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Keywords: steroid
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Articles
Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2015) 468 (1): 25–31.
Published: 05 May 2015
... and disordered sex development, found in 40% of patients of European ancestry is characterized by deficient flavin binding and impaired electron transfer from NADPH. adrenal hyperplasia cytochrome P450 molecular basis of disease mutation steroid Cytochrome P450 oxidoreductase (POR) is a 78 kDa...
Articles
Steroid-like signalling by interferons: making sense of specific gene activation by cytokines
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2012) 443 (2): 329–338.
Published: 27 March 2012
... in association with their respective ligands. EGFR and FGFR, like IFNGR1, have been shown to function as transcription/co-transcription factors. The RTKs also regulate other kinases that have epigenetic effects. Our IFNγ model, as well as the RTKs EGFR and FGFR, have similarities to that of steroid receptor...
Includes: Multimedia, Supplementary data
Articles
3-Keto-5α-steroid Δ 1 -dehydrogenase from Rhodococcus erythropolis SQ1 and its orthologue in Mycobacterium tuberculosis H37Rv are highly specific enzymes that function in cholesterol catabolism
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Journal:
Biochemical Journal
Biochem J (2008) 410 (2): 339–346.
Published: 12 February 2008
...Jan Knol; Karin Bodewits; Gerda I. Hessels; Lubbert Dijkhuizen; Robert van der Geize The Rhodococcus erythropolis SQ1 kstD3 gene was cloned, heterologously expressed and biochemically characterized as a KSTD3 (3-keto-5α-steroid Δ 1 -dehydrogenase). Upstream of kstD3 , an ORF (open reading frame...
Articles
Characterization of a sterol carrier protein 2/3-oxoacyl-CoA thiolase from the cotton leafworm ( Spodoptera littoralis ): a lepidopteran mechanism closer to that in mammals than that in dipterans
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Journal:
Biochemical Journal
Biochem J (2004) 382 (1): 93–100.
Published: 10 August 2004
... glands steroid Total RNA from various tissues was isolated using TRIzol® reagent (Invitrogen, Paisley, Renfrewshire, Scotland, U.K.). A 10 #x3BC;g portion of total RNA was fractionated on a formaldehyde/agarose gel, transferred to Electran® nylon membrane (Merck) and hybridized with a probe...
Articles
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)
Available to PurchaseNoam ZELCER, Glen REID, Peter WIELINGA, Annemieke KUIL, Ingrid van der HEIJDEN, John D. SCHUETZ, Piet BORST
Journal:
Biochemical Journal
Biochem J (2003) 371 (2): 361–367.
Published: 15 April 2003
... that Mrp4 is induced in the livers of Fxr (-/-) mice, which have increased levels of serum bile acids. Since MRP4, like MRP1–3, also mediates transport of a model steroid conjugate substrate, oestradiol 17-β- d -glucuronide (E 2 17βG), we tested whether MRP4 may be involved in the transport of steroid...
Articles
Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro
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Journal:
Biochemical Journal
Biochem J (2003) 370 (3): 763–769.
Published: 15 March 2003
...- differentiate into functional hepatocytes and that it could be possible to generate a limitless supply of functional hepatocyte- like cells in itro. Key words: cytochrome P450, liver, pancreas, stem cell, steroid. corticoid treatment [10]. More recently, they have suggested that B-13 cells expressCYP2B1}2...