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Keywords: thioredoxin
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Articles
Biochem J (2019) 476 (12): 1781–1790.
Published: 26 June 2019
...Keisuke Yoshida; Eriko Uchikoshi; Satoshi Hara; Toru Hisabori Thiol-based redox regulation is crucial for adjusting chloroplast functions under fluctuating light environments. We recently discovered that the thioredoxin-like2 (TrxL2)/2-Cys peroxiredoxin (2CP) redox cascade supports oxidative thiol...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (7): 1225–1233.
Published: 05 April 2018
... (LET and CET), which determines the ratio of NADPH/ATP produced. The STN7 kinase responds to the metabolic state of the chloroplast by sensing the stromal redox state. A high NADPH/ATP ratio leads to reduction of thioredoxin f (TRX f ), which reduces a CxxxC motif in the stromal domain of STN7 leading...
Articles
Biochem J (2018) 475 (6): 1091–1105.
Published: 20 March 2018
... not conserve the critical cysteines for regulation. Based on the thorough analyses of the redox regulation mechanisms of G6PDH from Anabaena 7120 and its activator protein OpcA, we found that m -type thioredoxin regulates G6PDH activity by changing the redox states of OpcA. Mass spectrometric analysis...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (22): 4205–4225.
Published: 10 November 2016
... in yeast expressing K13R hPDE3A ( Oxi dative stress S ensitive 1, OxiS1), compared with yeast expressing WT hPDE3A ( Oxi dative stress R esistant 1, OxiR1). In OxiR1, YAP1 and YAP1 -dependent antioxidant genes were up-regulated, accompanied by a reduction in thioredoxin peroxidase. In OxiS1, expression...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (20): 3611–3620.
Published: 11 October 2016
... evolution does not imply continuous progression, screening of the mutations between two evolutionarily related resurrected ancestral proteins may identify mutations that further stabilize the most stable one. To explore this approach, we have used a resurrected thioredoxin corresponding to the last common...
Articles
Biochem J (2015) 465 (3): 371–382.
Published: 22 January 2015
.... Alternatively, nSMase-2 expression in a bacterial strain that lacks endogenous thioredoxin, Rosetta-gami2, results in increased oligomer formation and lower enzyme activity. Phenotypic rescue was accomplished by treating nSMase-2 lysates with recombinant human thioredoxin. This indicates that nSMase-2 may...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (1): 117–125.
Published: 10 December 2013
...Guillaume Née; Magali Aumont-Nicaise; Mirko Zaffagnini; Sylvie Nessler; Marielle Valerio-Lepiniec; Emmanuelle Issakidis-Bourguet In chloroplasts, redox regulation of enzyme activities by TRXs (thioredoxins) allows the co-ordination of light/dark metabolisms such as the reductive (so-called Calvin...
Includes: Supplementary data
Articles
Biochem J (2012) 446 (3): 333–348.
Published: 28 August 2012
... 12 2011 28 6 2012 29 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 deglutathiolation glutaredoxin glutathione iron–sulfur cluster oxidative stress thioredoxin The cellular redox balance is essential for the regulation of protein activity...
Includes: Supplementary data
Articles
Biochem J (2012) 445 (3): 423–430.
Published: 13 July 2012
... toxicity than normal cells. Since selenite treatment leads to oxidative stress, and the Trx (thioredoxin) system is a major antioxidative system, we examined the interplay between TR1 (Trx reductase 1) and Trx1 deficiencies and selenite toxicity in DT cells, a malignant mouse cell line...
Includes: Supplementary data
Articles
Biochem J (2011) 439 (3): 479–485.
Published: 13 October 2011
... 3MP (3-mercaptopyruvate). Although a reducing substance is required for an intermediate persulfide at the active site of 3MST to release H 2 S, the substance has not been identified. In the present study we show that Trx (thioredoxin) and DHLA (dihydrolipoic acid) associate with 3MST to release H 2 S...
Articles
Biochem J (2011) 436 (1): 123–132.
Published: 27 April 2011
... the mGSH (mitochondrial glutathione) system, using the enzymes mGPx-1 (mitochondrial glutathione peroxidase-1), GRD (glutathione reductase) and mGSH, or the TRX-2 (thioredoxin-2) system, which uses the enzymes PRX-3 (peroxiredoxin-3) and TRX-2R (thioredoxin reductase-2) and TRX-2. In the present paper we...
Includes: Supplementary data
Articles
Biochem J (2010) 431 (1): 135–140.
Published: 14 September 2010
... to a change in the environment. In the present study we show that the small LuxR-type regulator PedR interacts with Trx (thioredoxin) to achieve photosynthetic electron-transport-dependent transcriptional regulation in the cyanobacterium Synechocystis sp. PCC 6803. TrxM, an isoform of Trx, was isolated...
Includes: Supplementary data
Articles
Biochem J (2010) 430 (2): 285–293.
Published: 13 August 2010
...Anton A. Turanov; Sebastian Kehr; Stefano M. Marino; Min-Hyuk Yoo; Bradley A. Carlson; Dolph L. Hatfield; Vadim N. Gladyshev The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation. Three TRs have been...
Includes: Supplementary data
Articles
Biochem J (2010) 425 (2): 313–325.
Published: 23 December 2009
...@otago.ac.nz ). 6 10 2009 10 11 2009 13 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 hydrogen peroxide mitochondria peroxiredoxin redox signalling thiol thioredoxin Prxs (peroxiredoxins) are a family of thiol peroxidases that scavenge...
Articles
Biochem J (2010) 425 (1): 195–208.
Published: 14 December 2009
... that the previously uncharacterized PDI family member TMX4 (thioredoxin-like transmembrane 4) is an N-glycosylated type I membrane protein that localizes to the ER. We also demonstrate that TMX4 contains a single ER-luminal thioredoxin-like domain, which, in contrast with similar domains in other PDIs, is mainly...
Includes: Supplementary data
Articles
Biochem J (2009) 424 (3): 491–500.
Published: 10 December 2009
... cultured in medium with extracellular Cys/CySS redox potentials ( E h ), ranging from 0 to −150 mV. Cellular and mitochondrial ROS production significantly increased in cells incubated under more oxidizing extracellular conditions (0 and −46 mV). Trx2 (thioredoxin-2) is a mitochondrial-specific...
Articles
Biochem J (2009) 422 (3): 521–531.
Published: 27 August 2009
...Anna-Maria G. Psarra; Stefan Hermann; George Panayotou; Giannis Spyrou Trx2 (mitochondrial thioredoxin) is an antioxidant and anti-apoptotic factor essential for cell viability. Trx1 (cytoplasmic thioredoxin) is a co-factor and regulator of redox-sensitive transcription factors such as the GR...
Articles
Biochem J (2009) 419 (1): 149–158.
Published: 13 March 2009
...Yoshihito Iuchi; Futoshi Okada; Satoshi Tsunoda; Noriko Kibe; Nobuyuki Shirasawa; Masahito Ikawa; Masaru Okabe; Yoshitaka Ikeda; Junichi Fujii Prx (peroxiredoxin) is a multifunctional redox protein with thioredoxin-dependent peroxidase activity. Prx4 is present as a secretory protein in most...
Articles
Biochem J (2008) 416 (2): 271–280.
Published: 12 November 2008
... of the nucleoprotein complex unique to −156 to −203 bp after streptavidin–agarose pull-down detected the presence of the redox-active protein thioredoxin. The presence of thioredoxin-1 in a nuclear extract from oxidatively stressed ECs was demonstrated after immunoprecipitation and immunoblotting. Transfection of ECs...
Includes: Supplementary data
Articles
Biochem J (2008) 412 (1): 73–80.
Published: 25 April 2008
.... Analysis of the distribution of Tsa1 in thioredoxin system mutants revealed that the ribosome-associated form of Tsa1 is increased in mutants lacking thioredoxin reductase ( trr1 ) and thioredoxins ( trx1 trx2 ) in parallel with the general increase in total Tsa1 levels which is observed in these mutants...
Articles
Biochem J (2007) 402 (1): 43–49.
Published: 25 January 2007
...Marcelo A. Comini; R. Luise Krauth-Siegel; Leopold Flohé In trypanosomes, the thioredoxin-type protein TXN (tryparedoxin) is a multi-purpose oxidoreductase that is involved in the detoxification of hydroperoxides, the synthesis of DNA precursors and the replication of the kinetoplastid DNA. African...
Includes: Supplementary data
Articles
Biochem J (2006) 399 (3): 483–491.
Published: 13 October 2006
... competent to generate 447-52D-like antibodies, the known epitope of 447-52D was inserted at three different surface loop locations in the small, stable protein Escherichia coli Trx (thioredoxin). At one of the three locations (between residues 74 and 75), the insertion was tolerated, the resulting protein...
Articles
Biochem J (2006) 398 (2): 269–277.
Published: 15 August 2006
...Simone A. Osborne; Hye-Jin Kim Hawkes; Ben L. Baldwin; Kylie A. Alexander; Terje Svingen; Frank M. Clarke; Kathryn F. Tonissen Thioredoxin is a redox-active protein that plays multiple roles in regulating cell growth, cell signalling and apoptosis. Here, we have demonstrated that a complex...
Articles
Biochem J (2006) 394 (1): 207–216.
Published: 27 January 2006
...Wendy L. Trigona; Isis K. Mullarky; Yuzhang Cao; Lorraine M. Sordillo Certain selenoproteins such as GPX-1 (glutathione peroxidase-1) and TrxR1 (thioredoxin reductase-1) possess important antioxidant defence functions in vascular endothelial cells. Reduced selenoprotein activity during dietary...
Articles
Biochem J (2005) 389 (3): 785–795.
Published: 26 July 2005
.... At 20 μM H 2 O 2 , changes were fewer, but GAPDH and peroxiredoxin 2 were still modified. Dinitrochlorobenzene treatment, which inhibited cellular thioredoxin reductase and partially depleted GSH, caused reversible oxidation of several proteins, including thioredoxin 1 and peroxiredoxins 1 and 2. Most...
Articles
Biochem J (2004) 383 (1): 139–147.
Published: 24 September 2004
... of 16 genes coding for thioredoxin- and glutathione-dependent redox system components. Quantifications were performed to examine the response to oxidants, to sudden temperature upshifts and in association with metabolic changes accompanying culture growth and to explore the contribution of mRNA decay...
Articles
Biochem J (2003) 373 (3): 875–883.
Published: 01 August 2003
...Emilia PEDONE; Simonetta BARTOLUCCI; Mosè ROSSI; Francesco Maria PIERFEDERICI; Andrea SCIRÈ; Tiziana CACCIAMANI; Fabio TANFANI The structure of thioredoxin from Alicyclobacillus acidocaldarius (previously named Bacillus acidocaldarius ) (BacTrx) and from Escherichia coli ( E. coli Trx) was studied...
Articles
Biochem J (2003) 373 (3): 845–853.
Published: 01 August 2003
...Jae J. SONG; Yong J. LEE Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation. Glucose deprivation disrupted the interaction between TRX/GRX and ASK1 and subsequently activated the ASK1–stress...
Articles
Biochem J (2001) 354 (1): 209–215.
Published: 08 February 2001
..., for completing its enzymic cycle. 1 To whom correspondence should be addressed (e-mail shekhar@imtech.ernet.in ). 14 9 2000 7 11 2000 1 12 2000 The Biochemical Society, London © 2001 2001 decamer DTT oxidation mycothiol peroxidase thioredoxin Biochem. J. (2001) 354...
Articles
Biochem J (2000) 352 (3): 783–788.
Published: 08 December 2000
... charged residues Glu 210 -Asp-Glu 212 close to the two cysteine residues and also on the following region from Leu 213 to Ile 230 , and investigated the modulation of ATPase activity by chloroplast thioredoxins. The mutant γ subunits were reconstituted with the α and β subunits from F 1...
Articles
Biochem J (2000) 352 (2): 583–591.
Published: 24 November 2000
... family. Thioredoxin is involved in this redox control. DNA binding and transactivating capacity of NF-κB are up-regulated by inducible phosphorylation. Here we demonstrate that the conserved redox cysteine in the c-Rel protein is involved in the phosphorylation regulation of the protein. When...
Articles
Biochem J (2000) 346 (2): 305–311.
Published: 22 February 2000
...). 13 9 1999 8 11 1999 8 12 1999 The Biochemical Society, London © 2000 2000 polyprotein processing redox regulation retroviruses thioredoxin viral maturation Biochem. J. (2000) 346, 305 311 (Printed in Great Britain) 305 HIV-2 protease is inactivated after oxidation...
Articles
Biochem J (1999) 339 (1): 1–10.
Published: 25 March 1999
... or more domains of roughly 95–110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing and one domain lacking a redox-active -Cys-Xaa-Xaa-Cys- tetrapeptide. In addition to their known...