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Keywords: supercoil
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Articles
DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 412 (1): 57–63.
Published: 25 April 2008
... of topoisomers of plasmid DNA with and without p53 target sequences, differing in their internal symmetry. Binding of p53 to DNA increased with increasing negative superhelix density (−σ). At −σ≤0.03, the relative effect of DNA supercoiling on protein–DNA binding was similar for DNA containing both symmetrical...
