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Keywords: topoisomerase poison
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An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3′-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme

Amit Roy, Benu Brata Das, Agneyo Ganguly, Somdeb Bose Dasgupta, Neeta V. M. Khalkho, Churala Pal, Sumit Dey, Venkatachalam Sesha Giri, Parasuraman Jaisankar, Sanjit Dey, Hemanta K. Majumder
Journal: Biochemical Journal
Biochem J (2008) 409 (2): 611–622.
https://doi.org/10.1042/BJ20071286
Published: 21 December 2007
... donovani reconstitution topoisomerase I topoisomerase poison DNA topoisomerases are a family of DNA-processing enzymes that catalyse the breakage and rejoining of DNA strands to govern the topological changes in DNA molecules [ 1 ]. These ubiquitous enzymes play a pivotal role in modulating...
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Includes: Supplementary data
Articles

Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I

Arnab Roy CHOWDHURY, Shalini SHARMA, Suparna MANDAL, Anindya GOSWAMI, Sibabrata MUKHOPADHYAY, Hemanta K. MAJUMDER
Journal: Biochemical Journal
Biochem J (2002) 366 (2): 653–661.
https://doi.org/10.1042/bj20020098
Published: 01 September 2002
... be addressed (e-mail [email protected] ). 13 1 2002 23 4 2002 23 5 2002 23 5 2002 The Biochemical Society, London ©2002 2002 cleavable complex DNA intercalator inhibitor topoisomerase poison Abbreviations used: CT, calf thymus; DTT, dithiothreitol; EMSA...
View article titled, Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I
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