...Hubert F. Becker; Kamel Djaout; Isabelle Lamarre; Jonathan E. Ulmer; Delphine Schaming; Véronique Balland; Ursula Liebl; Hannu Myllykallio; Marten H. Vos Thymidylate synthase ThyX, required for DNA synthesis in many pathogenic bacteria, is considered a promising antimicrobial target. It binds FAD...

...Melissa A. Vargo; W. Edward Martucci; Karen S. Anderson In contrast with most species, including humans, which have monofunctional forms of the folate biosynthetic enzymes TS (thymidylate synthase) and DHFR (dihydrofolate reductase), several pathogenic protozoal parasites, including Cryptosporidium...

...Maria Marjorette O. Peña; Yang Yang Xing; Sangita Koli; Franklin G. Berger Thymidylate synthase (TS) catalyses the reductive methylation of dUMP to form dTMP, a reaction that is essential for maintenance of nucleotide pools during cell growth. Because the enzyme is indispensable for DNA replication...

...Akio Kanai; Asako Sato; Jun Imoto; Masaru Tomita Using a stem–loop RNA oligonucleotide (19-mer) containing an AUG sequence in the loop region as a probe, we screened the protein library from a hyperthermophilic archaeon, Pyrococcus furiosus , and found that a flavin-dependent thymidylate synthase...

...Stephane HAZEBROUCK; Valerie MACHTELINCKX-DELMAS; Jean-Jacques KUPIEC; Pierre SONIGO Insertional mutagenesis of the Escherichia coli thymidylate synthase (TS) was used to address substrate recognition of HIV-1 protease in a well characterized structural context. By modifying the TS conformation...