... acids within the body into target cells following intravenous injection. Great hopes are pinned especially on therapy of metastatic and malignant cancers and blood diseases. Correspondence: Ondrej Slaby ( [email protected] ) or Richard Laga ( [email protected] ) © 2017 The Author(s...

... signalling axis to be capable of influencing growth, invasion, metastasis and even the therapeutic response of breast cancer. autotaxin breast cancer lysophosphatidic acid metastasis therapy Breast cancer is the most common malignancy among women worldwide, with an estimated 1.7 million...

... ]. Using a simple sequence-alignment statistics procedure, we have improved the stability, function and crystallization of a protein with biomedical interest. Thus this approach could have wide applications in gene- and enzyme-replacement therapies and in structural biology. inherited disease...

...Larissa S. Moniz; Bart Vanhaesebroeck The success of targeted therapies in treating cancer over the last decade has been tempered by acquired drug resistance that follows long-term treatment. There is also emerging evidence for innate mechanisms of cancer cell resistance to targeted therapy...

... will probably vary between cancer types and subtypes [ 1 ]. cancer fibroblast growth factor (FGF) fibroblast growth factor receptor (FGFR) receptor tyrosine kinase signalling therapy Cancers may be hereditary or sporadic depending on whether the tumour-causing mutations occur in the germline...