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Keywords: spliceosome
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Biochem J (2015) 469 (2): 223–233.
Published: 06 July 2015
... expressed and localized variously to the cytoplasm, nucleus or mitochondria. Surprisingly, all eight of the nuclear localized cyclophilins are found associated with spliceosomal complexes. However, their particular functions within this context are unknown. We have therefore adapted three established assays...
Biochem J (2012) 441 (2): 591–597.
Published: 21 December 2011
... by pull-down assay (Supplementary Figure S2). These results suggested that the ZnF domain indeed interacts with the RRM to form a stable structure in the absence of a connecting loop. RNA recognition motif nineteen complex (NTC) spliceosome structural biology zinc finger Intron removal...
Includes: Supplementary data
Biochem J (2010) 429 (1): 25–32.
Published: 14 June 2010
... cerevisiae Prp2. In the present study, we show that DHX16 is required for pre-mRNA splicing after the formation of a pre-catalytic spliceosome. We found that anti-DHX16 antiserum inhibited the splicing reaction in vitro and the antibody immunoprecipitated pre-mRNA, splicing intermediates and spliceosomal...
Includes: Supplementary data
Biochem J (2008) 416 (3): 365–374.
Published: 26 November 2008
... than 34 °C. In the present study we show that these stalled spliceosomes are compromised for an essential conformational switch that is triggered by Prp16 helicase. These results suggest a plausible mechanistic basis for the second-step arrest in prp17 Δ extracts and support a role for Prp17...
Includes: Supplementary data
Biochem J (2005) 388 (2): 593–603.
Published: 24 May 2005
... evolution. Therefore these results support the hypothesis that E3 ligases might generally be involved in substrate transport to the proteasome. Additionally, our results provide the first evidence for a physical link between components of the ubiquitin–proteasome system and the spliceosome. 1 To whom...
Biochem J (2004) 378 (1): 229–238.
Published: 15 February 2004
... of splicing factors. We have mapped a nuclear localization signal in the N-terminus of SIPP1, while the proline-rich C-terminal domain appeared to be required for its subnuclear targeting to the speckles. Finally, we found that SIPP1 is also a component of the spliceosomes and that a SIPP1-fragment inhibits...