Journal:
Biochemical Journal
Biochem J (2022) 479 (23): 2395–2417.
Published: 07 December 2022
... receptor signalling to control cell growth and survival and suppress lytic replication. Here, we show that the EBV transcription factors EBNA2, 3A, 3B and 3C bind to genomic sites around multiple B cell receptor (BCR) pathway genes, regulate their expression and affect BCR signalling. EBNA2 regulates...
Includes: Supplementary data
Articles
Su-Ping Ng, Wataru Nomura, Haruya Takahashi, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto, Yoshiharu Inoue
Journal:
Biochemical Journal
Biochem J (2022) 479 (21): 2279–2296.
Published: 04 November 2022
... shown to negatively influence systemic metabolism by inducing glucose intolerance, insulin resistance, and diabetic complications. MG plays a functional role as a signaling molecule that initiates signal transduction. However, the specific relationship between MG-induced activation of signal...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (4): 503–523.
Published: 23 February 2022
... restored by wild-type 3BP2, suggesting that 3BP2 was involved in the dectin-1-mediated signalling that led to NF-κB activation. Furthermore, we found that the phosphorylation of Tyr 183 is not essential for cytokine expression and that 3BP2 in combination with caspase recruitment domain family member 9...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (23): 4045–4070.
Published: 06 December 2021
...Katharina F. Sonnen; Claudia Y. Janda In multicellular organisms, cellular behaviour is tightly regulated to allow proper embryonic development and maintenance of adult tissue. A critical component in this control is the communication between cells via signalling pathways, as errors...
Articles
Lung-Yu Liang, Michael Roy, Christopher R. Horne, Jarrod J. Sandow, Minglyanna Surudoi, Laura F. Dagley, Samuel N. Young, Toby Dite, Jeffrey J. Babon, Peter W. Janes, Onisha Patel, James M. Murphy, Isabelle S. Lucet
Journal:
Biochemical Journal
Biochem J (2021) 478 (17): 3351–3371.
Published: 14 September 2021
... receptor family, which collectively serves as mediators of contact-dependent cell–cell communication to transmit extracellular cues into intracellular signals. As per their active counterparts, EphB6 and EphA10 deregulation is strongly linked to proliferative diseases. However, unlike active Eph receptors...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (17): 3331–3349.
Published: 14 September 2021
...Courtney M. Smith; Alice Li; Nithya Krishnamurthy; Mark A. Lemmon Co-signaling receptors for the T cell receptor (TCR) are important therapeutic targets, with blockade of co-inhibitory receptors such as PD-1 now central in immuno-oncology. Advancing additional therapeutic immune modulation...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (5): 1061–1083.
Published: 10 March 2021
...Katherine A. Young; Laura Biggins; Hayley J. Sharpe Adhesive structures between cells and with the surrounding matrix are essential for the development of multicellular organisms. In addition to providing mechanical integrity, they are key signalling centres providing feedback on the extracellular...
Includes: Supplementary data
Articles
Dominic P. Byrne, Christopher J. Clarke, Philip J. Brownridge, Anton Kalyuzhnyy, Simon Perkins, Amy Campbell, David Mason, Andrew R. Jones, Patrick A. Eyers, Claire E. Eyers
Journal:
Biochemical Journal
Biochem J (2020) 477 (13): 2451–2475.
Published: 02 July 2020
... kinase inhibitors exemplified by centrinone, which rapidly induces inhibitory effects on PLK4 and leads to on-target centrosome depletion. Despite this, relatively few PLK4 substrates have been identified unequivocally in human cells, and PLK4 signalling outside centriolar networks remains poorly...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (5): 769–778.
Published: 06 March 2019
...-specific functions via signalling pathways including the PI3K, MAPK, or JAK-STAT pathway. The cytokines FLT3-Ligand and c-Kit-Ligand are important for the early expansion of the B-cell precursors at different developmental stages and conditions. Interleukin 7 is essential for commitment to the B-cell...
Articles
In Collection
Awards
Journal:
Biochemical Journal
Biochem J (2019) 476 (4): 705–718.
Published: 28 February 2019
... that subsequently initiate signalling pathways to control a broad range of functional endpoints including cell migration, proliferation and survival. The α4 and α9 integrins form a small sub-family of receptors that share some specific ligands and binding partners. Although relatively poorly studied compared...
Articles
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Elaine C. Thomas, Sharon C. Hook, Alexander Gray, Alexandra Chadt, David Carling, Hadi Al-Hasani, Kate J. Heesom, D. Grahame Hardie, Jeremy M. Tavaré
Journal:
Biochemical Journal
Biochem J (2018) 475 (18): 2969–2983.
Published: 25 September 2018
... of a myriad of downstream targets. One target is TBC1D1 a Rab-GTPase-activating protein that regulates glucose uptake in muscle cells by integrating insulin signalling with that promoted by muscle contraction. Ser 237 in TBC1D1 is a target for phosphorylation by AMPK, an event which may be important...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (17): 2925–2935.
Published: 11 August 2017
... signaling [ 20 ]. The expression of lincRNA-Cox2 decreases or increases the expression of more than one thousand genes [ 20 ]. Many genes related to the immune response are upregulated when lincRNA-Cox2 is silenced. HnRNP A/B and hnRNP A2/B1 were identified as lincRNA-Cox2 binding partners. lincRNA-Cox2...
Articles
Grace Q. Gong, Jackie D. Kendall, James M.J. Dickson, Gordon W. Rewcastle, Christina M. Buchanan, William A. Denny, Peter R. Shepherd, Jack U. Flanagan
Journal:
Biochemical Journal
Biochem J (2017) 474 (13): 2261–2276.
Published: 26 June 2017
...Grace Q. Gong; Jackie D. Kendall; James M.J. Dickson; Gordon W. Rewcastle; Christina M. Buchanan; William A. Denny; Peter R. Shepherd; Jack U. Flanagan Phosphoinositide 3-kinases (PI3Ks) are major regulators of many cellular functions, and hyperactivation of PI3K cell signalling pathways is a major...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (9): 1453–1466.
Published: 13 April 2017
...Bernadette Carroll; Elaine A. Dunlop Much attention has recently been focussed on the lysosome as a signalling hub. Following the initial discovery that localisation of the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), to the lysosome was essential for mTORC1...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (4): 471–492.
Published: 03 February 2017
... genes. Here, I highlight recent advances in the field of cell wall signalling in plants, with emphasis on the role of plasma membrane receptor-like kinase complexes. In addition, possible roles for cell wall-mediated signalling beyond the maintenance of cell wall integrity are discussed. Given...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (12): 1719–1732.
Published: 10 June 2016
... kinase) cell signalling. In the present study, we model possible catalytic domain dimer interfaces of membrane-anchored GTP-bound K-Ras4B and H-Ras, and compare their conformations. The active helical dimers formed by the allosteric lobe are isoform-specific: K-Ras4B-GTP favours the α3 and α4 interface...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (5): 661–672.
Published: 24 February 2016
...Wei-Ju Liao; Ku-Chi Tsao; Ruey-Bing Yang SCUBE1 (S1), a secreted and membrane-bound glycoprotein, has a modular protein structure composed of an N-terminal signal peptide sequence followed by nine epidermal growth factor (EGF)-like repeats, a spacer region and three cysteine-rich (CR) motifs...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 469 (3): 325–346.
Published: 23 July 2015
... their regulatory contributions, their ability to integrate signals from cellular events towards providing most appropriate response to stress conditions and their importance for tumour suppression. These are fascinating aspects of molecular oncology that hold the key to understanding the molecular pathology...
Articles
Gitte W. Haxholm, Louise F. Nikolajsen, Johan G. Olsen, Jacob Fredsted, Flemming H. Larsen, Vincent Goffin, Stine F. Pedersen, Andrew J. Brooks, Michael J. Waters, Birthe B. Kragelund
Journal:
Biochemical Journal
Biochem J (2015) 468 (3): 495–506.
Published: 15 June 2015
...Gitte W. Haxholm; Louise F. Nikolajsen; Johan G. Olsen; Jacob Fredsted; Flemming H. Larsen; Vincent Goffin; Stine F. Pedersen; Andrew J. Brooks; Michael J. Waters; Birthe B. Kragelund Class 1 cytokine receptors regulate essential biological processes through complex intracellular signalling...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (2): 195–211.
Published: 06 January 2015
...Fiona P. Bailey; Dominic P. Byrne; Daniel McSkimming; Natarajan Kannan; Patrick A. Eyers Protein phosphorylation lies at the heart of cell signalling, and somatic mutation(s) in kinases drives and sustains a multitude of human diseases, including cancer. The human protein kinase superfamily...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (2): 185–194.
Published: 06 January 2015
... induced pluripotent stem cell (iPSC) regenerative therapy signalling vascular smooth muscle cell (VSMC) The use of autologous cells is the benchmark for regenerative therapy in vascular diseases, which includes both local transplantation of the vascular cells into injured organs...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (1): 1–26.
Published: 12 December 2014
...Johanna Heideker; Ingrid E. Wertz The post-translational modification of proteins with ubiquitin represents a complex signalling system that co-ordinates essential cellular functions, including proteolysis, DNA repair, receptor signalling and cell communication. DUBs (deubiquitinases), the enzymes...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 460 (3): 377–385.
Published: 29 May 2014
... polyphosphate multikinase (IPMK) phytase phytic acid (IP 6 ) plant biochemistry signalling 1 To whom correspondence should be addressed (email [email protected] ). 20 2 2014 24 3 2014 26 3 2014 26 3 2014 © The Authors Journal compilation © 2014 Biochemical Society...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 460 (3): 317–329.
Published: 29 May 2014
... and selectivity of LD motif interactions that has emerged from more than a decade of research. This overview highlights the intricate multi-level regulation and the inherently noisy and heterogeneous nature of signalling through short protein–protein interaction motifs. 1 To whom correspondence should...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 458 (2): 335–341.
Published: 14 February 2014
...Jijun Hao; Cristi L. Galindo; Truc-Linh Tran; Douglas B. Sawyer NRG-1β (neuregulin-1β) serves multiple functions during embryonic heart development by signalling through ErbB family receptor tyrosine kinases (ErbB2, ErbB3 and ErbB4). Previous studies reported that NRG-1β induces cardiomyogenesis...
Includes: Multimedia, Supplementary data
Articles
Prem Raj B. Joseph, Kirti V. Sawant, Angela Isley, Mesias Pedroza, Roberto P. Garofalo, Ricardo M. Richardson, Krishna Rajarathnam
Journal:
Biochemical Journal
Biochem J (2013) 456 (2): 241–251.
Published: 08 November 2013
... differences in ligand/receptor selectivity and the activation of multiple signalling pathways. In the present study, we show in neutrophil-activating chemokine CXCL8 that the highly conserved GP (glycine-proline) motif located distal to both N-terminal and N-loop residues couples Site-I and Site-II...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 453 (3): 475–485.
Published: 12 July 2013
... that promotes cell survival under conditions of oxidative stress. It may also be involved in redox signalling by binding to other proteins. In the present study we have searched for binding partners of Prx2 in H 2 O 2 -treated Jurkat and human umbilical vein endothelial cells and discovered...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 452 (3): 489–497.
Published: 31 May 2013
... to glucose by activating the Hxt5p (hexose transporter 5) glucose transporter, which provides an advantage during early phases after glucose resupply. cAMP and glucose FRET (fluorescence resonance energy transfer) sensors were used to identify three signalling pathways that co-operate in the anticipatory...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 452 (3): e11–e13.
Published: 31 May 2013
... that pre-exist as parallel signalling pathways. This aspect is explored by the Alessi group and collaborators from AstraZeneca in this issue of the Biochemical Journal , who identify a subset of breast cancer cell lines that are intrinsically resistant to Akt inhibition through constitutive up-regulation...
Articles
Mauro F. Azevedo, Paul R. Sanders, Efrosinia Krejany, Catherine Q. Nie, Ping Fu, Leon A. Bach, Gerhard Wunderlich, Brendan S. Crabb, Paul R. Gilson
Journal:
Biochemical Journal
Biochem J (2013) 452 (3): 433–441.
Published: 31 May 2013
... or [email protected] ). 22 1 2013 26 3 2013 3 4 2013 3 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 calcium calcium-dependent protein kinase 1 (CDPK1) malaria phosphorylation Plasmodium signalling Intracellular signalling events...
Includes: Supplementary data
Articles
Antonio García-Blesa, Mikolaj Klossowicz, Carmen López-Osuna, Mario Martínez-Florensa, Bernard Malissen, Francisco J. García-Cózar, Arkadiusz Miazek, Enrique Aguado
Journal:
Biochemical Journal
Biochem J (2013) 450 (3): 511–521.
Published: 28 February 2013
..., and thereby it recruits several cytosolic mediators for downstream signalling pathways. The Fas protein is essential for T-lymphocyte apoptosis, and following Fas engagement, many proteins are proteolytically cleaved, including several molecules that are important for the transduction of TCR intracellular...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 449 (2): 449–457.
Published: 14 December 2012
...Hannah V. McCue; Joanna D. Wardyn; Robert D. Burgoyne; Lee P. Haynes Distinct spatiotemporal Ca 2+ signalling events regulate fundamental aspects of eukaryotic cell physiology. Complex Ca 2+ signals can be driven by release of Ca 2+ from intracellular organelles that sequester Ca 2+ such as the ER...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 442 (1): 1–12.
Published: 27 January 2012
...Xiaolin Sun; William T. Jones; Erik H. A. Rikkerink IDPs (intrinsically disordered proteins) are highly abundant in eukaryotic proteomes and important for cellular functions, especially in cell signalling and transcriptional regulation. An IDR (intrinsically disordered region) within an IDP often...
Articles
Lennart Zabeau, Annick Verhee, Dominiek Catteeuw, Liesbeth Faes, Sylvie Seeuws, Tine Decruy, Dirk Elewaut, Frank Peelman, Jan Tavernier
Journal:
Biochemical Journal
Biochem J (2012) 441 (1): 425–434.
Published: 14 December 2011
... that it is possible to block LR signalling without affecting ligand binding. These nanobodies form new tools to study the mechanisms of BBB (blood–brain barrier) leptin transport and the effect of LR inhibition in disease models. 1 To whom correspondence should be addressed (email [email protected]...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 437 (2): 199–213.
Published: 28 June 2011
...Jørgen Wesche; Kaisa Haglund; Ellen Margrethe Haugsten FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly regulating cell proliferation, survival, migration and differentiation during development and adult life. Deregulation of FGFR signalling, on the other...
Includes: Multimedia, Supplementary data
Articles
Zhen-Bo Song, Yong-Li Bao, Yu Zhang, Xu-Guang Mi, Ping Wu, Yin Wu, Chun-Lei Yu, Ying Sun, Li-Hua Zheng, Yan-Xin Huang, Biao Liu, Yu-Xin Li
Journal:
Biochemical Journal
Biochem J (2011) 436 (2): 457–467.
Published: 13 May 2011
..., colony formation and tumour formation in nude mice. Taken together, the results of the present study suggest that TSP50 promotes cell proliferation, at least partially, through activation of the NF-κB signalling pathway. 2 11 2010 4 3 2011 8 3 2011 8 3 2011 © The Authors...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 435 (2): 539–544.
Published: 29 March 2011
.... is a National Health and Medical Research Council Senior Principal Research Fellow. References 1 Vasudevan K. M. Barbie D. A. Davies M. A. Rabinovsky R. McNear C. J. Kim J. J. Hennessy B. T. Tseng H. Pochanard P. Kim S. Y. AKT-independent signaling downstream...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 435 (2): 509–518.
Published: 29 March 2011
... by 5KR EPO-R, the lysine-less mutant produced weaker receptor activation and signalling than the wt receptor. We thus propose that EPO-R cytosolic lysine residues enhance receptor function, most probably through ubiquitination and/or other post-translational modifications. 1 To whom correspondence...
Articles
Cathal Wilson, Rossella Venditti, Laura R. Rega, Antonino Colanzi, Giovanni D'Angelo, M. Antonietta De Matteis
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 1–9.
Published: 15 December 2010
.../processing, basic metabolism, signalling and cell-fate decisional processes converge. Another class of compounds that is glycosylated at the GC are the sphingolipids, which include sphingomyelin and GSLs (glycosphingolipids) [ 31 ]. When transported to the GC, ceramide, the common sphingolipid precursor...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 429 (3): 403–417.
Published: 14 July 2010
...Ana Cuadrado; Angel R. Nebreda The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to interpret a wide range of external signals and respond appropriately by generating a plethora of different biological effects. The diversity and specificity in cellular outcomes...
Articles
Journal:
Biochemical Journal
Biochem J (2010) 427 (2): 189–196.
Published: 29 March 2010
...Philip M. Newton; Robert O. Messing The ε isoform of protein kinase C (PKCε) has important roles in the function of the cardiac, immune and nervous systems. As a result of its diverse actions, PKCε is the target of active drug-discovery programmes. A major research focus is to identify signalling...
Articles
Stuart A. Ritchie, Christine F. Kohlhaas, Alasdair R. Boyd, Krishna C. Yalla, Kenneth Walsh, John M. C. Connell, Ian P. Salt
Journal:
Biochemical Journal
Biochem J (2010) 426 (1): 85–90.
Published: 27 January 2010
... phosphorylation protein kinase B (PKB) signalling Type 2 diabetes is associated with a greatly increased risk of atherosclerosis, yet the molecular mechanisms that underlie this association remain poorly characterized. Endothelial dysfunction, characterized by reduced NO (nitric oxide) bioavailability...
Articles
Journal:
Biochemical Journal
Biochem J (2010) 426 (1): 65–72.
Published: 27 January 2010
... display only weak activation of the effectors: ERK1/2 (extracellular-signal-regulated kinase 1/2) and Akt. In order to identify key negative regulators of oncogenic Ras signalling we performed a phosphatome RNAi (RNA interference) screen in A549 cells and ranked their effects on phosphorylation of Ser 473...
Includes: Supplementary data
Articles
Oxidation of methionine residues: the missing link between stress and signalling responses in plants
Journal:
Biochemical Journal
Biochem J (2009) 422 (2): e1–e2.
Published: 13 August 2009
...Michael J. Emes In response to biotic and abiotic stresses, plants induce a complex array of pathways and protein phosphorylation cascades which generally lead to a response aimed at mitigating the particular insult. In many cases, H 2 O 2 has been implicated as the signalling molecule...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 422 (1): 1–10.
Published: 29 July 2009
...Susan Carpenter; Luke A. J. O'Neill TLRs (Toll-like receptors) are essential modulators of the innate immune response through their ability to respond to a diverse range of conserved structures within microbes. Recent advances have been made in our understanding of the initiation of TLR signals...
Articles
Bärbel Schröfelbauer, Johanna Raffetseder, Maria Hauner, Andrea Wolkerstorfer, Wolfgang Ernst, Oliver H. J. Szolar
Journal:
Biochemical Journal
Biochem J (2009) 421 (3): 473–482.
Published: 15 July 2009
...) pathway but also of the parallel MAPK (mitogen-activated protein kinase) signalling cascade upon stimulation with TLR9 and TLR4 agonists. Further analysis of upstream events revealed that glycyrrhizin treatment decreased cellular attachment and/or uptake of CpG-DNA and strongly impaired TLR4...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 421 (2): 145–156.
Published: 26 June 2009
...Hong-Wei Xue; Xu Chen; Yu Mei As an important metabolic pathway, phosphatidylinositol metabolism generates both constitutive and signalling molecules that are crucial for plant growth and development. Recent studies using genetic and molecular approaches reveal the important roles of phospholipid...
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