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Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in chloroplasts

Keisuke Yoshida, Eriko Uchikoshi, Satoshi Hara, Toru Hisabori

Biochem J (2019) 476 (12): 1781–1790.

https://doi.org/10.1042/BCJ20190336

Published: 26 June 2019

...Keisuke Yoshida; Eriko Uchikoshi; Satoshi Hara; Toru Hisabori Thiol-based redox regulation is crucial for adjusting chloroplast functions under fluctuating light environments. We recently discovered that the thioredoxin-like2 (TrxL2)/2-Cys peroxiredoxin (2CP) redox cascade supports oxidative thiol...

View article titled, Thioredoxin-like2/2-Cys peroxiredoxin redox cascade acts as oxidative activator of glucose-6-phosphate dehydrogenase in chloroplasts

Includes: Supplementary data

Articles

Metabolic regulation of photosynthetic membrane structure tunes electron transfer function

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Awards

Matthew P. Johnson

Biochem J (2018) 475 (7): 1225–1233.

https://doi.org/10.1042/BCJ20170526

Published: 05 April 2018

... (LET and CET), which determines the ratio of NADPH/ATP produced. The STN7 kinase responds to the metabolic state of the chloroplast by sensing the stromal redox state. A high NADPH/ATP ratio leads to reduction of thioredoxin f (TRX f), which reduces a CxxxC motif in the stromal domain of STN7 leading...

View article titled, Metabolic regulation of photosynthetic membrane structure tunes electron transfer function

Articles

Thioredoxin regulates G6PDH activity by changing redox states of OpcA in the nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120

Shoko Mihara, Hitomi Wakao, Keisuke Yoshida, Akiyoshi Higo, Kazunori Sugiura, Akihiro Tsuchiya, Jiro Nomata, Ken-ichi Wakabayashi, Toru Hisabori

Biochem J (2018) 475 (6): 1091–1105.

https://doi.org/10.1042/BCJ20170869

Published: 20 March 2018

... not conserve the critical cysteines for regulation. Based on the thorough analyses of the redox regulation mechanisms of G6PDH from Anabaena 7120 and its activator protein OpcA, we found that m -type thioredoxin regulates G6PDH activity by changing the redox states of OpcA. Mass spectrometric analysis...

View article titled, Thioredoxin regulates G6PDH activity by changing redox states of OpcA in the nitrogen-fixing cyanobacterium Anabaena sp. PCC 7120

Includes: Supplementary data

Articles

Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast

Dong Keun Rhee, Jung Chae Lim, Steven C. Hockman, Faiyaz Ahmad, Dong Ho Woo, Youn Wook Chung, Shiwei Liu, Allison L. Hockman, Vincent C. Manganiello

Biochem J (2016) 473 (22): 4205–4225.

https://doi.org/10.1042/BCJ20160572

Published: 10 November 2016

... in yeast expressing K13R hPDE3A ( Oxi dative stress S ensitive 1, OxiS1), compared with yeast expressing WT hPDE3A ( Oxi dative stress R esistant 1, OxiR1). In OxiR1, YAP1 and YAP1 -dependent antioxidant genes were up-regulated, accompanied by a reduction in thioredoxin peroxidase. In OxiS1, expression...

View article titled, Effects of heterologous expression of human cyclic nucleotide phosphodiesterase 3A (hPDE3A) on redox regulation in yeast

Includes: Supplementary data

Articles

Engineering ancestral protein hyperstability

M. Luisa Romero-Romero, Valeria A. Risso, Sergio Martinez-Rodriguez, Beatriz Ibarra-Molero, Jose M. Sanchez-Ruiz

Biochem J (2016) 473 (20): 3611–3620.

https://doi.org/10.1042/BCJ20160532

Published: 11 October 2016

... evolution does not imply continuous progression, screening of the mutations between two evolutionarily related resurrected ancestral proteins may identify mutations that further stabilize the most stable one. To explore this approach, we have used a resurrected thioredoxin corresponding to the last common...

View article titled, Engineering ancestral protein hyperstability

Articles

Neutral sphingomyelinase-2 is a redox sensitive enzyme: role of catalytic cysteine residues in regulation of enzymatic activity through changes in oligomeric state

P. Patrick Dotson, II, Alexander A. Karakashian, Mariana N. Nikolova-Karakashian

Biochem J (2015) 465 (3): 371–382.

https://doi.org/10.1042/BJ20140665

Published: 22 January 2015

.... Alternatively, nSMase-2 expression in a bacterial strain that lacks endogenous thioredoxin, Rosetta-gami2, results in increased oligomer formation and lower enzyme activity. Phenotypic rescue was accomplished by treating nSMase-2 lysates with recombinant human thioredoxin. This indicates that nSMase-2 may...

View article titled, Neutral sphingomyelinase-2 is a redox sensitive enzyme: role of catalytic cysteine residues in regulation of enzymatic activity through changes in oligomeric state

Includes: Supplementary data

Articles

Redox regulation of chloroplastic G6PDH activity by thioredoxin occurs through structural changes modifying substrate accessibility and cofactor binding

Guillaume Née, Magali Aumont-Nicaise, Mirko Zaffagnini, Sylvie Nessler, Marielle Valerio-Lepiniec, Emmanuelle Issakidis-Bourguet

Biochem J (2014) 457 (1): 117–125.

https://doi.org/10.1042/BJ20130337

Published: 10 December 2013

...Guillaume Née; Magali Aumont-Nicaise; Mirko Zaffagnini; Sylvie Nessler; Marielle Valerio-Lepiniec; Emmanuelle Issakidis-Bourguet In chloroplasts, redox regulation of enzyme activities by TRXs (thioredoxins) allows the co-ordination of light/dark metabolisms such as the reductive (so-called Calvin...

View article titled, Redox regulation of chloroplastic G6PDH activity by thioredoxin occurs through structural changes modifying substrate accessibility and cofactor binding

Includes: Supplementary data

Articles

The biological roles of glutaredoxins

Elke Ströher, A. Harvey Millar

Biochem J (2012) 446 (3): 333–348.

https://doi.org/10.1042/BJ20112131

Published: 28 August 2012

... ). deglutathiolation glutaredoxin glutathione iron–sulfur cluster oxidative stress thioredoxin The cellular redox balance is essential for the regulation of protein activity under normal conditions. However, it becomes even more important under stress conditions when cellular reductants are limiting...

View article titled, The biological roles of glutaredoxins

Includes: Supplementary data

Articles

Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism

Ryuta Tobe, Min-Hyuk Yoo, Noelia Fradejas, Bradley A. Carlson, Soledad Calvo, Vadim N. Gladyshev, Dolph L. Hatfield

Biochem J (2012) 445 (3): 423–430.

https://doi.org/10.1042/BJ20120618

Published: 13 July 2012

... toxicity than normal cells. Since selenite treatment leads to oxidative stress, and the Trx (thioredoxin) system is a major antioxidative system, we examined the interplay between TR1 (Trx reductase 1) and Trx1 deficiencies and selenite toxicity in DT cells, a malignant mouse cell line...

View article titled, Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism

Includes: Supplementary data

Articles

Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide

Yoshinori Mikami, Norihiro Shibuya, Yuka Kimura, Noriyuki Nagahara, Yuki Ogasawara, Hideo Kimura

Biochem J (2011) 439 (3): 479–485.

https://doi.org/10.1042/BJ20110841

Published: 13 October 2011

... 3MP (3-mercaptopyruvate). Although a reducing substance is required for an intermediate persulfide at the active site of 3MST to release H 2 S, the substance has not been identified. In the present study we show that Trx (thioredoxin) and DHLA (dihydrolipoic acid) associate with 3MST to release H 2 S...

View article titled, Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide

Articles

Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis

Damon A. Lowes, Helen F. Galley

Biochem J (2011) 436 (1): 123–132.

https://doi.org/10.1042/BJ20102135

Published: 27 April 2011

... the mGSH (mitochondrial glutathione) system, using the enzymes mGPx-1 (mitochondrial glutathione peroxidase-1), GRD (glutathione reductase) and mGSH, or the TRX-2 (thioredoxin-2) system, which uses the enzymes PRX-3 (peroxiredoxin-3) and TRX-2R (thioredoxin reductase-2) and TRX-2. In the present paper we...

View article titled, Mitochondrial protection by the thioredoxin-2 and glutathione systems in an in vitro endothelial model of sepsis

Includes: Supplementary data

Articles

The PedR transcriptional regulator interacts with thioredoxin to connect photosynthesis with gene expression in cyanobacteria

Mayumi Horiuchi, Kinu Nakamura, Kouji Kojima, Yoshitaka Nishiyama, Wakako Hatakeyama, Toru Hisabori, Yukako Hihara

Biochem J (2010) 431 (1): 135–140.

https://doi.org/10.1042/BJ20100789

Published: 14 September 2010

... to a change in the environment. In the present study we show that the small LuxR-type regulator PedR interacts with Trx (thioredoxin) to achieve photosynthetic electron-transport-dependent transcriptional regulation in the cyanobacterium Synechocystis sp. PCC 6803. TrxM, an isoform of Trx, was isolated...

View article titled, The PedR transcriptional regulator interacts with thioredoxin to connect photosynthesis with gene expression in cyanobacteria

Includes: Supplementary data

Articles

Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets

Anton A. Turanov, Sebastian Kehr, Stefano M. Marino, Min-Hyuk Yoo, Bradley A. Carlson, Dolph L. Hatfield, Vadim N. Gladyshev

Biochem J (2010) 430 (2): 285–293.

https://doi.org/10.1042/BJ20091378

Published: 13 August 2010

...Anton A. Turanov; Sebastian Kehr; Stefano M. Marino; Min-Hyuk Yoo; Bradley A. Carlson; Dolph L. Hatfield; Vadim N. Gladyshev The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation. Three TRs have been...

View article titled, Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets

Includes: Supplementary data

Articles

Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

Andrew G. Cox, Christine C. Winterbourn, Mark B. Hampton

Biochem J (2010) 425 (2): 313–325.

https://doi.org/10.1042/BJ20091541

Published: 23 December 2009

... 2009 10 11 2009 13 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 hydrogen peroxide mitochondria peroxiredoxin redox signalling thiol thioredoxin Prxs (peroxiredoxins) are a family of thiol peroxidases that scavenge peroxides in cells...

View article titled, Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling

Articles

A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

Doris Roth, Emily Lynes, Jan Riemer, Henning G. Hansen, Nils Althaus, Thomas Simmen, Lars Ellgaard

Biochem J (2010) 425 (1): 195–208.

https://doi.org/10.1042/BJ20091064

Published: 14 December 2009

... that the previously uncharacterized PDI family member TMX4 (thioredoxin-like transmembrane 4) is an N-glycosylated type I membrane protein that localizes to the ER. We also demonstrate that TMX4 contains a single ER-luminal thioredoxin-like domain, which, in contrast with similar domains in other PDIs, is mainly...

View article titled, A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

Includes: Supplementary data

Articles

Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species

Barry R. Imhoff, Jason M. Hansen

Biochem J (2009) 424 (3): 491–500.

https://doi.org/10.1042/BJ20091286

Published: 10 December 2009

... cultured in medium with extracellular Cys/CySS redox potentials ( E h ), ranging from 0 to −150 mV. Cellular and mitochondrial ROS production significantly increased in cells incubated under more oxidizing extracellular conditions (0 and −46 mV). Trx2 (thioredoxin-2) is a mitochondrial-specific...

View article titled, Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species

Articles

Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-κB modulates glucocorticoid receptor and NF-κB signalling in HEK-293 cells

Anna-Maria G. Psarra, Stefan Hermann, George Panayotou, Giannis Spyrou

Biochem J (2009) 422 (3): 521–531.

https://doi.org/10.1042/BJ20090107

Published: 27 August 2009

...Anna-Maria G. Psarra; Stefan Hermann; George Panayotou; Giannis Spyrou Trx2 (mitochondrial thioredoxin) is an antioxidant and anti-apoptotic factor essential for cell viability. Trx1 (cytoplasmic thioredoxin) is a co-factor and regulator of redox-sensitive transcription factors such as the GR...

View article titled, Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-κB modulates glucocorticoid receptor and NF-κB signalling in HEK-293 cells

Articles

Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress

Yoshihito Iuchi, Futoshi Okada, Satoshi Tsunoda, Noriko Kibe, Nobuyuki Shirasawa, Masahito Ikawa, Masaru Okabe, Yoshitaka Ikeda, Junichi Fujii

Biochem J (2009) 419 (1): 149–158.

https://doi.org/10.1042/BJ20081526

Published: 13 March 2009

...Yoshihito Iuchi; Futoshi Okada; Satoshi Tsunoda; Noriko Kibe; Nobuyuki Shirasawa; Masahito Ikawa; Masaru Okabe; Yoshitaka Ikeda; Junichi Fujii Prx (peroxiredoxin) is a multifunctional redox protein with thioredoxin-dependent peroxidase activity. Prx4 is present as a secretory protein in most...

View article titled, Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress

Articles

A requirement for thioredoxin in redox-sensitive modulation of T-cadherin expression in endothelial cells

Manjunath B. Joshi, Danila Ivanov, Maria Philippova, Emmanouil Kyriakakis, Paul Erne, Thérèse J. Resink

Biochem J (2008) 416 (2): 271–280.

https://doi.org/10.1042/BJ20080765

Published: 12 November 2008

... of the nucleoprotein complex unique to −156 to −203 bp after streptavidin–agarose pull-down detected the presence of the redox-active protein thioredoxin. The presence of thioredoxin-1 in a nuclear extract from oxidatively stressed ECs was demonstrated after immunoprecipitation and immunoblotting. Transfection of ECs...

View article titled, A requirement for thioredoxin in redox-sensitive modulation of T-cadherin expression in endothelial cells

Includes: Supplementary data

Articles

The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant

Eleanor W. Trotter, Jonathan D. Rand, Jill Vickerstaff, Chris M. Grant

Biochem J (2008) 412 (1): 73–80.

https://doi.org/10.1042/BJ20071634

Published: 25 April 2008

.... Analysis of the distribution of Tsa1 in thioredoxin system mutants revealed that the ribosome-associated form of Tsa1 is increased in mutants lacking thioredoxin reductase ( trr1 ) and thioredoxins ( trx1 trx2 ) in parallel with the general increase in total Tsa1 levels which is observed in these mutants...

View article titled, The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant

Articles

Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

Marcelo A. Comini, R. Luise Krauth-Siegel, Leopold Flohé

Biochem J (2007) 402 (1): 43–49.

https://doi.org/10.1042/BJ20061341

Published: 25 January 2007

...Marcelo A. Comini; R. Luise Krauth-Siegel; Leopold Flohé In trypanosomes, the thioredoxin-type protein TXN (tryparedoxin) is a multi-purpose oxidoreductase that is involved in the detoxification of hydroperoxides, the synthesis of DNA precursors and the replication of the kinetoplastid DNA. African...

View article titled, Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

Includes: Supplementary data

Articles

Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies

Kausik Chakraborty, Venuka Durani, Edward Roshan Miranda, Michael Citron, Xiaoping Liang, William Schleif, Joseph G. Joyce, Raghavan Varadarajan

Biochem J (2006) 399 (3): 483–491.

https://doi.org/10.1042/BJ20060588

Published: 13 October 2006

... competent to generate 447-52D-like antibodies, the known epitope of 447-52D was inserted at three different surface loop locations in the small, stable protein Escherichia coli Trx (thioredoxin). At one of the three locations (between residues 74 and 75), the insertion was tolerated, the resulting protein...

View article titled, Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies

Articles

The tert-butylhydroquinone-mediated activation of the human thioredoxin gene reveals a novel promoter structure

Simone A. Osborne, Hye-Jin Kim Hawkes, Ben L. Baldwin, Kylie A. Alexander, Terje Svingen, Frank M. Clarke, Kathryn F. Tonissen

Biochem J (2006) 398 (2): 269–277.

https://doi.org/10.1042/BJ20060076

Published: 15 August 2006

...Simone A. Osborne; Hye-Jin Kim Hawkes; Ben L. Baldwin; Kylie A. Alexander; Terje Svingen; Frank M. Clarke; Kathryn F. Tonissen Thioredoxin is a redox-active protein that plays multiple roles in regulating cell growth, cell signalling and apoptosis. Here, we have demonstrated that a complex...

View article titled, The tert-butylhydroquinone-mediated activation of the human thioredoxin gene reveals a novel promoter structure

Articles

Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells

Wendy L. Trigona, Isis K. Mullarky, Yuzhang Cao, Lorraine M. Sordillo

Biochem J (2006) 394 (1): 207–216.

https://doi.org/10.1042/BJ20050712

Published: 27 January 2006

...Wendy L. Trigona; Isis K. Mullarky; Yuzhang Cao; Lorraine M. Sordillo Certain selenoproteins such as GPX-1 (glutathione peroxidase-1) and TrxR1 (thioredoxin reductase-1) possess important antioxidant defence functions in vascular endothelial cells. Reduced selenoprotein activity during dietary...

View article titled, Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells

Articles

Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells

James W. Baty, Mark B. Hampton, Christine C. Winterbourn

Biochem J (2005) 389 (3): 785–795.

https://doi.org/10.1042/BJ20050337

Published: 26 July 2005

.... At 20 μM H 2 O 2 , changes were fewer, but GAPDH and peroxiredoxin 2 were still modified. Dinitrochlorobenzene treatment, which inhibited cellular thioredoxin reductase and partially depleted GSH, caused reversible oxidation of several proteins, including thioredoxin 1 and peroxiredoxins 1 and 2. Most...

View article titled, Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells

Articles

Absolute transcript levels of thioredoxin- and glutathione-dependent redox systems in Saccharomyces cerevisiae : response to stress and modulation with growth

Fernando MONJE-CASAS, Carmen MICHÁN, Carmen PUEYO

Biochem J (2004) 383 (1): 139–147.

https://doi.org/10.1042/BJ20040851

Published: 24 September 2004

... of 16 genes coding for thioredoxin- and glutathione-dependent redox system components. Quantifications were performed to examine the response to oxidants, to sudden temperature upshifts and in association with metabolic changes accompanying culture growth and to explore the contribution of mRNA decay...

View article titled, Absolute transcript levels of thioredoxin- and glutathione-dependent redox systems in Saccharomyces cerevisiae : response to stress and modulation with growth

Articles

Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1

Jae J. SONG, Yong J. LEE

Biochem J (2003) 373 (3): 845–853.

https://doi.org/10.1042/bj20030275

Published: 01 August 2003

...Jae J. SONG; Yong J. LEE Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation. Glucose deprivation disrupted the interaction between TRX/GRX and ASK1 and subsequently activated the ASK1–stress...

View article titled, Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1

Articles

Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study

Emilia PEDONE, Simonetta BARTOLUCCI, Mosè ROSSI, Francesco Maria PIERFEDERICI, Andrea SCIRÈ, Tiziana CACCIAMANI, Fabio TANFANI

Biochem J (2003) 373 (3): 875–883.

https://doi.org/10.1042/bj20021747

Published: 01 August 2003

...Emilia PEDONE; Simonetta BARTOLUCCI; Mosè ROSSI; Francesco Maria PIERFEDERICI; Andrea SCIRÈ; Tiziana CACCIAMANI; Fabio TANFANI The structure of thioredoxin from Alicyclobacillus acidocaldarius (previously named Bacillus acidocaldarius ) (BacTrx) and from Escherichia coli ( E. coli Trx) was studied...

View article titled, Structural and thermal stability analysis of Escherichia coli and Alicyclobacillus acidocaldarius thioredoxin revealed a molten globule-like state in thermal denaturation pathway of the proteins: an infrared spectroscopic study

Articles

Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity

Radha CHAUHAN, Shekhar C. MANDE

Biochem J (2001) 354 (1): 209–215.

https://doi.org/10.1042/bj3540209

Published: 08 February 2001

..., for completing its enzymic cycle. 1 To whom correspondence should be addressed (e-mail [email protected] ). 14 9 2000 7 11 2000 1 12 2000 The Biochemical Society, London © 2001 2001 decamer DTT oxidation mycothiol peroxidase thioredoxin Biochem. J. (2001) 354...

View article titled, Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity

Articles

Inverse regulation of F1-ATPase activity by a mutation at the regulatory region on the γ subunit of chloroplast ATP synthase

Hiroki KONNO, Masahide YODOGAWA, Michael T. STUMPP, Peter KROTH, Heinrich STROTMANN, Ken MOTOHASHI, Toyoki AMANO, Toru HISABORI

Biochem J (2000) 352 (3): 783–788.

https://doi.org/10.1042/bj3520783

Published: 08 December 2000

... charged residues Glu 210 -Asp-Glu 212 close to the two cysteine residues and also on the following region from Leu 213 to Ile 230 , and investigated the modulation of ATPase activity by chloroplast thioredoxins. The mutant γ subunits were reconstituted with the α and β subunits from F 1...

View article titled, Inverse regulation of F1-ATPase activity by a mutation at the regulatory region on the γ subunit of chloroplast ATP synthase

Articles

The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein

Corine GLINEUR, Elisabeth DAVIOUD-CHARVET, Bernard VANDENBUNDER

Biochem J (2000) 352 (2): 583–591.

https://doi.org/10.1042/bj3520583

Published: 24 November 2000

... family. Thioredoxin is involved in this redox control. DNA binding and transactivating capacity of NF-κB are up-regulated by inducible phosphorylation. Here we demonstrate that the conserved redox cysteine in the c-Rel protein is involved in the phosphorylation regulation of the protein. When...

View article titled, The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein

Articles

HIV-2 protease is inactivated after oxidation at the dimer interface and activity can be partly restored with methionine sulphoxide reductase

David A. DAVIS, Fonda M. NEWCOMB, Jackob MOSKOVITZ, Paul T. WINGFIELD, Stephen J. STAHL, Joshua KAUFMAN, Henry M. FALES, Rodney L. LEVINE, Robert YARCHOAN

Biochem J (2000) 346 (2): 305–311.

https://doi.org/10.1042/bj3460305

Published: 22 February 2000

...). 13 9 1999 8 11 1999 8 12 1999 The Biochemical Society, London © 2000 2000 polyprotein processing redox regulation retroviruses thioredoxin viral maturation Biochem. J. (2000) 346, 305 311 (Printed in Great Britain) 305 HIV-2 protease is inactivated after oxidation...

View article titled, HIV-2 protease is inactivated after oxidation at the dimer interface and activity can be partly restored with methionine sulphoxide reductase

Articles

The protein disulphide-isomerase family: unravelling a string of folds

David M. FERRARI, Hans-Dieter SÖLING

Biochem J (1999) 339 (1): 1–10.

https://doi.org/10.1042/bj3390001

Published: 25 March 1999

... or more domains of roughly 95–110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing and one domain lacking a redox-active -Cys-Xaa-Xaa-Cys- tetrapeptide. In addition to their known...

View article titled, The protein disulphide-isomerase family: unravelling a string of folds

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