... The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cancer immunotherapy epigenetic regulation expression pattern melanoma antigen family B 18 (Mageb18) proliferation subcellular localization To date, more than 120 MAGE (melanoma antigen) genes and pseudogenes have...

... 2011 DNA-binding activity DNA methyltransferase DNA methylation subcellular localization DNA fragments, i.e. MMTV145, 601.2×2 (two tandem repeats of 601.2) and 5S(RR), were prepared as described previously [ 24 , 25 ]. Fully methylated, hemimethylated and unmethylated oligonucleotides...

... microscope. Bet3 chondrocyte misfolding sedlin spondyloepiphyseal dysplasia tarda (SEDT) subcellular localization transport protein particle (TRAPP) SEDT (spondyloepiphyseal dysplasia tarda) is a late-onset X-linked recessive osteochondrodysplasia with a prevalence estimated at ∼1.7...

...-protein photoreceptor subcellular localization In vertebrate photoreceptors, light-activated rhodopsin initiates a photoresponse by inducing the exchange of GDP for GTP on the α subunit of the heterotrimeric G-protein transducin (G αt ). GTP-bound G αt activates cGMP PDE6 (phosphodiesterase 6...

... pleckstrin homology domain (PH domain) polyphosphoinositide subcellular localization CerK (ceramide kinase) was identified recently by Sugiura et al. [ 1 ]. It is so far the only established enzyme that uses ceramide as a substrate to produce C1P (ceramide 1-phosphate). A CerK-like protein as well...

... of lysosomes obtained by centrifugation always contain contaminant membranes, we combined biochemical and morphological methods to analyse the subcellular localization of p40. The results of subcellular fractionation of mouse liver homogenates validate the lysosomal residence of p40. In particular, a density...

... or function, have not been determined. Here we have investigated the cellular control of the IP3KB localization and its functional consequences. We provide evidence for the limited proteolysis of IP3KB in cells, which produces domains with unique subcellular localizations, and we demonstrate an influence...

... with the control levels. This differs from findings with other human sialidases. Although the isoforms were not distinguishable with regard to substrate specificity, they exhibited differential subcellular localizations. Immunofluorescence microscopy and biochemical fractionation demonstrated that an exogenously...

... cells to assess directly the interaction between GBR subunits and determine their subcellular localization. The results show that, in addition to forming heterodimers, GBR1 and GBR2 can associate as stable homodimers. Confocal microscopy indicates that, while GBR1/GBR1 homodimers are retained...

... retention glycosylation intracellular targeting Nramp1 Slc11a1 subcellular localization Solute carrier family 11 member 1 (Slc11a1, formerly Nramp1) is an extensively glycosylated, integral membrane protein with 12 putative TMDs (transmembrane domains), which is highly conserved across species...

...-kinase B (IP3K-B) co-localizes with the cytoskeleton, as well as with the endoplasmic reticulum and the plasma membrane. The domains responsible for these subcellular localizations are not yet identified. For the endogenous enzyme, we confirmed both actin and endoplasmic reticulum localization...

... To whom correspondence should be addressed (e-mail [email protected] ). 17 11 2003 5 1 2004 20 1 2004 20 1 2004 The Biochemical Society, London ©2004 2004 β-catenin subcellular localization transcriptional activity Wnt signalling Abbreviations used...

... nuclear export signal in determining the subcellular localization of this enzyme. Finally, whole-mount in situ hybridization studies in mouse embryos reveal that the Pyst3 gene is expressed specifically in the placenta, developing liver and in migratory muscle cells. Our results suggest that this enzyme...

...), and in each case co-expression of the type I isoform with type IIα results in recruitment of the latter from the cytosol to the plasma membrane of the cell. This change in subcellular localization could result in improved access of the type IIα PIPkin to its lipid substrates. 1 To whom correspondence...

... the accession number AY046059. 25 7 2001 15 10 2001 12 11 2001 The Biochemical Society, London ©2002 2002 association in vivo subcellular localization substrate in vivo yeast two-hybrid screen Abbreviations used: GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GFP...

..., and are thought to play an important role in protein transport. In the present study, we wondered what effect increased biosynthetic cell activity with resulting high levels of protein transport would have on the subcellular localization of p24. We examined p24 localization in Xenopus intermediate pituitary...

...- plemented the CV2 cells at 42 °C. Subcellular and submito- chondrial fractionation analysis demonstrated that both AK3 and AK4 are localized in the mitochondrial matrix. Key words: cDNA cloning, Northern-blot analysis, subcellular localization, Western-blot analysis. AK is indispensable for the growth...

... 2001 The Biochemical Society, London ©2001 2001 cellular localization lysosome macrophage molecular cloning subcellular localization Abbreviations used: PHT, peptide/histidine transporter; r, rat; PepT, peptide transporter; PEPT, oligopeptide transporter; LAMP1, lysosome...

... correspondence should be addressed ( [email protected] ). 30 4 1999 27 7 1999 17 8 1999 The Biochemical Society, London © 1999 1999 anchoring protein postsynaptic density signal transduction subcellular localization Biochem. J. (1999) 343, 443 452 (Printed in Great Britain) 443...