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Keywords: thioredoxin
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Articles
Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in chloroplasts
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2019) 476 (12): 1781–1790.
Published: 26 June 2019
...Keisuke Yoshida; Eriko Uchikoshi; Satoshi Hara; Toru Hisabori Thiol-based redox regulation is crucial for adjusting chloroplast functions under fluctuating light environments. We recently discovered that the thioredoxin-like2 (TrxL2)/2-Cys peroxiredoxin (2CP) redox cascade supports oxidative thiol...
Includes: Supplementary data
Articles
Metabolic regulation of photosynthetic membrane structure tunes electron transfer function
Available to PurchaseIn Collection
Awards
Journal:
Biochemical Journal
Biochem J (2018) 475 (7): 1225–1233.
Published: 05 April 2018
... (LET and CET), which determines the ratio of NADPH/ATP produced. The STN7 kinase responds to the metabolic state of the chloroplast by sensing the stromal redox state. A high NADPH/ATP ratio leads to reduction of thioredoxin f (TRX f), which reduces a CxxxC motif in the stromal domain of STN7 leading...
Articles
Thioredoxin regulates G6PDH activity by changing redox states of OpcA in the nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120
Available to PurchaseShoko Mihara, Hitomi Wakao, Keisuke Yoshida, Akiyoshi Higo, Kazunori Sugiura, Akihiro Tsuchiya, Jiro Nomata, Ken-ichi Wakabayashi, Toru Hisabori
Journal:
Biochemical Journal
Biochem J (2018) 475 (6): 1091–1105.
Published: 20 March 2018
... not conserve the critical cysteines for regulation. Based on the thorough analyses of the redox regulation mechanisms of G6PDH from Anabaena 7120 and its activator protein OpcA, we found that m -type thioredoxin regulates G6PDH activity by changing the redox states of OpcA. Mass spectrometric analysis...
Includes: Supplementary data
Articles
Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast
Available to PurchaseDong Keun Rhee, Jung Chae Lim, Steven C. Hockman, Faiyaz Ahmad, Dong Ho Woo, Youn Wook Chung, Shiwei Liu, Allison L. Hockman, Vincent C. Manganiello
Journal:
Biochemical Journal
Biochem J (2016) 473 (22): 4205–4225.
Published: 10 November 2016
... in yeast expressing K13R hPDE3A ( Oxi dative stress S ensitive 1, OxiS1), compared with yeast expressing WT hPDE3A ( Oxi dative stress R esistant 1, OxiR1). In OxiR1, YAP1 and YAP1 -dependent antioxidant genes were up-regulated, accompanied by a reduction in thioredoxin peroxidase. In OxiS1, expression...
Includes: Supplementary data
Articles
Engineering ancestral protein hyperstability
Available to PurchaseM. Luisa Romero-Romero, Valeria A. Risso, Sergio Martinez-Rodriguez, Beatriz Ibarra-Molero, Jose M. Sanchez-Ruiz
Journal:
Biochemical Journal
Biochem J (2016) 473 (20): 3611–3620.
Published: 11 October 2016
... evolution does not imply continuous progression, screening of the mutations between two evolutionarily related resurrected ancestral proteins may identify mutations that further stabilize the most stable one. To explore this approach, we have used a resurrected thioredoxin corresponding to the last common...
Articles
Neutral sphingomyelinase-2 is a redox sensitive enzyme: role of catalytic cysteine residues in regulation of enzymatic activity through changes in oligomeric state
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Journal:
Biochemical Journal
Biochem J (2015) 465 (3): 371–382.
Published: 22 January 2015
.... Alternatively, nSMase-2 expression in a bacterial strain that lacks endogenous thioredoxin, Rosetta-gami2, results in increased oligomer formation and lower enzyme activity. Phenotypic rescue was accomplished by treating nSMase-2 lysates with recombinant human thioredoxin. This indicates that nSMase-2 may...
Includes: Supplementary data
Articles
Redox regulation of chloroplastic G6PDH activity by thioredoxin occurs through structural changes modifying substrate accessibility and cofactor binding
Available to PurchaseGuillaume Née, Magali Aumont-Nicaise, Mirko Zaffagnini, Sylvie Nessler, Marielle Valerio-Lepiniec, Emmanuelle Issakidis-Bourguet
Journal:
Biochemical Journal
Biochem J (2014) 457 (1): 117–125.
Published: 10 December 2013
...Guillaume Née; Magali Aumont-Nicaise; Mirko Zaffagnini; Sylvie Nessler; Marielle Valerio-Lepiniec; Emmanuelle Issakidis-Bourguet In chloroplasts, redox regulation of enzyme activities by TRXs (thioredoxins) allows the co-ordination of light/dark metabolisms such as the reductive (so-called Calvin...
Includes: Supplementary data
Articles
The biological roles of glutaredoxins
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Journal:
Biochemical Journal
Biochem J (2012) 446 (3): 333–348.
Published: 28 August 2012
... ). deglutathiolation glutaredoxin glutathione iron–sulfur cluster oxidative stress thioredoxin The cellular redox balance is essential for the regulation of protein activity under normal conditions. However, it becomes even more important under stress conditions when cellular reductants are limiting...
Includes: Supplementary data
Articles
Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism
Available to PurchaseRyuta Tobe, Min-Hyuk Yoo, Noelia Fradejas, Bradley A. Carlson, Soledad Calvo, Vadim N. Gladyshev, Dolph L. Hatfield
Journal:
Biochemical Journal
Biochem J (2012) 445 (3): 423–430.
Published: 13 July 2012
... toxicity than normal cells. Since selenite treatment leads to oxidative stress, and the Trx (thioredoxin) system is a major antioxidative system, we examined the interplay between TR1 (Trx reductase 1) and Trx1 deficiencies and selenite toxicity in DT cells, a malignant mouse cell line...
Includes: Supplementary data
Articles
Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide
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Journal:
Biochemical Journal
Biochem J (2011) 439 (3): 479–485.
Published: 13 October 2011
... 3MP (3-mercaptopyruvate). Although a reducing substance is required for an intermediate persulfide at the active site of 3MST to release H 2 S, the substance has not been identified. In the present study we show that Trx (thioredoxin) and DHLA (dihydrolipoic acid) associate with 3MST to release H 2 S...
Articles
Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis
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Journal:
Biochemical Journal
Biochem J (2011) 436 (1): 123–132.
Published: 27 April 2011
... the mGSH (mitochondrial glutathione) system, using the enzymes mGPx-1 (mitochondrial glutathione peroxidase-1), GRD (glutathione reductase) and mGSH, or the TRX-2 (thioredoxin-2) system, which uses the enzymes PRX-3 (peroxiredoxin-3) and TRX-2R (thioredoxin reductase-2) and TRX-2. In the present paper we...
Includes: Supplementary data
Articles
The PedR transcriptional regulator interacts with thioredoxin to connect photosynthesis with gene expression in cyanobacteria
Available to PurchaseMayumi Horiuchi, Kinu Nakamura, Kouji Kojima, Yoshitaka Nishiyama, Wakako Hatakeyama, Toru Hisabori, Yukako Hihara
Journal:
Biochemical Journal
Biochem J (2010) 431 (1): 135–140.
Published: 14 September 2010
... to a change in the environment. In the present study we show that the small LuxR-type regulator PedR interacts with Trx (thioredoxin) to achieve photosynthetic electron-transport-dependent transcriptional regulation in the cyanobacterium Synechocystis sp. PCC 6803. TrxM, an isoform of Trx, was isolated...
Includes: Supplementary data
Articles
Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets
Available to PurchaseAnton A. Turanov, Sebastian Kehr, Stefano M. Marino, Min-Hyuk Yoo, Bradley A. Carlson, Dolph L. Hatfield, Vadim N. Gladyshev
Journal:
Biochemical Journal
Biochem J (2010) 430 (2): 285–293.
Published: 13 August 2010
...Anton A. Turanov; Sebastian Kehr; Stefano M. Marino; Min-Hyuk Yoo; Bradley A. Carlson; Dolph L. Hatfield; Vadim N. Gladyshev The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation. Three TRs have been...
Includes: Supplementary data
Articles
Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling
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Journal:
Biochemical Journal
Biochem J (2010) 425 (2): 313–325.
Published: 23 December 2009
... 2009 10 11 2009 13 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 hydrogen peroxide mitochondria peroxiredoxin redox signalling thiol thioredoxin Prxs (peroxiredoxins) are a family of thiol peroxidases that scavenge peroxides in cells...
Articles
A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4
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Journal:
Biochemical Journal
Biochem J (2010) 425 (1): 195–208.
Published: 14 December 2009
... that the previously uncharacterized PDI family member TMX4 (thioredoxin-like transmembrane 4) is an N-glycosylated type I membrane protein that localizes to the ER. We also demonstrate that TMX4 contains a single ER-luminal thioredoxin-like domain, which, in contrast with similar domains in other PDIs, is mainly...
Includes: Supplementary data
Articles
Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species
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Journal:
Biochemical Journal
Biochem J (2009) 424 (3): 491–500.
Published: 10 December 2009
... cultured in medium with extracellular Cys/CySS redox potentials ( E h ), ranging from 0 to −150 mV. Cellular and mitochondrial ROS production significantly increased in cells incubated under more oxidizing extracellular conditions (0 and −46 mV). Trx2 (thioredoxin-2) is a mitochondrial-specific...
Articles
Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-κB modulates glucocorticoid receptor and NF-κB signalling in HEK-293 cells
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Journal:
Biochemical Journal
Biochem J (2009) 422 (3): 521–531.
Published: 27 August 2009
...Anna-Maria G. Psarra; Stefan Hermann; George Panayotou; Giannis Spyrou Trx2 (mitochondrial thioredoxin) is an antioxidant and anti-apoptotic factor essential for cell viability. Trx1 (cytoplasmic thioredoxin) is a co-factor and regulator of redox-sensitive transcription factors such as the GR...
Articles
Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress
Available to PurchaseYoshihito Iuchi, Futoshi Okada, Satoshi Tsunoda, Noriko Kibe, Nobuyuki Shirasawa, Masahito Ikawa, Masaru Okabe, Yoshitaka Ikeda, Junichi Fujii
Journal:
Biochemical Journal
Biochem J (2009) 419 (1): 149–158.
Published: 13 March 2009
...Yoshihito Iuchi; Futoshi Okada; Satoshi Tsunoda; Noriko Kibe; Nobuyuki Shirasawa; Masahito Ikawa; Masaru Okabe; Yoshitaka Ikeda; Junichi Fujii Prx (peroxiredoxin) is a multifunctional redox protein with thioredoxin-dependent peroxidase activity. Prx4 is present as a secretory protein in most...
Articles
A requirement for thioredoxin in redox-sensitive modulation of T-cadherin expression in endothelial cells
Available to PurchaseManjunath B. Joshi, Danila Ivanov, Maria Philippova, Emmanouil Kyriakakis, Paul Erne, Thérèse J. Resink
Journal:
Biochemical Journal
Biochem J (2008) 416 (2): 271–280.
Published: 12 November 2008
... of the nucleoprotein complex unique to −156 to −203 bp after streptavidin–agarose pull-down detected the presence of the redox-active protein thioredoxin. The presence of thioredoxin-1 in a nuclear extract from oxidatively stressed ECs was demonstrated after immunoprecipitation and immunoblotting. Transfection of ECs...
Includes: Supplementary data
Articles
The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant
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Journal:
Biochemical Journal
Biochem J (2008) 412 (1): 73–80.
Published: 25 April 2008
.... Analysis of the distribution of Tsa1 in thioredoxin system mutants revealed that the ribosome-associated form of Tsa1 is increased in mutants lacking thioredoxin reductase ( trr1 ) and thioredoxins ( trx1 trx2 ) in parallel with the general increase in total Tsa1 levels which is observed in these mutants...
Articles
Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes
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Journal:
Biochemical Journal
Biochem J (2007) 402 (1): 43–49.
Published: 25 January 2007
...Marcelo A. Comini; R. Luise Krauth-Siegel; Leopold Flohé In trypanosomes, the thioredoxin-type protein TXN (tryparedoxin) is a multi-purpose oxidoreductase that is involved in the detoxification of hydroperoxides, the synthesis of DNA precursors and the replication of the kinetoplastid DNA. African...
Includes: Supplementary data
Articles
Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies
Available to PurchaseKausik Chakraborty, Venuka Durani, Edward Roshan Miranda, Michael Citron, Xiaoping Liang, William Schleif, Joseph G. Joyce, Raghavan Varadarajan
Journal:
Biochemical Journal
Biochem J (2006) 399 (3): 483–491.
Published: 13 October 2006
... competent to generate 447-52D-like antibodies, the known epitope of 447-52D was inserted at three different surface loop locations in the small, stable protein Escherichia coli Trx (thioredoxin). At one of the three locations (between residues 74 and 75), the insertion was tolerated, the resulting protein...
Articles
The tert-butylhydroquinone-mediated activation of the human thioredoxin gene reveals a novel promoter structure
Available to PurchaseSimone A. Osborne, Hye-Jin Kim Hawkes, Ben L. Baldwin, Kylie A. Alexander, Terje Svingen, Frank M. Clarke, Kathryn F. Tonissen
Journal:
Biochemical Journal
Biochem J (2006) 398 (2): 269–277.
Published: 15 August 2006
...Simone A. Osborne; Hye-Jin Kim Hawkes; Ben L. Baldwin; Kylie A. Alexander; Terje Svingen; Frank M. Clarke; Kathryn F. Tonissen Thioredoxin is a redox-active protein that plays multiple roles in regulating cell growth, cell signalling and apoptosis. Here, we have demonstrated that a complex...
Articles
Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells
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Journal:
Biochemical Journal
Biochem J (2006) 394 (1): 207–216.
Published: 27 January 2006
...Wendy L. Trigona; Isis K. Mullarky; Yuzhang Cao; Lorraine M. Sordillo Certain selenoproteins such as GPX-1 (glutathione peroxidase-1) and TrxR1 (thioredoxin reductase-1) possess important antioxidant defence functions in vascular endothelial cells. Reduced selenoprotein activity during dietary...
Articles
Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells
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Journal:
Biochemical Journal
Biochem J (2005) 389 (3): 785–795.
Published: 26 July 2005
.... At 20 μM H 2 O 2 , changes were fewer, but GAPDH and peroxiredoxin 2 were still modified. Dinitrochlorobenzene treatment, which inhibited cellular thioredoxin reductase and partially depleted GSH, caused reversible oxidation of several proteins, including thioredoxin 1 and peroxiredoxins 1 and 2. Most...
Articles
Absolute transcript levels of thioredoxin- and glutathione-dependent redox systems in Saccharomyces cerevisiae : response to stress and modulation with growth
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Journal:
Biochemical Journal
Biochem J (2004) 383 (1): 139–147.
Published: 24 September 2004
... of 16 genes coding for thioredoxin- and glutathione-dependent redox system components. Quantifications were performed to examine the response to oxidants, to sudden temperature upshifts and in association with metabolic changes accompanying culture growth and to explore the contribution of mRNA decay...
Articles
Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1
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Journal:
Biochemical Journal
Biochem J (2003) 373 (3): 845–853.
Published: 01 August 2003
...Jae J. SONG; Yong J. LEE Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation. Glucose deprivation disrupted the interaction between TRX/GRX and ASK1 and subsequently activated the ASK1–stress...
Articles
Emilia PEDONE, Simonetta BARTOLUCCI, Mosè ROSSI, Francesco Maria PIERFEDERICI, Andrea SCIRÈ, Tiziana CACCIAMANI, Fabio TANFANI
Journal:
Biochemical Journal
Biochem J (2003) 373 (3): 875–883.
Published: 01 August 2003
...Emilia PEDONE; Simonetta BARTOLUCCI; Mosè ROSSI; Francesco Maria PIERFEDERICI; Andrea SCIRÈ; Tiziana CACCIAMANI; Fabio TANFANI The structure of thioredoxin from Alicyclobacillus acidocaldarius (previously named Bacillus acidocaldarius ) (BacTrx) and from Escherichia coli ( E. coli Trx) was studied...
Articles
Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity
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Journal:
Biochemical Journal
Biochem J (2001) 354 (1): 209–215.
Published: 08 February 2001
..., for completing its enzymic cycle. 1 To whom correspondence should be addressed (e-mail [email protected] ). 14 9 2000 7 11 2000 1 12 2000 The Biochemical Society, London © 2001 2001 decamer DTT oxidation mycothiol peroxidase thioredoxin Biochem. J. (2001) 354...
Articles
Inverse regulation of F1-ATPase activity by a mutation at the regulatory region on the γ subunit of chloroplast ATP synthase
Available to PurchaseHiroki KONNO, Masahide YODOGAWA, Michael T. STUMPP, Peter KROTH, Heinrich STROTMANN, Ken MOTOHASHI, Toyoki AMANO, Toru HISABORI
Journal:
Biochemical Journal
Biochem J (2000) 352 (3): 783–788.
Published: 08 December 2000
... charged residues Glu 210 -Asp-Glu 212 close to the two cysteine residues and also on the following region from Leu 213 to Ile 230 , and investigated the modulation of ATPase activity by chloroplast thioredoxins. The mutant γ subunits were reconstituted with the α and β subunits from F 1...
Articles
The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein
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Journal:
Biochemical Journal
Biochem J (2000) 352 (2): 583–591.
Published: 24 November 2000
... family. Thioredoxin is involved in this redox control. DNA binding and transactivating capacity of NF-κB are up-regulated by inducible phosphorylation. Here we demonstrate that the conserved redox cysteine in the c-Rel protein is involved in the phosphorylation regulation of the protein. When...
Articles
HIV-2 protease is inactivated after oxidation at the dimer interface and activity can be partly restored with methionine sulphoxide reductase
Available to PurchaseDavid A. DAVIS, Fonda M. NEWCOMB, Jackob MOSKOVITZ, Paul T. WINGFIELD, Stephen J. STAHL, Joshua KAUFMAN, Henry M. FALES, Rodney L. LEVINE, Robert YARCHOAN
Journal:
Biochemical Journal
Biochem J (2000) 346 (2): 305–311.
Published: 22 February 2000
...). 13 9 1999 8 11 1999 8 12 1999 The Biochemical Society, London © 2000 2000 polyprotein processing redox regulation retroviruses thioredoxin viral maturation Biochem. J. (2000) 346, 305 311 (Printed in Great Britain) 305 HIV-2 protease is inactivated after oxidation...
Articles
The protein disulphide-isomerase family: unravelling a string of folds
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Journal:
Biochemical Journal
Biochem J (1999) 339 (1): 1–10.
Published: 25 March 1999
... or more domains of roughly 95–110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing and one domain lacking a redox-active -Cys-Xaa-Xaa-Cys- tetrapeptide. In addition to their known...