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Keywords: structure-based drug design
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Biochem J (2014) 460 (2): 211–222.
Published: 13 May 2014
... competition experiments, with K d values of 240 nM for the allosteric pocket and 8.2 μM for the ATP site ( Figure 1 B and Table 1 ). allosteric drug discovery inhibition mechanism interleukin-2-inducible T-cell kinase (ITK) kinase inhibitor structure-based drug design ITK (interleukin-2...
Includes: Supplementary data
Biochem J (2013) 454 (2): 191–200.
Published: 09 August 2013
... inhibitor structure-based drug design Antibiotic resistance is a serious global public health problem [ 1 ]. Resistance is an issue with all classes of currently used antibiotics, resulting in the emergence of pathogens untreatable using the available therapeutic arsenal. The genetic source of the...
Includes: Supplementary data