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Keywords: specificity
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Biochem J (2021) 478 (11): 2035–2050.
Published: 08 June 2021
...Kaare Teilum; Johan G. Olsen; Birthe B. Kragelund With the increased focus on intrinsically disordered proteins (IDPs) and their large interactomes, the question about their specificity — or more so on their multispecificity — arise. Here we recapitulate how specificity and multispecificity are...
Biochem J (2021) 478 (11): 2081–2099.
Published: 08 June 2021
... were resolved and probed with α-FLAG, α-HA, and α-GlmU antibodies. Bands corresponding to F-GlmU-H, with α-HA and GlmU C-ter with α-FLAG antibodies. α-GlmU antibodies confirmed the expression of GlmU in all lysates. α-GroEL1 antibodies were used to check the equal loading in each lane. Specific bands...
Includes: Supplementary data
Biochem J (2011) 433 (2): 277–284.
Published: 22 December 2010
...Sheng Chen; Hoi Ying Wan BoNTs (botulinum neurotoxins) are both deadly neurotoxins and natural toxins that are widely used in protein therapies to treat numerous neurological disorders of dystonia and spinal spasticity. Understanding the mechanism of action and substrate specificity of BoNTs is a...
Includes: Supplementary data
Biochem J (2009) 417 (2): 449–455.
Published: 23 December 2008
... binding domains of GluRS (glutamyl-tRNA synthetase) and GlnRS (glutaminyl-tRNA synthetase) in bacteria are structurally distinct. This originates from the unique evolutionary history of GlnRSs. Starting from the catalytic domain, eukaryotic GluRS evolved by acquiring the archaea/eukaryote-specific anti...
Biochem J (2005) 389 (1): 173–180.
Published: 21 June 2005
... its specificity for N-acetylated substrates. Based on the comparison of the substrate binding site of WbpP with that of other C4 epimerases that convert preferentially non-acetylated substrates, or that are able to convert both acetylated and non-acetylated substrates equally well, specific residues...
Biochem J (2003) 376 (3): 645–653.
Published: 15 December 2003
...Steven C. KING; Liaoyuan A. HU; Amy PUGH The Escherichia coli GABA (γ-aminobutyric acid) permease GabP is a prototypical APC (amine/polyamine/choline) super-family transporter that has a CAR (consensus amphipathic region) containing multiple specificity determinants, ostensibly organized on two...
Biochem J (2000) 350 (2): 563–568.
Published: 23 August 2000
...Henning R. STENNICKE; Martin RENATUS; Morten MELDAL; Guy S. SALVESEN Subsite interactions are considered to define the stringent specificity of proteases for their natural substrates. To probe this issue in the proteolytic pathways leading to apoptosis we have examined the P 4 , P 1 and P 1...
Biochem J (2000) 350 (1): 321–328.
Published: 09 August 2000
... amino acids at the P 1 site, such as valine, alanine or phenylalanine. The K m and k cat of the enzyme decrease with decreasing temperature, though not to the same degree with all substrates, suggesting that specificity changes with temperature. The protease is markedly stabilized by Ca 2+ ions. At 70...