... , J. et al. ( 2008 ) Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1 . Mol. Cancer Ther. 7 , 2394 – 2404 10.1158/1535-7163.MCT-07-2391 37 Tamaoki , T. , Nomoto , H. , Takahashi , I. , Kato , Y. , Morimoto...

... to screen new antibacterial agents that target FtsZ. antibacterial target cell division doxorubicin FtsZ small-molecule inhibitors Z-ring Bacterial infections continue to pose a major threat to global public health and more so in developing countries. Furthermore, ever-increasing...

... mice. On the basis of the in vivo efficacy of a cell-permeable JIP peptide, the JIP–JNK interaction appears to be a potential target for JNK inhibition. The goal of the present study was to identify small-molecule inhibitors that disrupt the JIP–JNK interaction to provide an alternative approach...

... 9 2007 14 9 2007 14 9 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 deacetylation histone deacetylase (HDAC) histone deacetylase isoforms (HDAC isoforms) small-molecule inhibitors tubulin HDACs (histone deacetylases) are a family of enzymes...