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Keywords: steroids
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Articles
Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male
Available to PurchaseIn Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2018) 475 (1): 75–85.
Published: 02 January 2018
...Anna M. Barron; Bin Ji; Seiji Kito; Tetsuya Suhara; Makoto Higuchi The translocator protein (TSPO) has been proposed to act as a key component in a complex important for mitochondrial cholesterol importation, which is the rate-limiting step in steroid hormone synthesis. However, TSPO function...
Articles
David R. Owen, Jinjiang Fan, Enrico Campioli, Sathvika Venugopal, Andrew Midzak, Edward Daly, Aline Harlay, Leeyah Issop, Vincenzo Libri, Dimitra Kalogiannopoulou, Eduardo Oliver, Enrique Gallego-Colon, Alessandro Colasanti, Les Huson, Eugenii A. Rabiner, Puvan Suppiah, Charles Essagian, Paul M. Matthews, Vassilios Papadopoulos
Journal:
Biochemical Journal
Biochem J (2017) 474 (23): 3985–3999.
Published: 21 November 2017
.... Matthews; Vassilios Papadopoulos The 18 kDa translocator protein (TSPO) is a ubiquitous conserved outer mitochondrial membrane protein implicated in numerous cell and tissue functions, including steroid hormone biosynthesis, respiration, cell proliferation, and apoptosis. TSPO binds with high affinity...
Includes: Supplementary data
Articles
TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (2): 107–121.
Published: 05 January 2016
... with high affinity synthetic and endogenous ligands, its core biochemical function resides in the translocation of cholesterol into the mitochondria influencing the subsequent steps of (neuro-)steroid synthesis and systemic endocrine regulation. Over the years, however, TSPO has also been linked to core...
