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Keyword: superoxide
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Articles
Biochem J (2018) 475 (21): 3451–3470.
Published: 09 November 2018
... pH 4.7 with peroxide (H 2 O 2 ), ‘superoxide’ (a ∼50 : 50 mixture of and ), hydroxyl radicals ( • OH, formed in Fenton mixtures), and illuminated riboflavin (generating singlet oxygen, 1 O 2 ). Products were monitored electrophoretically. DHA quenched H 2 O 2 far more effectively than superoxide, but...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (1): 139–146.
Published: 24 October 2013
... clusters to transfer electrons from the flavin to quinone and an eighth cluster (N1a) on the opposite side of the flavin. The role of cluster N1a is unknown, but Escherichia coli complex I has an unusually high-potential cluster N1a and its reduced flavin produces H 2 O 2 , not superoxide, suggesting that...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (3): 381–387.
Published: 13 July 2011
...Markus Schwarzländer; David C. Logan; Mark D. Fricker; Lee J. Sweetlove The properties of a cpYFP [circularly permuted YFP (yellow fluorescent protein)] reported to act as a superoxide sensor have been re-examined in Arabidopsis mitochondria. We have found that the probe has high pH sensitivity and...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2011) 436 (2): 493–505.
Published: 13 May 2011
...Philippe Pasdois; Joanne E. Parker; Elinor J. Griffiths; Andrew P. Halestrap Oxidized cytochrome c is a powerful superoxide scavenger within the mitochondrial IMS (intermembrane space), but the importance of this role in situ has not been well explored. In the present study, we investigated this...
Includes: Supplementary data
Articles
Biochem J (2010) 425 (1): 285–293.
Published: 14 December 2009
...Valdecir F. Ximenes; Ghassan J. Maghzal; Rufus Turner; Yoji Kato; Christine C. Winterbourn; Anthony J. Kettle During inflammatory events, neutrophils and platelets interact to release a variety of mediators. Neutrophils generate superoxide and hydrogen peroxide, and also discharge the haem enzyme...
Articles
Biochem J (2009) 422 (2): 373–382.
Published: 13 August 2009
...Kei Miyano; Hirofumi Koga; Reiko Minakami; Hideki Sumimoto Rac1 and Rac2, which belong to the Rho subfamily of Ras-related GTPases, play an essential role in activation of gp91 phox /Nox2 (cytochrome b -245, β polypeptide; also known as Cybb), the catalytic core of the superoxide-producing NADPH...
Articles
Biochem J (2009) 421 (1): 79–86.
Published: 12 June 2009
... models of inflammatory disease. They are believed to exert protective effects principally by acting as superoxide dismutase mimetics or radical scavengers. However, we show here that nitroxides can also potently inhibit MPO-mediated HOCl production, with the nitroxide 4-aminoTEMPO inhibiting HOCl...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (3): 773–781.
Published: 16 January 2009
... acids they produced. Addition of SOD (superoxide dismutase) doubled the amount of HOBr detected. Therefore we investigated the reaction of superoxide radicals with a range of bromamines and bromamides and found that superoxide radicals stimulated the decomposition of these species, with this occurring...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (1): 1–13.
Published: 12 December 2008
...Michael P. Murphy The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. Superoxide (O 2 •− ) is the proximal...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 415 (1): 57–65.
Published: 12 September 2008
... Rac1. NADPH-specific superoxide generating activity was reduced by 80% in the presence of either a flavoenzyme inhibitor DPI (diphenyleneiodonium) or NADP + . The plasma membranes from PMA-stimulated cells showed an increased amount of Rac1 (19.6 pmol/mg), as compared with the membranes from...
Articles
Biochem J (2008) 409 (2): 491–499.
Published: 21 December 2007
...Florian L. Muller; Yuhong Liu; Muhammad A. Abdul-Ghani; Michael S. Lustgarten; Arunabh Bhattacharya; Youngmok C. Jang; Holly Van Remmen Despite the considerable interest in superoxide as a potential cause of pathology, the mechanisms of its deleterious production by mitochondria remain poorly...
Articles
Biochem J (2007) 406 (1): 105–114.
Published: 26 July 2007
... type of ROS released from NOX4-expressing cells was H 2 O 2 , whereas superoxide (O 2 − ) was almost undetectable. Probes that allow detection of intracellular O 2 − generation yielded differential results: DHE (dihydroethidium) fluorescence and ACP (1-acetoxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine...
Articles
Biochem J (2005) 389 (2): 315–323.
Published: 05 July 2005
... synthase peroxynitrite superoxide Degradation of articular cartilage is a common pathogenic change seen in the degenerative joint diseases, such as RA (rheumatoid arthritis) and OA (osteoarthritis). It is known that IL-1 (interleukin-1) plays pivotal roles in the pathogenesis of OA as well as RA...
Articles
Biochem J (2004) 381 (1): 175–184.
Published: 22 June 2004
...Martin D. REES; Clare L. HAWKINS; Michael J. DAVIES Activated phagocytes release the haem enzyme MPO (myeloperoxidase) and also generate superoxide radicals (O 2 •− ), and hence H 2 O 2 , via an oxidative burst. Reaction of MPO with H 2 O 2 in the presence of chloride ions generates HOCl (the...
Articles
Biochem J (2004) 381 (1): 241–248.
Published: 22 June 2004
...Christine C. WINTERBOURN; Helena N. PARSONS-MAIR; Silvia GEBICKI; Janusz M. GEBICKI; Michael J. DAVIES Superoxide reacts rapidly with other radicals, but these reactions have received little attention in the context of oxidative stress. For tyrosyl radicals, reaction with superoxide is 3-fold...
Articles
Biochem J (2003) 375 (1): 215–220.
Published: 01 October 2003
..., and the inhibition was only partial at medium light intensity (50–200 μmol photons·m −2 ·s −1 ). The photoreduction was not significantly influenced by superoxide dismutase. The conclusion that cyt c could be reduced directly by the plastoquinone pool was confirmed by the observation that plastoquinol...
Articles
Biochem J (2002) 368 (2): 597–603.
Published: 01 December 2002
... The Biochemical Society, London ©2002 2002 peroxidation protein oxidation proton leak reactive oxygen species superoxide Abbreviations used: AASA, aminoadipic semialdehyde; CEL, N ∊ -(carboxyethyl)lysine; CML, N ∊ -(carboxymethyl)lysine; d4-AASA, [ 2 H 4 ]AASA; d4-CEL, [ 2 H 4...
Articles
Biochem J (2002) 368 (2): 545–553.
Published: 01 December 2002
... superoxide Abbreviations used: FCCP, p -trifluoromethoxyphenylhydrazone carbonyl cyanide; β-HOB, d -β-hydroxybutyrate; ROS, reactive oxygen species; ∗ROS site, site of superoxide generation. Biochem. J. (2002) 368, 545 553 (Printed in Great Britain) 545 Complex I-mediated reactive oxygen...
Articles
Biochem J (2002) 362 (2): 253–258.
Published: 22 February 2002
... whom correspondence should be addressed (e-mail bssdrb@bath.ac.uk ). 11 9 2001 12 11 2001 12 12 2001 The Biochemical Society, London ©2002 2002 copper manganese neurodegeneration scrapie superoxide Abbreviations used: BCA, bicinchoninic acid; NBT, Nitro Blue...
Articles
Biochem J (2002) 361 (1): 49–56.
Published: 17 December 2001
... uncoupled than empty-vector controls, particularly at concentrations that were 7-fold physiological. However, uncoupling by UCP3 was not stimulated by the known activators palmitate and superoxide; neither were they inhibited by GDP, suggesting that the observed uncoupling was a property of non-native...
Articles
Biochem J (2001) 358 (2): 315–324.
Published: 24 August 2001
... in the ability of gp91 phox to function as an H + pathway and in the binding of haem and FAD. We have investigated the ability of DEPC to inhibit H + flux and superoxide generation by human neutrophils. Proton flux through the NADPH oxidase-associated H + channel was inhibited by DEPC only if applied...
Articles
Biochem J (2001) 357 (1): 233–240.
Published: 25 June 2001
... homocysteine-treated monocytes. Further investigation revealed that the levels of superoxide were significantly elevated in cells incubated with homocysteine for 12–48h. The addition of superoxide dismutase, a scavenger of superoxide, to the culture medium abolished the stimulatory effect of homocysteine on...
Articles
Biochem J (2000) 349 (1): 113–117.
Published: 26 June 2000
... © 2000 2000 host defence oxygen radicals p47 phox respiratory burst superoxide Biochem. J. (2000) 349, 113 117 (Printed in Great Britain) 113 p40phox participates in the activation of NADPH oxidase by increasing the affinity of p47phox for flavocytochrome b558 Andrew R. CROSS Department...
Articles
Biochem J (2000) 349 (1): 369–375.
Published: 26 June 2000
... cytoskeleton F-actin magnesium ion phagocytosis superoxide Biochem. J. (2000) 349, 369 375 (Printed in Great Britain) 369 Deactivation of neutrophil NADPH oxidase by actin-depolymerizing agents in a cell-free system Minoru TAMURA1, Masamichi KANNO and Yaeta ENDO Department of Applied Biochemistry...
Articles
Biochem J (2000) 347 (2): 475–484.
Published: 10 April 2000
...Antonius C. F. GORREN; Astrid SCHRAMMEL; Christoph RIETHMÜLLER; Kurt SCHMIDT; Doris KOESLING; Ernst R. WERNER; Bernd MAYER Nitric oxide synthase (NOS) catalysis results in formation of NO or superoxide (O 2 -− ) depending on the presence or absence of the cofactor tetrahydrobiopterin (BH4). In the...
Articles
Biochem J (2000) 345 (2): 195–200.
Published: 10 January 2000
... effect of activation was sensitive to the antioxidant enzymes superoxide dismutase and catalase. When ascorbate was oxidized in situ by chemical or enzymic oxidation, the rates of uptake were similar to those after activation of the cells by phorbol ester; however, in the latter case the extracellular...
Articles
Biochem J (1999) 341 (2): 251–255.
Published: 08 July 1999
...Andrew R. CROSS; Richard W. ERICKSON; John T. CURNUTTE It is commonly assumed that activation of the superoxide-generating NADPH oxidase requires the formation of a stable complex between flavocytochrome b -245 (the gp91 phox /p22 phox heterodimer) and the cytosolic cofactors p47 phox , p67 phox...
Articles
Biochem J (1999) 340 (3): 657–669.
Published: 08 June 1999
... The Biochemical Society, London © 1999 1999 calcium nitric oxide peroxynitrite superoxide thiol modification Biochem. J. (1999) 340, 657 669 (Printed in Great Britain) 657 Protein modification during biological aging : selective tyrosine nitration of the SERCA2a isoform of the...
Articles
Biochem J (1999) 338 (2): 359–366.
Published: 22 February 1999
... Society, London © 1999 1999 NADPH oxidase phosphorylation Phox proteins superoxide Biochem. J. (1999) 338, 359 366 (Printed in Great Britain) 359 Characterization and partial purification of a novel neutrophil membrane- associated kinase capable of phosphorylating the respiratory burst...