... of NAD + -consuming enzymes in the immune defense against viral infections, with the hope that a better understanding of this process could help to develop better antiviral therapeutics targeting these enzymes. These NAD + -consuming enzymes include PARPs, sirtuins, CD38, and SARM1. Among...

... understood, but evidence suggests a potential regulatory role for the sirtuin family of lysine deacetylases. Thus, we hypothesized that the acetylation status of the major 2-HG-generating enzymes [lactate dehydrogenase (LDH), isocitrate dehydrogenase (IDH) and malate dehydrogenase (MDH)] may govern their 2...

... acetylation/deacetylation Drosophila melanogaster metabolic regulation notch signalling pathway sirtuins Silent information regulator 1 (Sirt1) is a member of the sirtuin family of protein deacetylases that have long garnered interest for their role in ageing and regulation of metabolism, immune...