...Jiawen Yang; Yilin Hou; Qing Li; Yu Li The bi-directional selective low toxicity/high flame retardancy organophosphorus fire retardants (OPFRs) derivatives were designed by a comprehensive effect 3D quantitative structure-activity relationship (QSAR) pharmacophore model, and the toxicity and flame...

... than the native A β 1–42 oligomers but with a significantly reduced cross- β signature. These off-pathway oligomers exhibited low immunoreactivity against oligomer-specific (A11) and fibril-specific (OC) antibodies and rescued neuronal cells from A β 1–42 oligomer toxicity as well as neuronal apoptosis...

... death both in vitro and in vivo . These results suggest that FE65 facilitates the accumulation of mutant Htt in cells by preventing its degradation via the UPS, and thereby enhances the toxicity of mutant Htt. 1 To whom correspondence should be addressed (email [email protected] ). 15 12...

... affecting cadmium content in the cell. Likewise, Arabidopsis transgenic plants overexpressing AtNRAMP6 were hypersensitive to cadmium, although plant cadmium content remained unchanged. Consistently, a null allele of AtNRAMP6 , named nramp6-1 , was more tolerant to cadmium toxicity, a phenotype...

...Mei YANG; Laran T. JENSEN; Allison J. GARDNER; Valeria C. CULOTTA Manganese is an essential, but potentially toxic, trace metal in biological systems. Overexposure to manganese is known to cause neurological deficits in humans, but the pathways that lead to manganese toxicity are largely unknown...

... mutagenesis oxidation sulphatase toxicity UV vanadate At least six lysosomal storage diseases are caused by deficiencies in a related family of mammalian sulphatase enzymes. ERT (enzyme-replacement therapy) provides a means of treating these disorders [ 1 ], but this approach presupposes...

... substituent. These characteristics enable us to predict whether or not a given carbonyl compound will induce the alc genes. activation of transcription aldehydes catabolism methyl ketones toxicity Abbreviations used: ADH, alcohol dehydrogenase; ALDH, aldehyde dehydrogenase. Biochem. J...

... shorter stubbier fibrils. Aged fibrillar preparations of E22Q Aβ are more potent than aged fibrils of native Aβ in inducing apoptotic changes and toxic responses in human neuroblastoma cell lines, whereas low-molecular-mass oligomers in briefly incubated solutions are much less potent. The differences...