...) irreversibly closed MAC. These compounds also blocked cytochrome c release and halted the onset of apoptotic markers normally induced by IL-3 (interleukin-3) deprivation or staurosporine. Our results reveal the tight link among MAC activity, cytochrome c release and apoptotic death, and indicate...

... [ 5 ]. aequorin apoptosis Bcl-2 Duchenne muscular dystrophy inositol 1,4,5-trisphosphate receptor staurosporine Long-term elevation of cytosolic Ca 2+ is linked to apoptosis [ 6 ] and mitochondrial Ca 2+ overload activates the PTP (permeability transition pore) leading to cell death...

... B103 cells, expression of wild-type human APP (hAPPwt), but not of FAD-mutant APP, inhibited staurosporine (STS)-induced apoptosis. This inhibition was further enhanced by expression of LSFwt, although LSFwt alone was not sufficient to inhibit STS-induced apoptosis. In contrast, expression of dominant...

..., indicating that spermine is dispensable for caspase activation. Spermine deficiency did not significantly influence caspase activity in cells treated with etoposide, cycloheximide or staurosporine, but sensitized the cells to UV irradiation, which triggered significantly higher caspase activity in Gy cells...

... on PKC, but that the extent to which PLD becomes activated depends largely, if not entirely, on the magnitude and duration of the agonist-induced increase in [Ca i . Key words: chelerythrine, phorbol ester, phospholipase D, staurosporine, thapsigargin. reaction [7]. To date, the physiological relevance...