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Keywords: thioredoxin
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Biochem J (2018) 475 (7): 1225–1233.
Published: 05 April 2018
... (LET and CET), which determines the ratio of NADPH/ATP produced. The STN7 kinase responds to the metabolic state of the chloroplast by sensing the stromal redox state. A high NADPH/ATP ratio leads to reduction of thioredoxin f (TRX f ), which reduces a CxxxC motif in the stromal domain of STN7 leading...
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Biochem J (2016) 473 (22): 4205–4225.
Published: 10 November 2016
... in yeast expressing K13R hPDE3A ( Oxi dative stress S ensitive 1, OxiS1), compared with yeast expressing WT hPDE3A ( Oxi dative stress R esistant 1, OxiR1). In OxiR1, YAP1 and YAP1 -dependent antioxidant genes were up-regulated, accompanied by a reduction in thioredoxin peroxidase. In OxiS1, expression...
Includes: Supplementary data
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Biochem J (2016) 473 (20): 3611–3620.
Published: 11 October 2016
... evolution does not imply continuous progression, screening of the mutations between two evolutionarily related resurrected ancestral proteins may identify mutations that further stabilize the most stable one. To explore this approach, we have used a resurrected thioredoxin corresponding to the last common...
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Biochem J (2012) 446 (3): 333–348.
Published: 28 August 2012
... (glyceraldehyde-3-phosphate dehydrogenase) [ 5 – 7 ]. 9 12 2011 28 6 2012 29 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 deglutathiolation glutaredoxin glutathione iron–sulfur cluster oxidative stress thioredoxin The cellular redox balance...
Includes: Supplementary data
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Biochem J (2011) 436 (1): 123–132.
Published: 27 April 2011
... the mGSH (mitochondrial glutathione) system, using the enzymes mGPx-1 (mitochondrial glutathione peroxidase-1), GRD (glutathione reductase) and mGSH, or the TRX-2 (thioredoxin-2) system, which uses the enzymes PRX-3 (peroxiredoxin-3) and TRX-2R (thioredoxin reductase-2) and TRX-2. In the present paper we...
Includes: Supplementary data
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Biochem J (2010) 430 (2): 285–293.
Published: 13 August 2010
...Anton A. Turanov; Sebastian Kehr; Stefano M. Marino; Min-Hyuk Yoo; Bradley A. Carlson; Dolph L. Hatfield; Vadim N. Gladyshev The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation. Three TRs have been...
Includes: Supplementary data
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Biochem J (2010) 425 (2): 313–325.
Published: 23 December 2009
[email protected] ). 6 10 2009 10 11 2009 13 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 hydrogen peroxide mitochondria peroxiredoxin redox signalling thiol thioredoxin Prxs are unique among the peroxidases in their utilization of cysteine...
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Biochem J (2010) 425 (1): 195–208.
Published: 14 December 2009
... that the previously uncharacterized PDI family member TMX4 (thioredoxin-like transmembrane 4) is an N-glycosylated type I membrane protein that localizes to the ER. We also demonstrate that TMX4 contains a single ER-luminal thioredoxin-like domain, which, in contrast with similar domains in other PDIs, is mainly...
Includes: Supplementary data
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Biochem J (2009) 424 (3): 491–500.
Published: 10 December 2009
... cultured in medium with extracellular Cys/CySS redox potentials ( E h ), ranging from 0 to −150 mV. Cellular and mitochondrial ROS production significantly increased in cells incubated under more oxidizing extracellular conditions (0 and −46 mV). Trx2 (thioredoxin-2) is a mitochondrial-specific...
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Biochem J (2009) 419 (1): 149–158.
Published: 13 March 2009
...Yoshihito Iuchi; Futoshi Okada; Satoshi Tsunoda; Noriko Kibe; Nobuyuki Shirasawa; Masahito Ikawa; Masaru Okabe; Yoshitaka Ikeda; Junichi Fujii Prx (peroxiredoxin) is a multifunctional redox protein with thioredoxin-dependent peroxidase activity. Prx4 is present as a secretory protein in most...
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Biochem J (2008) 416 (2): 271–280.
Published: 12 November 2008
... of the nucleoprotein complex unique to −156 to −203 bp after streptavidin–agarose pull-down detected the presence of the redox-active protein thioredoxin. The presence of thioredoxin-1 in a nuclear extract from oxidatively stressed ECs was demonstrated after immunoprecipitation and immunoblotting. Transfection of ECs...
Includes: Supplementary data
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Biochem J (2008) 412 (1): 73–80.
Published: 25 April 2008
.... Analysis of the distribution of Tsa1 in thioredoxin system mutants revealed that the ribosome-associated form of Tsa1 is increased in mutants lacking thioredoxin reductase ( trr1 ) and thioredoxins ( trx1 trx2 ) in parallel with the general increase in total Tsa1 levels which is observed in these mutants...
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Biochem J (2007) 402 (1): 43–49.
Published: 25 January 2007
...Marcelo A. Comini; R. Luise Krauth-Siegel; Leopold Flohé In trypanosomes, the thioredoxin-type protein TXN (tryparedoxin) is a multi-purpose oxidoreductase that is involved in the detoxification of hydroperoxides, the synthesis of DNA precursors and the replication of the kinetoplastid DNA. African...
Includes: Supplementary data
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Biochem J (2006) 394 (1): 207–216.
Published: 27 January 2006
...Wendy L. Trigona; Isis K. Mullarky; Yuzhang Cao; Lorraine M. Sordillo Certain selenoproteins such as GPX-1 (glutathione peroxidase-1) and TrxR1 (thioredoxin reductase-1) possess important antioxidant defence functions in vascular endothelial cells. Reduced selenoprotein activity during dietary...
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Biochem J (2005) 389 (3): 785–795.
Published: 26 July 2005
.... At 20 μM H 2 O 2 , changes were fewer, but GAPDH and peroxiredoxin 2 were still modified. Dinitrochlorobenzene treatment, which inhibited cellular thioredoxin reductase and partially depleted GSH, caused reversible oxidation of several proteins, including thioredoxin 1 and peroxiredoxins 1 and 2. Most...
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Biochem J (1999) 339 (1): 1–10.
Published: 25 March 1999
... or more domains of roughly 95–110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing and one domain lacking a redox-active -Cys-Xaa-Xaa-Cys- tetrapeptide. In addition to their known...