... on summarising the diversity within this superfamily. A key partition regards the identity of the phosphate donor, which can be ATP or inorganic pyrophosphate (PP i ). Considerable insights into functional and evolutionary aspects of the ATP- and PP i -dependent PFKs have come through structural biology, with 45...

... structural biology ubiquitin signalling Whereas PRT1 is restricted to the green lineage [ 76 ], PRT6 appears to be an orthologue of UBR1 and has a number of well characterised substrates. Despite having low sequence identity (∼15% pairwise identity) Arabidopsis PRT6 has a similar domain architecture...

..., leading to a vast interacting network of fibres within the biofilm matrix. Correspondence: Tanmay A.M. Bharat ( [email protected] ) bacteria biofilms extracellular matrix microbiology structural biology Biofilms are multicellular ordered communities of bacteria...

... metabolic disorders structural biology type 2 diabetes AMP-activated protein kinase (AMPK) is a conserved serine/threonine protein kinase that acts as a metabolic fuel sensor and is crucial for maintaining cellular energy homeostasis [ 1 , 2 ]. It is a heterotrimer composed of a catalytic α...

... microscopy imaging techniques structural biology Structure determination of biological macromolecules through single-particle analysis of cryo-EM images has recently reached a milestone by obtaining atomic resolution reconstructions [ 1 , 2 ]. With increasing resolutions, the applicability of cryo...

... under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . intrinsically disordered proteins multispecificity multivalency protein–protein interactions specificity structural biology Molecular communication is at the base of life, and to understand life, we need to understand...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 microbiota mucin mucinase O-glycosylation protease structural biology The human gastrointestinal tract harbors an astonishing number of microbial species, collectively called the gut microbiota...

... 2020 4 9 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cryo-EM origin recognition complex replication origin replicative helicase replisome structural biology Although the double helix structure of DNA is elegantly...

... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . co-operativity Mycobacterium tuberculosis regulation structural biology toxin-antitoxin system transcription...

... complexes that are enriched with IDPRs and, therefore, difficult for structural biology approaches [ 12 , 39 , 40 ]. Figure 1. Stoichiometry variations in 14-3-3 complexes. ( A ) Examples of 2 : 2, 1 : 2 : 1, and 2 : 1 stoichiometries observed in the co-crystal structures of 14-3-3 dimers...

... that Gremlin-1 does not inhibit BMP-2 by direct 1:1 binding, but possibly has a novel mechanism of sequestering BMP-2 into a larger oligomeric complex. bone morphogenetic protein (BMP) differential screening-aberrative in neuroblastoma (DAN) extracellular antagonism Gremlin structural biology...

... specificity protein–protein interaction Streptococcus pneumoniae structural biology The complement system is a major component of vertebrate innate immunity and one of the most important frontline defenders against microbial invaders [ 1 , 2 ]. Uncontrolled or inappropriate complement activation...

... of this is rapid advances in drug discovery approaches and technologies, with three major methods for antimalarial drug development emerging: (i) chemistry-based, (ii) target-based, and (iii) cell-based. Common to all three of these approaches is the unique ability of structural biology to inform and accelerate...

... respectively. 29 7 2011 27 9 2011 30 9 2011 30 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 1 These authors contributed equally to this work. RNA recognition motif nineteen complex (NTC) spliceosome structural biology zinc...

... (AMPAR) glutamate receptor ion channel N-terminal domain (ATD) structural biology iGluRs (ionotropic glutamate receptors) are ligand-gated ion channels that form transmembrane cation-permeable channels. iGluRs exist as three distinct sub-families according to their agonist specificity...

... 1 strand runs parallel to the subunits F strand instead of anti-parallel [ 38 ]. chaperone-usher protein secretion structural biology type IV secretion virulence factor Gram-negative bacteria have evolved several simple to complex machineries for transport of substrates across...