..., energy metabolism and steroidogenesis. We also report how it is involved in neuroinflammation, brain injury and diseases of the nervous system. biomarker neuroinflammation neuropathology neuroprotection steroidogenesis translocator protein (TSPO) Discovered in 1977 as an alternative...

...Barbara Costa; Eleonora Da Pozzo; Claudia Martini Two interesting papers by Barren et al. and Owen et al. have been very recently published in Biochemical Journal , reporting the role of translocator protein (TSPO) in steroidogenesis. The involvement of TSPO in the steroid biosynthesis has been...

... in steroidogenesis has recently been challenged by the development of TSPO knockout (TSPO-KO) mice, as they exhibit normal baseline gonadal testosterone and adrenal corticosteroid production. Here, we demonstrate that despite normal androgen levels in young male TSPO-KO mice, TSPO deficiency alters steroidogenic...

... of steroidogenesis. Previously, we have found that SF-1 induces the differentiation of mesenchymal stem cells into steroidogenic cells. To elucidate the molecular mechanisms of SF-1-mediated functions, we attempted to identify protein components of the SF-1 nuclear protein complex in differentiated cells. SF-1...

... and Y-1 cells respectively. Finally, we demonstrated that PGC-1α induces SF-1 gene expression in both αT3-1 and Y-1 cells. Taken together, our findings reveal the potential role of PGC-1α and suggest that it may play important roles in steroidogenesis, gonad development and sex differentiation through...

... enzyme lend support to the notion that particular GSTs play an important role in steroidogenesis. 1 To whom correspondence should be addressed (email [email protected] ). 8 6 2010 29 7 2010 30 7 2010 30 7 2010 © The Authors Journal compilation © 2010...

... (PIAS) steroidogenesis steroid receptor co-activator-1 (SRC-1) SUMOylation The PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of proteins was initially identified as inhibitors of STAT [ 21 , 22 ]. Subsequently, PIAS proteins have been...

...Alireza Roostaee; Élie Barbar; Jean-Guy LeHoux; Pierre Lavigne Steroidogenesis depends on the delivery of cholesterol from the outer to the inner mitochondrial membrane by StAR (steroidogenic acute regulatory protein). However, the mechanism by which StAR binds to cholesterol and its importance...

... steroidogenesis transcription Biochem. J. (2000) 350, 785 790 (Printed in Great Britain) 785 Contribution of steroidogenic factor 1 to the regulation of cholesterol synthesis Cristina MASCARO! , Alicia NADAL, Fausto G. HEGARDT, Pedro F. MARRERO and Diego HARO1 Department of Biochemistry and Molecular Biology...