...Sanketa Raut; Anita V. Kumar; Kushaan Khambata; Sharvari Deshpande; Nafisa H. Balasinor Spermatogenesis occurs in the seminiferous epithelium that shows the presence of estrogen receptors alpha (ERα) and beta (ERβ), both of which regulate gene transcription by binding to the DNA. Estrogen...

... signaling, mitochondria and relevant pathways for the nutritional support of spermatogenesis. Leptin signaling dysfunction seems to be associated with obesity-related inflammation via ER stress, through activation of specific inflammatory signaling pathways. ER is responsible for the correct folding...

...C. Yan Cheng; Dolores D. Mruk Spermiogenesis in the mammalian testis is the most critical post-meiotic developmental event occurring during spermatogenesis in which haploid spermatids undergo extensive cellular, molecular and morphological changes to form spermatozoa. Spermatozoa are then released...

..., with the emphasis on the role of MTMs and MTMRs in spermatogenesis. We also describe a working model to explain how MTMR2 interacts with other proteins such as c-Src, dynamin 2, EPS8 (growth factor receptor pathway substrate 8) and ARP2/3 (actin-related protein 2/3) at the apical ES and the apical TBC (tubulobulbar...

..., and therefore are likely to be sites of mRNA degradation or storage. Pacman is shown to be required for normal Drosophila spermatogenesis, suggesting that control of mRNA stability is crucial in the testis differentiation pathway. 1 To whom correspondence should be addressed (email [email protected]...

... and cell polarity will be better illuminated. For now, we can add spermatogenesis to the list of physiological processes for which LKB1 is required in mammals, alongside suppression of tumorigenesis, control of cell polarity, and control of glucose metabolism. Work in the author's laboratory...

...Roberto R. Monarez; Clinton C. Macdonald; Brinda Dass CstF-64 (cleavage stimulation factor-64), a major regulatory protein of polyadenylation, is absent during male meiosis. Therefore a paralogous variant, τCstF-64 is expressed in male germ cells to maintain normal spermatogenesis. Based...

... and in the cyst cells that surround the elongating spermatid bundles in adult testis, suggesting roles for the peptidase in renal function and in spermatogenesis. D. melanogaster NEP2 was found in vesicle-like structures in the syncytial cytoplasm of the spermatid bundles, suggesting that the protein was acquired...

... crystallography inhibitor of apoptosis protein (IAP) spermatogenesis The gene family encoding IAP (inhibitor of apoptosis) proteins, originally found in baculoviruses, are present in organisms from viruses to yeast to humans [ 1 ]. Their characteristic protein motif is the BIR (baculovirus IAP repeat...

... ]. cAMP-response element modulator (CREM) seleno-protein sperm nuclei phospholipid hydroperoxide glutathione peroxidase (snPHGPx) spermatogenesis transcription factor During male germ-cell differentiation, important changes in gene expression occur. The genes specifically transcribed during...

... of juvenile rats, when Hst70 gene ex- pression is repressed, contain proteins that specifically bind to the Oct (octamer) sequence localized directly downstream of the T1 site. Key words: gene regulation, heat shock protein, Oct sequence, spermatogenesis, transcription start sites, transgenic mice...

... 26 7 2001 The Biochemical Society, London ©2001 2001 hsp70 spermatogenesis testis-specific transgenic mice Abbreviations used: CAT, chloramphenicol acetyltransferase; poly(A) + , polyadenylated; RT-PCR, reverse transcriptase-mediated PCR; UTR, untranslated region...

... transcripts. Both are developmentally regulated. A 2.2 kb transcript is strongly expressed in mature testis and is up-regulated with spermatogenesis. A 3 kb RNA is predominant in the embryo and is expressed primarily in the CNS during the neurogenic phase, decreasing after birth. In situ hybridization...