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Keywords: sirtuin
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Biochem J (2012) 444 (1): 1–10.
Published: 26 April 2012
...Albert Giralt; Francesc Villarroya SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in energy metabolism processes, including the respiratory chain, tricarboxylic...
Biochem J (2011) 439 (2): 341–348.
Published: 28 September 2011
... + synthesis niacin Preiss–Handler pathway sirtuin The generic model gave rise to 113 EFMs listed in the Supplementary Online Data. They can be visualized by the tool available at http://pinguin.biologie.uni-jena.de/bioinformatik/networks/ . Three of these EFMs contain enzymes absent from...
Includes: Supplementary data
Biochem J (2011) 433 (3): 505–514.
Published: 14 January 2011
... important mechanism for controlling a broad array of proteins mediating cellular adaptation to metabolic fuels. Acetylation is governed, in part, by SIRTs (sirtuins), class III NAD + -dependent deacetylases that regulate lipid and glucose metabolism in liver during fasting and aging. However, the role of...
Includes: Supplementary data
Biochem J (2008) 411 (2): 279–285.
Published: 27 March 2008
... 11 2007 21 1 2008 23 1 2008 23 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 deacetylase immunofluorescence import leptomycin B mitochondrial sirtuin An important aspect of the regulation of chromatin remodelling and consequently...
Includes: Supplementary data
Biochem J (2007) 406 (3): 511–518.
Published: 29 August 2007
... show here that resveratrol inhibits, in vitro and in cultured muscle cell lines, class IA PI3K and its downstream signalling at the same concentration range at which it activates sirtuins. Our observations define class IA PI3K as a target of resveratrol that may contribute to the longevity-promoting...
Includes: Supplementary data