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Keywords: stability
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Biochem J (2022) 479 (18): 1999–2011.
Published: 30 September 2022
... does not aggregate into amyloid fibrils in vivo or in vitro . We examined the hydrophobic residues responsible for the high-stability and low-aggregation properties of murine transthyretin using site-directed mutagenesis. Urea-induced unfolding and thioflavin T fluorescence aggregation assay revealed...
Includes: Supplementary data
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Biochem J (2014) 460 (1): 103–119.
Published: 25 April 2014
... been described, but interpretation is problematic because discrimination is lacking between the effect of global changes in native stability and specific effects on structural mechanism. We show that the temperature midpoint ( T m ) of thermal denaturation reflects the transition of α 1 -antitrypsin...
Includes: Supplementary data
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Biochem J (2012) 444 (2): 279–289.
Published: 11 May 2012
... compilation © 2012 Biochemical Society 2012 angiomotin (AMOT) degradation neural-precursorcell-expressed developmentally down-regulated 4 (Nedd4) stability ubiquitination Yes-associated protein (YAP) Protein ubiquitination has emerged as a fundamental mechanism for regulating the half lives...
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Biochem J (2012) 441 (1): 227–236.
Published: 14 December 2011
... in inactivation in various human cancers. RASSF1A is implicated in the regulation of apoptosis, microtubule stability and cell cycle arrest. However, little is known about the regulation and function of RASSF1C. In the present study we show that exogenously expressed RASSF1C is a very unstable protein...
Includes: Supplementary data
Articles
Biochem J (2008) 414 (2): 221–229.
Published: 12 August 2008
...-mediated ubiquitination and degradation. Therefore the present study reveals that the C-terminus of PTEN plays a critical role in stabilizing PTEN via antagonizing NEDD4-1-induced PTEN protein decay; conversely, truncation of the PTEN C-terminus results in rapid NEDD4-1-mediated PTEN degradation...
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Biochem J (2008) 409 (3): 691–699.
Published: 15 January 2008
...Paul Evans; Christine Slingsby; B. A. Wallace Age-related cataract is a result of crystallins, the predominant lens proteins, forming light-scattering aggregates. In the low protein turnover environment of the eye lens, the crystallins are susceptible to modifications that can reduce stability...
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Biochem J (2007) 402 (2): 331–337.
Published: 12 February 2007
... for the application of the Equilibrium Model to non-ideal enzyme reactions. enzyme activity Equilibrium Model kinetics stability thermal-dependence The effect of temperature on enzyme activity has been described by two well-established thermal parameters: the Arrhenius activation energy, which...
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Biochem J (2003) 374 (2): 529–535.
Published: 01 September 2003
... previously been characterized structurally. Its tertiary structure is similar to that of DHFR from E. coli but it is the only DHFR characterized so far that relies on dimerization for stability. The midpoint of the thermal unfolding of TmDHFR was at approx. 83 °C, which was 30 °C higher than the melting...
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Biochem J (2000) 346 (2): 375–384.
Published: 22 February 2000
... in the presence of Fe(II) and Zn(II) ions with properties identical to the native protein. Nevertheless the protein has lower stability than native Da FdIII during chromatography. The one-dimensional 600 MHz NMR spectrum of the apoprotein indicates an unstructured protein with random coil chemical shifts whereas...