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Keywords: substrate recognition
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Biochem J (2021) 478 (10): 1985–1997.
Published: 28 May 2021
...). Published by Portland Press Limited on behalf of the Biochemical Society 2021 base excision repair DNA glycosylase substrate recognition Guanine:thymine mispairs are the most abundant mismatches found in genomic DNA ( Figure 1 ) [ 1–3 ]. These mismatches are produced by various pathways...
Includes: Supplementary data
Biochem J (2021) 478 (9): 1749–1767.
Published: 10 May 2021
..., phosphatidic acid and 1-inositol phosphate. Comparisons of these structures with the wild-type SaPLD show a larger binding site able to accommodate a bulkier secondary alcohol substrate as well as changes to the position of a flexible surface loop proposed to be involved in substrate recognition. The complex...
Includes: Supplementary data
Biochem J (2019) 476 (21): 3197–3209.
Published: 05 November 2019
...-molecule inhibitors substrate recognition Fragile X syndrome (FXS) is a genetic disorder caused by a mutation in the Fragile X mental retardation 1 ( FMR1 ) gene [ 1 ]. Affected individuals show developmental delay and reduced intellectual abilities, often paired with autism, social anxiety and...
Includes: Supplementary data
Biochem J (2019) 476 (2): 211–223.
Published: 18 January 2019
... desuccinylation Sirt5 substrate recognition Sirtuin 5 (Sirt5) belongs to the sirtuin (yeast Sir2-like proteins) protein family, which includes nicotinamide adenine dinucleotide-dependent deacetylases that remove acetyl groups from protein lysine residues [ 1 , 2 ]. Sirtuins play crucial roles in the...
Includes: Supplementary data
Biochem J (2015) 467 (1): 103–113.
Published: 20 March 2015
... stabilization and molecular mechanism for substrate recognition of αTAT1 1 To whom correspondence should be addressed (email hsumi@med.kyushu-u.ac.jp ). Crystal structures of the αTAT domain of MEC-17 in complex with acetoacetyl-CoA at a resolution of 1.25 Å and in complex with CoA at resolutions of...
Biochem J (2014) 458 (2): 301–311.
Published: 14 February 2014
... suggest the decarboxylase activity is restricted to oxaloacetate as a substrate. decarboxylase mechanism enzyme evolution oxaloacetate analogue oxaloacetate decarboxylase pyruvate kinase substrate recognition 1 To whom correspondence should be addressed (email m.walkinshaw@ed.ac.uk...
Includes: Supplementary data
Biochem J (2009) 418 (3): 605–614.
Published: 25 February 2009
... β1,4-GalT7 fused with the maltose-binding protein to study substrate recognition. Calorimetric binding studies showed that the binding of the donor substrate UDP-Gal largely promoted binding of the acceptor substrate. To identify the structural basis governing substrate recognition, we used a fragment...
Includes: Supplementary data
Biochem J (2007) 401 (2): 597–605.
Published: 21 December 2006
... 37 °C for 30 min. The reaction was stopped by adding 10 μl of 3% SDS and 10 mM vanadate. cholesterol drug-binding pocket multidrug resistance substrate recognition MDR1 (multidrug resistance 1; ABCB1) is a plasma membrane-located glycoprotein that confers multidrug resistance on...
Biochem J (2003) 372 (1): 247–252.
Published: 15 May 2003
... Society, London ©2003 2003 chimaera glucose transporter saturation mutagenesis substrate recognition yeast Abbreviations used: MFS, major facilitator superfamily; TM, transmembrane segment. Biochem. J. (2003) 372, 247 252 (Printed in Great Britain) 247 Transmembrane segments 1, 5, 7...
Biochem J (2001) 354 (3): 501–509.
Published: 08 March 2001
...%. These structures provide important new insights into substrate recognition and ligand-induced conformational changes. Comparison of these structures with the structures of OTCase complexed with the bisubstrate analogue PALO or CP and L -norvaline reveals that binding of the first substrate, CP, induces...
Biochem J (2000) 346 (3): 679–690.
Published: 07 March 2000
...Julio J. CARAMELO; Jorge FLORÍN-CHRISTENSEN; Mónica FLORÍN-CHRISTENSEN; José M. DELFINO A set of radioiodinatable phosphatidylcholines (PCs) derivatized with the Bolton-Hunter reagent (BHPCs) was synthesized to probe the substrate recognition and activity of phospholipases. A common feature of this...