... of serum phosphate levels. It has been demonstrated previously that renal Npt2a protein and its mRNA expression are both up-regulated by the thyroid hormone T 3 (3,3′,5-tri-iodothyronine) in rats. However, it has never been established whether the induction was mediated by a direct effect of thyroid...

... neurodegeneration selenium selenocysteine selenoprotein thyroid hormone The trace element selenium (Se), originally viewed as a toxin, is now understood to be an important micronutrient [ 1 ]. Selenium is incorporated into proteins not simply though ionic association, as most metals...

... (3000 Ci/mmol) and T4 RNA ligase as described by the manufacturer (New England Biolabs), and then purified as described above. aptamer riboswitch RNA ligand thyroid hormone thyroxine (T4) tri-iodothyronine (T3) Several of the original discoveries of biological molecules binding RNA...

... status also modulate UCP3 gene expression, albeit by unknown mechanisms. We created transgenic mice bearing the entire human UCP3 gene to investigate the effect of thyroid hormones on human UCP3 gene expression. Treatment of human UCP3 transgenic mice with thyroid hormones induced the expression...

...Keiko NAKANO; Akio MATSUSHITA; Shigekazu SASAKI; Hiroko MISAWA; Kozo NISHIYAMA; Yumiko KASHIWABARA; Hirotoshi NAKAMURA The molecular mechanism involved in the liganded thyroid hormone receptor suppression of the TSHβ (thyroid-stimulating hormone β, or thyrotropin β) gene transcription...

... (IGF-1), dexamethasone, thyroid hormones and PMA was studied. HepG2 cells were transfected transiently with luciferase reporter gene constructs containing DNA fragments flanking the 5′-region of the human CYP27A1 gene. GH, IGF-1 and dexamethasone increased the promoter activity by 2–3-fold, whereas...

...Xia CAO; Fukushi KAMBE; Takashi MIYAZAKI; Devanand SARKAR; Sachiko OHMORI; Hisao SEO We identified a thyroid hormone [3,5,3′-tri-iodothyronine (T 3 )]-responsive gene, ZAKI-4, in cultured human skin fibroblasts. It belongs to a family of genes that encode proteins containing a conserved motif...

...-fold ( P < 0.025) increase in mitochondrial monolysocardiolipin acyltransferase activity. The results demonstrate that the acylation of cardiac monolysocardiolipin is regulated by thyroid hormone. Thus an elevation in cardiolipin biosynthesis is accompanied by an elevation in monolysocardiolipin...